Selective CD8+ T cells accumulate in the lungs of patients with allergic asthma after allergen bronchoprovocation

Clinical and Experimental Immunology

Volumn 112, Issue 1, 1998, Pages 1-9

  Wahlstrom J ^a,b   Dahlen B ^a   Ihre, E ^a   Wigzell, H ^a   Grunewald, J ^a   Eklund, A ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Allergic asthma; T cell expansion; T cell receptor

Indexed keywords

ALLERGEN; CD4 ANTIGEN; CD8 ANTIGEN; MONOCLONAL ANTIBODY; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ADULT; ALLERGIC ASTHMA; ARTICLE; CLINICAL ARTICLE; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INHALATION TEST; LUNG LAVAGE; LYMPHOCYTE PROLIFERATION; MALE; PRIORITY JOURNAL; T LYMPHOCYTE RECEPTOR GENE; T LYMPHOCYTE SUBPOPULATION;

ADULT; ASTHMA; BRONCHIAL PROVOCATION TESTS; CD8-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; FEMALE; HUMANS; LUNG; LYMPHOCYTE ACTIVATION; MALE; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTE SUBSETS;

EID: 0031971267     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1998.00544.x     Document Type: Article

References (39)

1. Djukanovic R, Roche W, Wilson J et al. Mucosal inflammation in asthma. Am Rev Respir Dis 1940; 142:434-57.
2. Kay A. Asthma and inflammation. J Allergy Clin Immunol 1991; 87:893-910.
3. Wilson J, Djukanovic R, Howarth P, Holgate S. Lymphocyte activation in bronchoalveolar lavage and peripheral blood in atopic asthma. Am Rev Respir Dis 1992; 145:958-60.
4. Azzawi M, Bradley B, Jeffery P et al. Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am Rev Respir Dis 1990; 142:1407-13.
5. Bradley B, Azzawi M, Jacobson M et al. Eosinophils. T-lymphocytes, mast cells, neutrophils and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness. J Allergy Clin Immunol 1991; 88:661-74.
6. Wilson J, Djukanovic R, Howarth P, Holgate S. Inhaled beclomethasone dipropionate downregulates airway lymphocyte activation in atopic asthma. Am J Respir Crit Care Med 1994; 149:86-90.
7. Moss P, Rosenberg W, Bell J. The human T cell receptor in health and disease. Annu Rev Immunol 1992; 10:71-96.
8. Davis M, Bjorkman P. T-cell antigen receptor genes and T-cell recognition. Nature 1988; 334:395-402.
9. Arden B, Clark S, Kabelitz D, Mak T. Human T-cell receptor variable gene segment families. Immunogenetics 1995; 42:455-500.
10. Grunewald J, Wigzell H. T cell expansions in healthy individuals. Immunologist 1996; 4:99-103.
11. Dahlén B, Zetterström O, Björck T, Dahlén S-E. The leukotriene-antagonist ICI-204,219 inhibits the early airway reaction to cumulative bronchial challenge with allergen in atopic asthmatics. Eur Resp J 1994; 7:324-31.
12. Eklund A, Blaschke E. Relationship between changed alveolar-capillary permeability and angiotensin converting enzyme activity in serum in sarcoidosis. Thorax 1986; 41:629-34.
13. + T cells in bronchoalveolar lavage fluid and peripheral blood of sarcoidosis patients. Proc Natl Acad Sci USA 1994; 91:4965-9.
14. Gulwani-Akolkar B, Posnett D, Janson C et al. T cell receptor V-segment frequencies in peripheral blood T cells correlate with human leukocyte antigen type. J Exp Med 1991; 174:1139-46.
15. Olerup O, Zetterquist H. HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours: an alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation. Tissue Antigens 1992; 39:225-35.
16. Forman J, Klein J, Silver R, Liu M, Greenlee B, Moller D. Selective activation and accumulation of oligoclonal Vβ-specific T cells in active pulmonary sarcoidosis. J Clin Invest 1994; 94:1533-42.
17. Yurovsky V, Bleecker E, White B. Restricted T-cell antigen receptor repertoire in bronchoalveolar T cells from normal humans. Human Immunol 1996; 50:22-37.
