Major histocompatibility complex-independent recognition of a distinctive pollen antigen, most likely a carbohydrate, by human CD8+ α/β T cells

Journal of Experimental Medicine

Volumn 186, Issue 6, 1997, Pages 899-908

  Corinti, Silvia ^a   De Palma, Raffaele ^b   Fontana, Angelo ^c   Gagliardi, Cristina ^a   Pini, Carlo ^a   Sallusto, Federica ^a,d  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c CNR   (Italy)

^d BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE ANTIGEN; CYTOKINE; POLLEN ANTIGEN;

ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; ATOPY; HUMAN; HUMAN CELL; LYMPHOCYTE CLONE; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; SUPPRESSOR CELL; T LYMPHOCYTE SUBPOPULATION;

ALLERGENS; AMINO ACID SEQUENCE; ANTIGEN PRESENTATION; BASE SEQUENCE; CARBOHYDRATES; CD8-POSITIVE T-LYMPHOCYTES; CLONE CELLS; DNA; HUMANS; HYPERSENSITIVITY, IMMEDIATE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR SEQUENCE DATA; POLLEN; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA;

EID: 0030885973     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.186.6.899     Document Type: Article

References (46)

1. Porcelli, S.A., C.T. Morita, and R.L. Modlin. 1996. T cell recognition of non-peptide antigens. Curr. Opin. Immunol. 8: 510-516.
2. - T lymphocytes to a microbial antigen. Nature (Lond.). 360:593-596.
3. + T cells. Nature (Lond.). 372: 691-694.
4. Sieling, P.A., D. Chatterjee, S.A. Porcelli, T.I. Prigozy, T. Soriano, M.B. Brenner, M. Kronenberg, P.J. Brennan, and R.L. Modlin. 1995. CD1-restricted T cell recognition of microbial lipoglycans. Science (Wash. DC). 269:227-230.
5. Constant, P., F. Davodeau, M.-A. Peyrat, Y. Poquet, G. Puzo, M. Bonneville, and J.-J. Fournié. 1994. Stimulation of human γδ T cells by nonpeptidic mycobacterial ligands. Science (Wash. DC). 264:267-270.
6. Morita, C.T., E.M. Beckman, J.F. Bukowski, Y. Tanaka, H. Band, B.R. Bloom, D.E. Golan, and M.B. Brenner. 1995. Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells. Immunity 3:495-507.
7. Burk, M.R., L. Mori, and G. De Libero. 1995. Human Vγ9-Vδ2 cells are stimulated in a cross-reactive fashion by a variety of phosphorylated metabolites. Eur. J. Immunol. 25:2052-2058.
8. Harding, C.V., J. Kihlberg, M. Elofsson, G. Magnusson, and E.R. Unanue. 1993. Glycopeptide bind MHC molecules and elicit specific T cell responses. J. Immunol. 151:2419-2425.
9. Haurum, J.S., G. Arsequell, A.C. Lellouch, S.Y.C. Wong, R.A. Dweck, A.J. McMichael, and T. Elliott. 1994. Recognition of carbohydrate by major histocompatibility complex class I-restricted, glycopeptide-specific cytotoxic T lymphocytes. J. Exp. Med. 180:739-744.
10. Michaelsson, E., V. Malmsdtrom, S. Reis, A. Engstrom, H. Burkhardt, and R. Holmdahl. 1994. T cell recognition of carbohydrates on type II collagen. J. Exp. Med. 180:745-749.
11. Dudler, T., F. Altmann, J.M. Carballido, and K. Blaser. 1995. Carbohydrate-dependent, HLA class II-restricted, human T cell response to bee venom allergen phospholipase A2 in allergic patients. Eur. J. Immunol. 25:538-542.
12. Martin, S., and H.U. Weltzien. 1994. T cell recognition of haptens, a molecular view. Int. Arch. Allergy Immunol. 104: 10-16.
13. Ishioka, G.Y., A.G. Lamont, D. Thomson, N. Bulbow, F.C.A. Gaeta, A. Sette, and H.M. Grey. 1992. MHC interaction and T cell recognition of carbohydrate and glycopeptide. J. Immunol. 148:2446-2451.
14. Harding, C.V., R.W. Roof, P.M. Allen, and E.R. Unanue. 1991. Effect of pH and polysaccharides on peptide binding to class II major histocompatibility complex molecules. Proc. Natl. Acad. Sci. USA. 88:2740-2744.
15. D'Amato, G., and G. Lobefalo. 1989. Allergenic pollens in the southern Mediterranean area. J. Allergy Clin. Immunol. 83: 116-122.
16. Sallusto, F., S. Corinti, C. Pini, M.M. Biocca, G. Bruno, and G. Di Felice. 1996. Parietaria judaica-specific T-cell clones from atopic patients: heterogeneity in restriction, Vβ usage, and cytokine profile. J. Allergy Clin. Immunol. 97:627-637.
17. Sallusto, F., and A. Lanzavecchia. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J. Exp. Med. 179:1109-1118.
18. Lanzavecchia, A. 1985. Antigen-specific interaction between T and B cell. Nature (Lond.). 314:537-539.
19. Elsasser-Beile, U., S. von Kleist, and H. Gallati. 1991. Evaluation of a test system for measuring cytokine production in human whole blood cell cultures. J. Immunol. Methods 139: 191-195.
20. Giuliani, A., C. Pini, S. Bonini, N. Mucci, L. Ferroni, and G. Vicari. 1987. Isolation and purification of a major allergen from Parietaria officinalis pollen. Allergy. 42:434-440.
21. Bradford, M.M. 1976. A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
22. Edge, A.S.B., C.R. Faltinek, L. Hof, L.E. Reichert, Jr., and P. Weber. 1981. Deglycosylation of glycoproteins by trifluoromethanesulfonic acid. Anal. Biochem. 118:131-137.
