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Volumn 12, Issue 7, 1998, Pages 1010-1021

Molecular genetic analysis of the heterodimeric splicing factor U2AF: The RS domain on either the large or small Drosophila subunit is dispensable in vivo

Author keywords

Fruitfly; Pre mRNA splicing; RNA binding proteins; RS domains; SR proteins

Indexed keywords

MESSENGER RNA PRECURSOR; RNA BINDING PROTEIN;

EID: 0032054197     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.12.7.1010     Document Type: Article
Times cited : (48)

References (51)
  • 1
    • 0030911051 scopus 로고    scopus 로고
    • Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals
    • Abovich, N. and M. Rosbash. 1997. Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals. Cell 89: 1-10.
    • (1997) Cell , vol.89 , pp. 1-10
    • Abovich, N.1    Rosbash, M.2
  • 2
    • 0028324929 scopus 로고
    • The role of specific protein-RNA and protein-protein interactions in positive and negative control of pre-mRNA splicing by Transformer 2
    • Amrein, H., M.L. Hedley, and T. Maniatis. 1994. The role of specific protein-RNA and protein-protein interactions in positive and negative control of pre-mRNA splicing by Transformer 2. Cell 76: 735-746.
    • (1994) Cell , vol.76 , pp. 735-746
    • Amrein, H.1    Hedley, M.L.2    Maniatis, T.3
  • 3
    • 0003455528 scopus 로고
    • Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • Ashburner, M. 1989. Drosophila: A laboratory handbook. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
    • (1989) Drosophila: A Laboratory Handbook
    • Ashburner, M.1
  • 4
    • 0023988471 scopus 로고
    • A molecular analysis of doublesex, a bifunctional gene that controls both male and female sexual differentiation in Drosophila melanogaster
    • Baker, B.S. and M.F. Wolfner. 1988. A molecular analysis of doublesex, a bifunctional gene that controls both male and female sexual differentiation in Drosophila melanogaster. Genes & Dev. 2: 477-489.
    • (1988) Genes & Dev. , vol.2 , pp. 477-489
    • Baker, B.S.1    Wolfner, M.F.2
  • 5
    • 0027753933 scopus 로고
    • Analysis of the RNA-recognition motif and RS and RGG domains: Conservation in metazoan pre-mRNA splicing factors
    • Birney, E., S. Kumar, and A.R. Krainer. 1993. Analysis of the RNA-recognition motif and RS and RGG domains: Conservation in metazoan pre-mRNA splicing factors. Nucleic Acids Res. 1921: 5803-5316.
    • (1993) Nucleic Acids Res. , vol.1921 , pp. 5803-15316
    • Birney, E.1    Kumar, S.2    Krainer, A.R.3
  • 6
    • 0029382603 scopus 로고
    • Finding splice sites within a wilderness of RNA
    • Black, D.L. 1995. Finding splice sites within a wilderness of RNA. RNA 1: 763-771.
    • (1995) RNA , vol.1 , pp. 763-771
    • Black, D.L.1
  • 7
    • 0025879069 scopus 로고
    • Eukaryotic start and stop translation sites
    • Cavener, D.R. and S.C. Ray. 1991. Eukaryotic start and stop translation sites. Nucleic Acids Res. 19: 3185-3192.
    • (1991) Nucleic Acids Res. , vol.19 , pp. 3185-3192
    • Cavener, D.R.1    Ray, S.C.2
  • 8
    • 0030300044 scopus 로고    scopus 로고
    • Vive la difference: Males vs females in flies vs worms
    • Cline, T.W. and B.J. Meyer. 1996. Vive la difference: Males vs females in flies vs worms. Annu. Rev. Genet. 30: 637-702.
    • (1996) Annu. Rev. Genet. , vol.30 , pp. 637-702
    • Cline, T.W.1    Meyer, B.J.2
  • 9
    • 0030611640 scopus 로고    scopus 로고
    • 65 recruits a novel human DEAD box protein required for assembly of U2 snRNP-branch point interaction
    • 65 recruits a novel human DEAD box protein required for assembly of U2 snRNP-branch point interaction. Genes & Dev. 11: 1864-1872.
