Expression of selectin-binding epitopes and cytokines by CD4+ T cells repopulating scid mice with colitis

European Journal of Immunology

Volumn 28, Issue 6, 1998, Pages 1785-1797

  Thoma, Stefan ^a   Bonhagen, Kerstin ^a   Vestweber, Dietmar ^b   Hamann, Alf ^c   Reimann, Jörg ^a  

^a UNIVERSITY OF ULM   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c UNIVERSITY OF HAMBURG   (Germany)

Author keywords

CD4+ T cell; Endothelial selectin; Mucosa immunity; Murine inflammatory bowel disease; Scid mouse

Indexed keywords

CD4 ANTIGEN; CYTOKINE; EPITOPE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; SELECTIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLITIS; CONTROLLED STUDY; ENDOTHELIUM; IMMUNOCOMPETENCE; LAMINA PROPRIA; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; T LYMPHOCYTE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; COLITIS; CYTOKINES; ENDOTHELIUM, LYMPHATIC; EPITOPES, T-LYMPHOCYTE; FEMALE; IMMUNOLOGIC MEMORY; INTERFERON TYPE II; LIGANDS; LYMPHOCYTE ACTIVATION; LYMPHOID TISSUE; MALE; MICE; MICE, INBRED BALB C; MICE, SCID; P-SELECTIN; TH1 CELLS; TH2 CELLS; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 0031842726     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199806)28:06<1785::AID-IMMU1785>3.0.CO;2-Y     Document Type: Article

References (52)

