Alternatively spliced variants: A new view of the integrin cytoplasmic domain

Matrix Biology

Volumn 16, Issue 4, 1997, Pages 185-193

  Fornaro, Mara ^a   Languino, Lucia R ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alternatively spliced isoforms; Integrin cytoplasmic domain

Indexed keywords

INTEGRIN;

ALTERNATIVE RNA SPLICING; CELL MIGRATION; CELL PROLIFERATION; CELL SPECIFICITY; CELL TYPE; CELLULAR DISTRIBUTION; CYTOPLASM; DEVELOPMENT; GENE EXPRESSION; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN VARIANT; RAT; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

EID: 0031258105     PISSN: 0945053X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0945-053X(97)90007-X     Document Type: Short Survey

References (58)

1. 1 subunit with a unique cytoplasmic domain generated by alternative mRNA processing. Gene. 95:1990;261-266.
2. Argraves W.S., Suzuki S., Arai H., Thompson K., Pierschbacher M.D., Ruoslahti E. Amino acid sequence of the human fibronectin receptor. J. Cell Biol. 105:1987;1183-1190.
3. Balzac F., Belkin A.M., Koteliansky V.E., Balabanov Y.V., Altruda F., Silengo L., Tarone G. Expression and functional analysis of a cytoplasmic domain variant of the β1 integrin subunit. J. Cell Biol. 121:1993;171-178.
4. 1B integrin isoform in CHO cells results in a dominant negative effect on cell adhesion and motility. J. Cell Biol. 127:1994;557-565.
5. 1C integrin splice variants. Cell Adhes. Commun. 4:1996;1-11.
6. 1A isoform in striated muscles: localization at junctional structures and signaling potential in non-muscle cells. J. Cell Biol. 132:1996;211-226.
7. 4 integrin subunit. J. Cell Biol. 136:1997;1333-1347.
8. Burridge K., Chrzanowska-Wodnicka M. Focal adhesions, contractility, and signaling. Annu. Rev. Cell Dev. Biol. 12:1996;463-519.
9. 1 integrin laminin receptor in the ventral plasma membrane of embryonic fibroblasts. J. Cell Sci. 108:1995;3067-3078.
10. Clarke A.S., Lotz M.M., Mercurio A.M. A novel structural variant of the human β4 integrin cDNA. Cell Adhes. Commun. 2:1994;1-6.
11. Collo G., Starr L., Quaranta V. A new isoform of the laminin receptor integrin α7β1 is developmentally regulated in skeletal muscle. J. Biol. Chem. 268:1993;19019-19024.
12. Cooper H.M., Tamura R.N., Quaranta V. The major laminin receptor of mouse embryonic stem cells is a novel isoform of the α6β1 integrin. J. Cell Biol. 115:1991;843-850.
13. Delwel G.O., de Melker A.A., Hogervorst F., Jaspars L.H., Fles D.L.A., Kuikman I., Lindblom A., Paulsson M., Timpl R., Sonnenberg A. Distinct and overlapping ligand specificities of the α3Aβ1 and α6Aβ1 integrins: recognition of laminin isoforms. Mol. Biol. Cell. 5:1994;203-215.
14. Delwel G.O., Hogervorst F., Kuikman I., Paulsson M., Timpl R., Sonnenberg A. Expression and function of the cytoplasmic variants of the integrin α6 subunit in transfected K562 cells. Activation-dependent adhesion and interaction with isoforms of laminin. J. Biol. Chem. 268:1993;25865-25875.
15. de Melker A.A., Sterk L.M.Th., Delwel G.O., Fles D.L.A., Daams H., Weening J.J., Sonnenberg A. The A and B variants of the α3 integrin subunit: tissue distribution and functional characterization. Lab. Invest. 76:1997;547-563.
16. DiPersio C.M., Shah S., Hynes R.O. α3Aβ1 integrin localizes to focal contacts in response to diverse extracellular matrix proteins. J. Cell Sci. 108:1995;2321-2336.
17. Echtermeyer F., Schober S., Poschl E., von der Mark H., von der Mark K. Specific induction of cell motility on laminin by α7 integrin. J. Biol. Chem. 271:1996;2071-2075.
18. Fitzgerald L.A., Steiner B., Rall S.C., Lo S.-S., Phillips D.R. Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone: identity with platelet glycoprotein IIIa and similarity to "Integrin" J. Biol. Chem. 262:1987;3936-3939.