    • (1997) Genes & Dev. , vol.11 , pp. 1864-1872
    • Fleckner, J.1    Zhang, M.2    Valcárcel, J.3    Green, M.4
  • 10
    • 0029372979 scopus 로고
    • The superfamily of arginine/serine-rich splicing factors
    • Fu, X.D. 1995. The superfamily of arginine/serine-rich splicing factors. RNA 1: 663-680.
    • (1995) RNA , vol.1 , pp. 663-680
    • Fu, X.D.1
  • 12
    • 0025745243 scopus 로고
    • Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro
    • Hedley, M. L. and T. Maniatis. 1991. Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro. Cell 65: 579-586.
    • (1991) Cell , vol.65 , pp. 579-586
    • Hedley, M.L.1    Maniatis, T.2
  • 13
    • 0025285522 scopus 로고
    • Molecular analysis of no-ontransient, A, a gene required for normal vision in Drosophila
    • Jones, K.R. and G.M. Rubin. 1990. Molecular analysis of no-ontransient, A, a gene required for normal vision in Drosophila. Neuron 4: 711-723.
    • (1990) Neuron , vol.4 , pp. 711-723
    • Jones, K.R.1    Rubin, G.M.2
  • 14
    • 0027445241 scopus 로고
    • The conserved pre-mRNA splicing factor U2AF from Drosophila: Requirement for viability
    • Kanaar, R., S.E. Roche, E.L. Beall, M.R. Green, and D.C. Rio. 1993. The conserved pre-mRNA splicing factor U2AF from Drosophila: Requirement for viability. Science 262: 569-573.
    • (1993) Science , vol.262 , pp. 569-573
    • Kanaar, R.1    Roche, S.E.2    Beall, E.L.3    Green, M.R.4    Rio, D.C.5
  • 16
    • 0029891101 scopus 로고    scopus 로고
    • The structure and function of proteins involved in mammalian pre-mRNA splicing
    • Kramer, A. 1996. The structure and function of proteins involved in mammalian pre-mRNA splicing. Annu. Rev. Biochem. 65: 367-409.
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 367-409
    • Kramer, A.1
  • 17
    • 0027143943 scopus 로고
    • A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding
    • Lavigueur, A., H. La Branche, A.R. Kornblihtt, and B. Chabot. 1993. A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding. Genes & Dev. 7: 2405-2417.
    • (1993) Genes & Dev. , vol.7 , pp. 2405-2417
    • Lavigueur, A.1    La Branche, H.2    Kornblihtt, A.R.3    Chabot, B.4
  • 18
    • 0029767662 scopus 로고    scopus 로고
    • SR proteins and splicing control
    • Manley, J.L. and R. Tacke. 1996. SR proteins and splicing control. Genes & Dev. 10: 1569-1579.
    • (1996) Genes & Dev. , vol.10 , pp. 1569-1579
    • Manley, J.L.1    Tacke, R.2
  • 19
    • 0001877802 scopus 로고
    • Splicing of precursors to mRNAs by the spliceosome
    • (ed. R.F. Gesteland and J.F. Atkins), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • Moore, M.J., C.C. Query, and P.A. Sharp. 1993. Splicing of precursors to mRNAs by the spliceosome. In The RNA world (ed. R.F. Gesteland and J.F. Atkins), pp. 303-357. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
    • (1993) The RNA World , pp. 303-357
    • Moore, M.J.1    Query, C.C.2    Sharp, P.A.3
  • 20
    • 0025189682 scopus 로고
    • Regulation of sex-specific RNA splicing at the Drosophila doublesex gene: Cis-acting mutations in exon sequences alter sex-specific RNA splicing patterns
    • Nagoshi, R.N. and B.S. Baker. 1990. Regulation of sex-specific RNA splicing at the Drosophila doublesex gene: Cis-acting mutations in exon sequences alter sex-specific RNA splicing patterns. Genes & Dev. 4: 89-97.
    • (1990) Genes & Dev. , vol.4 , pp. 89-97
    • Nagoshi, R.N.1    Baker, B.S.2
  • 21
    • 0024294339 scopus 로고
    • The control of alternative splicing at genes regulating sexual differentiation in D. melanogaster
    • Nagoshi, R.N., M. McKeown, K.C. Burtis, J.M. Belote, and B.S. Baker. 1988. The control of alternative splicing at genes regulating sexual differentiation in D. melanogaster. Cell 53: 229-236.
