Philadelphia chromosome-positive (Ph+) childhood acute lymphoblastic leukemia: Good initial steroid response allows early prediction of a favorable treatment outcome

Blood

Volumn 92, Issue 8, 1998, Pages 2730-2741

  Schrappe, Martin ^a   Aricò, Maurizio ^b   Harbott, Jochen ^b   Biondi, Andrea ^b   Zimmermann, Martin ^b   Conter, Valentine ^b   Reiter, Alfred ^b   Valsecchi, Maria G ^b   Gadner, Helmut ^b   Basso, Giuseppe ^b   Bartram, Claus R ^b   Lampert, Fritz ^a   Riehm, Hansjörg ^b   Masera, Giuseppe ^b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ASPARAGINASE; CYTARABINE; DAUNORUBICIN; DEXAMETHASONE; ETOPOSIDE; GRANULOCYTE COLONY STIMULATING FACTOR; IFOSFAMIDE; MERCAPTOPURINE; METHOTREXATE; PREDNISONE; STEROID; TIOGUANINE; VINCRISTINE; VINDESINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; CANCER CHEMOTHERAPY; CANCER SURVIVAL; CHILD; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; INTRATHECAL DRUG ADMINISTRATION; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PHILADELPHIA 1 CHROMOSOME; PREDICTION; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; TREATMENT OUTCOME;

ADOLESCENT; ANTINEOPLASTIC AGENTS, HORMONAL; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHILD; CHILD, PRESCHOOL; CLINICAL TRIALS; COHORT STUDIES; DISEASE-FREE SURVIVAL; DRUG RESISTANCE, NEOPLASM; EUROPE; FEMALE; HUMANS; INFANT; LEUKEMIA, LYMPHOCYTIC, ACUTE, L2; MALE; MULTICENTER STUDIES; PHILADELPHIA CHROMOSOME; PREDNISONE; PROGNOSIS; REGRESSION ANALYSIS; REMISSION INDUCTION; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 0032532289     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Reiter A, Schrappe M. Ludwig W-D, Hiddemann W, Sauter S, Henze G. Zimmermann M, Lampert F, Havers W, Niethammer D, Odenwald E, Ritter J, Mann G, Welte K, Gadner H, Riehm H: Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALL-BFM 86. Blood 84:3122, 1994
2. Pui C-H, Crist WM, Look AT: Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia. Blood 76:1449, 1990
3. Ribeiro RC, Abromowitch M, Raimondi SC, Murphy SB, Behm F, Williams DL: Clinical and biologic hallmarks of the Philadelphia chromosome in childhood acute lymphoblastic leukemia. Blood 70: 948, 1987
4. Fletcher JA, Lynch EA, Kimball VM, Donnelly M, Tantravahi R, Sallan SE: Translocation (9;22) is associated with extremely poor prognosis in intensively treated children with acute lymphoblastic leukemia. Blood 77:435, 1991
5. Crist W. Carroll A, Shuster J, Jackson J, Head D, Borowitz M, Behm F, Link M, Steuber P, Ragab A, Hirt A, Brock B, Land V, Pullen J: Philadelphia chromosome positive childhood acute lymphoblastic leukemia: Clinical and cytogenetic characteristics and treatment outcome. A Pediatric Oncology Group study. Blood 76:489, 1990
6. Chessells JM, Bailey C, Richards SM: Intensification of treatment and survival in all children with lymphoblastic leukaemia: Results of UK Medical Research Council trial UKALLX. Lancet 345:143, 1995
7. Kantarjian HM, Talpaz M, Dhingra K, Estey E, Keating MJ, Ku S, Trujillo J, Huh Y, Stass S, Kurzrock R: Significance of the P210 versus P190 molecular abnormalities in adults with Philadelphia chromosome-positive acute leukemia. Blood 78:2411, 1991
8. Maurer J, Janssen JWG, Thiel E, van Denderen J, Ludwig W-D, Aydemir Ü, Heinze B. Fonatsch C, Harbott J, Reiter A, Riehm H, Hoelser D, Bartram CR: Detection of chimeric BCR/ABL genes in acute lymphoblastic leukaemia by the polymerase chain reaction. Lancet 337:1055, 1991
9. Dewald GW, Schad CR, Christensen ER. Tiede AL, Zinsmeister AR, Spurbeck JL, Thibodeau SN, Jalal SM: The application of fluorescent in situ hybridization to detect Mbcr/abl fusion in variant Ph chromosomes in CML and ALL. Cancer Genet Cytogent 71:7, 1993
