Effects of the class III antiarrhythmic drug ambasilide on outward currents in human atrial myocytes

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 353, Issue 2, 1996, Pages 226-232

  Koidl, Bernd ^a   Flaschberger, Peter ^a   Schaffer, Peter ^a   Pelzmann, Brigitte ^a   Bernhart, Eva ^a   Mächler, Heinrich ^b   Rigler, Bruno ^b  

^a UNIVERSITY OF GRAZ   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Ambasilide; Class III antiarrhythmic drug; Human atrial myocytes; Sustained outward current; Transient outward current

Indexed keywords

AMBASILIDE; ANTIARRHYTHMIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; DIGITALIS; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; NITRATE;

ADULT; AGED; ARTICLE; CARDIOVASCULAR DISEASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTROSTIMULATION; FEMALE; HEART ATRIUM; HEART MUSCLE CELL; HUMAN; HUMAN CELL; ION CONDUCTANCE; MALE; MEMBRANE CURRENT; SODIUM CURRENT;

AGED; AGED, 80 AND OVER; AMINOBENZOIC ACIDS; ANTI-ARRHYTHMIA AGENTS; BICYCLO COMPOUNDS, HETEROCYCLIC; CORONARY DISEASE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEART; HUMANS; MALE; MEMBRANE POTENTIALS; MIDDLE AGED;

EID: 0030049942     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00168761     Document Type: Article

References (35)

