Increases in IL-12 messenger RNA+ cells accompany inhibition of allergen-induced late skin responses after successful grass pollen immunotherapy

Journal of Allergy and Clinical Immunology

Volumn 99, Issue 2, 1997, Pages 254-260

  Hamid, Quatyba A ^a   Schotman, Elsa ^a   Jacobson, Mikila R ^b   Walker, Samantha M ^b   Durham, Stephen R ^b  

^a MCGILL UNIVERSITY   (Canada)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

cytokines; Immunotheraphy; late responses IL 12

Indexed keywords

ALLERGEN; INTERLEUKIN 12; MESSENGER RNA;

ADULT; ALLERGY; ARTICLE; CLINICAL ARTICLE; FEMALE; GRASS; GRASS POLLEN; HAY FEVER; HUMAN; IMMUNOTHERAPY; MALE; PRIORITY JOURNAL; SKIN TEST;

EID: 0031041686     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(97)70106-4     Document Type: Article

References (31)

1. BSACI Working Party. Position paper on allergen immunotherapy. Clin Exp Allergy.1993;23(suppl 3):1-44.
2. Mailing HJ, Weeke B. Immunotherapy. Position paper of the European Academy of Allergology and Immunology. Allergy 1993;48(suppl 14):1-35.
3. Varney V, Gaga M, Frew AJ, Aber VA, Kay AB, Durham SR. Usefulness of immunotherapy in patients with severe summer hayfever uncontrolled by antiallergic drugs. Br Med J 1991;302:265-9.
4. Varney VA, Hamid QA, Gaga M, Sun Ying, Jacobson M, Frew AJ, et al. Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses. J Clin Invest 1993;92:644-51.
5. + T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-γ. J Allergy Clin Immunol 1996;97:1356-65.
6. Durham SR, Varney VA, Gaga M, Jacobson MR, Frew AJ, Kay AB. Immunotherapy and allergic inflammation. Clin Exp Allergy 1991;21(suppl 1):206-10.
7. Clerici M, Lucey DR, Berzofsky JA, Pinto LA, Wynn TA, Blatt SP, et al. Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro. Science 1993;262:1721-4.
8. Hsieh C-S, Macatonia SE, Tripp CS, Wolf SF, O'Garra A, Murphy KM. Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 1993;260:547-9.
9. Manetti R, Parronchi P, Giudizi MG, Piccinni M-P, Maggi E, Trinchieri G, et al. Natural killer cell stimulatory factor (interleukin-12 {IL-12})induces T helper type 1 (Th-1)-specific immune responses and inhibits the development of IL-4 producing Th cells. J Exp Med 1993;177:1199-204.
10. Kiniwa M, Gately M, Gubler U, Fargeas C, Delespesse GJ. Recombinant interleukin-12 suppresses the synthesis of immunoglobulin E by interleukin-4 stimulated human lymphocytes. J Clin Invest 1992;90:262-6.
11. Walker SM, Varney VA, Jacobson MR, Durham SR. Grass pollen immunotherapy: efficacy and safety during a four year follow-up study. Allergy 1995;50:405-13.
12. Bette M, Jin SC, Germann T, Schazer MK, Weike E, Rude E, et al. Differential expression of mRNA encoding interleukin-12 p35 and p40 subunits in situ. J Immunol 1994;10:2435-40.
13. Chan-Palay V, Yasargil G, Hamid Q, Polak JM, Palay SL. Simultaneous demonstration of neuropeptide Y gene expression and peptide storage in single neurons of the human brain. Proc Natl Acad Sci 1988;88:3213-5.
14. Hamid Q, Wharton J, Terenghi G, Hassall CJS, Aimi J, Taylor KM, et al. Localization of atrial natriuretic peptide mRNA and immunoreactivity in the rat heart and human atrial appendage. Proc Natl Acad Sci 1987;84:6760-4.
15. Fling JA, Ruff ME, Parker WA, Whisman BA, Martin ME, Moss RB, et al. Suppression of the late cutaneous response by immunotherapy. J Allergy Clin Immunol 1989;83:101-9.
