메뉴 건너뛰기




Volumn 7, Issue 2, 1997, Pages 205-211

Regulation of pre-mRNA splicing in metazoa

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PHOSPHOTRANSFERASE; PROTEIN; TRANS ACTING FACTOR;

EID: 0031009398     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(97)80130-X     Document Type: Article
Times cited : (100)

References (53)
  • 1
    • 0001877802 scopus 로고    scopus 로고
    • Splicing of precursors to messenger RNAs by the spliceosome
    • Edited by Gesteland RF, Atkins JF. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
    • Moore MJ, Query CC, Sharp PA: Splicing of precursors to messenger RNAs by the spliceosome. In The RNA World. Edited by Gesteland RF, Atkins JF. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 193:303-358.
    • The RNA World , vol.193 , pp. 303-358
    • Moore, M.J.1    Query, C.C.2    Sharp, P.A.3
  • 2
    • 0029372979 scopus 로고
    • The superfamily of arginine/senne-rich splicing factors
    • Fu XD: The superfamily of arginine/senne-rich splicing factors. RNA 1995, 1:663-630.
    • (1995) RNA , vol.1 , pp. 663-1630
    • Fu, X.D.1
  • 3
    • 0029767662 scopus 로고    scopus 로고
    • SR proteins and splicing control
    • Manley JL, Tacke R: SR proteins and splicing control. Genes Dev 1996, 10:1569-1579.
    • (1996) Genes Dev , vol.10 , pp. 1569-1579
    • Manley, J.L.1    Tacke, R.2
  • 4
    • 0028556367 scopus 로고
    • Dynamic RNA-RNA interactions in the spliceosome
    • Madhani HD, Guthrie C: Dynamic RNA-RNA interactions in the spliceosome. Annu Rev Genet 1994, 28:126.
    • (1994) Annu Rev Genet , vol.28 , pp. 126
    • Madhani, H.D.1    Guthrie, C.2
  • 5
    • 0029890441 scopus 로고    scopus 로고
    • Biochemistry and regulation of pre-mRNA splicing
    • Adams MD, Runder DZ, Rio DC: Biochemistry and regulation of pre-mRNA splicing. Curr Opin Cell Biol 1996, 8:331-339.
    • (1996) Curr Opin Cell Biol , vol.8 , pp. 331-339
    • Adams, M.D.1    Runder, D.Z.2    Rio, D.C.3
  • 6
    • 0028034324 scopus 로고
    • Complementation by SR proteins of pre-mRNA splicing reactions depleted of U1 snRNP
    • Crispino JD, Blencowe BJ. Sharp PA: Complementation by SR proteins of pre-mRNA splicing reactions depleted of U1 snRNP. Science 1994, 265:1866-1869.
    • (1994) Science , vol.265 , pp. 1866-1869
    • Crispino, J.D.1    Blencowe, B.J.2    Sharp, P.A.3
  • 7
    • 0028072388 scopus 로고
    • SR proteins can compensate for the loss of U1 snRNP functions in vitro
    • Tarn WY, Steitz JA: SR proteins can compensate for the loss of U1 snRNP functions in vitro. Genes Dev 1994, 8:2704-2717.
    • (1994) Genes Dev , vol.8 , pp. 2704-2717
    • Tarn, W.Y.1    Steitz, J.A.2
  • 8
    • 0028941920 scopus 로고
    • Modulation of 5′ splice site choice in premessenger RNA by two distinct steps
    • Tarn WY, Steitz JA: Modulation of 5′ splice site choice in premessenger RNA by two distinct steps. Proc Natl Acad Sci USA 1995, 92:2504-2508.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 2504-2508
    • Tarn, W.Y.1    Steitz, J.A.2
  • 9
    • 0029089334 scopus 로고
    • A U6 snRNA: Pre-mRNA interaction can be rate-limiting for U1- Independent splicing
    • Crispino JD, Sharp PA: A U6 snRNA: pre-mRNA interaction can be rate-limiting for U1- independent splicing. Genes Dev 1995, 9:2314-2323.
    • (1995) Genes Dev , vol.9 , pp. 2314-2323
    • Crispino, J.D.1    Sharp, P.A.2
  • 10
    • 0029377886 scopus 로고
    • SR proteins escort U4/6.U5 tri-snRNP to the spliceosome
    • Roscigno RF, Garcia-Blanco MA: SR proteins escort U4/6.U5 tri-snRNP to the spliceosome. RNA 1995, 1:692-706.