1. Amos GJ, Wettwer E, Li Q, Himmel HM, Ravens U (1994) Differences in outward currents of human atrial and ventricular myocytes (abstract). Circulation 90:1-581
2. Amos GJ, Li Q, Wettwer E, Himmel HM, Metzger F, Ravens U (1995) Kinetics of clofilium block of human atrial outward currents (abstract). Naunyn Schmiedeberg's Arch Pharmacol 351 (suppl):R105
3. Berger F, Borchard U, Hafner D (1989) Effects of the calcium entry blocker bepridil on repolarizing and pacemaker currents in sheep cardiac Purkinje fibres. Naunyn Schmiedeberg's Arch Pharmacol 339:638-646
4. + currents in isolated human ventricular myocytes from patients with terminal heart failure. Cire Res 73:379-385
5. Colatsky TJ, Follmer CH, Starmer CF (1990) Channel specificity in antiarrhythmic drug action. Mechanism of potassium channel block and its role in suppressing and aggravating cardiac arrhythmias. Circulation 82:2235-2242
6. Coraboeuf E, Nargeot J (1993) Electrophysiology of human cardiac cells. Cardiovasc Res 27:1713-1725
7. Duan D, Fermini B, Nattel S (1993) Potassium channel blocking properties of propafenone in rabbit atrial myocytes. J Pharmacol Exp Ther 264:1113-1123
8. + currents in mammalian cardiac and glial cells. J Pharmacol Exp Ther 254:560-569
9. Escande D, Coulombe A, Faivre J-F, Deroubaix E, Coraboeuf E (1987) Two types of transient outward currents in adult human atrial cells. Am J Physiol 252:H142-H148
10. Fermini B, Wang Z, Duan D, Nattel S (1992) Differences in rate dependence of transient outward current in rabbit and human atrium. Am J Physiol 263:H1747-H1754
11. Himmel HM, Li Q, Amos GH, Wettwer E, Metzger F, Ravens U (1995) Pharmacological modulation of the transient outward current in human ventricular myocytes (abstract). Naunyn Schmiedeberg's Arch Pharmacol 351 (suppl):R105
12. Hondeghem LM, Snyders DJ (1990) Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence. Circulation 81:686-690
13. Jacobson SL, Altschuld RA, Hohl CM (1990) Muscle cell cultures from human heart. In: Piper HM (ed) Cell culture techniques in heart and vessel research. Springer, Berlin Heidelberg New York, pp 75-98
14. Jahnel U, Klemm P, Nawrath H (1994) Different mechanisms of the inhibition of the transient outward current in rat ventricular myocytes. Naunyn Schmiedeberg's Arch Pharmacol 349:87-94
15. Le Grand B, Hatem S, Deroubaix E, Couétil J-P, Coraboeuf E (1994) Depressed transient outward and calcium currents in dilated human atria. Cardiovasc Res 28:548-556
16. Li Q, Himmel HM, Ravens U (1995) Effects of the antiarrhythmic drug clofilium on the transient outward current in rat and human ventricular myocytes (abstract). Naunyn Schmiedebcrg's Arch Pharmacol 351 (suppl):R105
17. Mansourati J, Le Grand B (1993) Transient outward current in young and adult diseased human atria. Am J Physiol 265: H1466-H1470
18. Näbauer M, Beuckelmann DJ (1992) Block of transient outward current by class Ic antiarrhythmic agents propafenone and flecainide in human ventricular myocytes (abstract). Circulation 86:I-697
19. Näbauer M, Beuckelmann DJ, Erdmann E (1993) Characteristics of transient outward current in human ventricular myocytes from patients with terminal heart failure. Circ Res 73:386-394
20. Ohler A, Ravens U (1994) Effects of E-4031, almokalant and tedisamil on postrest action potential duration of human papillary muscles. J Pharmacol Exp Ther 270:460-465
21. Pelzmann B, Schaffer P, Mächler H, Rigler B, Koidl B (1995) Adenosine inhibits the L-type calcium current in human atrial myocytes. Naunyn-Sehmiedeberg's Arch Pharmacol 351: 293-297
22. Schaffer P, Pelzmann B, Bernhart E, Lang P, Mächler H, Rigler B, Koidl B (1995) Effects of propafenone on outward currents in human atrial myocytes. In: Vereecke J, Bogaert PP van, Verdonck F (eds) Potassium channels in normal and pathological conditions. Leuven University Press, Leuven, pp 396-399
23. Shibata EF, Drury T, Refsum H, Aldrete V, Giles W (1989) Contributions of a transient outward current to repolarization in human atrium. Am J Physiol 257:H1773-1781
24. + channel blocking actions of flecainide compared with those of propafenone and quinidine in adult rat ventricular myocytes. J Pharmacol Exp Ther 269:66-74
25. Takanaka C, Sarma JSM, Singh BN (1992) Electrophysiologic effects of ambasilide (LU 47110), a novel class III antiarrhythmic agent, on the properties of isolated rabbit and canine cardiac muscle. J Cardiovasc Pharmacol 19:290-298
26. Tseng G-N, Hoffman BF (1989) Two components of transient outward current in canine ventricular myocytes. Circ Res 64: 633-647
27. Varró A, Nánási PP, Lathrop DA (1993) Potassium currents in isolated human atrial and ventricular cardiocytes. Acta Physiol Scand 149:133-142
28. Wang J, Feng J, Nattel S (1994) Class III antiarrhythmic drug action in experimental atrial fibrillation. Differences in reverse use dependence and effectiveness between D-sotalol and the new antiarrhythmic drug ambasilide. Circulation 90:2032-2040
29. Wang Z, Fermini B, Nattel S (1993a) Delayed rectifier outward current and repolarization in human atrial myocytes. Circ Res 73:276-285
30. Wang Z, Fermini B, Nattel S (1993b) Sustained depolarization-induced outward current in human atrial myocytes. Circ Res 73:1061-1076
31. Wang Z, Fermini B, Nattel S (1995) Effects of flecainide, quinidine, and 4-aminopyridine on transient outward and ultrarapid delayed rectifier currents in human atrial myocyles. J Pharmacol Exp Ther 272:184-196
32. Wettwer E, Amos G, Gath J, Zerkowski H-R, Reidemeister J-C, Ravens U (1993) Transient outward current in human and rat ventricular myocytes. Cardiovasc Res 27:1662-1669
33. Wettwer E, Amos GJ, Posival H, Ravens U (1994) Transient outward current in human ventricular myocytes of subepicardial and subendocardial origin. Circ Res 75:473-482
34. Zhang Z-H, Follmer CH, Sarma JSM, Chen F, Singh BN (1992) Effect of ambasilide, a new class III agent, on plateau currents in isolated guinea pig ventricular myocytes: block of delayed outward potassium current. J Pharmacol Exp Ther 263:40-48
35. Zhang Z-H, Boutjdir M, El-Sherif N (1994) Ketanserin inhibits depolarization-activated outward potassium current in rat ventricular myocytes. Circ Res 75:711-721