Rush immunotherapy results in allergen-specific alterations in lymphocyte function and interferon-γ production in CD4+ T cells

Journal of Allergy and Clinical Immunology

Volumn 99, Issue 4, 1997, Pages 530-538

  Lack, Gideon ^b   Nelson, Harold S ^b   Amran, David ^b   Oshiba, Akihiro ^b   Jung, Thomas ^b   Bradley, Katherine L ^b   Giclas, Patricia C ^b   Gelfand, Erwin W ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b NONE

Author keywords

B cells; interferon ; Rush immunotherapy; specificity; T cells

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CD4 ANTIGEN; CD8 ANTIGEN; CORTICOSTEROID; CYTOKINE; GAMMA INTERFERON; HOUSE DUST ALLERGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E ANTIBODY; INTERLEUKIN 2; INTERLEUKIN 4; PREDNISONE; THEOPHYLLINE;

ADOLESCENT; ALLERGIC ASTHMA; ARTICLE; B LYMPHOCYTE; CHILD; CLINICAL ARTICLE; DERMATOPHAGOIDES PTERONYSSINUS; FEMALE; FLOW CYTOMETRY; HOUSE DUST; HUMAN; HUMAN CELL; IMMUNOTHERAPY; INHALATIONAL DRUG ADMINISTRATION; LYMPHOCYTE PROLIFERATION; MALE; MONONUCLEAR CELL; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROVOCATION TEST; SKIN TEST; T LYMPHOCYTE;

EID: 0030902319     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(97)70081-2     Document Type: Article

References (46)