10. Schlieben S, Borkhardt A, Reinisch I, Ritterbach J, Janssen JWG, Ratei R, Schrappe M, Repp R, Zimmermann M, Kabisch H, Janka-Schaub G, Bartram CR, Ludwig W-D, Riehm H, Lampert F, Harbott J: Incidence and clinical outcome of children with BCR/ABL-positive acute lymphoblastic leukemia (ALL). A prospective RT-PCR study based on 673 patients enrolled in the German pédiatric multicenter therapy trials ALL-BFM 90 and CoALL-05-92. Leukemia 10:957, 1996
11. Riehm H, Reiter A, Schrappe M, Berthold F, Dopfer R, Gerein H, Ludwig R, Ritter J, Stollmann B, Henze G: Die Corticosteroidabhängige Dezimierung der Leukämiezellzahl im Blut als Prognosefaktor bei der akuten lymphoblastischen Leukämie im Kindesalter (Therapiestudie ALL-BFM 83) [The in vivo response on corticesteroid therapy as an additional prognostic factor in childhood acute lymphoblastic leukemia (therapy study ALL-BFM 83)]. Klin Pädiatr 199:151, 1987
12. Schrappe M, Reiter A. Welte K, Ludwig W-D, Harbott J, Lampert F, Henze G, Riehm H: Risk adapted treatment in childhood acute lymphoblastic leukemia: Data from the Berlin-Frankfurt-Münster group, in Büchner T, Hiddemann W, Wörmann B, Schellong G, Ritter J, Creutzig U (eds): Haematology and Blood Transfusion: Acute Leukemias: Prognostic Factors and Treatment Strategies. Berlin, Germany, York, Springer, 1997, p 601
13. Arico M, Basso G, Mandelli F, Rizzari C, Colella R, Barisone E, Zanesco L, Rondelli R, Pession A, Masera G: Good steroid response in vivo predicts a fovorable outcome in children with T-cell acute lymphoblastic leukemia. Cancer 75:1684, 1995
14. Gaynon PS, Bleyer WA, Steinherz PG, Finklestein JZ, Littman P, Miller DR, Reaman G, Sather H, Hammond GD: Day 7 marrow response and outcome for children with acute lymphoblastic leukemia and unfavorable presenting features. Med Pediatr Oncol 18:273, 1990
15. Steinherz PG, Gaynon PS, Breneman JC, Cherlow JM, Grossman NJ, Kersey JH, Johnstone HS, Sather HN, Trigg ME, Chappell R, Hammond D, Bleyer WA: Cytoreduction and prognosis in acute lymphoblastic leukemia - the importance of early marrow response: Report from the Childrens Cancer Group. J Clin Oncol 14:389, 1996
16. Gajjar A, Ribeiro R, Hancock ML, Rivera GK, Mahmoud H, Sandlund JT, Crist WM. Pui CH: Persistence of circulating blasts after 1 week of multiagent chemotherapy confers a poor prognosis in childhood acute lymphoblastic leukemia. Blood 86:1292, 1995
17. Pieters R, Huismans DR, Loonen AH. Hählen K, van der Does van den Berg A, van Wering ER, Veerman AJP: Relation of cellular drug resistance to long-term clinical outcome in childhood acute lymphoblastic leukaemia. Lancet 338:399, 1991
18. Roberts WM. Rivera GK, Raimondi SC, Santana VM, Sandlund JT, Crist WM, Pui C-H: Intensive chemotherapy for Philadelphiachromosome-positive acute lymphoblastic leukaemia. Lancet 343:331, 1994
19. Barren AJ, Horowitz MM, Ash RC, Atkinson K, Gale RP, Goldman JM, Henslee-Downey PJ, Herzig RH, Speck B, Zwaan FE, Bortin MM: Bone marrow transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood 79:3067, 1992
20. Ribeiro RC, Broniscer A, Rivera GK, Hancock ML, Raimondi SC, Sandlund JT, Crist W, Evans WE, Pui C-H: Philadelphia chromosome-positive acute lymphoblastic leukemia in children: durable responses to chemotherapy associated with low initial white blood cell counts. Leukemia 11:1493, 1997
21. Schrappe M, Reiter A, Sauter S, Ludwig W-D, Wörmann B, Harbott J. Bender-Götze C, Dörffel W, Dopfer R, Frey E, Havers W, Henze G, Kühl J, Richter R, Ritter J, Treuner J, Zintl F, Odenwald E, Weite K, Riehm H: Konzeption und Zwischenergebnis der Therapiestudie ALL-BFM 90 zur Behandlung der akuten lymphoblastischen Leukämie bei Kindern und Jugendlichen: Die Bedeutung des initialen Therapieansprechens in Blut und Knochenmark [Concept and interim result of the ALL-BFM 90 therapy study in treatment of acute lymphoblastic leukemia in children and adolescents: The significance of initial therapy response in blood and bone marrow]. Klin Padiatr 206:208, 1994
