PTEN regulates motility but not directionality during leukocyte chemotaxis

Journal of Cell Science

Volumn 117, Issue 25, 2004, Pages 6207-6215

  Lacalle, Rosa Ana ^a   Gómez Moutón, Concepcion ^a   Barber, Domingo F ^a   Jiménez Baranda, Sonia ^a   Mira, Emilia ^a   Martínez A , Carlos ^a   Carrera, Ana C ^a   Mañes, Santos ^a  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

Actin cytoskeleton; Cell migration; Lipid rafts; PI3K; Polarization

Indexed keywords

CHEMOATTRACTANT; GREEN FLUORESCENT PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; SMALL INTERFERING RNA;

ACTIN POLYMERIZATION; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL FRACTIONATION; CELL STIMULATION; CELL STRAIN HL 60; CELLULAR DISTRIBUTION; CHIMERA; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; DRUG SENSITIVITY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LEUKOCYTE MOTILITY; NEUTROPHIL CHEMOTAXIS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; STRAIN DIFFERENCE; VELOCITY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTINS; BLOTTING, WESTERN; CATALYSIS; CELL MOVEMENT; CHEMOTACTIC FACTORS; CHEMOTAXIS; CLONING, MOLECULAR; CYTOPLASM; CYTOSOL; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; GREEN FLUORESCENT PROTEINS; HL-60 CELLS; HUMANS; JURKAT CELLS; LEUKOCYTES; MEMBRANE MICRODOMAINS; MICROSCOPY, FLUORESCENCE; MICROSCOPY, VIDEO; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN STRUCTURE, TERTIARY; PTEN PHOSPHOHYDROLASE; RNA, SMALL INTERFERING; SUBCELLULAR FRACTIONS; TIME FACTORS; TUMOR SUPPRESSOR PROTEINS;

DICTYOSTELIUM; MAMMALIA;

EID: 9644270459     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.01545     Document Type: Article

References (35)

