PI3K induced actin filament remodeling through Akt and p70S6K1: Implication of essential role in cell migration

American Journal of Physiology - Cell Physiology

Volumn 286, Issue 1 55-1, 2004, Pages

  Qian, Yong ^a,b   Corum, Linda ^b   Meng, Qiao ^b   Blenis, John ^c   Zheng, Jenny Z ^b   Shi, Xianglin ^a   Flynn, Daniel C ^b   Jiang, Bing Hua ^b  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^b WEST VIRGINIA UNIVERSITY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Actin filaments; Phosphatidylinositol 3 kinase; Rac

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P70 S6 KINASE 1; PROTEIN P70S6K1; RAC PROTEIN; S6 KINASE; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL MIGRATION; CELL MOTILITY; CELL STRUCTURE; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALIA; GALLUS GALLUS;

EID: 0347358005     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00142.2003     Document Type: Article

References (38)

1. Aoki M, Batista O, Bellacosa A, Tsichlis P, and Vogt PK. The Akt kinase: molecular determinants of oncogenicity. Proc Natl Acad Sci USA 95: 14950-14955, 1998.
2. Aoki M, Blazek E, and Vogt PK. A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt. Proc Natl Acad Sci USA 98: 136-141, 2001.
3. Bakin AV, Tomlinson AK, Bhowmick NA, Moses HL, and Arteaga CL. Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration. J Biol Chem 275: 36803-36810, 2000.
4. Berven LA and Crouch MF. Cellular function of p70S6K: a role in regulating cell motility. Immunol Cell Biol 78: 447-451, 2000.
5. Brazil DP and Hemmings BA. Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem Sci 26: 657-664, 2001.
6. Burgering BM and Coffer PJ. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376: 599-602, 1995.
7. Chan TO, Rittenhouse SE, and Tsichlis PN. AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation. Annu Rev Biochem 68: 965-1014, 1999.
8. Chang HW, Aoki M, Fruman D, Auger KR, Bellacosa A, Tsichlis PN, Cantley LC, Roberts TM, and Vogt PK. Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase. Science 276: 1848-1850, 1997.
9. Chou MM and Blenis J. The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Racl. Cell 85: 573-583, 1996.
10. Crouch MF. Regulation of thrombin-induced stress fibre formation in Swiss 3T3 cells by the 70-kDa S6 kinase. Biochem Biophys Res Commun 233: 193-199, 1997.
11. Defilippi P, Olivo C, Venturino M, Dolce L, Silengo L, and Tarone G. Actin cytoskeleton organization in response to integrin-mediated adhesion. Microsc Res Tech 47: 67-78, 1999.
12. Edlund S, Landstrom M, Heldin CH, and Aspenstrom P. Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA. Mol Biol Cell 13: 902-914, 2002.
13. Golenhofen N, Doctor RB, Bacallao R, and Mandel LJ. Actin and villin compartmentation during ATP depletion and recovery in renal cultured cells. Kidney Int 48: 1837-1845, 1995.
14. Hall A. Rho GTPases and the actin cytoskeleton. Science 279: 509-514. 1998.
15. Hauck CR, Hsia DA, Puente XS, Cheresh DA, and Schlaepfer DD. FRNK blocks v-Src-stimulated invasion and experimental metastases without effects on cell motility or growth. EMBO J 21: 6289-6302, 2002.
16. Hauck CR, Hsia DA, and Schlaepfer DD. Focal adhesion kinase facilitates platelet-derived growth factor-BB-stimulated ERK2 activation required for chemotaxis migration of vascular smooth muscle cells. J Biol Chem 275: 41092-41099, 2000.
17. Higuchi M, Masuyama N, Fukui Y, Suzuki A, and Gotoh Y. Akt mediates Rac/Cdc42-regulated cell motility in growth factor-stimulated cells and in invasive PTEN knockout cells. Curr Biol 11: 1958-1962, 2001.
18. Irani C, Goncharova EA, Hunter DS, Walker CL, Panettieri RA, and Krymskaya VP. Phosphatidylinositol 3-kinase but not tuberin is required for PDGF-induced cell migration. Am J Physiol Lung Cell Mol Physiol 282: L854-L862, 2002.
