A synthetic mimetic of CD4 is able to suppress disease in a rodent model of immune colitis

European Journal of Immunology

Volumn 29, Issue 1, 1999, Pages 355-366

  Okamoto, Susumu ^a   Watanabe, Mamoru ^a   Yamazaki, Motomi ^a   Yajima, Tomoharu ^a   Hayashi, Tatsuhiko ^a   Ishii, Hiromasa ^a   Mukai, Makio ^a   Yamada, Takaya ^b   Watanabe, Noriaki ^b   Jameson, Bradford A ^d   Hibi, Toshifumi ^a,c  

^a KEIO UNIVERSITY   (Japan)

^b KITASATO INSTITUTE HOSPITAL   (Japan)

^c Keio Caner Center   (Japan)

^d Keio Cancer Center ^*

Author keywords

CD4; Crohn's disease; Experimental colitis; Th1 cell

Indexed keywords

CD4 ANTIGEN; CD45 ANTIGEN; GAMMA INTERFERON; MESSENGER RNA; TRINITROBENZENESULFONIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; COLITIS; COLON MUCOSA; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; DIARRHEA; FEMALE; IMMUNIZATION; IMMUNOPATHOLOGY; INTRAVENOUS DRUG ADMINISTRATION; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; WASTING SYNDROME;

ANIMALS; ANTIGENS, CD4; BASE SEQUENCE; CD4-POSITIVE T-LYMPHOCYTES; CROHN DISEASE; CYTOKINES; DISEASE MODELS, ANIMAL; DNA PRIMERS; FEMALE; GENE EXPRESSION; HUMANS; IMMUNITY, MUCOSAL; IMMUNOSUPPRESSIVE AGENTS; INTESTINAL MUCOSA; MICE; MICE, INBRED BALB C; OLIGOPEPTIDES; RNA, MESSENGER; SERUM ALBUMIN, BOVINE;

EID: 0032921746     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199901)29:01<355::AID-IMMU355>3.0.CO;2-G     Document Type: Article

References (32)