19. Fornaro M., Tallini G., Bofetiado C.J.M., Bosari S., Languino L.R. Down-regulation of β1C integrin, an inhibitor of cell proliferation, in prostate carcinoma. Am. J. Pathol. 149:1996;765-773.
20. Fornaro M., Zheng D.Q., Languino L.R. The novel structural motif Gln795-Gln802 in the integrin β1C cytoplasmic domain regulates cell proliferation. J. Biol. Chem. 270:1995;24666-24669.
21. Ginsberg M.H., Du X., Plow E.F. Inside-out integrin signaling. Curr. Opin. Cell Biol. 4:1992;766-771.
22. Hemler M.E., Weitzman J.B., Pasqualini R., Kawaguchi S., Kassner P.D., Berdichevsky F.B. Structure, biochemical properties, and biological functions of integrin cytoplasmic domains. Takada Y. Integrins: the Biological Problems. 1995;1-35 CRC Press, Inc. Boca Raton.
23. Hogervorst F., Admiraal L.G., Niessen C., Kuikman I., Janssen H., Daams H., Sonnenberg A. Biochemical characterization and tissue distribution of the A and B variants of the integrin α6 subunit. J. Cell Biol. 121:1993;179-191.
24. Hogervorst F., Kuikman I., von dem Borne A.E.G., Sonnenberg A. Cloning and sequence analysis of β4 cDNA: an integrin subunit that contains a unique 118 kD cytoplasmic domain. EMBO J. 9:1990;765-770.
25. Hynes R.O. Targeted mutations in cell adhesion genes: what have we learned from them? Dev. Biol. 180:1996;402-412.
26. Jiang R., Grabel L.B. Function and differential regulation of the α6 integrin isoforms during parietal endoderm differentiation. Exp. Cell Res. 217:1995;195-204.
27. Juliano R. Cooperation between soluble factors and integrin-mediated cell anchorage in the control of cell growth and differentiation. BioEssays. 18:1996;911-917.
28. LaFlamme S.E., Thomas L.A., Yamada S.S., Yamada K.M. Single subunit chimeric integrins as mimics and inhibitors of endogenous integrin functions in receptor localization, cell spreading and migration, and matrix assembly. J. Cell Biol. 126:1994;1287-1298.
29. Languino L.R., Ruoslahti E. An alternative form of the integrin β1 subunit with a variant cytoplasmic domain. J. Biol. Chem. 267:1992;7116-7120.
30. Mainiero F., Pepe A., Wary K.K., Spinardi L., Mohammadi M., Schlessinger J., Giancotti F.G. Signal transduction by the α6β4 integrin: distinct β4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes. EMBO J. 14:1995;4470-4481.
31. Martin P.T., Kaufman S.J., Kramer R.H., Sanes J.R. Synaptic integrins in developing, adult and mutant muscle: selective association of α1, α7A, and α7B integrins with the neuromuscular junction. Dev. Biol. 174:1996;125-139.
32. Meredith J. Jr., Takada Y., Fornaro M., Languino L.R., Schwartz M.A. Inhibition of cell cycle progression by the alternatively spliced integrin β1C. Science. 269:1995;1570-1572.
33. Morini M., Piccini D., Barbieri O., Astigiano S. Modulation of α6/β1 integrin expression during differentiation of F9 murine embryonal carcinoma cells to parietal endoderm. Exp. Cell Res. 232:1997;304-312.
34. Niessen C.M., Hogervorst F., Jaspars L.H., de Melker A.A., Delwel G.O., Hulsman E.H.M., Kuikman I., Sonnenberg A. The α6β4 integrin is a receptor for both laminin and kalinin. Exp. Cell Res. 211:1994;360-367.
35. Niessen C.M., Hulsman E.H.M., Rots E.S., Sanchez-Aparicio P., Sonnenberg A. Integrin α6β4 forms a complex with the cytoskeletal protein HD1 and induces its redistribution in transfected COS-7 cells. Mol. Biol. Cell. 8:1997;555-566.
36. Ruoslahti E., Reed J.C. Anchorage dependence, integrins and apoptosis. Cell. 77:1994;477-478.
37. Sastry S., Lakonishok M., Thomas D., Muschler J., Horwitz A.F. Integrin α subunit ratios, cytoplasmic domains, and growth factor synergy regulate muscle proliferation and differentiation. J. Cell Biol. 133:1996;169-184.
38. Schwartz M.A., Schaller M.D., Ginsberg M.H. Integrins: emerging paradigms of signal transduction. Annu. Rev. Cell Dev. Biol. 11:1995;549-599.
39. Shaw L.M., Lotz M.M., Mercurio A.M. Inside-out integrin signaling in macrophages. J. Biol. Chem. 268:1993;11401-11408.
