Expression of p21WAF1/CIP1/SDI1 and p53 in apoptotic cells in the adrenal cortex and induction by ischemia/reperfusion injury

Journal of Clinical Investigation

Volumn 97, Issue 7, 1996, Pages 1723-1731

  Didenko, Vladimir V ^a   Wang, Xiangdong ^a   Yang, Lianqing ^a   Hornsby, Peter J ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Cell death; Cyclin dependent kinases; Heat shock proteins; Immunohistochemistry; Tumor suppressor genes

Indexed keywords

DNA; HEAT SHOCK PROTEIN; MESSENGER RNA; NUCLEAR PROTEIN; PROTEIN P21; PROTEIN P53;

ADRENAL CORTEX CELL; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; FLUORESCENCE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOREACTIVITY; ISCHEMIA; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

ADRENAL CORTEX; ANIMALS; APOPTOSIS; CELLS, CULTURED; CHILD; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA DAMAGE; ENZYME INHIBITORS; GENE EXPRESSION; GENES, P53; HSP70 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, ELECTRON; MIDDLE AGED; RATS; REPERFUSION INJURY; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0029912396     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118599     Document Type: Article

References (69)

1. El-Deiry, W.S., T. Tokino, V.E. Velculescu, D.B. Levy, R. Parsons J.M. Trent, D. Lin, W.E. Mercer, K.W. Kinzler, and B. Vogelstein. 1993. WAF1, a potential mediator of p53 tumor suppression. Cell. 75:817-825.
2. Harper, J.W., G.R. Adami, N. Wei, K. Keyomarsi, and S.J. Elledge. 1993. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 75 805-816.
3. Gu, Y., C.W Turck, and D.O. Morgan. 1993. Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature (Lond ) 366:707-710.
4. Xiong, Y., G.J. Hannon, H. Zhang, D. Casso, R. Kobayashi, and D. Beach. 1993. p21 is a universal inhibitor of cyclin kinases. Nature (Lond ). 366: 701-704
5. Noda, A., Y. Ning, S F. Venable, O.M. Pereira-Smith, and J R. Smith. 1994. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res. 211:90-98.
6. Smith, J.R. 1992. Inhibitors of DNA synthesis derived from senescent human diploid fibroblasts. Exp. Gerontol. 27:409 412.
7. Johnson, M., D. Dimitrov, P.J Vojta, J.C. Barrett, A. Noda, O M. Pereira-Smith, and J.R. Smith. 1994. Evidence for a p53-independent pathway for upregulation of SDI1/CIP1/WAF1/p21 RNA in human cells. Mol. Carcinog. 11:59-64.
8. Dulic, V., W.K. Kaufmann, S.J. Wilson, T.D. Tlsty, E. Lees, J W Harper, S.J. Elledge, and S.I. Reed. 1994. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell. 76:1013-1023.
9. Michieh, P., M. Chedid, D. Lin, J.H. Pierce, W.E. Mercer, and D. Givol. 1994 Induction of WAF1/CIP1 by a p53-independent pathway. Cancer Res 54: 3391-3395.
10. Slebos, R.J.C., M.H. Lee, B.S Plunkett, T.D. Kessis, B.O. Williams, T. Jacks, L. Hedrick, M.B. Kastan, and K.R. Cho. 1994. p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papilloma virus 16 E7 oncoprotein. Proc Natl. Acad Sci. USA. 91:5320-5324
11. Sheikh, M.S., X.-S. Li, J.-C. Chen, Z.-M. Shao, J V. Ordonez, and J A Fontana. 1994. Mechanisms of regulation of WAF1/Cip1 gene expression in human breast carcinoma: role of p53-dependent and independent signal tranduction pathways. Oncogene. 9:3407-3415.
12. Shivji, M.K.K., S J. Grey, U.P. Strausfeld, R.D. Wood, and J J. Blow. 1994. Cip1 inhibits DNA replication but not PCNA-dependent nucleotide excision-repair. Curr. Biol. 4:1062-1068
13. Elledge, S.J., and J.W. Harper. 1994. Cdk inhibitors: on the threshold of checkpoints and development. Curr Opin. Cell Biol. 6:847-852.
14. Canman, C.E., C.-Y. Chen, M.-H. Lee, and M.B. Kastan. 1994. DNA damage responses. p53 induction, cell cycle perturbations, and apoptosis Cold Spring Harbor Symp. Quant. Biol. 59:277-286.
15. El-Deiry, W.S , J.W Harper, P M O'Connor, V.E. Velculescu, C.E Canman, J. Jackman, J.A Pietenpol, M. Burrell, D E. Hill, Y. Wang, et al. 1994. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis Cancer Res. 54:1169-1174.
16. WAF1/CIP1 expression in normal and neoplastic tissues. Cancer Res. 55:2910-2919.
17. Parker, S.B., G. Eichele, P. Zhang, A. Rawls, A.T. Sands, A. Bradley, E N. Olson, J.W. Harper, and S.J. Elledge. 1995 p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science (Wash. DC). 267:1024-1027.