1. Oritz-Oritz, L. and Weigle, W. O., Cellular events in the induction of experimental allergic encephalomyelitis in rats. J. Exp. Med. 1976. 144: 604-416.
2. Mokhtarian, F., McFarlin, D. E. and Raine, C. S., Adoptive transfer of myelin basic protein sensitized T cells produce chronic relapsing demyelinating disease in mice. Nature 1984. 309: 356-358.
3. O'Neil, J. K., Baker, D., Davison, A. N., Allen, S. J., Butter, C., Waldmann, H. and Turk, J. L., Control of immune-mediated disease of the central nervous system with monoclonal (CD4-specific) antibodies. J. Neuroimmunol. 1993. 45: 1-14.
4. Spiram, S. and Roberts, C. A., Treatment of established chronic relapsing experimental allergic encephalomyelitis with anti-L3T4 antibodies. J. Immunol. 1986. 136: 4464-4469.
5. Steinman, L., The use of monoclonal antibodies for treatment of autoimmune disease. J. Clin. Immunol. 1990. 10: 30-39.
6. Jameson, B. A., McDonnell, J. M., Marini, J. C. and Korngold, R., A rationally designed CD4 Analogue inhibits experimental allergic encephalomyelitis. Nature 1994. 368: 744: 746.
7. Watanabe, M., Hayashi, A., Hosoda, Y., Ohara, M., Iwao, Y., Ishii, H., Ishikawa, H., Nanno, M. and Hibi, T., Preferential activation of CD4+ Vβ5.2/5.3+ intestinal intraepithelial lymphocytes in the inflamed lesions of Crohn's disease. Clin. Immunol. Immunopathol. 1996. 78: 130-139.
8. Watanabe, M., Takaishi, H., Hosoda, Y., Ezaki, T., Yajima, T., Inoue, N., Ueno, Y., Iwao, Y., Ishii, H., Ishikawa, H. and Hibi, T., CD4+ intestinal mucosal lymphocytes in the pathogenesis of Crohn's disease. J. Gastroenterol. 1995. 30: 73-75.
9. Morris, G. P., Beck, P. L., Herridge, M. S., Depew, W. T., Szewczuk, M. R. and Wallage, J. L., Hapten-induced model of chronic inflammation and ulceration in the rat colon. Gastroenterology 1989. 96: 795-803.
10. Elson, C. O., Beagley, K. W., Sharmanov, A. T., Fujihashi, K., Kiyono, H., Tennyson, G. S., Cong, Y., Black, C. A., Ridwan, B. W. and McGhee, J. R., Hapten-induced model of murine inflammatory bowel disease. J. Immunol. 1996. 157: 2174-2185.
11. Neurath, M. F., Fuss, I., Kelsall, B. L., Stuber, E. and Strober, W., Antibodies to interleukin 12 abrogate established experimental colitis in mice. J. Exp. Med. 1995. 182: 1281-1290.
12. Stumbles, P. and Mason, D., Activation of CD4 T cells in the presence of a nondepleting monoclonal antibody to CD4 induces a Th2-type response in vitro. J. Exp. Med. 1995. 182: 5-13.
13. Stronkhorst, A., Tytgat, G. N. J. and Van Deventer S. J. H., CD4 antibody treatment in Crohn's Disease. Gastroeterology 1992. 27: 194: 61-65.
14. Rice, J. D. and Bucy R. P., Differences in the degree of depletion, rate of recovery, and the preferential elimination of native CD4+ T cells by ant-CD4 monoclonal antibody (GK1.5) in young and aged mice. J. Immunol. 1995. 154: 6644-6654.
15. Chase, J. H., Cowdery, J. S. and Field, E. H., Effect of anti-CD4 on CD4 subsets. J. Immunol. 1994. 152: 405-412.
16. McDonnel, J. M., Blank, K. J., Rao, P. E. and Jameson, B. A., Direct involvement of the CDR3-like domain of CD4 in T helper cell activation. J. Immunol. 1992. 149: 1626-1630.
17. Marini, J. C., Jameson, B. A., Lublin, F. D. and Korngold, R., A CD4-CDR3 peptide analogue inhibits both primary and secondary autoreactive CD4+ T cell responses in experimental allergic encephalomyelitis. J. Immunol. 1996. 157: 3706-3715.
18. Podolsky, D. K., Inflammatory bowel disease. N. Engl. J. Med. 1991. 325: 928-937.
19. Haggitt, R. C., Granulamatous diseases of the gastrointestinal tract. In Joachim, H. L. (Ed.) Pathology of granulomas. Raven Press, New York 1983, pp 257-305.
20. Renno, T., Zeine, R., Girard, J. M., Gillani, S., Dodelet, V. and Owens, T., Selective enrichment of Th1 CD45RBIo CD4+ T cells in autoimmune infiltrates in experiment allergic encephalomyelitis. Int. Immunol. 1994. 6: 347-354.
21. Lee, W. T., Yin, X. M. and Vietta, E. S., Functional and 1ogenetic analysis of murine CD45Rhi and CD45RIo CD4+ T cells. J. Immunol. 1990. 144: 3288-3295.
22. Bradley, L. M., Croft, M. and Swain, S. L., T-cell memory: new perspectives. Immunol. Today 1993. 14: 197-199.
23. Powrie, F., Leach, M. W., Mauze, S., Caddle, L. B. and Coffman, R. L., Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int. Immunol. 1993. 5: 1461-1470.
24. Aranda, R., Sydora, B. C., McAllister, P. L., Binder, S. W., Yang, H. Y., Targan, S. R. and Kronenberg, M., Analysis of intestinal lymphocytes in mouse colitis mediated by transfer of CD45RBhigh T cells to SCID recipients. J. Immunol. 1997. 158: 3464-3473.
25. Watanabe, M., Ueno, Y., Yajima, T., Iwao, Y., Tsuchiya, M., Ishikawa, H., Aiso, S., Hibi, T. and Ishii, H., Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes. J. Clin. Invest. 1995. 95: 2945-2953.
26. Watanabe, M., Ueno, Y., Yajima, T., Okamoto, S., Hayashi, T., Yamazaki, M., Iwao, Y., Ishii, H., Habu, S., Uehira, M., Nishimoto, H., Ishikawa, H., Hata, J. and Hibi, T., Interleukin-7 transgenic mice develop chronic colitis with decrease of interleukin-7 protein accumulation in the colonic mucosa. J. Exp. Med. 1998. 187: 389-402.
27. Fuss, I. J., Neurath, M., Boirivant, M., Klein, J. S., de la Motte, C., Strong, S. A., Fiocchi, C. and Strober, W., Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. J. Immunol. 1996. 157: 1261-1270.
28. Fiocchi, C., Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 1998. 115: 182-205.
29. Dianzani, U., Luqman, M., Rojo, J., Baron, J. L., Woods, A., Janeway, C. A., Jr and Bottomly, K., Molecular associations on the T cell surface correlate with immunological memory. Eur. J. Immunol. 1990. 20: 2249-2257.
30. Leitenberg, D., Novak, T. J. and Farber, D., The extra-cellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation. J. Exp. Med. 1996. 183: 249-259.
31. Langedijk, J. P. M., Puijk, W. C., Van Hoorn, W. P. and Heloen, R. H., Location of CD4 dimerization site explains critical role of CDR3-like region in HIV-1 infection and T-cell activation and implies a model for complex of coreceptor-MHC. J. Biol. Chem. 1993. 268: 168-175.
32. Ishikawa, H., Li, Y., Abeliovich, A., Yamamoto, S., Kaufmann, S. H. E. and Tonegawa, S., Cytotoxic and Interferon γ-producing activities of γδ T cells in the mouse intestinal epithelium are strain dependent. Proc. Natl. Acad. Sci. USA 1993. 90: 8204-8208.