Evidences of antagonism between amiodarone and triiodothyronine on the K+ channel activities of cultured rat cardiomyocytes

Journal of Molecular and Cellular Cardiology

Volumn 29, Issue 2, 1997, Pages 617-627

  Guo, Weinong ^a   Kamiya, Kaichiro ^a   Toyama, Junji ^a  

^a NAGOYA UNIVERSITY   (Japan)

Author keywords

Amiodarone; Cardiomyocytes; Cell culture; K+ currents; Triiodothyronine

Indexed keywords

AMIODARONE; LIOTHYRONINE; POTASSIUM CHANNEL; POTASSIUM ION;

ANIMAL CELL; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; CULTURE MEDIUM; DOSE RESPONSE; DRUG EFFECT; HEART CELL CULTURE; HEART MUSCLE CELL; NEWBORN; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; REPOLARIZATION; STEADY STATE;

EID: 0031080286     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.1996.0305     Document Type: Article

References (42)

1. + currents in isolated adult rat ventricular myocytes. J Gen Physiol 97: 973-1011.
2. 1 receptor protein. Endocrinology 134: 1665-1670.
3. BUGAISKY LB, 1988. The use of cell culture to study cardiac myocyte growth and adaptation to stress. J Appl Cardiol 3: 311-326.
4. BURGER A, DINICHERT D, NICOD P, JENNY M, LEMARCHAND-BERAUD T, VALLOTTON MB, 1976. Effect of amiodarone on serum triiodothyronine, reverse triiodothyronine, thyroxine and thyrotropin. J Clin Invest 58: 255-259.
5. + current in cardiac cells: Requirements for efficient antiarrhythmic activity. In: Toyama J, Hiraoka M, Kodama I (eds). Recent Progress in Electropharmacology of the Heart. CRC Press: 133-138.
6. CEPPI JA, ZANINOVICH AA, 1989. Effects of amiodarone on 5′-deiodination of thyroxine to triiodothyronine in rat myocardium. J Endocrinol 121: 431-434.
7. CODY V AND LUFT J, 1989. Structure-activity relationships of antiarrhythmics: crystal structure of amiodarone hydrochloride and two derivatives, and their conformational comparison with thyroxine. Acta Cryst B 45: 172-178.
8. COHEN NM AND LEDERER WJ, 1988. Changes in the calcium current of rat heart ventricular myocytes during development. J Physiol 406: 115-146.
9. DILLMANN W, 1990. Biochemical basis of thyroid hormone action in the heart. Am J Med 88: 626-630.
10. DOVAL HC, NUL DR, GRANCELLI HO, PERRONE SV, BORTMAN GR, CURIEL R, 1994. Randomised trial of low-dose amiodarone in severe congestive heart failure. Lancet 344: 493-498.
11. DUSSAILLANT G, JALIL JE, CESPEDES C, 1994. Amiodarone protection against myocardial injury and fibrosis induced by isoprenaline is abolished by thyroid hormone. Cardiovasc Res 28: 1008-1013.
12. GUO W, KAMIYA K, TOYAMA J, 1995. bFGF promotes the functional expressions of transient outward currents in cultured neonatal rat ventricular cells. Pflugers Archiv Eur J Physiol 430: 1015-1017.
13. max of action potential in single ventricular myocytes. Br J Pharmacol 102: 651-656.
14. IKEDA N, NADEMANEE K, KANNAN R, SINGH BN, 1984. Electrophysiological effects of amiodarone: experimental and clinical observation relative to serum and tissue drug concentrations. Am Heart J 108: 890-898.
15. KAMIYA K, CHENG J, KODAMA I, TOYAMA J, 1995a. Acute and chronic effects of amiodarone on action potential and ionic currents in single rabbit ventricular myocytes. In: Toyama J, Hiraoka M, Kodama I (eds). Recent Progress in Electropharmacology of the Heart. CRC Press: 139-149.
16. KAMIYA K, KAMBE F, NISHIYAMA A, GUO W, SEO H, TOYAMA J, 1995b. Modulation of repolarizing potassium channels and Kv1.5 mRNA by long-term treatment with amiodarone. Circulation 92: I-372.
17. KASANUKI H, 1993. Amiodarone therapy. Coronary 10: 267-278. (in Japanese)
18. KILBORN MJ AND FEDIDA D, 1990. A study of the developmental changes in outward currents of rat ventricular myocytes. J Physiol 430: 37-60.
