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40
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of outstanding interest. In this study, noncoding immunostimulating sequences (ISS)-enriched plasmid DNAs or ISS oligonucleotides stimulated immune responses to coadministered antigens. The ISS-enriched DNAs suppressed IgE synthesis but promoted IgG and IFN-γ production; furthermore they appear to initiate the production of IFN-γ, IFN-α, IFN-β, IL-12 and IL-18 - all of which foster Th1 responses and enhance cell-mediated immunity.
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Roman M, Martin-Orozco E, Goodman JS, Nguyen MD, Sato Y, Ronaghy A, Kornbluth RS, Richman DD, Carson DA, Raz E. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. of outstanding interest Nat Med. 3:1997;849-854 In this study, noncoding immunostimulating sequences (ISS)-enriched plasmid DNAs or ISS oligonucleotides stimulated immune responses to coadministered antigens. The ISS-enriched DNAs suppressed IgE synthesis but promoted IgG and IFN-γ production; furthermore they appear to initiate the production of IFN-γ, IFN-α, IFN-β, IL-12 and IL-18 - all of which foster Th1 responses and enhance cell-mediated immunity.
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52
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Crossreactivity and T-cell epitope specificity of Bet v 1-specific T cells suggest the involvement of multiple isoallergens in sensitization to birch pollen
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+) reacted with affinity-purified Bet v 1 but showed different reactivities with recombinant Bet v 1 and with group 1 allergens from other Fagales species.
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+) reacted with affinity-purified Bet v 1 but showed different reactivities with recombinant Bet v 1 and with group 1 allergens from other Fagales species.
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Dichotomy of blood- And skin-derived IL-4-producing allergen-specific T cells and restricted V beta repertoire in nickel-mediated contact dermatitis
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+ T lymphocytes were type 0 or type 2 - indicating that their cytokine profile was modified by their environment.
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+ T lymphocytes were type 0 or type 2 - indicating that their cytokine profile was modified by their environment.
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Werfel, T.1
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+ T cells were increased.
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+ T cells were increased.
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Lack, G.1
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55
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+ clones had a Th1-like phenotype, with high IFN-γ and TNF-α production.
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+ clones had a Th1-like phenotype, with high IFN-γ and TNF-α production.
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Direct, MHC-dependent presentation of the drug sulfamethoxazole to human αβ T cell clones
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+ sulfamethoxazole-specific T cell clones with glutaraldehyde-fixed antigen-presenting cells (APCs). There was no cross-reactivity with other sulphonamides. The continuous presence of sulfamethoxazole and MHC-compatible APCs was required. This suggests that binding to MHC did not require antigen processing.
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+ sulfamethoxazole-specific T cell clones with glutaraldehyde-fixed antigen-presenting cells (APCs). There was no cross-reactivity with other sulphonamides. The continuous presence of sulfamethoxazole and MHC-compatible APCs was required. This suggests that binding to MHC did not require antigen processing.
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Schnyder, B.1
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+ T cells
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+ T cells producing IL-4 and IL-10, which function to limit the magnitude and the duration of the response.
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+ T cells producing IL-4 and IL-10, which function to limit the magnitude and the duration of the response.
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Xu, H.1
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59
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Products from mast cells influence T lymphocyte proliferation and cytokine production relevant to allergic asthma?
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+ T cell clone towards a more pronounced Tc1 type of response, simultaneously decreasing T cell numbers. This might represent a negative feed-back mechanism operating in allergic subjects, by which the Th2-driven IgE production and eosinophilia are counteracted.
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+ T cell clone towards a more pronounced Tc1 type of response, simultaneously decreasing T cell numbers. This might represent a negative feed-back mechanism operating in allergic subjects, by which the Th2-driven IgE production and eosinophilia are counteracted.
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Van Halteren, A.G.1
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63
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+ T cell responses
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of outstanding interest. This reports that Dermatophagoides pteronyssinus contains potential binding motifs for MHC class I. These Der p 1 residues 111-119 (FGIS-NYCQI, using single-letter code for amino acids) contain motifs for H-2Db and H-2Kb. Immunization of C57BL/6 mice with virus-like particles carrying Der p 1 (111-139) primed Der p 1 (111-119)-specific H-2Db-restricted CTLs.
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+ T cell responses. of outstanding interest Int Immunol. 9:1997;273-280 This reports that Dermatophagoides pteronyssinus contains potential binding motifs for MHC class I. These Der p 1 residues 111-119 (FGIS-NYCQI, using single-letter code for amino acids) contain motifs for H-2Db and H-2Kb. Immunization of C57BL/6 mice with virus-like particles carrying Der p 1 (111-139) primed Der p 1 (111-119)-specific H-2Db-restricted CTLs.
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Harris, S.J.1
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+ T cells in a mouse model of allergen-induced sensitization. J Immunol. 152:1994;351-360.
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of outstanding interest. This demonstrates that CTLs cultured with or without antigen can act as memory T cells when parked for 100 days in unirradiated, syngeneic recipients without antigen. The precursor frequency was identical in the spleens of normal and β2-microglobulin-knockout recipients but significantly less in IL-2-knockout mice.
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+ cytotoxic T lymphocytes. of outstanding interest J Exp Med. 187:1998;49-57 This demonstrates that CTLs cultured with or without antigen can act as memory T cells when parked for 100 days in unirradiated, syngeneic recipients without antigen. The precursor frequency was identical in the spleens of normal and β2-microglobulin-knockout recipients but significantly less in IL-2-knockout mice.
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Hoyne GF, Jarnicki AG, Thomas WR, Lamb JR. Characterization of the specificity and duration of T cell tolerance to intranasally administered peptides in mice: a role for intramolecular epitope suppression. of outstanding interest Int Immunol. 9:1997;1165-1173 In this report, induction of tolerance by the nasally administered immunodominant allergen lead to a diminution in all T-cell-derived cytokines and modulation of delayed-type hypersensitivity responses but IgE production did not seem to be affected.
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+ T cells produced IL-4 compared with nonallergic controls. In contrast, the frequency of IFN-γ-producing cells was comparable between the allergic and nonallergic individuals.
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+ T cells produced IL-4 compared with nonallergic controls. In contrast, the frequency of IFN-γ-producing cells was comparable between the allergic and nonallergic individuals.
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