1. Podolsky, D. K., Inflammatory bowel disease. N. Engl. J. Med. 1991. 325: 928-937.
2. Strober, W. and Ehrhardt, R. O., Chronic intestinal inflammation: an unexpected outcome in cytokine or T cell receptor mutant mice. Cell 1993. 75: 203-205.
3. Conner, E. M., Aiko, S. and Grisham, M., Genetically engineered models of inflammatory bowel disease. Curr. Opin. Gastroenterol. 1994. 10: 358-364.
4. Powrie, F., T cells in inflammatory bowel disease: protective and pathogenic roles. Immunity 1995. 3: 171-174.
5. Reimann, J., Rudolphi, A. and Claesson, M. H., Novel experimental approaches in the study of the immunopathology in inflammatory bowel disease. J. Mol. Med. 1995. 73: 133-140.
6. lo T cells. Res. Immunol. 1994. 145: 357-362.
7. + T cells are important for the balance between protective and pathogenic cell-mediated immunity. J. Exp. Med. 1994. 179: 589-600.
8. Ma, A., Datta, M., Margosian, E., Chen, J. and Horak, I., T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice. J. Exp. Med. 1995. 182: 1567-1572.
9. + T cells are responsible for murine interleukin-2-deficient colitis. Eur. J. Immunol. 1995. 25: 2618-2625.
10. + TH1-like responses. J. Clin. Invest. 1996. 98: 1010-1020.
11. Neurath, M. F., Fuss, I., Kelsall, B. L., Presky, D. H., Waegell, W. and Strober, W., Experimental granulomatous colitis in mice is abrogated by induction of TGF-β-mediated oral tolerance. J. Exp. Med. 1996. 183: 2605-2616.
12. Ehrhardt, R. O., Ludviksson, B. R., Gray, B., Neurath, M. F. and Strober, W., Induction and prevention of colonic inflammation in IL-2-deficient mice. J. Immunol. 1997. 158: 566-573.
13. + T cells and proinflammatory Th1-type cytokines. J. Immunol. 1997. 158: 1068-1077.
14. Wagner, N., Lohler, J., Kunkel, E. J., Ley, K., Leung, E., Krissansen, G., Rajewsky, K. and Müller, W., Critical role for β7 integrins in formation of the gut-associated lymphoid tissue. Nature 1996. 382: 366-370.
15. + T cell population in severe-combined immunodeficient mice expressing a rearranged, transgenic class I-restricted αβ T cell receptor. Eur. J. Immunol. 1995. 25: 1643-1653.
16. + αβ T cells in the colonic lamina propria of seid mice with colitis. Eur. J. Immunol. 1996. 26: 1156-1163.
17. + αβ T cells in SCID mice with colitis. Eur. J. Immunol. 1996. 26: 3074-3083.
18. + T cells in the pathogenesis of murine inflammatory bowel disease. Eur. J. Immunol. 1994. 24: 2803-2812.
19. Weller, A., Isenmann, S. and Vestweber, D., Cloning of the mouse endothelial selectins. Expression of both E-and P-selectin is inducible by tumor necrosis factor α. J. Biol. Chem. 1992. 267: 15176-15183.
20. Gotsch, U., Jager, U., Dominis, M. and Vestweber, D., Expression of P-selectin on endothelial cells is upregulated by LPS and TNFα in vivo. Cell Adhes. Commun. 1994. 2: 7-14.
21. McEver, R. P., Regulation of expression of E-selectin and P-selectin. In Vestweber, D. (Ed.), The selectins: initiators of leukocyte endothelial adhesion, Harwood Academic Publishers, Amsterdam 1997, p. 31-47.
22. Mayadas, T. N., Johnson, R. C., Rayburn, H., Hynes, R. O. and Wagner, D. D., Lekocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell 1993. 74: 541-554.
23. Bosse, R. and Vestweber, D., Only simultaneous blocking of the L-and P-selectin completely inhibits neutrophil migration into mouse peritoneum. Eur. J. Immunol. 1994. 24: 3019-3024.
24. Labow, M. A., Norton, C. R., Rumberger, J. M., Lombard, G. K., Shuster, D. J., Hubbard, J., Bertko, R., Knaack, P. A., Terry, R. W. and Harbison, M. L., Characterization of E-selectin-deficient mice: demonstration of overlapping function of the endothelial selectins. Immunity 1994. 1: 709-720.
25. Frenette, P. S., Mayadas, T. N., Rayburn, H., Hynes, R. O. and Wagner, D. D., Susceptibility to infection and altered hematopoiesis in mice deficient in both P-and E-selectins. Cell 1996. 84: 563-574.
26. Austrup, F., Vestweber, D., Borges, E., Lohning, M., Brauer, R., Herz, U., Renz, H., Hallmann, R., Scheffold, A., Radbruch, A. and Hamann, A., P-and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues. Nature 1997. 385: 81-83.
27. Bullard, D. C. and Beaudet, A. L., Analysis of selectin-deficient mice. In Vestweber, D. (Ed.), The selectins: initiators of leukocyte endothelial adhesion, Harwood Academic Publishers, Amsterdam 1997, p. 133-142.
28. Yamada, S., Mayadas, T. N., Yuan, F., Wagner, D. D., Hynes, R. O., Melder, R. J. and Jain, R. K., Rolling in P-selectin-deficient mice is reduced but not eliminated in the dorsal skin. Blood 1995. 86: 3487-3492.
29. Staite, N. D., Justen, J. M., Sly, L. M., Beaudet, A. L. and Bullard, D. C., Inhibition of delayed-type contact hypersensitivity in mice deficient in both E-selectin and P-selectin. Blood 1996. 88: 2973-2979.