    • (1995) RNA , vol.1 , pp. 692-706
    • Roscigno, R.F.1    Garcia-Blanco, M.A.2
  • 11
    • 0030595187 scopus 로고    scopus 로고
    • Interaction of U2AF65 RS region with pre-mRNA of branch point and promotion base pairing with U2 snRNA
    • Valcárcel J, Gaur RK, Singh R, Green MR: Interaction of U2AF65 RS region with pre-mRNA of branch point and promotion base pairing with U2 snRNA. Science 1996, 273:1706-1709. Discovery of a novel function of the U2AF65 RS domain: it binds to the pre-mRNA branch site and promotes U2 snRNA-branch site base pairing.
    • (1996) Science , vol.273 , pp. 1706-1709
    • Valcárcel, J.1    Gaur, R.K.2    Singh, R.3    Green, M.R.4
  • 12
    • 0029949594 scopus 로고    scopus 로고
    • Cis-acting elements distinct from the 5′ splice site promote U1-independent pre-mRNA splicing
    • Crispino JD, Mermoud JE, Lamond AL, Sharp PA: Cis-acting elements distinct from the 5′ splice site promote U1-independent pre-mRNA splicing. RNA 1996, 2:664-673. Splicing of certain substrates occurs in U1 snRNP-depleted nuclear extract without addition of SR proteins. Cis-acting sequences other than splicing signals are required for U1 snRNP-independent splicing.
    • (1996) RNA , vol.2 , pp. 664-673
    • Crispino, J.D.1    Mermoud, J.E.2    Lamond, A.L.3    Sharp, P.A.4
  • 13
    • 0029064220 scopus 로고
    • The human splicing factors ASF/SF2 and SC35 possess different, functionally significant RNA binding specificities
    • Tacke R, Manley JL: The human splicing factors ASF/SF2 and SC35 possess different, functionally significant RNA binding specificities. EMBO J 1995, 14:3540-3551.
    • (1995) EMBO J , vol.14 , pp. 3540-3551
    • Tacke, R.1    Manley, J.L.2
  • 14
    • 0029665533 scopus 로고    scopus 로고
    • The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancerdependent splicing
    • Zuo P, Maniatis T: The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancerdependent splicing. Genes Dev 1996, 10:1356-1368. This study establishes the essential role of U2AF35 in constitutive and enhancer-dependent splicing and further shows that U2AF35 is required for enhancer-dependent binding of U2AF65 to the 3′ splice site.
    • (1996) Genes Dev , vol.10 , pp. 1356-1368
    • Zuo, P.1    Maniatis, T.2
  • 15
    • 0028025033 scopus 로고
    • A splicing enhancer exhibits both constitutive and regulated activities
    • Tian M, Maniatis T: A splicing enhancer exhibits both constitutive and regulated activities. Genes Dev 1994, 8:1703-1712.
    • (1994) Genes Dev , vol.8 , pp. 1703-1712
    • Tian, M.1    Maniatis, T.2
  • 16
    • 0028926275 scopus 로고
    • Synergistic interactions between two distinct elements of a regulated splicing enhancer
    • Lynch KW, Maniatis T: Synergistic interactions between two distinct elements of a regulated splicing enhancer. Genes Dev 1995, 9:234-293.
    • (1995) Genes Dev , vol.9 , pp. 234-293
    • Lynch, K.W.1    Maniatis, T.2
  • 17
    • 0029858338 scopus 로고    scopus 로고
    • Assembly of specific SR protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancer
    • Lynch KW, Maniatis T: Assembly of specific SR protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancer. Genes Dev 1996, 10:2089-2101. A detailed study of protein binding on Drosophila doublesex splicing enhancer. Splicing factors Transformer, Transformer 2 are shown to recruit different SR proteins to the repeat region and the purine-rich element of the doublesex splicing enhancer. The binding of Transformer, Transformer 2 and SR proteins to the RNA is synergistic. The relative positions of these bound splicing factors on the RNA were determined.
    • (1996) Genes Dev , vol.10 , pp. 2089-2101
    • Lynch, K.W.1    Maniatis, T.2
  • 18
    • 0029114121 scopus 로고
    • The Drosophila SR protein RBP1 contributes to the regulation of doublesex alternative splicing by recognizing RBP1 RNA target sequences
    • Heinrichs V, Baker BS: The Drosophila SR protein RBP1 contributes to the regulation of doublesex alternative splicing by recognizing RBP1 RNA target sequences. EMBO J 1995, 14:3987-4000.