18. sdd in adrenocortical cells when they are placed in culture. Exp. Cell Res. 221:126-131
19. Hornsby, P J. 1985. The regulation of adrenocortical function by control of growth and structure. In Adrenal Cortex. D C Anderson and J.S.D. Winter, editors. Butterworth, London. 1-31.
20. Ponten, F., B Berne, Z.-P. Ren, M Ntster, and J. Ponten. 1995. Ultraviolet light induces expression of p53 and p21 in human skin: effect of sunscreen and constitutive p21 expression in skin appendages. J. Invest. Dermatol 105, 402-406.
21. WAF1/CIP1 in psoriasis and after the application of irritants and tape stripping. J. Invest. Dermatol 105:274-279.
22. Southard, J.H 1995. Development and optimization of preservation solutions. In Cell Biology of Trauma, J.J. Lemasters and C Oliver, editors. CRC Press, Boca Raton, FL. 289-297.
23. Hornsby, P.J., and J.M McAllister. 1991. Culturing steroidogenic cells. In Methods in Enzymology, Vol. 206. M.R. Waterman and E.F. Johnson, editors. Academic Press, Inc., San Diego, 371-380.
24. McAllister, J.M , and P.J. Hornsby. 1987. Improved clonal and non-clonal growth of human, rat, and bovine adrenocortical cells in culture. In Vitro Cell & Dev Biol. 23:677-685.
25. Hornsby, P.J., and S E. Harris. 1987. Oxidative damage to DNA and replicative life span in cultured adrenocortical cells Exp. Cell Res 168:203-217.
26. Bradshaw, K.D., M.R. Waterman, R.T. Couch, E.R. Simpson, and M.X. Zuber. 1987. Characterization of complementary deoxyribonucleic acid for human adrenocortical 17α-hydroxylase: a probe for analysis of 17α-hydroxylase deficiency. Mol Endocrinol. 1:348-354.
27. Oonk, R.B., J.S. Krasnow, W.G. Beattie, and J.S. Richards, 1989. Cyclic AMP-dependent and -independent regulation of cholesterol side chain cleavage cytochrome P-450 (P-450scc) in rat ovarian granulosa cells and corpora lutea. cDNA and deduced amino acid sequence of rat P-450scc. J Biol. Chem. 264:21934-21942.
28. Brown, E.R., G.T. Coker III, and K.L. O'Malley. 1987. Organization and evolution of the rat tyrosine hydroxylase gene. Biochemistry. 26:5208-5212.
29. Naseeruddin, S.A , and P J. Hornsby 1990. Regulation of 11β- and 17α-hydroxylases in cultured bovine adrenocortical cells: cyclic adenosine 3′.5′-monophosphate, insulin-like growth factor-I. and activators of protein kinase C. Endocrinology. 127:1673-1681.
30. Zhu, L., E. Harlow, and B.D. Dynlacht. 1995. p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F. Genes & Dev. 9:1740-1752.
31. Gannon, J.V., R. Greaves, R. Iggo, and D.P. Lane. 1990. Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form. EMBO (Eur. Mol. Biol. Organ.) J. 9:1595-1602.
32. Gavrieli, Y., Y. Sherman, and S A. Ben-Sasson. 1992. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:493-501.
33. Aharoni, D., A. Dantes, M Oren, and A. Amsterdam. 1995. cAMP-mediated signals as determinants for apoptosis in primary granulosa cells. Exp. Cell Res. 218:271-282.
34. Kovacs, K , R. Carroll, and E. Tapp. 1966. Temporary ischaemia of the rat adrenal gland. J Pathol Bacteriol 91:235-240.
35. Dobbie, J.W , and T. Symington. 1966. The human adrenal gland with special reference to the vasculature. J. Endocrinol 34:479-489.
36. Di Leonardo, A , S.P. Linke, K. Clarkin, and G.M. Wahl 1994. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes & Dev 8:2540-2551.
37. Li, Y., C W. Jenkins, M.A. Nichols, and Y. Xiong. 1994 Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21. Oncogens. 9.2261-2268.
38. Mehta, H.B., B.K. Popovich, and W.H Dillmann. 1988. Ischemia induces changes in the level of mRNAs coding for stress protein 71 and creatine kinase M. Circ. Res. 63:512-517.
39. Brown, I.R. 1990. Induction of heat shock (stress) genes m the mammalian brain by hyperthermia and other traumatic events: a current perspective. J. Neurosci Res. 27:247-255.
40. Lovis, C., F. Mach, Y.R. Donati, J.V. Bonventre, and B.S. Polla. 1994 Heat shock proteins and the kidney. Renal Fail. 16:179-192.
41. Neville, A.M. 1978. The nodular adrenal. Invest Cell Pathol. 1:99-111.
42. Wyllie, A.H., J.F.R. Kerr, and A.R. Currie. 1980. Cell death: the significance of apoptosis. Int. Rev. Cytol. 68:251-280.
