메뉴 건너뛰기




Volumn 276, Issue 6 39-6, 1999, Pages

Effects of troglitazone on substrate storage and utilization in insulin- resistant rats

Author keywords

Free fatty acid metabolism; Glucose metabolism; Insulin resistance; Non insulin dependent diabetes mellitus; Thiazolidinedione

Indexed keywords

GLYCOGEN; INSULIN; LIPOPROTEIN LIPASE; PALMITIC ACID; PYRUVATE DEHYDROGENASE; TROGLITAZONE;

EID: 0033032470     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1999.276.6.e1119     Document Type: Article
Times cited : (55)

References (39)
  • 1
    • 0029964729 scopus 로고    scopus 로고
    • Contributions of de novo synthesis of fatty acids to total VLDL-triglyceride secretion during prolonged hyperglycemia/hyperinsulinemia in normal man
    • Aarsland, A., D. Chinkes, and R. R. Wolfe. Contributions of de novo synthesis of fatty acids to total VLDL-triglyceride secretion during prolonged hyperglycemia/hyperinsulinemia in normal man. J. Clin. Invest. 98: 2008-2017, 1996.
    • (1996) J. Clin. Invest. , vol.98 , pp. 2008-2017
    • Aarsland, A.1    Chinkes, D.2    Wolfe, R.R.3
  • 2
    • 0024851469 scopus 로고
    • In vitro study of human skeletal muscle strips: Effect of nonesterified fatty acid supply on glucose storage
    • Argyraki, M., P. D. Wright, C. W. Venables, G. Proud, and R. Taylor. In vitro study of human skeletal muscle strips: effect of nonesterified fatty acid supply on glucose storage. Metabolism 38: 1183-1187, 1989.
    • (1989) Metabolism , vol.38 , pp. 1183-1187
    • Argyraki, M.1    Wright, P.D.2    Venables, C.W.3    Proud, G.4    Taylor, R.5
  • 3
    • 0031014830 scopus 로고    scopus 로고
    • Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
    • Boden, G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46: 3-10, 1997.
    • (1997) Diabetes , vol.46 , pp. 3-10
    • Boden, G.1
  • 4
    • 0021522550 scopus 로고
    • Insulin resistance in denervated skeletal muscle: A model for impaired receptor function coupling
    • Endocrinol. Metab. 10
    • Burant, C. F., S. K. Lemon, M. K. Treutelaar, and M. G. Buse. Insulin resistance in denervated skeletal muscle: a model for impaired receptor function coupling. Am. J. Physiol. 247 (Endocrinol. Metab. 10): E657-E666, 1984.
    • (1984) Am. J. Physiol. , vol.247
    • Burant, C.F.1    Lemon, S.K.2    Treutelaar, M.K.3    Buse, M.G.4
  • 6
    • 0031753812 scopus 로고    scopus 로고
    • Five-hour fatty acid elevation increases muscle lipids and impairs glycogen synthesis in the rat
    • Chalkley, S. M., M. Gettiarachchi, D. J. Chishom, and E. W. Kraegen. Five-hour fatty acid elevation increases muscle lipids and impairs glycogen synthesis in the rat. Metabolism 47: 1121-1126, 1998.
    • (1998) Metabolism , vol.47 , pp. 1121-1126
    • Chalkley, S.M.1    Gettiarachchi, M.2    Chishom, D.J.3    Kraegen, E.W.4
  • 7
    • 18544405906 scopus 로고
    • Starvation reduces pyruvate dehydrogenase phosphate phosphatase activity in rat kidney
    • Cockburn, B. N., and H. G. Coore. Starvation reduces pyruvate dehydrogenase phosphate phosphatase activity in rat kidney. Mol. Cell. Biochem. 149-150: 131-136, 1995.
    • (1995) Mol. Cell. Biochem. , vol.149-150 , pp. 131-136
    • Cockburn, B.N.1    Coore, H.G.2
  • 9
    • 0026708888 scopus 로고
    • Effect of insulin on oxidative and nonoxidative pathways of free fatty acid metabolism in human obesity
    • Endocrinol. Metab. 26
    • Groop, L. C., R. C. Bonadonna, D. C. Simonson, A. S. Petrides, L. Shank, and R. A. DeFronzo. Effect of insulin on oxidative and nonoxidative pathways of free fatty acid metabolism in human obesity. Am. J. Physiol. 263 (Endocrinol. Metab. 26): E79-E84, 1992.