    • (1995) EMBO J , vol.14 , pp. 3987-4000
    • Heinrichs, V.1    Baker, B.S.2
  • 19
    • 0028999992 scopus 로고
    • Identification of positive and negative splicing regulatory elements within the terminal tat-rev exon of human immunodeficiency virus type I
    • Staffa A, Cochrane A: Identification of positive and negative splicing regulatory elements within the terminal tat-rev exon of human immunodeficiency virus type I. Mol Cell Biol 1995, 15:4597-4605.
    • (1995) Mol Cell Biol , vol.15 , pp. 4597-4605
    • Staffa, A.1    Cochrane, A.2
  • 20
    • 0029025083 scopus 로고
    • Presence of exon splicing silencers within human immunodeficiency virus type 1 tat exon 2 and tal-rev exon 3: Evidence for inhibition mediated by cellular factors
    • Amendt BA, Si Z-H, Stoltzfus CM: Presence of exon splicing silencers within human immunodeficiency virus type 1 tat exon 2 and tal-rev exon 3: evidence for inhibition mediated by cellular factors. Mol Cell Biol 1995, 15:4606-4615.
    • (1995) Mol Cell Biol , vol.15 , pp. 4606-4615
    • Amendt, B.A.1    Si, Z.-H.2    Stoltzfus, C.M.3
  • 21
    • 0030007649 scopus 로고    scopus 로고
    • Selection of the bovine papillornavirus type 1 nucleotide 3225 3 splice site is regulated through an exonic splicing enhancer and its juxtaposed exonic splicing suppressor
    • Zheng ZM, He P, Baker CC: Selection of the bovine papillornavirus type 1 nucleotide 3225 3 splice site is regulated through an exonic splicing enhancer and its juxtaposed exonic splicing suppressor. J Virol 1996, 70:4891-4699.
    • (1996) J Virol , vol.70 , pp. 4891-14699
    • Zheng, Z.M.1    He, P.2    Baker, C.C.3
  • 22
    • 0029815612 scopus 로고    scopus 로고
    • Novel exploitation of a nuclear function by influenza virus: The cellular SF2/ASF splicing factor controls the amount of the essential viral M2 ion channel protein in infected cells
    • Shih SR, Krug RM: Novel exploitation of a nuclear function by influenza virus: the cellular SF2/ASF splicing factor controls the amount of the essential viral M2 ion channel protein in infected cells. EMBO J 1996, 15:5415-5427. An exon-splicing enhancer on influenza virus pre-mRNA stimulates viral M2 mRNA splicing. ASF/SF2 was shown to bind the enhancer and to activate M2 splicing in vitro. The amount of M2 mRNA and protein produced in different virus-infected cell lines correlates with the levels of ASF/SF2.
    • (1996) EMBO J , vol.15 , pp. 5415-5427
    • Shih, S.R.1    Krug, R.M.2
  • 23
    • 0029954587 scopus 로고    scopus 로고
    • Essential nucleotides direct neuron-specific splicing of γ2 pre-mRNA
    • Zhang L, Ashiya M, Sherman TG, Grabowski PJ: Essential nucleotides direct neuron-specific splicing of γ2 pre-mRNA. RNA 1996, 2:682-698.
    • (1996) RNA , vol.2 , pp. 682-698
    • Zhang, L.1    Ashiya, M.2    Sherman, T.G.3    Grabowski, P.J.4
  • 24
    • 0030010743 scopus 로고    scopus 로고
    • Muscle-specific splicing enhancers regulate inclusion of the cardiac troponin T alternative exon in embryonic skeletal muscle
    • Ryan KJ, Cooper TA: Muscle-specific splicing enhancers regulate inclusion of the cardiac troponin T alternative exon in embryonic skeletal muscle. Mol Cell Biol 1996, 16:4014-4023.
    • (1996) Mol Cell Biol , vol.16 , pp. 4014-4023
    • Ryan, K.J.1    Cooper, T.A.2
  • 25
    • 0029739149 scopus 로고    scopus 로고
    • Transformerns-acting factors regulate the expression of CD44 splice variants
    • König H, Moll J, Ponta H, Herrlich P: Transformerns-acting factors regulate the expression of CD44 splice variants. EMBO J 1996, 15:4030-4039.