40. Shaw L.M., Mercurio A.M. Regulation of α6β1 integrin laminin receptor function by the cytoplasmic domain of the a6 subunit. J. Cell Biol. 123:1993;1017-1025.
41. Shaw L.M., Mercurio A.M. Regulation of cellular interactions with laminin by integrin cytoplasmic domains: the A and B structural variants of the α6β1 integrin differentially modulate the adhesive strength, morphology, and migration of macrophages. Mol. Biol. Cell. 5:1994;679-690.
42. Shaw L.M., Turner C.E., Mercurio A.M. The α6Aβ1 and α6Bβ1 integrin variants signal differences in the tyrosine phosphorylation of paxillin and other proteins. J. Biol. Chem. 270:1995;23648-23652.
43. Solowska J., Edelman J.M., Albelda S.M., Buck C.A. Cytoplasmic and transmembrane domain of integrins β1 and β3 subunits are functionally interchangeable. J. Cell Biol. 114:1991;1079-1088.
44. Song W.K., Wang W., Sato H., Bielser D.A., Kaufman S.J. Expression of α7 integrin cytoplasmic domains during skeletal muscle development: alternate forms, conformational change, and homologies with serine/threonine kinases and tyrosine phosphatases. J. Cell Sci. 106:1993;1139-1152.
45. Spinardi L., Einheber S., Cullen T., Milner T.A., Giancotti F.G. A recombinant tail-less integrin β4 subunit disrupts hemidesmosomes, but does not suppress α6β4-mediated cell adhesion to laminins. J. Cell Biol. 129:1995;473-487.
46. Suzuki S., Naitoh Y. Amino acid sequence of a novel integrin β4 subunit and primary expression of the mRNA in epithelial cells. EMBO J. 9:1990;757-763.
47. Takada Y., Murphy E., Pil P., Chen C., Ginsberg M.H., Hemler M.E. Molecular cloning and expression of the cDNA for α3 subunit of human α3β1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen. J. Cell Biol. 115:1991;257-266.
48. Tamura R.N., Rozzo C., Starr L., Chambers J., Reichardt L.F., Cooper H.M., Quaranta V. Epithelial integrin α6β4: complete primary structure of α6 and variant forms of β4. J. Cell Biol. 111:1990;1593-1604.
49. Tamura R.N., Cooper H.M., Collo G., Quaranta V. Cell type-specific integrin variants with alternative alpha chain cytoplasmic domains. Proc. Natl. Acad. Sci. USA. 88:1991;10183-10187.
50. van der Flier A., Kuikman I., Baudoin C., van der Neut R., Sonnenberg A. A novel β1 integrin isoform produced by alternative splicing: unique expression in cardiac and skeletal muscle. FEBS Lett. 369:1995;340-344.
51. van Kuppevelt T.H.M.S.M., Languino L.R., Gailit J.O., Suzuki S., Ruoslahti E. An alternative cytoplasmic domain of the integrin β3 subunit. Proc. Natl. Acad. Sci. USA. 86:1989;5415-5418.
52. Vidal F., Aberdam D., Miquel C., Christiano A.M., Pulkkinen L., Uitto J., Ortonne J.-P., Meneguzzi G. Integrin β4 mutations associated with junctional epidermolysis bullosa with pyloric atresia. Nat. Genet. 10:1995;229-234.
53. Williams M.J., Hughes P.E., O'Toole T.E., Ginsberg M.H. The inner world of cell adhesion: integrin cytoplasmic domains. Trends Cell Biol. 4:1994;109-112.
54. Yamada K.M., Miyamoto S. Integrin transmembrane signaling and cytoskeletal control. Curr. Opin. Cell Biol. 7:1995;681-689.
55. Yao C.C., Ziober B.L., Squillace R.M., Kramer R.H. α7 integrin mediates cell adhesion and migration on specific laminin isoforms. J. Biol. Chem. 271:1996;25598-25603.
56. Yao C.C., Ziober B.L., Sutherland A.E., Mendrick D.L., Kramer R.H. Laminins promote the locomotion of skeletal myoblasts via the α7 integrin receptor. J. Cell Sci. 109:1996;3139-3150.
57. Zhidkova N.I., Belkin A.M., Mayne R. Novel isoform of β1 integrin expressed in skeletal and cardiac muscle. Biochem. Biophys. Res. Commun. 214:1995;279-285.
58. Ziober B.L., Vu M.P., Waleh N., Crawford J., Lin C.S., Kramer R.H. Alternative extracellular and cytoplasmic domains of the integrin α7 subunit are differentially expressed during development. J. Biol. Chem. 268:1993;26773-26783.