1. Devey E, Wilson DV, Wheeler AW. The IgG subclasses of antibodies to grass pollen allergens produced in hay fever patients during hyposensitization. Clin Allergy 1976;6:227-36.
2. Aalbers R, Van der Gaag R, Van Leeuwen J. Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4 restricted response. J Immunol 1983;130:722-6.
3. Djurup R. The subclass nature and clinical significance of the IgG antibody response in patients undergoing allergen-specific immunotherapy. Allergy 1985;40:469-86.
4. Djurup R, Osterballe O. IgG subclass antibody response in grass pollen-allergic patients undergoing specific immunotherapy. Allergy 1984;39:433-41.
5. Djurup R, Mailing HJ, Sondergaard I, Weeke B. The IgE and IgG subclass antibody response in patients allergic to yellow jacket venom undergoing different regimens of venom immunotherapy. J Allergy Clin Immunol 1985;76:46-55.
6. Urbanek R, Kemeny DM, Richards D. Subclass of IgG anti-bee venom antibody produced during bee venom immunotherapy and its relationship to long-term protection from bee stings and following termination of venom immunotherapy. Clin Allergy 1986;16:317-22.
7. Moss RB, Hsu YP, Kwasnicki JM, Sullivan MM, Reid MJ. Isotypic and antigenic restriction of the blocking antibody response to rye grass pollen: correlation of rye group I antigen-specific IgG1 with clinical response. J Allergy Clin Immunol 1987;79:387-98.
8. Mailing HJ, Djurup R. Diagnosis and immunotherapy of mold allergy. VII. IgG subclass response and relation to the clinical efficacy of immunotherapy with Cladosporium. Allergy 1988;43:60-70.
9. Peng Z, Naclerio RM, Norman PS, Adkinson NF Jr. Quantitative IgE- and IgG-subclass responses during and after long-term ragweed immunotherapy. J Allergy Clin Immunol 1992;89:519-29.
10. Rocklin RE, Sheffer AL, Greineder DK, Melmon KL. Generation of antigen-specific suppressor cells during allergy desensitization. N Engl J Med 1980;302:1213-9.
11. Rak S, Lowhagen O, Venge P. The effect of immunotherapy on bronchial hyper-responsiveness and eosinophil cationic protein in pollen-allergic patients. J Allergy Clin Immunol 1988;82:470-80.
12. Kuna P, Alam R, Kuzminska B, Rozniecki J. The effect of preseasonal immunotherapy on the production of histamine-releasing factor (HRF) by mononuclear cells from patients with seasonal asthma: results of a double-blind, placebo-controlled randomized study. J Allergy Clin Immunol 1989;83:816-24.
13. Oppenheiner JJ, Nelson HS, Bock SA, Christensen F, Leung DYM. Treatment of peanut allergy with rush immunotherapy. J Allergy Clin Immunol 1992;90:256-62.
14. Lilja G, Sundin B, Graff-Lonnevig V, Hedlin G, Heilborn H, Norrlind K, et al. Immunotherapy with cat- and dog-dander extracts. IV. Effects of 2 years of treatment. J Allergy Clin Immunol 1989;83:37-44.
15. Hedlin G, Graff-Lonnevig V, Heilborn H, Lilja G, Norrlind K, Pegelow K, et al. Immunotherapy with cat- and dog-dander extracts. V. Effects of 3 years of treatment. J Allergy Clin Immunol 1991;87:955-64.
16. Otsuka H, Mezawa A, Ohnishi M, Okubo K, Seki H, Okuda M. Changes in nasal metachromatic cells during allergen immunotherapy. Clin Exp Allergy 1991;21:115-9.
17. Rak S, Bjornson A, Hakanson L, Sorenson S, Venge P. The effect of immunotherapy on eosinophil accumulation and production of eosinophil chemotactic activity in the lung of subjects with asthma during natural pollen exposure. J Allergy Clin Immunol 1991;88:878-88.
18. Tipton WR, Nelson HS. Experience with daily immunotherapy in 59 adult allergic patients. J Allergy Clin Immunol 1982;69:194-9.
19. Bousquet J, Maasch H, Martinot B, Hejjaoui A, Wahl R, Michel FB. Double-blind, placebo-controlled immunotherapy with mixed grasspollen allergoids. J Allergy Clin Immunol 1988;82:439-46.
20. HayGlass KT, Stefura BP. Anti-interferon-γ treatment blocks the ability of glutaraldehyde-polymerized allergens to inhibit specific IgE responses. J Exp Med 1991;173:279-85.
21. Varney VA, Hamid QA, Gaga M, Ying S, Jacobson M, Frew AJ, et al. Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses. J Clin Invest 1993;92:644-51.
22. + T cells from allergic individuals. J Exp Med 1993;178:2123-30.
23. Bousquet J, Lebel B, Khivert H, Bataille Y, Martinot B, Michel FB. Nasal challenge with pollen grains, skin-prick tests and specific IgE in patients with grass pollen allergy. Clin Allergy 1987;17:529-36.
24. Jung T, Schauer U, Heusser C, Neumann C, Rieger CHL. Detection of intracellular cytokines by flow cytometry. J Immunol Methods 1993;159:197-207.
25. Nagata M, Yamamoto H, Tabe K, Kimura T, Houya I, Kuramitsu K, et al. Effect of rush immunotherapy in house-dust-mite (HDM) sensitive adult bronchial asthma: changes in in vivo and in vitro responses to HDM. Intern Med 1993;32:702-9.
26. Tamir R, Castracane JM, Rocklin RE. Generation of suppressor cells in atopic patients during immunotherapy that modulate IgE synthesis. J Allergy Clin Immunol 1987;79:591-8.
27. Lamb JR, Skidmore BJ, Green N, Chiller JM, Feldmann M. Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin. J Exp Med 1983;157:1434-47.
28. Gajewski TF, Fitch FW. Anti-proliferative effect of IFN-γ in im-mune regulation. I. IFN-γ inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. J Immunol 1988;140:4245-52.
29. Wiereng E, Snoek M, de Groot C, Chretien I, Bos JD, et al. Evidence for compartmentalization of functional subsets of CD4+ T lymphocytes in atopic patients. J Immunol 1990;144:4651-6.
30. Abed NS, Chace JH, Fleming AL, Cowdery JS. Interferon-γ regulation of B lymphocyte differentiation: activation of B cells is a prerequisite for IFN-γ mediated inhibition of B cell differentiation. Cell Immunol 1994;153:356-66.
31. Novelli F, Giovarelli M, Gentz R, Zucca M, diPierro F, Garotta G, et al. Modulation of interferon-gamma receptor during human T lymphocyte activation. Eur J Immunol 1993;23:1226-31.
32. Walker C, Bode E, Boer L, Hansel TT, Blaser K, Virchow JC. Allergic and non-allergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am Rev Respir Dis 1992;146:109-15.
33. Canonica GW, Mingari MC, Melioli G, Colombatti M, Moretta L. Imbalances of T cell subpopulations in patients with atopic diseases and effect of specific immunotherapy. J Immunol 1979;123:2669-72.
34. Robinson LD. Gamma Interferon induced changes in CD4/CD8 populations in hyper IgE syndrome [abstract]. J Allergy Clin Immunol 1993;91:141.
35. Jutel M, Fichler WJ, Skrbic D, Urwyler A, Dahinden C, Muller UR. Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-γ secretion in specific allergen-stimulated T cell cultures. J Immunol 1995;154:4187-94.
36. Thyphronitis G, Tsokos GC, June CH, Levine AD, Finkelman FD. IgE secretion by Epstein-Barr virus-infected purified human B lymphocytes is stimulated by interleukin 4 and suppressed by IFN-γ. Proc Natl Acad Sci USA 1989;86:5580-4.
37. Takagi M, Kenichi K, Nakahata T. Antiproliferative effect of IFN-γ on proliferation of mouse connective tissue-type mast cells. J Immunol 1990;145:1880-4.
38. Nafziger J, Arock M, Guillosson J-J, Wietzerbin J. Specific highaffinity receptors for interferon-γ on mouse bone marrow-derived mast cells: inhibitory effect of interferon-γ on mast cell precursors. Eur J Immunol 1990;20:113-7.
39. Coleman JW, Morris AG. Identification of a spleen cell-derived factor that inhibits sensitization of murine peritoneal mast cells as interferon-gamma. Int Arch Allergy Appl Immunol 1991;94:179-80.
40. Coleman JW, Buckely MG, Holliday MR, Morris AG. Interferon-γ inhibits serotonin release from mouse peritoneal mast cells. Eur J Immunol 1991;21:2559-64.
41. + T cells. J Exp Med 1993;177:573-6.
42. Fujisawa T, Abu-Ghazaleh R, Kita H, Sanderson CJ, Gleich GJ. Regulatory effect of cytokines on eosinophil degranulation. J Immunol 1990;144:642-6.
43. Lack G, Renz H, Saloga J, Bradley KL, Loader J, Leung DYM, et al. Nebulized but not parenteral IFN-γ decreases IgE production and normalizes airways function in a murine model of allergen sensitization. J Immunol 1994;152:2546-54.
44. Saloga J, Renz H, Lack G, Bradley KL, Greenstein JL, Larsen G, et al. Development and transfer of immediate cutaneous hypersensitivity in mice exposed to aerosolized antigen. J Clin Invest 1993;91:133-40.
45. Parish CR, Liew FY. Immune response to chemically modified flagellin. III. Enhanced cell-mediated immunity during high and low zone antibody tolerance to flagellin. J Exp Med 1972;135:298-311.
46. + T cells. J Immunol 1992;149:3468-76.