19. KODAMA I, SUZUKI R, KAMIYA K, IWATA H, TOYAMA J, 1992. Effects of long-term oral administration of amiodarone on the electro-mechanical performance of rabbit ventricular muscles. Br J Pharmacol 107: 502-509.
20. + current in human ventricular myocytes. Circ Res 78: 689-696.
21. LINDENMEYER M, SPORRI S, STAUBLI M, STUDER A, STUDER HS, 1984. Does amiodarone affect heart rate by inhibiting the intracellular generation of triiodothyronine from thyroxine? Br J Pharmacol 82: 275-280.
22. MEAD RS AND HARRISON DC, 1984. Therapy with investigational antiarrhythmic drugs. Med Clin North Am 68: 1321-1337.
23. NABAUER M, BEUCKELMANN DJ, ERDMANN E, 1993. Characteristics of transient outward current in human ventricular myocytes from patients with terminal heart failure. Circ Res 73: 386-394.
24. NADEMANEE K, SINGH BN, STEVENSON WG, WEISS JN, 1993. Amiodarone and post-MI patients. Circulation 88: 764-774.
25. NAG AC, LEE ML, SHEPARD, D, 1990. Effect of amiodarone on the expression of myosin isoforms and cellular growth of cardiac muscle cells in culture. Circ Res 67: 51-60.
26. NEMECZ G, AL-ACHI, ANTOINE, GREENWOOD R, JENDRASIAK GL, 1995. A possible nonspecific site of action of amiodarone on newborn rat heart cell in culture. Res Commun Mol Pathol Pharmacol 87: 187-197.
27. NORTHOVER, BJ, 1984. Alterations to the electrical activity of atrial muscle isolated from the rat heart, produced by exposure in vitro to amiodarone. Br J Pharmacol 82: 191-197.
28. 3 at the receptor level. An additional mechanism for its in vivo hypothyroid-like effects. Can J Physiol Pharmacol 69: 865-870.
29. PEELE ME, 1995. Transcriptional regulation of rat KvI.5 potassium channel gene by amiodarone and thyroid hormone. Circulation 92(8): I-373.
30. POLIKAR R, GAY JJ, SCHLAPFER J, LEMARCHAND-BERAUD T, BIOLLAZ J, MAGNENAT P, NICOD P, 1986. Effect of oral triiodothyronine during amiodarone treatment for ventricular premature complexes. Am J Cardiol 58: 987-991.
31. SHARP NA, NEEL DS, PARSONS RL, 1985. Influence of thyroid hormone levels on the electrical and mechanical properties of rabbit papillary muscle. J Mol Cell Cardiol 17: 119-132.
32. SHIMONI Y, BANNO H, CLARK RB, 1992. Hyperthyroidism selectively modified a transient potassium current in rabbit ventricular and atrial myocytes. J Physiol 457: 369-389.
33. SHIMONI Y AND SEVERSON DL, 1995. Thyroid status and potassium current in rat ventricular myocytes. Am J Physiol 268: H576-583.
34. SINGH BN, NADEMANEE K, KANNAN R, IKEDA N, 1984. The clinical results of amiodarone in cardiac arrhythmias: optimal dosing. Pacing Clin Electrophysiol 7(1): 109-124.
35. SINGH BN AND VAUGHAN-WILLIAMS, EM, 1970. The effect of amiodarone, a new antianginal drug, on cardiac muscle. Br J Pharmacol 39: 657-667.
36. TALAJIC M, NATTEL S, DAVIES M, MCCANS, J, 1989. Attenuation of class 3 and sinus node effects of amiodarone by experimental hypothyroidism. J Cardiovasc Pharmacol 13: 447-450.
37. 1-receptor protein. Mol Cell Endocrinol 112: 15-19.
38. VAUGHAN-WILLIAMS EM, 1984. A classification of antiarrhythmic actions reassessed after a decade of new drugs. J Clin Pharmacol 24: 129-147.
39. + channels in mouse heart. Circ Res 79: 79-85.
40. WANG Z, FERMINI B, NATTEL S, 1994. Rapid and slow components of delayed rectifier current in human atrial myocytes. Cardiovasc Res 28: 1540-1546.
41. WELLENS HJ, BRUGADA P, ABDOLLAH H, DASSEN WR, 1984. A comparison of the electrophysiologic effects of intravenous and oral amiodarone in the same patient. Circulation 69: 120-124.
42. 3 and amiodarone on the contractility and the density of β-adrenoceptors of chicken cardiac myocytes. Eur J Pharmacol 261: 97-104.