30. Tipping, P. G., Huang, X. R., Berndt, M. C. and Holdsworth, S. R., P-selectin directs T lymphocyte-mediated injury in delayed-type hypersensitivity responses: studies in glomerulonephritis and cutaneous delayed-type hypersensitivity. Eur. J. Immunol. 1996. 26: 454-460.
31. Kanwar, S., Bullard, D. C., Hickey, M. J., Smith, C. W., Beaudet, A. L., Wolitzky, B. A. and Kubes, P., The association between α4-integrin, P-selectin, and E-selectin in an allergic model of inflammation. J. Exp. Med. 1997. 185: 1077-1087.
32. Tang, T., Frenette, P. S., Hynes, R. O., Wagner, D. D. and Mayadas, T. N., Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins. J. Clin. Invest. 1996. 97: 2485-2490.
33. Bullard, D. C., Kunkel, E. J., Kubo, H., Hicks, M. J., Lorenzo, I., Doyle, N. A., Doerschuk, C. M., Ley, K. and Beaudet, A. L., Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice. J. Exp. Med. 1996. 183: 2329-2336.
34. Moore, K. L., Stults, N. L., Diaz, S., Smith, D. F., Cummings, R. D., Varki, A. and McEver, R. P., Identification of a specific glycoprotein ligand for P-selectin (CD62) on myeloid cells. J. Cell Biol. 1992. 118: 445-456.
35. Sako, D., Chang, X. J., Barone, K. M., Vachino, G., White, H. M., Shaw, G., Veldman, G. M., Bean, K. M., Ahern, T. J. and Furie, B., Expression cloning of a functional glycoprotein ligand for P-selectin. Cell 1993. 75: 1179-1186.
36. Moore, K. L., Patel, K. D., Bruehl, R. E., Li, F., Johnson, D. A., Lichenstein, H. S., Cummings, R. D., Bainton, D. F. and McEver, R. P., P-selectin glycoprotein ligand-1 mediates rolling of human neutrophils on P-selectin. J. Cell Biol. 1995. 128: 661-671.
37. Pouyani, T. and Seed, B., PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus. Cell 1995. 83: 333-343.
38. Sako, D., Comess, K. M., Barone, K. M., Camphausen, R. T., Cumming, D. A. and Shaw, G. D., A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding. Cell 1995. 83: 323-331.
39. Li, F., Wilkins, P. P., Crawley, S., Weinstein, J., Cummings, R. D. and McEver, R.P., Posttranslational modifications of recombinant P-selectin glycoprotein ligand-1 required for binding to P-and E-selectin. J. Biol. Chem. 1996. 271: 3255-3264.
40. Laszik, Z., Jansen, P. J., Cummings, R. D., Tedder, T. F., McEver, R. P. and Moore, K. L., P-selectin glycoprotein ligand-1 is broadly expressed in cells of myeloid, lymphoid, and dendritic lineage and in some nonhematopoietic cells. Blood 1996. 88: 3010-3021.
41. Borges, E., Eytner, R., Moll, T., Steegmaier, M., Campbell, M. A., Ley, K., Mossmann, H. and Vestweber, D., The P-selectin glycoprotein ligand-1 is important for recruitment of neutrophils into inflamed mouse peritoneum. Blood 1997. 90: 1934-1942.
42. Borges, E., Tietz, W., Steegmaier, M., Moll, T., Hallmann, R., Hamann, A. and Vestweber, D., P-selectin glycoprotein ligand-1 (PSGL-1) on T helper 1 but not on T helper 2 cells binds to P-selectin and supports migration into inflamed skin. J. Exp. Med. 1997. 185: 573-578.
43. Dorshkind, K., Pollack, S. B., Bosma, M. J. and Phillips, R. A., Natural killer (NK) cells are present in mice with severe combined immunodeficiency (scid). J. Immunol. 1985. 134: 3798-3801.
44. Bancroft, G. J., Schreiber, R. D. and Unanue, E. R., Natural immunity: a T-cell-independent pathway of macrophage activation, defined in the scid mouse. Immunol. Rev. 1991. 124: 5-23.
45. + T lymphocytes injected into seid mice lead to an inflammatory and lethal bowel disease. Clin. Immunol. Immunopathol. 1996. 104: 491-498.
46. Breese, E. J., Michie, C. A., Nicholls, S. W., Murch, S. H., Williams, C. B., Domizio, P., Walker Smith, J. A. and MacDonald, T. T., Tumor necrosis factor α-producing cells in the intestinal mucosa of children with inflammatory bowel disease. Gastroenterology 1994. 106: 1455-1466.
47. Murch, S. H., Braegger, C. P., Walker Smith, J. A. and MacDonald, T. T., Distribution and density of TNF immunoreactivity in chronic inflammatory bowel disease. Adv. Exp. Med. Biol. 1995. 371B: 1327-1330.
48. Neurath, M. F., Fuss, I., Pasparakis, M., Alexopoulou, L., Haralambous, S., Meyer zum Büschenfelde, K.-H., Strober, W. and Kollias, G., Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice. Eur. J. Immunol. 1997. 27: 1743-1750.
49. Picker, L. J., Control of lymphocyte homing. Curr. Opin. Immunol. 1994. 6: 394-406.
50. Walter, U. M. and Issekutz, A. C., Role of E-and P-selectin in migration of monocytes and polymorphonuclear leucocytes to cytokine and chemoattractant-induced cutaneous inflammation in the rat. Immnology 1997. 92: 290-299.
51. Harriman, G. R., Hörnqvist, E. and Lycke, N. Y., Antigen-specific and polyclonal CD4+ lamina propria T-cell lines: phenotypic and functional characterization. Immunology 1992. 75: 66-73.
52. Ladel, C. H., Flesch, I. E., Arnoldi, J. and Kaufmann, S. H., Studies with MHC-deficient knockout mice reveal impact of both MHC I-and MHC II-dependent T cell responses on Listeria monocytogenes infection. J. Immunol. 1994. 153: 3116-3122.