43. Kerr, J.F.R , C M. Winterford, and B.V. Harmon. 1994. Morphological criteria for identifying apoptosis. In Cell Biology. A Laboratory Handbook, Vol. 1, J.E. Cells, editor. Academic Press, Inc., San Diego. 319-329.
44. Neville, A.M., and M.J. O'Hare. 1982. The Human Adrenal Cortex. Pathology and Biology - An Integrated Approach. Springer-Verlag, Berlin.
45. Huppi, K., D Siwarski, J. Dosik, P Michieli, M. Chedid, S. Reed, B. Mock, D. Givol, and J.F. Mushinski 1994. Molecular cloning, sequencing, chromosomal localization and expression of mouse p21 (Waf1), Oncogene. 9:3017-3020
46. Lane, D.P. 1992. p53, guardian of the genome. Nature (Lond ). 358:15-16.
47. Pines, J. 1994. Cell cycle. p21 inhibits cyclin shock. Nature (Lond.). 369: 520-521.
48. Wyllie, A.H. 1994. Apoptosis. Death gets a brake. Nature (Lond.). 369: 272-273.
49. Floyd, R.A., and J.M. Carney. 1992. Free radical damage to protein and DNA: mechanisms involved and relevant observations on brain undergoing oxidative stress. Ann. Neurol. 32(Suppl.).S22-S27.
50. Sato, T., K. Koyama, T. Takemasa, S. Yoshida, Y. Sato, S. Omokawa, and N.J. Lygidakis, 1992. Damage and repair of hepatocyte nuclear DNA after hepatic inflow occlusion. Hepato-gastroenterology. 39:252-256.
51. Schumer, M., M.C. Colombel, I.S. Sawczuk, G. Gobe, J. Connor, K.M. O'Toole, C.A. Olsson, G.J. Wise, and R. Buttyan. 1992. Morphologic, biochemical, and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia. Am. J Pathol. 140:831-838.
52. Li, Y., M Chopp, Z G. Zhang, C. Zaloga, L. Niewenhuis, and S. Gautam. 1994. p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats Stroke. 25:849-856.
53. MacManus, J.P , I E. Hill, Z.G. Huang, I. Rasquinha, D. Xue, and A.M. Buchan. 1994. DNA damage consistent with apoptosis in transient focal ischaemic neocortex. Neuroreport 5:493-496.
54. Gottlieb, R.A., K.O. Burleson, R.A. Kloner, B.M. Babior, and R L. Engler 1994. Reperfusion injury induces apoptosis in rabbit cardiomyocytes. J. Clin. Invest. 94:1621-1628.
55. Chopp, M. 1993. The roles of heat shock proteins and immediate early genes in central nervous system normal function and pathology. Curr. Opin. Neurol. Neurosurg. 6 6-10.
56. King, K.L., and J.A. Cidlowski. 1995. Cell cycle and apoptosis: common pathways to life and death. J. Cell. Biochem. 58:175-180.
57. Meikrantz, W., and R. Schlegel. 1995 Apoptosis and the cell cycle. J. Cell Biochem 58:160-174
58. CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell. 82:675-684.
59. Wyllie, A.H., J.F Kerr, I.A. Macaskill, and A.R. Currie. 1973. Adrenocortical cell deletion: the role of ACTH J. Pathol. 111.85-94.
60. Ceccatelli, S., A. Diana, M.J. Villar, and P. Nicotera 1995. Adrenocortical apoptosis in hypophysectomized rats is selectively reduced by ACTH. Neuroreport. 6:342-344.
61. Donehower, L.A., M. Harvey, B.L. Slagle, M.J. McArthur, C.A. Montgomery, Jr., J S Butel, and A. Bradley. 1992. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours Nature (Lond.). 356:215-221.
62. Ryzhavskii, B.I. 1978. Izmenenie kory nadpochechnikov krys pri stresse posle udaleniia gipofiza, shchitovidnoi zhelezy i iaichka. Arkh. Anat. Gistol. Embriol. 74(4):40-46.
63. Blake, M.J., R. Udelsman, G.J. Feulner, D.D. Norton, and N.J. Holbrook. 1991. Stress-induced heat shock protein 70 expression in adrenal cortex: an adrenocorticotropic hormone-sensitive, age-dependent response. Proc Natl. Acad Sci. USA. 88:9873-9877.
64. Siegel, L M , S.K. Grinspoon, G J. Garvey, and J.P Bilezikian. 1994. Sepsis and adrenal function Trends Endocrinol. Metab 5.324-328.
65. Giampaolo, C., A.T. Gray, R.A. Olshen, and S. Szabo. 1991. Predicting chemically induced duodenal ulcer and adrenal necrosis with classification trees. Proc. Natl. Acad. Sci. USA. 88:6298-6302.
66. Rao, R.H. 1995. Bilateral massive adrenal hemorrhage Med. Clin. N. Am. 79:107-129
67. Lindh, A., K. Carlstrom, J. Eklund. and N. Wilking. 1992. Serum steroids and prolactin during and after major surgical trauma. Acta Anaesthesiol Scand. 36.119-124.
68. Hornsby, P.J. 1995. Biosynthesis of DHEAS by the human adrenal cortex and its age-related decline. Ann. NY Acad Sci 774:29-46.
69. Dobbie, J.W. 1969. Adrenocortical nodular hyperplasia: the aging adrenal. J Pathol. 99:1-18.