22. Conter V, Arico M, Valsecchi MG, Rizzari C, Testi AM, Messina C, Mori PG, Miniero R, Colella R, Basso G, Rondelli R, Pession A, Masera G: Extended intrathecal methotrexate may replace cranial irradiation for prevention of CNS relapse in children with intermediate-risk acute lymphoblastic leukemia treated with Berlin-Frankfurt-Munster-based intensive chemotherapy. The Associazione Italiana di Ematologia ed Oncologia Pediatrica. J Clin Oncol 13:2497, 1995
23. Conter V, Schrappe M, Arico M, Reiter A, Rizzari C, Dördel-mann M, Valsecchi MG, Zimmermann M, Ludwig W-D, Basso G, Masera G, Riehm H: Role of cranial radiotherapy for childhood T-cell acute lymphoblastic leukemia with high WBC count and good response to prednisone.J Clin Oncol 15:2786, 1997
24. Bennett JM, Catovski D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C: Proposals for the classification of the acute leukaemias. French-American-British (FAB) cooperative group. Br J Haematol 33:451, 1976
25. Harbott J, Ritterbach J, Ludwig W-D, Bartram CR, Reiter A, Lampert F: Clinical significance of cytogenetic studies in childhood acute lymphoblastic leukemia: Experience of the BFM trials. Recent Results Cancer Res 131:123, 1993
26. European Group for the Immunolgical Characterisation of Leukaemias (EGIL), Bene MC, Castoldi G, Knapp W, Ludwig WD, Matutes E, Orfao A, van't Veer MB: Proposals for the immunological classification of acute leukaemias. Leukemia 9:1783, 1995
27. van der Does van den Berg A, Bartram CR, Basso G, Benoit YC, Biondi A, Debatin KM, Haas OA, Harbott J, Kamps WA, Koller U, Lampert F, Ludwig W-D, Niemeyer CM, van Wering ER: Minimal requirements for the diagnosis, classification, and evaluation of the treatment of childhood acute lymphoblastic leukemia (ALL) in the "BFM Family" Cooperative Group, Med Pediatr Oncol 20:497, 1992
28. Langermann H-J, Henze G, Wulf M, Riehm H: Abschätzung der Tumorzellmasse bei der akuten lymphoblastischen Leukämie im Kinde- salter: Prognostische Bedeutung und praktische Anwendung. Klin Pädiatr 194:209, 1982
29. Buhrer C, Hartmann R, Fengler R, Rath B, Schrappe M, Janka-Schaub G, Henze G: Peripheral blast counts at diagnosis of late isolated bone marrow relapse of childhood acute lymphoblastic leukemia predict response to salvage chemotherapy and outcome. J Clin Oncol 14:2812, 1996
30. Welte K, Reiter A, Mempel K, Pfetsch M, Schwab G, Schrappe M, Riehm H: A randomized phase-III study of the efficacy of granulocyte colony-stimulating factor in children with high-risk acute lymphoblastic leukemia. Berlin-Frankfurt-Munster Study Group. Blood 87:3143, 1996
31. Mantel N: Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 50:163, 1966
32. Goldmann AI: The cure model and time confounded risk in the analysis of survival and other timed events. J Clin Epidemiol 44:1327, 1991
33. Cox DR: Regression models and life tables. J R Stat Soc 34:187, 1972
34. Stram DO, Sather H, Wang L: Analysis of time to death after transplantation when transplants are only given to patients in remission. Biometrics 52:1079, 1996
35. Pui C-H, Behm FG, Crist WM: Clinical and biologic relevance of immunologic marker studies in childhood acute lymphoblastic leukemia. Blood 82:343, 1993
36. Azuma E, Umemoto M, Kubo M, Ohta Y, Zhang SL, Komada Y, Ito M, Sakurai M: CD34 antigen expression in children with Philadelphia chromosome-positive acute lymphoblastic leukemia. Cancer 67: 1565, 1991
37. Russo C, Carroll A, Kohler S, Borowitz M, Amylon M, Homans A, Kedar A, Shuster J, Land V, Crist W, Pullen J, Link M: Philadelphia chromosome and monosomy 7 in childhood acute lymphoblastic leukemia: A Pediatric Oncology Group study. Blood 77:1050, 1991
38. Sierra J, Radlich J, Hansen JA, Martin PJ, Petersdorf EW, Bjerke J, Bryant E, Nash RA, Sanders JE, Storb R, Sullivan KM, Appelbaum FR, Anasetti C: Marrow transplants from unrelated donors for treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood 90:1410, 1997