    • (1996) EMBO J , vol.15 , pp. 4030-4039
    • König, H.1    Moll, J.2    Ponta, H.3    Herrlich, P.4
  • 26
    • 0028867814 scopus 로고    scopus 로고
    • The generally expressed hnRNP F is involved in a neural- Specific pre-mRNA splicing event
    • Min H, Chan RC, Black DL: The generally expressed hnRNP F is involved in a neural- specific pre-mRNA splicing event. Genes Dev 1996, 10:2659-2671. See annotation [27*].
    • (1996) Genes Dev , vol.10 , pp. 2659-2671
    • Min, H.1    Chan, R.C.2    Black, D.L.3
  • 27
    • 0030969572 scopus 로고    scopus 로고
    • A new regulatory protein, KSR, mediates exon inclusion through an intronic splicing enhancer
    • in press
    • Min H, Turck CW, Black DL: A new regulatory protein, KSR, mediates exon inclusion through an intronic splicing enhancer. Genes Dev 1997, in press. By using neural-specific inclusion of c-src N1 exon as a working model, these authors have identified and characterized a 75 kDa protein, KSR, required for N1 splicing in vitro. KSR contains KH-type RNA binding motifs and may play an important role in neural-specific splicing.
    • (1997) Genes Dev
    • Min, H.1    Turck, C.W.2    Black, D.L.3
  • 28
    • 0030061154 scopus 로고    scopus 로고
    • SR protein splicing factors interact with the Rous sarcoma virus negative regulator of splicing element
    • McNally LM, McNally MT: SR protein splicing factors interact with the Rous sarcoma virus negative regulator of splicing element. J Virol 1996, 70:1163-1172.
    • (1996) J Virol , vol.70 , pp. 1163-1172
    • McNally, L.M.1    McNally, M.T.2
  • 29
    • 85030299885 scopus 로고
    • SR proteins that are essential for generic pre-mRNA splicing inhibit splicing of a regulated adenovirus pre-mRNA
    • Kanopka A Mühlemann O, Akusjärvi G: SR proteins that are essential for generic pre-mRNA splicing inhibit splicing of a regulated adenovirus pre-mRNA. Nature 1995, 381:535-538. An intronic sequence element is shown to repress splicing of adenovirus IIIa mRNA splicing. SR proteins, specifically ASF/SF2, are found to bind the element and to mediate splicing inhibition, probably by steric hindrance. The position of the element in the pre-mRNA determines whether its effect is either positive or negative.
    • (1995) Nature , vol.381 , pp. 535-538
    • Kanopka, A.1    Mühlemann, O.2    Akusjärvi, G.3
  • 30
    • 0029383406 scopus 로고    scopus 로고
    • Titration of serine/arginine (SR) splicing factors during adenoviral infection modulates E1A pre-mRNA alternative splicing
    • Himmelspach M, Cavaloc Y, Chebli K, Stevenin J, Gattoni R: Titration of serine/arginine (SR) splicing factors during adenoviral infection modulates E1A pre-mRNA alternative splicing. RNA 1996, 2:794-306.
    • (1996) RNA , vol.2 , pp. 794-1306
    • Himmelspach, M.1    Cavaloc, Y.2    Chebli, K.3    Stevenin, J.4    Gattoni, R.5
  • 31
    • 0028146254 scopus 로고
    • Regulation of tissue-specific P element pre-mRNA splicing requires the RNA-binding protein PSI
    • Siebel CW, Kanaar R, Rio DC: Regulation of tissue-specific P element pre-mRNA splicing requires the RNA-binding protein PSI. Genes Dev 1994, 8:1713-1725.
    • (1994) Genes Dev , vol.8 , pp. 1713-1725
    • Siebel, C.W.1    Kanaar, R.2    Rio, D.C.3
  • 32
    • 0028914042 scopus 로고
    • Soma-specific expression and cloning of PSI, a negative regulator of P element pre-mRNA splicing
    • Siebel CW, Admon A, Rio DC: Soma-specific expression and cloning of PSI, a negative regulator of P element pre-mRNA splicing. Genes Dev 1995, 9:269-233.