    • (1992) Am. J. Physiol. , vol.263
    • Groop, L.C.1    Bonadonna, R.C.2    Simonson, D.C.3    Petrides, A.S.4    Shank, L.5    DeFronzo, R.A.6
  • 10
    • 0030664299 scopus 로고    scopus 로고
    • Insulin resistance of muscle glucose transport in rats fed a high-fat diet: A reevaluation
    • Han, D. H., P. A. Hansen, H. H. Host, and J. O. Hollozy. Insulin resistance of muscle glucose transport in rats fed a high-fat diet: a reevaluation. Diabetes 46: 1761-1767, 1997.
    • (1997) Diabetes , vol.46 , pp. 1761-1767
    • Han, D.H.1    Hansen, P.A.2    Host, H.H.3    Hollozy, J.O.4
  • 11
    • 0030894895 scopus 로고    scopus 로고
    • Role of glycogen concentration and epinephrine on glucose uptake in rat epitrochlearis muscle
    • Endocrinol. Metab. 35
    • Jensen, J., R. Aslesen, J. L. Ivy, and O. Brors. Role of glycogen concentration and epinephrine on glucose uptake in rat epitrochlearis muscle. Am. J. Physiol. 272 (Endocrinol. Metab. 35): E649-E655, 1997.
    • (1997) Am. J. Physiol. , vol.272
    • Jensen, J.1    Aslesen, R.2    Ivy, J.L.3    Brors, O.4
  • 12
    • 0030720085 scopus 로고    scopus 로고
    • Tissue triglycerides, insulin resistance, and insulin production: Implications for hyperinsulinemia of obesity
    • Endocrinol. Metab. 36
    • Koyama, K., G. Chen, Y. Le, and R. H. Unger. Tissue triglycerides, insulin resistance, and insulin production: implications for hyperinsulinemia of obesity. Am. J. Physiol. 273 (Endocrinol. Metab. 36): E708-E713, 1997.
    • (1997) Am. J. Physiol. , vol.273
    • Koyama, K.1    Chen, G.2    Le, Y.3    Unger, R.H.4
  • 13
    • 0027947379 scopus 로고
    • Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: Impairment in adipocyte-beta-cell relationships
    • Lee, Y. H., H. Hirose, M. Ohneda, J. H. Johnson, J. D. McGarry, and R. H. Unger. Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc. Natl. Acad. Sci. USA 91: 10878-10882, 1994.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 10878-10882
    • Lee, Y.H.1    Hirose, H.2    Ohneda, M.3    Johnson, J.H.4    McGarry, J.D.5    Unger, R.H.6
  • 15
  • 18
    • 0031043030 scopus 로고    scopus 로고
    • The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis
    • McGarry, J. D., and N. F. Brown. The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. Eur. J. Biochem. 244: 1-14, 1997.
    • (1997) Eur. J. Biochem. , vol.244 , pp. 1-14
    • McGarry, J.D.1    Brown, N.F.2
  • 19
    • 0026499695 scopus 로고
    • Lactate production and pyruvate dehydrogenase activity in fat and skeletal muscle from diabetic rats
    • Mondon, C. E., I. R. Jones, S. Azhar, C. B. Hollenbeck, and G. M. Reaven. Lactate production and pyruvate dehydrogenase activity in fat and skeletal muscle from diabetic rats. Diabetes 41: 1547-1554, 1992.
    • (1992) Diabetes , vol.41 , pp. 1547-1554
    • Mondon, C.E.1    Jones, I.R.2    Azhar, S.3    Hollenbeck, C.B.4    Reaven, G.M.5
  • 21
    • 0021701812 scopus 로고
    • Coomassie brilliant blue staining of lipids on thin-layer plates
    • Nakamura, K., and S. Handa. Coomassie brilliant blue staining of lipids on thin-layer plates. Anal. Biochem. 142: 406-410, 1984.
    • (1984) Anal. Biochem. , vol.142 , pp. 406-410
    • Nakamura, K.1    Handa, S.2
  • 22
    • 0017202148 scopus 로고
    • A stable, radioactive substrate emulsion for assay of lipoprotein lipase
    • Nilsson-Ehle, P., and M. C. Shotz. A stable, radioactive substrate emulsion for assay of lipoprotein lipase. J. Lipid Res. 17: 536-541, 1976.
