Aerosol-induced immunoglobulin (Ig)-E unresponsiveness to ovalbumin does not require CD8+ or T cell receptor (TCR)-γ/δ+ T cells or interferon (IFN)-γ in a murine model of allergen sensitization

Journal of Experimental Medicine

Volumn 187, Issue 5, 1998, Pages 721-731

  Seymour, Brian W P ^a,b   Gershwin, Laurel J ^b   Coffman, Robert L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; INTERFERON; OVALBUMIN; PROTEOLIPID; T LYMPHOCYTE RECEPTOR;

AEROSOL; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; DEMYELINATING DISEASE; HELPER CELL; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; KNOCKOUT MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PEYER PATCH; PRIORITY JOURNAL; PROPHYLAXIS; SENSITIZATION;

AEROSOLS; ALLERGENS; ANIMALS; BETA 2-MICROGLOBULIN; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; DESENSITIZATION, IMMUNOLOGIC; EOSINOPHILS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INTERFERON TYPE II; LUNG; LYMPHOCYTE DEPLETION; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; OVALBUMIN; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTE SUBSETS; TH2 CELLS;

EID: 0032473551     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.187.5.721     Document Type: Article

References (49)

1. Holt, P.G., and C. McMenamin. 1989. Defence against allergic sensitization in the healthy lung: the role of inhalation tolerance. Clin. Exp. Allergy. 19:255-262.
2. Garlisi, C.G., A. Falcone, T.T. Kung, D. Stelts, K.J. Pennline, A.J. Beavis, S.R. Smith, R.W. Egan, and S.P. Umland. 1995. T cells are necessary for Th2 cytokine production and eosinophil accumulation in airways of antigen-challenged allergic mice. Clin. Immunol. Immunopathol. 75:75-83.
3. Robinson, D.S., Q. Hamid, S. Ying, A. Tsicopoulos, J. Barkans, A.M. Bentley, C. Corrigan, S.R. Durham, and A.B. Kay. 1992. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 326: 298-304.
4. Walker, C., E. Bode, L. Boer, T.T. Hansel, K. Blaser, and J.J. Virchow. 1992. Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am. Rev. Respir. Dis. 146:109-115.
5. Del Prete, G.F., M. De Carli, M.M. D'Elios, P. Maestrelli, M. Ricci, L. Fabbri, and S. Romagnani. 1993. Allergen exposure induces the activation of allergen-specific Th2 cells in the airway mucosa of patients with allergic respiratory disorders. Eur. J. Immunol. 23:1445-1449.
6. Coffman, R.L., J. Ohara, M.W. Bond, J. Carty, A. Zlotnik, and W.E. Paul. 1986. B cell stimulatory factor 1 enhances the IgE response of lipopolysaccharide activated B-cells. J. Immunol. 136:4538-4541.
7. Punnonen, J., G. Aversa, B.G. Cocks, A.N. McKenzie, S. Menon, G. Zurawski, R. de Waal Malefyt, and J.E. de Vries. 1993. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc. Natl. Acad. Sci. USA. 90:3730-3734.
8. Defrance, T., P. Carayon, G. Billian, J.C. Guillemot, A. Minty, D. Caput, and P. Ferrara. 1994. Interleukin 13 is a B cell stimulating factor. J. Exp. Med. 179:135-143.
9. Kay, A.B. 1992. "Helper" (CD4+) T cells and eosinophils in allergy and asthma. Am. Rev. Respir. Dis. 145:S22-S26.
10. Bousquet, J., P. Chanez, J.Y. Lacoste, G. Barneon, N. Ghavanian, I. Enander, P. Venge, S. Ahlstedt, J. Simony-Lafontaine, and P. Godard. 1990. Eosinophilic inflammation in asthma. N. Engl. J. Med. 323:1033-1039.
11. Janson, C., and M. Herala. 1992. Blood eosinophil count as risk factor for relapse in acute asthma. Respir. Med. 86:101-104.
12. Mosmann, T.R., and R.L. Coffman. 1989. Two types of mouse helper T cell clone: implications for immune regulation. Immunol. Today. 8:223-227.
