Depletion of cd8+ t cells following primary immunization with ovalbumin results in a high and persistent ige response

International Archives of Allergy and Immunology

Volumn 113, Issue 1-3, 1997, Pages 160-162

  Holmes, B J ^a   MacAry, P A ^a   Kemeny, D M ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

CD8+ T cell; IgE; Immune regulation; Th1; Th2

Indexed keywords

CD8 ANTIGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; OVALBUMIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; CELLULAR IMMUNITY; CONFERENCE PAPER; CONTROLLED STUDY; HELPER CELL; IMMUNIZATION; IMMUNOGLOBULIN PRODUCTION; IMMUNOREGULATION; LYMPH NODE; NONHUMAN; PRIORITY JOURNAL; RAT; SPLEEN; SUPPRESSOR CELL; T LYMPHOCYTE;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; IMMUNIZATION; IMMUNOGLOBULIN E; LYMPHOCYTE DEPLETION; MALE; OVALBUMIN; RATS;

EID: 0030993524     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000237534     Document Type: Article

References (15)

1. Mosmann TR, Chcrwinski H, Bond MW, Gie-dlin MA, Coffman RL, Two types of murine helper T cell clones, I, Definition according to profiles of lymphokinc activities and secreted proteins, J Immunol 1986;135:2348-2357.
2. Snapper CM, Paul WE: Intcrfcron-y and B cell stimulatory factor-1 reciprocally regulate Ig isotype production, Science, 1987:236:944-947.
3. Del-Prete GF, De-Carli M, Ricci M, Romagnani S: Helper activity for immunoglobulin synthesis of T helper type I (Thl) and Th2 human T cell clones: The help of Thl clones is limited by their cytolytic capacity, J Exp Med 1991; 174:809-813.
4. Kay AB: Helper (CD4(+)) T cells and eosinophils in allergy and asthma, Am Rev Rcspir Dis 1992; 145:22-26.
5. Noble A, Diaz-Sanchez D, Staynov D, Lee T, Kemeny DM: Elimination of IgE regulatory rat CDS t T cells in vivo increases the co-ordinate expression of the Th2 cytokines IL-4. IL-5 and IL-IO, Immunology 1993;80:326-329.
6. Diaz-Sanchez D, Noble A, Staynov DZ, Lee TI L Kemeny DM: Elimination of IgE regulatory CD8+ T cells in vivo differentially modulates the ability of splenocytcs to produce IL-4 and IFNy but not IL-2. Immunology 1993:78: 513-519.
7. Diaz-Sanchez D, Lee TH, Kemeny DM: Ricin enhances IgE responses by inhibiting a subpopulation of early-activated CD8+ T cells, Immunology 1993:78:226-236.
8. Kemeny DM, Noble A, Holmes B, I, Diaz-Sanchez D: Immune regulation: A new job for the CDS i T cell, Immunol Today 1994:15:107-110.
9. McMenamin C, Holt PG: The natural immune response to inhaled soluble protein antigens involves major histocompatability complex (MHC) class-l-restricted CD8+ T cell mediated, but MHC class ll-restrictcd CD4+ Tcell-dependent immune deviation resulting in selective suppression of immunoglobulin F, production, J Exp Med 1993;178:889-899.
10. McMenamin C, Pimm C, McKersey M, Holt PCi: Regulation of lgF, responses to inhaled antigen in mice by antigen-specific gamma delta Tcells, Science 1994:265:1869-1871.
11. Holmes BJ, Diaz-Sanchez D, Lawrence RA, Maizcls RM, Kemeny DM: The contrasting effects of CD8+ T cells on primary, established and Nippostrongylus hrasiUensis-induced IgE responses, Immunology 1996;88:252-260.
12. McMenamin C, McKersey M, Kuhnlein P, lu-nig T, lolt PG: Gamma delta T cells down-reg-ulatc primary IgE responses in rats to inhaled soluble protein antigens, J Immunol 1995:154: 4390-4394.
13. Holmes BJ, MacAry PA, Kemeny DM: In vivo depletion of CD8+ T cells following the primary immune response results in a high and persistent IgE response in IgE hyporesponsive rats, Eur J Immunol, submitted
14. MacAry PA, Holmes BJ, Kemeny DM, IgE inhibitory ovalbumin-specific MHC class 1-rc-strictcd, aJ TcR positive rat Tc I and TcO CD8+ T cell clones generated using lipid solubilised ovalbumin peptides, J Immunol, submitted
15. Noble A, MacAry PA, Kemeny DM, IFN-y and IL-4 regulate the differentiation of CD8+ Tcells into subpopulations with distinct cytokine profiles, J Immunol 1995;155:2928-2937