Prediction of murine MHC class I epitopes in a major house dust mite allergen and induction of T1-type CD8+ T cell responses

International Immunology

Volumn 9, Issue 2, 1997, Pages 273-280

  Harris, Stephen J ^a   Roth, Jeanne Françoise ^a   Savage, Nigel ^a   Woodrow, Sarah A ^a   Hemingway, Ian K ^a   Hoyne, Gerard F ^b   Lamb, Jonathan R ^b   Layton, Guy T ^a  

^a British Biotech Pharmaceuticals Ltd   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Allergen presentation; Allergen specific CD8+ T cells; T(h)1 T1 T cell priming

Indexed keywords

CD8 ANTIGEN; EPITOPE; HOUSE DUST ALLERGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ALLERGIC DISEASE; ALLERGIC REACTION; ARTICLE; CYTOTOXIC T LYMPHOCYTE; HOUSE DUST; HOUSE DUST ALLERGY; PREDICTION; PRIORITY JOURNAL; REGULATORY MECHANISM; T LYMPHOCYTE; TECHNIQUE;

ADMINISTRATION, INTRANASAL; ALLERGENS; ANIMALS; ANTIGENS, CD5; ANTIGENS, CD8; ANTIGENS, DERMATOPHAGOIDES; CYTOKINES; CYTOTOXICITY TESTS, IMMUNOLOGIC; FEMALE; GENES, MHC CLASS I; GLYCOPROTEINS; IMMUNODOMINANT EPITOPES; INJECTIONS, INTRAMUSCULAR; INJECTIONS, INTRAPERITONEAL; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MITES; SPLEEN; T-LYMPHOCYTES, CYTOTOXIC; TH1 CELLS;

EID: 0031051249     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/9.2.273     Document Type: Article

References (43)