    • (1995) Genes Dev , vol.9 , pp. 269-1233
    • Siebel, C.W.1    Admon, A.2    Rio, D.C.3
  • 33
    • 0031033741 scopus 로고    scopus 로고
    • The alternative splicing factor PSI regulates P-element third intron splicing in vivo
    • Adams MD, Tarng RS, Rio DC: The alternative splicing factor PSI regulates P-element third intron splicing in vivo. Genes Dev 1997, 11:129-138. Experiments carried out in Drosophila demonstrate that PSI is a tissue specific splicing inhibitor in vivo. Ectopic expression of PSI in the female germline inhibits P element IVS3 silencing and blocking expression of PSI results in activation of IVS3 splicing in soma.
    • (1997) Genes Dev , vol.11 , pp. 129-138
    • Adams, M.D.1    Tarng, R.S.2    Rio, D.C.3
  • 34
    • 0028077730 scopus 로고
    • Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors
    • Cáceres JF, Stamm S, Helfman DM, Krainer AR: Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. Science 1994, 265:1706-1709.
    • (1994) Science , vol.265 , pp. 1706-1709
    • Cáceres, J.F.1    Stamm, S.2    Helfman, D.M.3    Krainer, A.R.4
  • 35
    • 0029295349 scopus 로고
    • Overexpression of the SR proteins ASF/SF2 and SC35 influences alternative splicing in vivo in diverse ways
    • Wang J, Manley JL: Overexpression of the SR proteins ASF/SF2 and SC35 influences alternative splicing in vivo in diverse ways. RNA 1995, 1:335-346.
    • (1995) RNA , vol.1 , pp. 335-346
    • Wang, J.1    Manley, J.L.2
  • 37
    • 0029027778 scopus 로고
    • Overexpression of the arginine-rich carboxyl-terminal region of U1 snRNP 70K inhibits both splicing and nucleocytoplasmic transport of mRNA
    • Romac JMJ, Keene J: Overexpression of the arginine-rich carboxyl-terminal region of U1 snRNP 70K inhibits both splicing and nucleocytoplasmic transport of mRNA. Genes Dev 1995, 9:1400-1410.
    • (1995) Genes Dev , vol.9 , pp. 1400-1410
    • Romac, J.M.J.1    Keene, J.2
  • 38
    • 0027137934 scopus 로고
    • Specific interactions between proteins implicated in splice site selection and regulated alternative splicing
    • Wu JY, Maniatis T: Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. Cell 1993, 75:1061-1070.
    • (1993) Cell , vol.75 , pp. 1061-1070
    • Wu, J.Y.1    Maniatis, T.2
  • 40
    • 0027321180 scopus 로고
    • Novel delayed-early and highly insulin-induced growth response genes: Identification of HRS, a potential regulator of alternative pre-mRNA splicing
    • Diamond RH, Du K, Lee VM, Mohn KL, Haber BA, Tewari DS, Taub R: Novel delayed-early and highly insulin-induced growth response genes: identification of HRS, a potential regulator of alternative pre-mRNA splicing. J Biol Chem 1993, 268:15185-15192.
    • (1993) J Biol Chem , vol.268 , pp. 15185-15192
    • Diamond, R.H.1    Du, K.2    Lee, V.M.3    Mohn, K.L.4    Haber, B.A.5    Tewari, D.S.6    Taub, R.7
  • 41
    • 0027160003 scopus 로고
    • Distinct functions of SR proteins in alternative pre-mRNA splicing
    • Zahler AM, Neugenbauer KM, Lane WS, Roth MB: Distinct functions of SR proteins in alternative pre-mRNA splicing. Science 1993, 260:219-222.
    • (1993) Science , vol.260 , pp. 219-222
    • Zahler, A.M.1    Neugenbauer, K.M.2    Lane, W.S.3    Roth, M.B.4
  • 42
    • 0028046121 scopus 로고
    • The SR protein B52/SRp55 is essential for Drosophila development
    • Ring HZ, Lis JT: The SR protein B52/SRp55 is essential for Drosophila development Mol Cell Biol 1994, 14:7499-7506.
    • (1994) Mol Cell Biol , vol.14 , pp. 7499-7506
    • Ring, H.Z.1    Lis, J.T.2
  • 43
    • 0028832642 scopus 로고
    • Genetic enhancement of RNA processing defects by a dominant mutation in B52, the Drosophila gene for an SR protein splicing factor
    • Peng X, Mount SM: Genetic enhancement of RNA processing defects by a dominant mutation in B52, the Drosophila gene for an SR protein splicing factor. Mol Cell Biol 1995, 15:6273-6232.