1. Anzelon, A., Wu, H. and Rickert, R. (2003). Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. Nat. Immunol. 4, 287-294.
2. Borlado, L., Redondo, C., Alvarez, B., Jimenez, C., Criado, L., Flores, J., Marcos, M., Martinez-A., C., Balomenos, D. and Carrera, A. (2000). Increased phosphoinositide 3-kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo. FASEB J. 14, 895-903.
3. Cronshaw, D. G., Owen, C., Brown, Z. and Ward, S. G. (2004). Activation of phosphoinositide 3-kinases by the CCR4 ligand macrophage-derived chemokine is a dispensable signal for T lymphocyte chemotaxis. J. Immunol. 172, 7761-7770.
4. Das, S., Dixon, J. and Cho, W. (2003). Membrane-binding and activation mechanism of PTEN. Proc. Natl. Acad. Sci. USA 100 7491-7496.
5. Deichmann, M., Thome, M., Benner, A., Egner, U., Hartschuh, W. and Naher, H. (2002). PTEN/MMAC1 expression in melanoma resection specimens. Br. J. Cancer 87, 1431-1436.
6. Fox, J., Ung, K., Tanlimco, S. and Jirik, F. (2002). Disruption of a single Pten allele augments the chemotactic response of B lymphocytes to stromal cell-derived factor-1. J. Immunol. 169 49-54.
7. Friedl, P., Brocker, E. and Zanker, K. (1998). Integrins, cell matrix interactions and cell migration strategies: fundamental differences in leukocytes and tumor cells. Cell Adhes. Commun. 6, 225-236.
8. Funamoto, S., Meili, R., Lee, S., Parry, L. and Firtel, R. (2002). Spatial and temporal regulation of 3-phosphoinositides by PI3-Kinase and PTEN mediates chemotaxis. Cell 109, 611-623.
9. Georgescu, M., Kirsch, K., Akagi, T., Shishido, T. and Hanafusa, H. (1999). The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region. Proc. Natl. Acad. Sci. USA 96, 10182-10187.
10. Gimm, O., Perren, A., Weng, L., Marsh, D., Yeh, J., Ziebold, U., Gil, E., Hinze, R., Delbridge, L., Lees, J. et al. (2000). Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumours. Am. J. Pathol. 156, 1693-1700.
11. Gómez-Moutón, C., Abad, J., Mira, E., Lacalle, R., Gallardo, E., Jiménez-Baranda, S., Illa, I., Bernad, A., Mañ es, S. and Martínez-A., C. (2001). Segregation of leading-edge and uropod components into specific lipid rafts during T cell polarization. Proc. Natl. Acad. Sci. USA 98, 9642-9647.
12. Gómez-Moutón, C., Lacalle, R., Mira, E., Jiménez-Baranda, S., Barber, D., Carrera, A., Martínez-A., C. and Mañes, S. (2004). Dynamic redistribution of raft domains as an organizing platform for signaling during cell chemotaxis. J. Cell Biol. 164, 759-768.
13. Gu, J., Tamura, M., Pankov, R., Danen, E., Takino, T., Matsumoto, K. and Yamada, K. (1999). She and FAK differentially regulate cell motility and directionality modulated by PTEN. J. Cell Biol. 146, 389-403.
14. Iijima, M. and Devreotes, P. (2002). Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell 109, 599-610.
15. Li, Z., Hannigan, M., Mo, Z., Liu, B., Lu, W., Wu, Y., Smrcka, A., Wu, G., Li, L., Liu, M. et al. (2003). Directional sensing requires Gβγ-mediated PAK1 and PIXα-dependent activation of Cdc42. Cell 114, 215-227.
16. Liliental, J., Moon, S., Lesche, R., Mamillapalli, R., Li, D., Zheng, Y., Sun, H. and Wu, H. (2000). Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases. Curr Biol. 10, 401-404.
17. Maehama, T. and Dixon, J. (1998). The tumor suppressor. PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273, 13375-13378.
18. Mañes, S., Lacalle, R., Gómez-Moutón, C. and Martínez-A., C. (2003). From rafts to crafts: membrane asymmetry in moving cells. Trends Immunol. 24, 320-326.
19. Mira, E., Lacalle, R., González, M., Gómez-Moutón, C., Abad, J., Bernad, A., Martí nez-A., C. and Mañes, S. (2001). A role for chemokine receptor transactivation in growth factor signaling. EMBO Rep. 2, 151-156.
20. Myers, M., Pass, I., Batty, I., van der Kaay, J., Stolarov, J., Hemmings, B., Wigler, M., Downes, C. and Tonks, N. (1998). The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc. Natl. Acad. Sci. USA 95, 13513-13518.
21. Nombela-Arrieta, C., Lacalle, R. A., Montoya, M. C., Kunisaki, Y., Megías, D., Marqués, M., Carrera, A. C., Mañes, S., Fukui, Y., Martínez-A., C. et al. (2004). Differential requirements for DOCK2 and phosphoinositide-3-kinaseγ during T and B lymphocyte homing. Immunity 21, 429-441.
22. Raftopoulou, M., Etienne-Manneville, S., Self, A., Nicholls, S. and Hall, A. (2004). Regulation of cell migration by the C2 domain of the tumor suppressor PTEN. Science 303, 1179-1181.
23. Sakai, A., Thieblemont, C., Wellmann, A., Jaffe, E. and Raffeld, M. (1998). PTEN gene alterations in lymphoid neoplasms. Blood 92, 3410-3415.
24. Seminario, M. and Wange, R. (2002). Signaling pathways of D3-phosphoinositide-binding kinases in T cells and their regulation by PTEN. Semin. Immunol. 14, 27-36.
25. Sotsios, Y., Whittaker, G., Westwick, J. and Ward, S. (1999). The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-Kinase in T lymphocytes. J. Immunol. 163, 5954-5963.
26. Stambolic, V., Suzuki, A., de la Pompa, J., Brothers, G., Mirtsos, C., Sasaki, T., Ruland, J., Penninger, J., Siderovski, D. and Mak, T. (1998). Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95, 29-39.
27. Suzuki, A., Kaisho, T., Ohishi, M., Tsukio-Yamaguchi, M., Tsubata, T., Koni, P., Sasaki, T., Mak, T. and Nakano, T. (2003). Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination. J. Exp. Med. 197, 657-667.
28. Tamura, M., Gu, J., Matsumoto, K., Aota, S., Parsons, R. and Yamada, K. (1998). Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 280, 1614.
29. Tamura, M., Gu, J., Takino, T. and Yamada, K. (1999). Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas. Cancer Res. 59, 442-449.
30. Torres, J. and Pulido, R. (2001). The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation. J. Biol. Chem. 276, 993-998.
31. van Buul, J., Voermans, C., van Gelderen, J., Anthony, E., van der Schoot, C. and Hordijk, P. (2003). Leukocyte-endothelium interaction promotes SDF-1-dependent polarization of CXCR4. J. Biol. Chem. 278, 30302-30310.
32. Ward, S. G. (2004). Do phosphoinositide 3-kinases direct lymphocyte navigation? Trends Immunol. 25, 67-74.
33. Wu, X., Hepner, K., Castelino-Prabhu, S., Do, D., Kaye, M., Yuan, X., Wood, J., Ross, C., Sawyers, C. and Whang, Y. (2000). Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2. Proc. Natl. Acad. Sci. USA 97, 4233-4238.
34. Xu, J., Wang, F., van Keymeulen, A., Herzmark, P., Straight, A., Kelly, K., Takuwa, Y., Sugimoto, N., Mitchison, T. and Bourne, H. (2003). Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell 114, 201-214.
35. Xu, Z., Stokoe, D., Kane, L. and Weiss, A. (2002). The inducible expression of the tumor suppressor gene PTEN promotes apoptosis and decreases cell size by inhibiting the P13K/Akt pathway in Jurkat T cells. Cell Growth Differ. 13, 285-296.