Dual actions of the novel class III antiarrhythmic drug NE-10064 on delayed potassium channel currents in guinea pig ventricular and sinoatrial node cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 276, Issue 3, 1996, Pages 1149-1154

  Davies, Michael P ^a   Freeman, Lisa C ^a   Kass, Robert S ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIARRHYTHMIC AGENT; AZIMILIDE; IMIDAZOLE DERIVATIVE; IMIDAZOLIDINE DERIVATIVE; PIPERAZINE DERIVATIVE; POTASSIUM CHANNEL;

ANIMAL; ARTICLE; DOSE RESPONSE; DRUG EFFECT; GUINEA PIG; HEART; SINUS NODE;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; HEART; IMIDAZOLES; IMIDAZOLIDINES; PIPERAZINES; POTASSIUM CHANNELS; SINOATRIAL NODE;

EID: 0030098796     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. ANUMONWO, J. M. B., FREEMAN, L. C., KWOK, W M, AND KASS, R. S.: Delayed rectification in single cells isolated from guinea pig sino-atrial node. Am. J. Physiol. 262: H921-H925, 1992.
2. ARENA, J. P. AND KASS, R. S.: Block of heart potassium channels by clofilium and its tertiary analogs: relationship between drug structure and type of channel blocked. Mol. Pharmacol. 34: 60-66, 1988.
3. BLACK, S. C., BUTTERFIELD, J. L. AND LUCCHESI, B. R.: Protection against programmed electrical stimulation-induced ventricular tachycardia and sudden death by NE-10064, a class III antiarrhythmic drug. J. Cardiovase. Pharmacol. 22: 810-818, 1993.
4. BRANDT, M. A. AND MAYNARD, A. E : NE-10064 exhibits class III antiarrhythmic effects after intravenous or oral administration in concious dogs. FASEB J. 8: A7, 1994.
5. BUSCH, A. E., MALLOY, K J., VARNUM, M. D., ADELMAN, J. P., NORTH, R. A. AND MAYLIE, J.: A slowly-activating potassium current IKs is the target for the class III antiarrhythmic drug NE-10064. Circulation 88: I231, 1993.
6. BUSCH, A. E. AND MAYLIE, J.: MinK channels: A minimal channel protein with a maximal impact. Cell Physiol. Biochem. 3: 270-276, 1993.
7. KS in guinea pig cardiac myocytes. Biochem. Biophys. Res. Commun. 202: 265-270, 1994.
8. CONDER, M. L., HESS, T. A., SMITH, M. A., D'ALONZO, A. J. AND MCCULLOUGH, J. R.: The effects of NE-10064 on cardiac sodium channels. FASEB J. 8: A609, 1994a.
9. - currents in cardiac cells. Biophys. J. 66: A326, 1994b.
10. FREEMAN, L. C. AND KASS, R. S.: Delayed rectifier potassium channels in ventricle and sinoatrial node of the guinea pig: Molecular and regulatory properties. Cardiovasc. Drugs Ther 7: 627-635, 1993.
11. KS) in guinea pig sino-atrial node is not mediated by muscarinic receptors. Mol. Pharmacol. 47: 1248-1254, 1995
12. + current in Mammalian heart involves G proteins. Am. J. Physiol. 257: H818-H823, 1989.
13. KASS, R. S.: Nisoldipine. A new, more selective calcium current blocker in cardiac Purkinje fibers J. Pharmacol. Exp. Ther. 223: 446-456, 1982.
14. LEE, N. H. AND EL-FAKAHANY E. E.: Allosteric antagonists of the muscarinie acetylcholine receptor. Biochem. Pharmacol. 42: 199-205, 1991.
15. MCINTOSH, M. A , TANIRA, M., PACINI, D. AND KANE, K. A.: Comparison of the cardiac electrophysiologic effects of NE-10064 with sotalol and E-4031 and their modification by simulated ischaemia. J. Cardiovasc. Pharmacol. 23: 653-657, 1994.
16. NAVARRO-POLANCO, R. AND SANCHEZ-CHAPULA, J.: 4-aminopyridine activates a potassium current by activation of a muscarinic receptor. Biophys. J. 68: A108, 1995.
17. PONG, S. F., KINNEY, C. M. AND MOOREHEAD, T. J.: Binding profile of NE-10064, a novel class III antiarrhythmic agent, to rat brain receptors. FASEB J. 7: A474, 1993.
18. K and screens membrane surface charge in cardiac cells. Am. J Physiol. 259: H1881-H1889, 1990a.
19. i current. Differential sensitivity to block by class III antiarrhythmic agents. J. Gen. Physiol. 96: 195-215, 1990b.
20. SANGUINETTI, M. C. AND JURKIEWICZ, N K.: Delayed rectifier outward K current is composed of two currents in guinea pig atrial cells. Am. J. Physiol. 260: H393-H399, 1991.
21. SHIBASAKI, T.: Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart. J. Physiol. 387: 227-250, 1987.
22. Ks, the slow component of the cardiac delayed rectifier. Biophys. J. 66: A209, 1994.
23. TATLA, D. S., DAVID, B. C., MALLOY, K. J. AND MOOREHEAD, T. J.: In vitro electrophysiology of NE-10064, a novel and highly selective class III antiarrhythmic agent. FASEB J. 7: A107, 1993.
24. + current activation in guinea pig ventricular myocytes. Circ. Res 74: 687-699, 1994.
25. WALSH, K. B., BEGENISICH, T. B. AND KASS, R. S.: β-adrenergic modulation of cardiac ion channels: Differential temperature-sensitivity of potassium and calcium currents. J. Gen. Physiol. 93: 841-854, 1989.
26. WALSH, K. B. AND KASS, R. S.: Regulation of a heart potassium channel by protein kinase A and C. Science 242: 67-69, 1988.
27. K by protein kinases A and C Am J. Physiol. 261: C1081-C1090, 1991.
28. YAZAWA, K. AND KAMEYAMA, M.: Mechanism of receptor-mediated modulation of the delayed outward potassium current in guinea-pig ventricular myocytes. J. Physiol. 421: 135-150, 1990.
29. ZHANG, Z. H., BOUTJDIR, M., BROOKS, R., CHEN, L. AND EL-SHERIF, N.: Characterization of azimilide effects on ion currents of the repolarization phase. Biophys. J. 68: A111, 1995.