    • (1988) Cell , vol.53 , pp. 229-236
    • Nagoshi, R.N.1    McKeown, M.2    Burtis, K.C.3    Belote, J.M.4    Baker, B.S.5
  • 22
    • 0027492990 scopus 로고
    • U2AF homolog required for splicing in vivo
    • Potashkin, J., K. Naik, and K. Wentz-Hunter. 1993. U2AF homolog required for splicing in vivo. Science 262: 573-575.
    • (1993) Science , vol.262 , pp. 573-575
    • Potashkin, J.1    Naik, K.2    Wentz-Hunter, K.3
  • 23
    • 0029933504 scopus 로고    scopus 로고
    • Initial splice-site recognition and pairing during pre-mRNA splicing
    • Reed, R. 1996. Initial splice-site recognition and pairing during pre-mRNA splicing. Curr. Opin. Genet. Dev. 6: 215-220.
    • (1996) Curr. Opin. Genet. Dev. , vol.6 , pp. 215-220
    • Reed, R.1
  • 24
    • 0028046121 scopus 로고
    • The SR protein B52/SRp55 is essential for Drosophila development
    • Ring, H.Z. and J.T. Lis. 1994. The SR protein B52/SRp55 is essential for Drosophila development. Mol. Cell. Biol. 14: 7499-7506.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 7499-7506
    • Ring, H.Z.1    Lis, J.T.2
  • 25
    • 0029814786 scopus 로고    scopus 로고
    • Mutations in the small subunit of the Drosophila U2AF splicing factor cause lethality and developmental defects
    • Rudner, D.Z., R. Kanaar, K.S. Breger, and D.C. Rio. 1996. Mutations in the small subunit of the Drosophila U2AF splicing factor cause lethality and developmental defects. Proc. Natl. Acad. Sci. 93: 10333-10337.
    • (1996) Proc. Natl. Acad. Sci. , vol.93 , pp. 10333-10337
    • Rudner, D.Z.1    Kanaar, R.2    Breger, K.S.3    Rio, D.C.4
  • 26
    • 0031924788 scopus 로고    scopus 로고
    • Interaction between subunits of the heterodimeric splicing factor U2AF is essential in vivo
    • in press
    • Rudner, D.Z., R. Kanaar, K.S. Breger, and D.C. Rio. 1998. Interaction between subunits of the heterodimeric splicing factor U2AF is essential in vivo. Mol. Cell. Biol. (in press).
    • (1998) Mol. Cell. Biol.
    • Rudner, D.Z.1    Kanaar, R.2    Breger, K.S.3    Rio, D.C.4
  • 27
    • 0023834880 scopus 로고
    • A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly
    • Ruskin, B., P.D. Zamore, and M.R. Green. 1988. A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly. Cell 52: 207-219.
    • (1988) Cell , vol.52 , pp. 207-219
    • Ruskin, B.1    Zamore, P.D.2    Green, M.R.3
  • 29
    • 0025351553 scopus 로고
    • Enhanced translational efficiency with two-cistron expression system
    • (ed. D.V. Goeddel), Academic Press, San Diego, CA
    • Schoner, B.E., R.M. Belagaje, and R.G. Schoner. 1990. Enhanced translational efficiency with two-cistron expression system. In Methods in enzymology (ed. D.V. Goeddel), pp. 94-103. Academic Press, San Diego, CA.
    • (1990) Methods in Enzymology , pp. 94-103
    • Schoner, B.E.1    Belagaje, R.M.2    Schoner, R.G.3
  • 30
    • 0028307171 scopus 로고
    • Split genes and RNA splicing
    • Sharp, P.A. 1994. Split genes and RNA splicing. Cell 77: 805-815.
    • (1994) Cell , vol.77 , pp. 805-815
    • Sharp, P.A.1
  • 31
    • 0025737866 scopus 로고
    • Cloning of a yeast U1 snRNP 70K protein homologue: Functional conservation of an RNA-binding domain between humans and yeast
    • Smith, V. and B.C. Barrell. 1991. Cloning of a yeast U1 snRNP 70K protein homologue: Functional conservation of an RNA-binding domain between humans and yeast. EMBO J. 10: 1627-2634.