23. Spiro, R.G. 1967. Studies on the renal glomerular basement membrane. Nature of the carbohydrate units and their attachment to the peptide portion. J. Biol. Chem. 242:1943-1948.
24. Ashwell, G. 1966. New colorimetric methods of sugar analysis. In Methods in Enzymology. S.P. Colowick and N.O. Kaplan, editors. Academic Press Inc., New York. VIII:93-95.
25. Valitutti, S., M. Dessing, K. Aktories, H. Gallati, and A. Lanzavecchia. 1995. Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton. J. Exp. Med. 181:577-584.
26. De Palma, R., and J. Gorsky. 1995. Restricted and conserved T-cell repertoire involved in allorecognition of class II major histocompatibility complex. Proc. Natl. Acad. Sci. USA. 92: 8836-8840.
27. Pamer, E.G., C.-R. Wang, L. Flaherty, K. Fischer-Lindahl, and M.J. Bevan. 1992. H-2M3 presents a Listeria monocytogenes peptide to cytotoxic T lymphocytes. Cell. 70:215-223.
28. Nataraj, C., M.L. Brown, R.M. Poston, S.M. Shawar, R.R. Rich, K. Fisher Lindahl, and R.J. Kurlander. 1996. H2-M3wt-restricted, Listeria monocytogenes-specific CD8 T cells recognize a novel, Hydrophobic, protease-resistant, periodate-sensitive antigen. Int. Immunol. 8:367-378.
29. Steinman, R.M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:271-295.
30. Valitutti, S., S. Muller, M. Cella, E. Padovan, and A. Lanzavecchia. 1995. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature (Lond.). 375:148-151.
31. Di Felice, G., A. Mari, N. Mucci, C. Afferni, G. Bruno, and C. Pini. 1989. T cell responses to a Parietaria judaica pollen extract: comparison between Parietaria-sensitive patients, other atopies and healthy controls. Allergy. 44:322-329.
32. Salgame, P., J.S. Abrams, C. Clayberger, H. Goldstein, J. Convit, R.L. Modlin, and B.R. Bloom. 1991. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science (Wash. DC). 254:279-281.
33. Sad, S., R. Marcotte, and T.R. Mosmann. 1995. Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines. Immunity. 2:271-279.
34. Romagnani, S. 1994. Lymphokine production by human T cells in disease state. Annu. Rev. Immunol. 12:227-257.
35. Yoshimoto, T., A. Bendelac, J. Hu-Li, and W.E. Paul. 1995. Defective IgE production by SJL mice is linked to the absence of CD4+, NK1.1+ T cells that promptly produce interleukin 4. Proc. Natl. Acad. Sci. USA. 92:11931-11934.
36. Maggi, E., M.G. Giudizi, R. Biagiotti, F. Annunziato, R. Manetti, M.-P. Piccinni, P. Parronchi, S. Sampognaro, L. Giannarini, G. Zuccati, et al., 1994. Th2-like CD8+ T cells showing B cell helper function and reduced cytolytic activity in human immunodeficiency virus type I infection. J. Exp. Med. 180:489-495.
37. Paganelli, R., E. Scala, I.J. Ansotegui, C.M. Ausiello, E. Halapi, E. Fanales-Belasio, G. D'Offizi, I. Mezzaroma, F. Pandolfi, M. Fiorilli, et al., 1995. CD8+ T lymphocytes provide helper activity for IgE synthesis in human immunodeficiency virus-infected patients with hyper-IgE. J. Exp. Med. 181: 423-428.
38. Bloom, B.R., R.L. Modlin, and P. Salgame. 1992. Stigma variations: observations on suppressor T cells and leprosy. Annu. Rev. Immunol. 10:453-487.
39. Seder, R.A., and G.G. Le Gros. 1995. The functional role of CD8+ T helper type 2 cells. J. Exp. Med. 181:5-7.
40. Baer, H., and S.D. Chaparas. 1964. Tuberculin reactivity of a carbohydrate component of unheated BCG culture filtrate. Science (Wash. DC). 146:245-247.
41. Baker, P.J., P.W. Stashak, D.F. Amsbaugh, B. Prescott, and R.F. Barth. 1970. Evidence for the existence of two functionally distinct types of cells which regulate the antibody response to type III pneumococcal polysaccharide. J. Immunol. 105:1581-1586.
42. Shapiro, M.E., A.B. Onderdonk, D.L. Kasper, and R.W. Finberg. 1982. Cellular immunity to Bacteroides fragilis capsular polysaccharide. J. Exp. Med. 155:1188-1197.
43. Bellamy, A., A.N. Davison, and M. Feldmann. 1986. Derivation of ganglioside-specific T cell lines of suppressor or helper phenotype from cerebrospinal fluid of multiple sclerosis patients. J. Neuroimmunol. 12:107-120.
44. Katsuki, M., K. Kakimoto, S. Kawata, S. Kotani, and T. Koga. 1987. Induction of delayed-type hypersensitivity by the T cell line specific to bacterial peptidoglycans. J. Immunol. 139:3570-3572.
45. Henningsson, C.M., S. Selvaraj, G.D. MacLean, M.R. Suresh, A.A. Noujaim, and B.M. Longenecker. 1987. T cell recognition of a tumor-associated glycoprotein and its synthetic carbohydrate epitopes: stimulation of anti-cancer T cell immunity in vivo. Cancer Immunol. Immunother. 25:231-241.
46. Moll, H., G.F. Mitchell, M.J. McConville, and E. Handman. 1989. Evidence for T-cell recognition in mice of a purified lipophosphoglycan from Leishmania major. Infect. Immun. 57: 3349-3356.