18. Burastero S, Borgonovo B, Gaffi D et al. The repertoire of T-lymphocytes recovered by bronchoalveolar lavage from healthy nonsmokers. Eur Respir J 1996; 9:319-27.
19. Burastero S, Crimi E, Balbo A et al. Oligoclonality of lung T lymphocytes following exposure to allergen in asthma. J Immunol 1995; 155:5836-46.
20. Boitel B, Ermonval M, Panina-Bordignon P, Mariuzza R, Lanzavecchia A, Acuto O. Preferential Vβ gene usage and lack of junctional sequence conservation among human T cell receptors specific for a tetanus toxin-derived peptide: evidence for a dominant role of a germline-encoded V region in antigen/major histocompatibility complex recognition. J Exp Med 1992; 175:765-77.
21. Kaufmann S. Heat shock proteins and the immune response. Immunol Today 1990; 11:129-36.
22. Ulrich R, Bavari S, Olson M. Bacterial superantigens in human disease: structure, function and diversity. Trends Microbiol 1995; 3:463-8.
23. van Neerven R, Ebner C, Yssel H, Kapsenberg M, Lamb J. T-cell responses to allergens: epitope-specificity and clinical relevance. Immunol Today 1996; 17:526-32.
24. Lanzavecchia A. Mechanisms of antigen uptake for presentation. Curr Opin Immunol 1996; 8:348-54.
25. + T-cell-dependent immune deviation resulting in suppression of IgE production. J Exp Med 1993; 178:889-99.
26. Jerne N. Toward a network theory of the immune system. Ann Immunol 1974; 125C:373-89.
27. Gonzales M, Diaz P, Galleguillos F, Ancic P, Cromwell O, Kay A. Allergen-induced recruitment of bronchoalveolar helper (OKT4) and suppressor (OKT8) T-cells in asthma: relative increases in OKT8 cells in single early responders compared with those in late-phase responders. Am Rev Respir Dis 1987; 136:600-4.
28. Kelly C, Stenton S, Ward C, Bird G, Hendrick D, Walters E. Lymphocyte subsets in bronchoalveolar lavage fluid obtained from stable asthmatics, and their correlations with bronchial responsiveness. Clin Exp Allergy 1989; 19:169-75.
29. + T cells in the development of airway hyperresponsiveness in a murine model of airway sensitization. J Exp Med 1996; 183:1719-29.
30. Wahlström J, Berlin M, Lundgren R et al. Lung and blood T-cell receptor repertoire in extrinsic allergic alveolitis. Eur Respir J 1997; 10:772-9.
31. Renz H, Bradley K, Gelfand E. Production of interleukin-4 and interferon-γ by TCR-Vβ-expressing T-cell subsets in allergen-sensitized mice. Am J Respir Cell Mol Biol 1996; 14:36-43.
32. Renz H, Saloga J, Bradley K et al. Specific Vβ T cell subsets mediate the immediate hypersensitivity response to ragweed allergen. J Immunol 1993; 151:1907-17.
33. Parijs L, Ibraghimov A, Abbas A. The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance. Immunity 1996; 4:321-8.
34. Schwartz R. Models of T-cell anergy: is there a common molecular mechanism? J Exp Med 1996; 184:1-8.
35. Kearney E, Pape K, Loh D, Jenkins M. Visualization of peptide-specific T-cell immunity and peripheral tolerance induction in vivo. Immunity 1994; 1:327-39.
36. Posnett D, Sinha R, Kabak S, Russo C. Clonal populations of T cells in normal elderly humans: the T cell equivalent to 'Benign Monoclonal Gammapathy'. J Exp Med 1994; 179:609-18.
37. Grunewald J, Tehrani M, Andersson R, DerSimonian H, Wigzell H. A persistent monoclonal T cell expansion in the peripheral blood of a normal adult male: a new clinical entity? Clin Exp Immunol 1992; 89:279-84.
38. Stewart G, Lockey R. Systemic reactions from allergen immunotherapy. J Allergy Clin Immunol 1992; 90:567-78.
39. Hoyne G, O'Hehir R, Wraith D, Thomas W, Lamb J. Inhibition of T cell and antibody responses to the house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice. J Exp Med 1993; 178:1783-8.