An alternatively spliced C. elegans ced-4 RNA encodes a novel cell death inhibitor

Cell

Volumn 86, Issue 2, 1996, Pages 201-208

  Shaham, Shai ^a,b   Horvitz, H Robert ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH INHIBITOR; CELL PROTEIN; PROTEIN CED 4; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; APOPTOSIS; ARTICLE; CAENORHABDITIS ELEGANS; CELL PROTECTION; INHIBITION KINETICS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SEQUENCE ANALYSIS; TRANSCRIPTION REGULATION;

EID: 0030602837     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80092-6     Document Type: Article

References (44)

1. Boise, L.H., Gonzalez-Garcia, M., Postema, C.E., Ding, L., Lindsten, T., Turka, L.A., Mao, X., Nunez, G., and Thompson, C.B. (1993). bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74, 597-608.
2. Brenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94.
3. Chittenden, T., Harrington, E.A., O'Connor, R., Flemington, C., Lutz, R.J., Evan, G.I., and Guild, B.C. (1995). Induction of apoptosis by the Bcl-2 homologue Bak. Nature 374, 733-736.
4. Cortazzo, M., and Schor, N.F. (1996). Potentiation of enediyne-induced apoptosis and differentiation by Bcl-2. Cancer Res. 56, 1199-1203.
5. Duvall, E., and Wyllie, A.H. (1986). Death and the cell. Immunol. Today 7, 115-119.
6. Ellis, H.M., and Horvitz, H.R. (1986). Genetic control of programmed cell death in the nematode C. elegans. Cell 44, 817-829.
7. Ellis, R.E., Yuan, J., and Horvitz, H.R. (1991). Mechanisms and functions of cell death. Annu. Rev. Cell Biol. 7, 663-698.
8. Emmons, S.W. (1988). The genome. In The Nematode Caenorhabditis elegans, W.B. Wood and the Community of C. elegans Researchers, eds. (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press), pp. 47-80.
9. Farrow, S.N., White, J.H., Martinou, I., Raven, T., Pun, K.T., Grinham, C.J., Martinou, J.C., and Brown, R. (1995). Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K. Nature 374, 731-733.
10. Faucheu, C., Diu, A., Chan, A.W., Blanchet, A.M., Miossec, C., Herve, F., Collard-Dutilleul, V., Gu, Y., Aldape, R.A., and Lippke, J.A. (1995). A novel human protease similar to the interleukin-1β converting enzyme induces apoptosis in transfected cells. EMBO J. 14, 1914-1922.
11. Fernandes-Alnemri, T., Litwack, G., and Alnemri, E.S. (1994). CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1β-converting enzyme. J. Biol. Chem. 269, 30761-30764.
12. Fernandes-Alnemri, T., Litwack, G., and Alnemri, E.S. (1995). Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family. Cancer Res. 55, 2737-2742.
13. Fire, A. (1986). Integrative transformation of Caenorhabditis elegans. EMBO J. 5, 2673-2680.
14. Garcia, I., Martinou, I., Tsujimoto, Y., and Martinou, J.C. (1992). Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene. Science 258, 302-304.
15. Glücksmann, A. (1950). Cell deaths in normal vertebrate ontogeny. Biol. Rev. Camb. Philos. Soc. 26, 59-86.
16. Hengartner, M.O., and Horvitz, H.R. (1994a). Activation of C. elegans cell death protein CED-9 by an amino-acid substitution in a domain conserved in Bcl-2. Nature 369, 318-320.
17. Hengartner, M.O., and Horvitz, H.R. (1994b). C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian protooncogene bcl-2. Cell 76, 665-676.
18. Hengartner, M.O., Ellis, R.E., and Horvitz, H.R. (1992). Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature 356, 494-499.
19. Horvitz, H.R., Brenner, S., Hodgkin, J., and Herman, R.K. (1979). A uniform genetic nomenclature for the nematode Caenorhabditis elegans. Mol. Gen. Genet. 175, 129-133.
20. Horvitz, H.R., Shaham, S., and Hengartner, M.O. (1994). The genetics of programmed cell death in the nematode Caenorhabditis elegans. Cold Spring Harbor Symp. Quant. Biol. 59, 377-385.
21. Kiefer, M.C., Brauer, M.J., Powers, V.C., Wu, J.J., Umansky, S.R., Tomei, L.D., and Barr, P.J. (1995). Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. Nature 374, 736-739.