1. Vercelli, D., Jabara, H. H., Arai, K.-I. and Geha, R. S. 1989. Induction of human IgE synthesis requires interleukin 4 and T/B cell interaction involving the T cell receptor/CD23 complex and MHC class II antigens. J. Exp. Med. 169:1295.
2. Kubota, E., McKenzie, D. T., Dutton, R. W. and Swain, S. L. 1991. Role of T cells in the B cell response: glutaraldehyde-fixed T helper hybridoma cells synergize with the lymphokine IL-4 to induce B-cell activation and proliferation. Immunology 72:40.
3. Mosman, T. R., Cherwinski, H., Bond, M. W., Giedlin, M. A. and Coffman, R. L. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348.
4. Renz, H., Smith, H. R., Henson, J. E., Ray, B. S., Irvin, C. G. and Gelfand, E. W. 1992. Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airways responsiveness in the mouse. J. Allergy Clin, Immunol 89:1127.
5. - lymphocytes. Immunology 74:234.
6. Snapper, C. M.,and Paul, W. E. 1987. Interferon-gammaand B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 236:944,
7. h1 murine helper T lymphocyte clones. J. Immunol. 140:425.
8. + cells. Trends Biotechnol. 13:186.
9. Yssel, H., Johnson K. E., Schneider, P. V., Wideman, J., Terr, A., Kastelein, R. and de Vries, J. E. 1992. T cell activation inducing epitopes of the house dust mite allergen Der p 1. Induction of a stricted cytokine production profile of Der p 1-specific T cell clones upon antigen-specific activation. J. Immunol. 148:738.
10. Briner, T. J., Kuo, M.-C., Keating, K. M., Rogers, B. L. and Greenstein, J. L. 1993. Peripheral T-cell tolerance induced in naive and primed mice by subcutaneous injection of peptides from the major cat allergen Fel d I. Proc. Natl Acad. Sci. USA 90:7608.
11. Hoyne, G. F., O'Hehir, R. E., Wraith, D. C., Thomas, W. R. and Lamb, J. R. 1993. Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice. J. Exp. Med. 178:1783.
12. Hoyne, G. F., Callow, M. G., Kuo, M.-C. and Thomas, W. R. 1994. Inhibition of T cell responses by feeding peptides containing major and cryptic epitopes: studies with the Der p I allergen. Immunology 83:190.
13. Higgins, J. A., Lamb, J. R., Marsh, S. G. E., Tonks, S., Hayball, J. D., Rosen-Bronson, S., Bodmer, J. G. and O'Hehir, R. E. 1992. Peptide-induced non-responsiveness of HLA-DP restricted human T cells reactive with Dermatophagoides spp. (house dust mite) J. Allergy Clin. Immunol. 90:749.
14. h1 immune response and inhibition of specific IgE antibody formation by plasmid DNA injection. Proc. Natl Acad. Sci. USA 93:5141.
15. Finkleman, F. D., Katona, I. M., Urban, J. F., Jr, Snapper, C. M., Ohara, J. and Paul, W. E. 1986. Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1. Proc. Natl Acad. Sci. USA 83:9675.
16. Finkleman, F. D., Katona, I. M., Mosmann, T. R. and Coffman, R. L. 1988. IFN-γ regulates the isotypes of Ig secreted during in vivo humoral immune responses. J. Immunol, 140:1022.
17. + T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production. J. Exp. Med. 178:889.
18. Renz H., Lack G., Saloga, J., Schwinzer, R., Bradley, K., Loader, J., Kupfer, A., Larsen, G. L. and Gelfand, E. W. 1994. Inhibition of IgE production and normalization of airways responsiveness by sensitized CD8 T cells in a mouse model of allergen-induced sensitization. J. Immunol. 152:351.
19. Hsu, C.-H., Chua, K.-Y., Tao, M.-H., Lai, Y-L., Wu, H.-D., Huang, S,-K and Hsieh, K.-H. 1996. Immunoprophylaxis of allergen-induced immunoglobulin E synthesis and airway hyperresponsiveness in vivo by genetic immunization. Nature Medicine 2:540.
20. Chua, K. Y., Stewart, G. A., Thomas, W. R., Simpson, R. J., Dilworth, R. J., Plozza, T. M. and Turner, K. J. 1988. Sequence analysis of cDNA coding for a major house dust mite allergen, Der p 1: homology with cysteine proteases. J. Exp. Med. 167:175.
21. Elliot, T., Smith, M., Driscoll, P. and McMichael, A. 1993. Peptide selection by class I molecules of the major histocompatability complex. Curr. Biol. 3:854.
22. Deres, K., Beck, W., Faath, S., Jung, G. and Rammensee, H.-G. 1993. MHC/peptide binding studies indicate hierarchy of anchor residues. Cell. Immunol. 151:158.
23. Harris, S. J., Gearing, A. J. H., Layton, G. T., Adams, S. E. and Kingsman, A. J. 1992. Enhanced proliferative cellular responses to HIV-1 V3 peptide and gp120 following immunisation with V3:Ty virus-like particles. Immunology 77:315.
24. Layton, G. T., Harris, S. J., Gearing, A. J. H., Hill-Perkins, M., Cole, J. S., Griffiths, J. C., Burns, N. R., Kingsman, A. J. and Adams, S. E. 1993. Induction of HIV-specific cytotoxic T lymphocytes in vivo with hybrid HIV-1 V3:Ty-virus-like particles. J. Immunol. 151:1097.
25. Layton, G. T., Harris, S. J., Myhan, J., West, D., Gotch, F., Hill-Perkins, M., Cole, J. S., Meyers, N., Woodrow, S.,. French, T. J. Adams, S. E. and Kingsman, A. J. 1996. Induction of single and dual cytotoxic T-lymphocyte responses to viral proteins in mice using recombinant hybrid Ty-virus-like particles. Immunology 87:171.
26. Adams, S. E., Richardson, S. M. H., Kingsman, S. M. and Kingsman, A. J. 1991. Expression vectors for the construction of brid Ty-VLP. In Collins, M., ed., Methods in Molecular Biology 8, p. 265. Humana Press, Clifton, NJ.
27. Burns, N. R., Gilmour, J. E. M., Kingsman, S. M., Kingsman, A. J. and Adams, S. E. 1991. Production and purification of hybrid Ty-VLP. In Collins, M., ed., Methods in Molecular Biology 8, p. 277. Humana Press, Clifton, NJ.
28. Rudensky, A. Y., Preston-Hurlburt, P., Al-Ramadi, B. K., Rothbard, J. and Janeway, C. A. 1992. Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs. Nature 359:429.
29. Varney, V. A., Hamid, Q. A., Gaga, M., Ying, S., Jacobson, M., Frew, A. J., Kay, A. B. and Durham, S. R. 1993. Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late cutaneous responses. J. Clin. Invest. 92:644.
30. + T cell. Immunol. Today 15:107.
31. Chomarat P., Rissoan, M.-C., Banchereau, J. and Miossec, P. 1993. Interferon-γ inhibits interleukin 10 production by monocytes. J. Exp. Med. 177:523.
32. P. Scott. 1993. IL-12: initiation cytokine for cell-mediated immunity. Science 260:496.
33. Jumper M. D., Nishioka, Y., Davies, L. S., Lipsky, P. E. and Meek, K. 1995. Regulation of human B cell function by recombinant CD40 ligand and other TNF-related ligands. J. Immunol. 155:2369.
34. Zheng L., Fisher, G., Miller, R. E., Peshon, J., Lynch, D. H. and Lenardo, M. J. 1995. Induction of apoptosis in mature T cells by tumour necrosis factor. Nature 377:348.
35. + T cells in the development of airway hyperresponsiveness in a murine model of airway sensitization. J. Exp. Med. 183:1719.
36. + cells can switch to interleukin 5 production and induce airway eosinophilia. J. Exp. Med. 181:1229.
37. h2 cytokines and help B cells. Science 260:1802.
38. Croft, M., Carter, L., Swain, S. L. and Dutton, R. W. 1994. Generation of polarized antigen- specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. J. Exp. Med. 180:1715.
39. Carbone, F. R. and Bevan, M. J. 1990. Class-I restricted processing and presentation of exogenous cell-associated antigen in vivo. J. Exp. Med. 171:377
40. Rock, K. L., Rothstein, L., Gamble, S. and Fleischacker, C. 1993. Characterization of antigen-presenting cells that present exogenous antigens in association with class I MHC molecules. J. Immunol. 150:438.
41. Carbone, F. R. and Bevan, M. J. 1989. Induction of ovalbumin-specific cytotoxic T cells by in vivo peptide immunization. J. Exp. Med. 169:603.
42. Harris, S. J., Woodrow, S. A., Gearing, A. J. H., Adams, S. E., Kingsman, A. J. and Layton, G. T. 1996. The effects of adjuvants on CTL induction by V3:Ty-virus-like particles. Vaccine, in press.
43. Vaz, E. M., Vaz, N. M. and Levine, B. B. 1971. Persistent formation of reagins in mice injected with low doses of ovalbumin. Immunology 21:11.