    • (1991) EMBO J. , vol.10 , pp. 1627-2634
    • Smith, V.1    Barrell, B.C.2
  • 32
    • 0001868286 scopus 로고
    • P element-mediated transformation
    • (ed. D.B. Roberts), IRL Press, Washington, D.C.
    • Spradling, A.C. 1986. P element-mediated transformation. In Diosophila: A practical approach (ed. D.B. Roberts), pp. 175-197. IRL Press, Washington, D.C.
    • (1986) Diosophila: A Practical Approach , pp. 175-197
    • Spradling, A.C.1
  • 33
    • 0028006713 scopus 로고
    • SR proteins promote the first specific recognition of pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex
    • Staknis, D. and R. Reed. 1994. SR proteins promote the first specific recognition of pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex. Mol. Cell. Biol. 14: 7670-7682.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 7670-7682
    • Staknis, D.1    Reed, R.2
  • 34
    • 0027715743 scopus 로고
    • General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer
    • Sun, Q., A. Mayeda, R.K. Hampson, A.R. Krainer, and P.M. Rottman. 1993. General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer. Genes & Dev. 7: 2598-2608.
    • (1993) Genes & Dev. , vol.7 , pp. 2598-2608
    • Sun, Q.1    Mayeda, A.2    Hampson, R.K.3    Krainer, A.R.4    Rottman, P.M.5
  • 35
    • 0031037690 scopus 로고    scopus 로고
    • Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: Creation of an SRp40-specific splicing enhancer
    • Tacke, R., Y. Chen, and J.L. Manley. 1997. Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: Creation of an SRp40-specific splicing enhancer. Proc. Natl. Acad. Sci. 94: 1148-1153.
    • (1997) Proc. Natl. Acad. Sci. , vol.94 , pp. 1148-1153
    • Tacke, R.1    Chen, Y.2    Manley, J.L.3
  • 36
    • 0027185151 scopus 로고
    • A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA
    • Tian, M. and T. Maniatis. 1993. A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA. Cell 74: 105-114.
    • (1993) Cell , vol.74 , pp. 105-114
    • Tian, M.1    Maniatis, T.2
  • 37
    • 0039769985 scopus 로고    scopus 로고
    • 65 and SR proteins in splicing of pre-mRNA
    • 65 and SR proteins in splicing of pre-mRNA. Nature 388: 397-400.
    • (1997) Nature , vol.388 , pp. 397-400
    • Tronchère, H.1    Wang, J.2    Fu, X.3
  • 38
    • 0030595187 scopus 로고    scopus 로고
    • 65 RS region with pre-mRNA of branch point and promotion base pairing with U2 snRNA
    • 65 RS region with pre-mRNA of branch point and promotion base pairing with U2 snRNA. Science 273: 1706-1709.
    • (1996) Science , vol.273 , pp. 1706-1709
    • Valcárcel, T.1    Gaur, R.K.2    Singh, R.3    Green, M.R.4
  • 39
    • 0027400786 scopus 로고
    • The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA
    • Valcárcel, J., R. Singh, P.D. Zamore, and M.R. Green. 1993. The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA. Nature 362: 171-175.
    • (1993) Nature , vol.362 , pp. 171-175
    • Valcárcel, J.1    Singh, R.2    Zamore, P.D.3    Green, M.R.4
  • 40
    • 0029859659 scopus 로고    scopus 로고
    • Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability
    • Wang, J., Y. Takagaki, and J.L. Manley. 1996. Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability. Genes & Dev. 10: 2588-2599.
    • (1996) Genes & Dev. , vol.10 , pp. 2588-2599
    • Wang, J.1    Takagaki, Y.2    Manley, J.L.3
  • 41
    • 0029258817 scopus 로고
    • Intrinsic U2AF binding is modulated by exon enhancer signals in parallel with changes in splicing activity
    • Wang, Z., H.M. Hoffmann, and P.J. Grabowski. 1995. Intrinsic U2AF binding is modulated by exon enhancer signals in parallel with changes in splicing activity. RNA 1: 21-35.