    • (1995) Mol Cell Biol , vol.15 , pp. 6273-16232
    • Peng, X.1    Mount, S.M.2
  • 44
    • 0029859659 scopus 로고    scopus 로고
    • Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability
    • Wang J, Takagaki Y, Manley JL: Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability. Genes Dev 1996, 10:2588-2599. Development of a genetic system to disrupt an essential gene in vertebrate cells. These authors used this system to demonstrate that ASF/SF2 is required for cell viability and to define domains at the protein essential for function in vivo.
    • (1996) Genes Dev , vol.10 , pp. 2588-2599
    • Wang, J.1    Takagaki, Y.2    Manley, J.L.3
  • 45
    • 0028043718 scopus 로고
    • Regulation of mammalian spliceosome assembly by a protein phosphorylation mechanism
    • Mermoud J, Cohen PTW, Lamond AL: Regulation of mammalian spliceosome assembly by a protein phosphorylation mechanism. EMBO J 1994, 13:5679-5638.
    • (1994) EMBO J , vol.13 , pp. 5679-15638
    • Mermoud, J.1    Cohen, P.T.W.2    Lamond, A.L.3
  • 46
    • 0027305702 scopus 로고
    • Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors
    • Woppmann A, Will CL, Kornstadt U, Zuo P, Manley JL, Lührmann R: Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors. Nucleic Acids Res 1993, 21:2815-2822.
    • (1993) Nucleic Acids Res , vol.21 , pp. 2815-2822
    • Woppmann, A.1    Will, C.L.2    Kornstadt, U.3    Zuo, P.4    Manley, J.L.5    Lührmann, R.6
  • 47
    • 0028286596 scopus 로고
    • A serine kinase regulates intracellular localization of splicing factors in the cell cycle
    • Gui JF, Lane WS, Fu XD: A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Nature 1994, 369:678-682.
    • (1994) Nature , vol.369 , pp. 678-682
    • Gui, J.F.1    Lane, W.S.2    Fu, X.D.3
  • 48
    • 0030028882 scopus 로고    scopus 로고
    • The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intracellular distribution
    • Colwill K, Pawson T, Andrews B, Prasad J, Manley JL, Bell JC, Duncan PI: The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intracellular distribution. EMBO J 1996, 15:265-275. Clk/Sty kinase is shown to interact with SR proteins in yeast two-hybrid screening. In vitro assays indicate that Clk/Sty phosphorylates the RS domain of ASF/SF2 in a manner very similar to that detected in vivo. Clk/Sty colocalizes with SR proteins in vivo.
    • (1996) EMBO J , vol.15 , pp. 265-275
    • Colwill, K.1    Pawson, T.2    Andrews, B.3    Prasad, J.4    Manley, J.L.5    Bell, J.C.6    Duncan, P.I.7
  • 51
    • 0031037690 scopus 로고    scopus 로고
    • Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: Creation of an SRp40-specific splicing enhancer
    • Tacke R, Chen Y, Manley JL: Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: creation of an SRp40-specific splicing enhancer. Proc Natl Acad Sci USA 1997, 94:1146-1153. This study shows that phosphorylation of the RS domain of SRp40 is essential for sequence-specific RNA binding. High-affinity binding sites for SRp40 selected by SELEX function as splicing enhancers in vitro.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 1146-1153
    • Tacke, R.1    Chen, Y.2    Manley, J.L.3
  • 52
    • 0031042396 scopus 로고    scopus 로고
    • Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing
    • Xiao SH, Manley JL: Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing. Genes Dev 1997, 11:334-344. Phosphorylation of ASF/SF2 enhances an RS domain-mediated interaction with U1 70K protein and with U1 snRNP. Conditions are described in which phosphorylation of ASF/SF2 is found to be necessary for efficient splicing in vitro.
    • (1997) Genes Dev , vol.11 , pp. 334-344
    • Xiao, S.H.1    Manley, J.L.2
  • 53
    • 0027938872 scopus 로고
    • Characterization by cDNA cloning of two new human protein kinases: Evidence by sequence comparison of a new family of mammalian protein kinases
    • Hanes J. Von Der Kammer H, Klaudiny J, Scheit KH: Characterization by cDNA cloning of two new human protein kinases: evidence by sequence comparison of a new family of mammalian protein kinases. J Mol Biol 1994, 244:565-672.
    • (1994) J Mol Biol , vol.244 , pp. 565-672
    • Hanes, J.1    Von Der Kammer, H.2    Klaudiny, J.3    Scheit, K.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.