13. Coffman, R.L., B.W.P Seymour, D.A. Lebman, D.D. Hiraki, J.A. Christiansen, B. Shrader, H.M. Cherwinski, H.F. Savelkoul, F.D. Finkelman, M.W. Bond et al. 1988. The role of helper T cell products in mouse B cell differentiation and isotype regulation. Immunol. Rev. 102:5-28.
14. + T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production. J. Exp. Med. 178:889-899.
15. McMenamin, C., M. McKersey, P. Kuhnlein, T. Hunig, and P.G. Holt. 1995. γδ T cells down-regulate primary IgE responses in rats to inhaled soluble protein antigens. J. Immunol. 154:4390-4394.
16. McMenamin, C., C. Pimm, M. McKersey, and P.G. Holt. 1994. Regulation of IgE responses to inhaled antigen in mice by antigen-specific γδ T cells. Science. 265:1869-1871.
17. Finkleman, F.D., I.M. Katona, T.R. Mosmann, and R.L. Coffman. 1988. IFN-γ regulates the isotypes of ig secreted during in vivo humoral immune responses. J. Immunol. 140: 1022-1027.
18. Colley, D.G. 1972. Schistosoma mansoni: eosinophilia and the development of lymphocyte blastogenesis in response to soluble egg antigen in inbred mice. Exp. Parasitol. 32:520-526.
19. Abrams, J. 1995. Immunoenzymetric assay of mouse and human cytokines using NIP-labelled anticytokine antibodies. In Current Protocols in Immunology. Vol. 6. R. Roico, editor. John Wiley & Sons, Inc., New York. 6.20.1.
20. van Halteren, A.G.S., M.J.F. van der Cammen, J. Biewenga, H.F.J. Savelkoul, and G. Kraal. 1997. IgE and mast cell responses on intestinal allergen exposure: a murine model to study the onset of food allergy. J. Allergy Clin. Immunol. 99: 94-99.
21. Coffman, R.L., and J. Carty. 1986. A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-γ. J. Immunol. 136:949-954.
22. Seymour, B.W.P., K.E. Pinkerton, K.E. Friebertshauser, R.L. Coffman, and L.J. Gershwin. 1997. Second-hand smoke is an adjuvant for T helper 2 responses in a murine model of allergy. J. Immunol. 159:6169-6175.
23. Sedgwick, J.D., and P.G. Holt. 1983. Induction of IgE isotype specific tolerance by passive antigenic stimulation of the respiratory mucosa. Immunology. 50:625-630.
24. Friedman, A., and H.L. Weiner. 1994. Induction of anergy or active suppression after oral tolerance is determined by antigen dosage. Proc. Natl. Acad. Sci. USA. 91:6688-6692.
25. Marth, T., W. Strober, and B.L. Kelsall. 1996. High dose oral tolerance in ovalbumin TCR-transgenic mice: systemic neutralization of IL-12 augments TGF-β secretion and T cell apoptosis. J. Immunol. 157:2348-2357.
26. Melamed, D., J. Fishman-Lovell, Z. Uni, H.L. Weiner, and A. Friedman. 1996. Peripheral tolerance of Th2 lymphocytes induced by continuous feeding of ovalbumin. Int. Immunol. 8:717-724.
27. Hessel, E.M., A.J. Van Oosterhout, C.L. Hofstra, J.J. De Bie, J. Garssen, H. Van Loveren, A.K. Verheyen, H.F. Savelkoul, and F.P. Nijkamp. 1995. Bronchoconstriction and airway hyperresponsiveness after ovalbumin inhalation in sensitized mice. Eur. J. Pharmacol. 293:401-412.
28. Sedgwick, J.D., and P.G. Holt. 1984. Suppression of IgE responses in inbred rats by repeated respiratory tract exposure to antigen: responder phenotype influences isotype specificity of induced tolerance. Eur. J. Immunol. 14:893-897.
29. Holt, P.G., D. Britten, and J.D. Sedgwick. 1987. Suppression of IgE responses by antigen inhalation: studies on the role of genetic and environmental factors. Immunology. 60:97-102.