    • (1995) RNA , vol.1 , pp. 21-35
    • Wang, Z.1    Hoffmann, H.M.2    Grabowski, P.J.3
  • 42
    • 0029890769 scopus 로고    scopus 로고
    • The small subunit of the splicing factor U2AF is conserved in fission yeast
    • Wentz-Hunter, K. and J. Potashkin. 1996. The small subunit of the splicing factor U2AF is conserved in fission yeast. Nucleic Acids Res. 24: 1849-1854.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 1849-1854
    • Wentz-Hunter, K.1    Potashkin, J.2
  • 43
    • 0030447656 scopus 로고    scopus 로고
    • Metal binding properties and secondary structure of the zinc-binding domain of Nup475
    • Worthington, M.T., B.T. Amann, D. Nathans, and J.M. Berg. 1996. Metal binding properties and secondary structure of the zinc-binding domain of Nup475. Proc. Natl. Acad. Sci. 93: 13754-13759.
    • (1996) Proc. Natl. Acad. Sci. , vol.93 , pp. 13754-13759
    • Worthington, M.T.1    Amann, B.T.2    Nathans, D.3    Berg, J.M.4
  • 44
    • 0027137934 scopus 로고
    • Specific interactions between proteins implicated in splice site selection and regulated alternative splicing
    • Wu, J. and T. Maniatis. 1993. Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. Cell 75: 1061-1070.
    • (1993) Cell , vol.75 , pp. 1061-1070
    • Wu, J.1    Maniatis, T.2
  • 45
    • 0031042396 scopus 로고    scopus 로고
    • Phosphorylation of the ASF/ SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing
    • Xiao, S.H. and J.L. Manley. 1997. Phosphorylation of the ASF/ SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing. Genes & Dev. 11: 334-344.
    • (1997) Genes & Dev. , vol.11 , pp. 334-344
    • Xiao, S.H.1    Manley, J.L.2
  • 46
    • 0024408832 scopus 로고
    • Identification, purification, and biochemical characterization of U2 small nuclear ribonucleoprotein auxiliary factor
    • Zamore, P.D. and M.R. Green. 1989. Identification, purification, and biochemical characterization of U2 small nuclear ribonucleoprotein auxiliary factor. Proc. Natl. Acad. Sci. 86: 9243-9247.
    • (1989) Proc. Natl. Acad. Sci. , vol.86 , pp. 9243-9247
    • Zamore, P.D.1    Green, M.R.2
  • 47
    • 0026026981 scopus 로고
    • Biochemical characterization of U2 snRNP auxiliary factor: An essential pre-mRNa splicing factor with a novel intranuclear distribution
    • Zamore, P.D. and M.R. Green. 1991. Biochemical characterization of U2 snRNP auxiliary factor: An essential pre-mRNA splicing factor with a novel intranuclear distribution. EMBO J. 10: 207-214.
    • (1991) EMBO J. , vol.10 , pp. 207-214
    • Zamore, P.D.1    Green, M.R.2
  • 48
    • 0026569967 scopus 로고
    • Cloning and domain structure of the mammalian splicing factor U2AF
    • Zamore, P.D., J.G. Patton, and M.R. Green. 1992. Cloning and domain structure of the mammalian splicing factor U2AF. Nature 355: 609-614.
    • (1992) Nature , vol.355 , pp. 609-614
    • Zamore, P.D.1    Patton, J.G.2    Green, M.R.3
  • 49
    • 0026649523 scopus 로고
    • Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit
    • Zhang, M., P.D. Zamore, M. Carmo-Fonseca, A.I. Lamond, and M.R. Green. 1992. Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit. Proc. Natl. Acad. Sci. 89: 8769-8773.
    • (1992) Proc. Natl. Acad. Sci. , vol.89 , pp. 8769-8773
    • Zhang, M.1    Zamore, P.D.2    Carmo-Fonseca, M.3    Lamond, A.I.4    Green, M.R.5
  • 51
    • 0029665533 scopus 로고    scopus 로고
    • 35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing
    • 35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing. Genes & Dev. 10: 1356-1368.
    • (1996) Genes & Dev. , vol.10 , pp. 1356-1368
    • Zuo, P.1    Maniatis, T.2


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