22. Knudson, C.M., Tung, K.S.K., Tourtellotte, W.G., Brown, G.A.J., and Korsmeyer, S.J. (1995). Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270, 96-99.
23. Kumar, S., Kinoshita, M., Noda, M., Copeland, N.G., and Jenkins, N.A. (1994). Induction of apoptosis by the mouse Nedd-2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1β-converting enzyme. Genes Dev. 8, 1613-1626.
24. Mello, C.C., Kramer, J.M., Stinchcomb, D., and Ambros, V. (1991). Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J. 10, 3959-3970.
25. Miura, M., Zhu, H., Rotello, R., Hartwieg, E.A., and Yuan, J. (1993). Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 75, 653-660.
26. Munday, N.A., Vaillancourt, J.P., Ali, A., Casano, F.J., Miller, D.K., Molineaux, S.M., Yamin, T.T., Yu, V.L., and Nicholson, D.W. (1995). Molecular cloning and pro-apoptotic activity of ICEreIII and ICEreIIII, members of the ICE/CED-3 family of cysteine proteases. J. Biol. Chem. 270, 15870-15876.
27. Nunez, G., London, L., Hockenbery, D., Alexander, M., McKearn, J.P., and Korsmeyer, S.J. (1990). Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hematopoietic cells lines. J. Immunol. 144, 3602-3610.
28. Oppenheim, R.W. (1991). Cell death during development of the nervous system. Annu. Rev. Neurosci. 14, 453-501.
29. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press).
30. Savage, C., Hamelin, M., Culloti, J.G., Coulson, A., Albertson, D.G., and Chalfie, M. (1989). mec-7 is a β-tubulin gene required for the production of 15 protofilament microtubules in Caenorhabditis elegans. Genes Dev. 3, 870-881.
31. Sentman, C.L., Shutter, J.R., Hockenbery, D., Kanagawa, O., and Korsmeyer, S.J. (1992). Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67, 879-888.
32. Shaham, S., and Horvitz, H.R. (1996). Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities. Genes Dev. 10, 578-591.
33. Sulston, J.E., and Horvitz, H.R. (1977). Post-embryonic cell lineages of the nematode Caenorhabditis elegans. Dev. Biol. 82, 110-156.
34. Sulston, J.E., Schierenberg, E., White, J.G., and Thomson, N. (1983). The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev. Biol. 100, 64-119.
35. Sulston, J.E., Du, Z., Thomas, K., Wilson, R., Hillier, L., Staden, R., Halloran, N., Green, P., Thierry-Mieg, J., Qiu, L., Dear, S., Coulson, A., Craxton, M., Durbin, R., Berks, M., Metzstein, M., Hawkins, T., Ainscough, R., and Waterston, R. (1992). The C. elegans genome sequencing project: a beginning. Nature 356, 37-41.
36. Trent, C., Tsung, N., and Horvitz, H.R. (1983). Egg-laying defective mutants of the nematode Caenorhabditis elegans. Genetics 104, 619-647.
37. Vaux, D.L., Cory, S., and Adams, J.M. (1988). Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335, 440-442.
38. Wang, L., Miura, M., Bergeron, L., Zhu, H., and Yuan, J. (1994).Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell 78, 739-750.
39. Way, J.C., and Chalfie, M. (1988). mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans. Cell 54, 5-16.
40. Yin, X.-M., Oltvai, Z.N., and Korsmeyer, S.J. (1994). BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosisand heterodimerization with Bax. Nature 369, 321-323.
41. Yuan, J., and Horvitz, H.R. (1990). Genetic mosaic analyses of ced-3 and ced-4, two genes that control programmed cell death in the nematode C. elegans. Dev. Biol. 138, 33-41.
42. Yuan, J., and Horvitz, H.R. (1992). The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death. Development 116, 309-320.
43. Yuan, J., Shaham, S., Ledoux, S., Ellis, H.M., and Horvitz, H.R. (1993). The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell 75, 641-652.
44. Yunis, J.J., Frizzera, G., Oken, M.M., Mckenna, J., Theologides, A., and Arnesen, M. (1987). Multiple recurrent genomic defects in follicular lymphoma: a possible model for cancer. N. Engl. J. Med. 316, 79-84.