30. Renz, H., G. Lack, J. Saloga, R. Schwinzer, K. Bradley, J. Loader, A. Kupfer, G.L. Larsen, and E.W. Gelfand. 1994. Inhibition of IgE production and normalization of airways responsiveness by sensitized CD8 T cells in a mouse model of allergen-induced sensitization. J. Immunol. 152:351-360.
31. Finkelman, F.D., J. Holmes, I.M. Katona, J.J. Urban, M.P. Beckmann, L.S. Park, K.A. Schooley, R.L. Coffman, T.R. Mosmann, and W.E. Paul. 1990. Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol. 8:303-333.
32. Lack, G., H. Renz, J. Saloga, K.L. Bradley, J. Loader, D.Y. Leung, G. Larsen, and E.W. Gelfand. 1994. Nebulized but not parenteral IFN-γ decreases IgE production and normalizes airways function in a murine model of allergen sensitization. J. Immunol. 152:2546-2554.
33. Lack, G., K.L. Bradley, E. Hamelmann, H. Renz, J. Loader, D.Y.M. Leung, G. Larsen, and E.W. Gelfand. 1996. Nebulized IFN-γ inhibits the development of secondary allergic responses in mice. J. Immunol. 157:1432-1439.
34. Hayglass, K.T., and W.P. Stefura. 1991. Antigen-specific inhibition of ongoing murine IgE responses. 2. Inhibition of IgE responses induced by treatment with glutaraldehyde-modified allergens is paralleled by reciprocal increases in IgG2a synthesis. J. Immunol. 147:2455-2460.
35. + cells in the pathogenesis of allergic diseases. Proc. Soc. Exp. Biol. Med. 215:11-20.
36. Kim, T.S., R.H. DeKruyff, R. Rupper, H.T. Maecker, S. Levy, and D.T. Umetsu. 1997. An ovalbumin-IL-12 fusion protein is more effective than ovalbumin plus free recombinant IL-12 in inducing a T helper cell type 1-dominant immune response and inhibiting antigen-specific IgE production. J Immunol. 158:4137-4144.
37. Brunda, M.J. 1994. Interleukin-12. J. Leukocyte Biol. 55: 280-288.
38. van Halteren, A.G., M.J. van der Cammen, D. Copper, H.F. Savelkoul, G. Kraal, and P.G. Holt. 1997. Regulation of antigen-specific IgE, IgG1, and mast cell responses to ingested allergen by mucosal tolerance induction. J. Immunol. 159: 3009-3015.
39. + T cells precedes the development of tolerance in vivo. Int. Immunol. 8:335-342.
40. Ke, Y., K. Pearce, J.P. Lake, H.K. Ziegler, and J.A. Kapp. 1997. γδ T lymphocytes regulate the induction and maintenance of oral tolerance. J. Immunol. 158:3610-3618.
41. + T cells are required for the induction of oral tolerance. Int. Immunol. 7:501-504.
42. + cells on the induction and maintenance of oral tolerance. Cell. Immunol. 163:19-29.
43. Haneda, K., K. Sano, G. Tamura, T. Sato, S. Habu, and K. Shirato. 1997. TGF-β induced by oral tolerance ameliorates experimental tracheal eosinophilia. J. Immunol. 159: 4484-4490.
44. Marth, T., W. Strober, and B.L. Kelsall. 1996. High dose oral tolerance in ovalbumin TCR-transgenic mice. Systemic neutralization of IL-12 augments TGF-β secretion and T cell apoptosis. J. Immunol. 157:2348-2357.
45. Strober, W., B. Kelsall, I. Fuss, T. Marth, B. Ludviksson, R. Ehrhardt and M. Neurath. 1997. Reciprocal IFN-γ and TGF-β responses regulate the occurrence of mucosal inflammation. Immunol. Today. 18:61-64.
46. Weiner, H.L. 1997. Oral tolerance: immune mechanisms and treatment of autoimmune diseases. Immunol. Today. 19:335-343.
47. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature. 389:737-742.
48. + T cells. J. Exp. Med. 177:573-576.
49. Laberge, S., L. Wu, R. Olivenstein, L.J. Xu, P.M. Renzi, and J.G. Martin. 1996. Depletion of CD8+ T cells enhance pulmonary inflammation but not airway responsiveness after antigen challenge in rats. J. Allergy Clin. Immunol. 98:617-627.