16. Nish WA, Charlesworth EN, Davis TL, Whisman BA. Valtier S, Charlesworth MG, et al. The effect of immunotherapy on the cutaneous late phase response to antigen. J Allergy Clin Immunol 1994;93:484-93.
17. Lichtenstein LM, Ishizaka K, Norman PS, Kagey-Sobotka A, Hill BM. IgE antibody measurements in ragweed hayfever. Relationship to clinical severity and the results of immunotherapy. J Clin Invest 1973;52:472-82.
18. Djurup R. The subclass nature and clinical significance of the IgG antibody response in patients undergoing allergen specific immunotherapy. Allergy 1985;40:469-86.
19. Otsuka H, Mezawa HA, Ohnishi M, Okubo K, Seki H, Okuda M. Changes in nasal metachromatic cells during allergen immunotherapy. Clin Exp Allergy 1991;21:115-9.
20. Creticos PS, Adkinson NF Jr, Kagey-Sobotka A, Proud D, Meier HL, Naclerio RM, et al. Nasal challenge with ragweed in hayfever patients: effects of immunotherapy. J Clin Invest 1985;76:2247-53.
21. Furin MJ, Norman PS, Creticos PS, Proud D, Kagey-Sobotka A, Lichtenstein LM, et al. Immunotherapy decreases antigen-induced eosinophil migration into the nasal cavity. J Allergy Clin Immunol 1991;88:27-32.
22. Secrist H, Cheten CJ, Wen Y, Marshall JD, Umetsu DT. Allergen immunotherapy decreases interleukin-4 production in CD4+ T cells from allergic individuals. J Exp Med 1993;178:2123-30.
23. McHugh SM, Deighton J, Stewart AG, Lachmann PJ, Ewan PW. Bee venom immunotherapy induces a shift in cytokine response from a TH-2 to a TH-1 dominant pattern: comparison of rush and conventional immunotherapy. Clin Exp Allergy 1995;25:828-38.
24. Jutel M, Pichler WJ, Skrbic D, Urwyler A, Dahinden C, Muller UR. Bee venom immunotherapy results in decrease of IL-4 and TL-5 and increase of IFN-γ secretion in specific allergen stimulated T cell cultures. J Immunol 1995;154:4187-94.
25. Sallusto F, Quintieri F, Pugliese O, Reale G, Pini C, Di Felice G. T cells and antibody response to Parietaria judaica allergenic fractions in atopic and non-atopic individuals. Allergy 1993;48:37-44.
26. Imada M, Simons FER, Jay FT, Hayglass KT. Allergen-stimulated interleukin-4 and interferon-γ production in primary culture: responses of subjects with allergic rhinitis and normal controls. Immunotherapy 1995;85:373-80.
27. Manetti R, Gerosa F, Giudizi MG, Biagiotti R, Parronchi P, Piccinni M, et al. Interleukin-12 induces stable priming for interferon-γ (IFN-γ) production during differential of human Thelper (Th) cells and transient IFN-γ production established Th2 cell clones. J Exp Med 1994;179:1273-83.
28. Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 1995;13:251-76.
29. O'Hehir RE, Yssel H, Verma S, et al. Clonal analysis of differential lymphokine production in peptide and superantigen induced T-cell allergy. Int Immunol 1991;3:819-26.
30. Lack G, Renz H, Saloga J, Bradley KL, Loader J, Leung DYM, et al. Nebulized but not parenteral IFN-γ decreases IgE production and normalises airways function in a murine model of allergen sensitisation. J Immunol 1994;152:2546-54.
31. Wynn TA, Cheever AQ, Jankovic D, Poindexter RW, Casper P, Lewis FA, et al. An IL-12 based vaccination method for preventing fibrosis induced by schistosome infection. Nature 1995;376:594-6.