19. Jiang BH, Zheng JZ, Aoki M, and Vogt PK. Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc Natl Acad Sci USA 97: 1749-1753, 2000.
20. Jiang BH, Zheng JZ, and Vogt PK. An essential role of phosphatidylinositol 3-kinase in myogenic differentiation. Proc Natl Acad Sci USA 95: 14179-14183, 1998.
21. Jimenez C, Portela RA, Mellado M, Rodriguez-Frade JM, Collard J, Serrano A, Martinez AC, Avila J, and Carrera AC. Role of the PI3K regulatory subunit in the control of actin organization and cell migration. J Cell Biol 151: 249-262, 2000.
22. Khayat ZA, Tong P, Yaworsky K, Bloch RJ, and Klip A. Insulin-induced actin filament remodeling colocalizes actin with phosphatidylinositol 3-kinase and GLUT4 in L6 myotubes. J Cell Sci 113: 279-290, 2000.
23. Kotani K, Yonezawa K, Hara K, Ueda H, Kitamura Y, Sakaue H, Ando A, Chavanieu A, Calas B, Grigorescu F, Nishiyama M, Waterfield MD, and Kasuga M. Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling. EMBO J 13: 2313-2321, 1994.
24. Krasilnikov MA. Phosphatidylinositol-3 kinase dependent pathways: the role in control of cell growth, survival, and malignant transformation. Biochemistry (Mosc) 65: 59-67, 2000.
25. Lange K, Brandt U, Gartzke J, and Bergmann J. Action of insulin on the surface morphology of hepatocytes: role of phosphatidylinositol 3-kinase in insulin-induced shape change of microvilli. Exp Cell Res 239: 139-151, 1998.
26. Ma AD, Metjian A, Bagrodia S, Taylor S, and Abrams CS. Cytoskeletal reorganization by G protein-coupled receptors is dependent on phosphoinositide 3-kinase gamma, a Rac guanosine exchange factor, and Rac. Mol Cell Biol 18: 4744-4751, 1998.
27. 4 integrin. Semin Cancer Biol 11: 129-141, 2001.
28. Morales-Ruiz M, Fulton D, Sowa G, Languino LR, Fujio Y, Walsh K, and Sessa WC. Vascular endothelial growth factor-stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt. Circ Res 86: 892-896, 2000.
29. Papakonstanti EA and Stournaras C. Association of PI-3 kinase with PAK1 leads to actin phosphorylation and cytoskeletal reorganization. Mol Biol Cell 13: 2946-2962, 2002.
30. Qi JH and Claesson-Welsh L. VEGF-induced activation of phosphoinositide 3-kinase is dependent on focal adhesion kinase. Exp Cell Res 263: 173-182, 2001.
31. Qian Y, Baisden JM, Westin EH, Guappone AC, Koay TC, and Flynn DC. Src can regulate carboxy terminal interactions with AFAP-110, which influence self-association cell localization and actin filament integrity. Oncogene 16: 2185-2195, 1998,
32. Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ, Waterfield MD, and Downward J. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370: 527-532, 1994.
33. Rodriguez-Viciana P, Warne PH, Khwaja A, Marte BM, Pappin D, Das P, Waterfield MD, Ridley A, and Downward J. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell 89: 457-467, 1997.
34. Sheetz MP, Felsenfeld D, Galbraith CG, and Choquet D. Cell migration as a five-step cycle. Biochem Soc Symp 65: 233-243, 1999.
35. Stupack DG, Cho SY, and Klemke RL. Molecular signaling mechanisms of cell migration and invasion. Immunol Res 21: 83-88, 2000.
36. Takenawa T and Itoh T. Phosphoinositides, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane. Biochim Biophys Acta 1533: 190-206, 2001.
37. Tsakiridis T, Tong P, Matthews B, Tsiani E, Bilan PJ, Klip A, and Downey GP. Role of the actin cytoskeleton in insulin action. Microsc Res Tech 47: 79-92, 1999.
38. Wennstrom S, Hawkins P, Cooke F, Hara K, Yonezawa K, Kasuga M, Jackson T, Claesson-Welsh L, and Stephens L. Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling. Curr Biol 4: 385-393, 1994.