    • (1976) J. Lipid Res. , vol.17 , pp. 536-541
    • Nilsson-Ehle, P.1    Shotz, M.C.2
  • 23
    • 0030784947 scopus 로고    scopus 로고
    • Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: Parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA
    • Oakes, N. D., K. S. Bell, S. M. Furler, S. Camilleri, A. K. Saha, N. B. Ruderman, D. J. Chisholm, and E. W. Kraegen. Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA. Diabetes 46: 2022-2028, 1997.
    • (1997) Diabetes , vol.46 , pp. 2022-2028
    • Oakes, N.D.1    Bell, K.S.2    Furler, S.M.3    Camilleri, S.4    Saha, A.K.5    Ruderman, N.B.6    Chisholm, D.J.7    Kraegen, E.W.8
  • 24
    • 0030689043 scopus 로고    scopus 로고
    • Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding
    • Oakes, N. D., G. J. Cooney, S. Camilleri, D. J. Chisolm, and E. W. Kraegen. Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding. Diabetes 46: 1768-1774, 1997.
    • (1997) Diabetes , vol.46 , pp. 1768-1774
    • Oakes, N.D.1    Cooney, G.J.2    Camilleri, S.3    Chisolm, D.J.4    Kraegen, E.W.5
  • 26
    • 0029787329 scopus 로고    scopus 로고
    • Intramuscular triglyceride and muscle insulin sensitivity: Evidence for a relationship in nondiabetic subjects
    • Phillips, D. I., S. Caddy, V. Ilic, B. A. Fielding, D. N. Frayn, A. C. Borhtwick, and R. Taylor. Intramuscular triglyceride and muscle insulin sensitivity: evidence for a relationship in nondiabetic subjects. Metabolism 45: 947-950, 1996.
    • (1996) Metabolism , vol.45 , pp. 947-950
    • Phillips, D.I.1    Caddy, S.2    Ilic, V.3    Fielding, B.A.4    Frayn, D.N.5    Borhtwick, A.C.6    Taylor, R.7
  • 27
    • 0030844586 scopus 로고    scopus 로고
    • Postnatal development of the ob gene system: Elevated leptin levels in suckling fa/fa rats
    • Regulatory Integrative Comp. Physiol. 42
    • Rayner, D. V., G. D. Dalgliesh, J. S. Duncan, L. J. Hardie, N. Hoggard, and P. Trayhurn. Postnatal development of the ob gene system: elevated leptin levels in suckling fa/fa rats. Am. J. Physiol. 273 (Regulatory Integrative Comp. Physiol. 42): R446-R450, 1997.
    • (1997) Am. J. Physiol. , vol.273
    • Rayner, D.V.1    Dalgliesh, G.D.2    Duncan, J.S.3    Hardie, L.J.4    Hoggard, N.5    Trayhurn, P.6
  • 28
    • 0027512732 scopus 로고
    • Role of insulin resistance in human disease (Syndrome X): An expanded definition
    • Reaven, G. M. Role of insulin resistance in human disease (Syndrome X): an expanded definition. Annu. Rev. Med. 44: 121-131, 1993.
    • (1993) Annu. Rev. Med. , vol.44 , pp. 121-131
    • Reaven, G.M.1
  • 30
    • 0029995670 scopus 로고    scopus 로고
    • Thiazolidinediones in the treatment of insulin resistance and type II diabetes
    • Saltiel, A. R., and J. M. Olefsky. Thiazolidinediones in the treatment of insulin resistance and type II diabetes. Diabetes 45: 1661-1669, 1996.
    • (1996) Diabetes , vol.45 , pp. 1661-1669
    • Saltiel, A.R.1    Olefsky, J.M.2
  • 31
    • 0032488968 scopus 로고    scopus 로고
    • Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats
    • Shimabukuro, M., Y. T. Zhou, Y. Lee, and R. H. Unger. Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats. J. Biol. Chem. 273: 3547-3550, 1998.
    • (1998) J. Biol. Chem. , vol.273 , pp. 3547-3550
    • Shimabukuro, M.1    Zhou, Y.T.2    Lee, Y.3    Unger, R.H.4
  • 32
    • 0029852840 scopus 로고    scopus 로고
    • Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria
    • Sidossis, L. S., C. A. Stuart, G. I. Shulman, G. D. Lopaschuk, and R. R. Wolfe. Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria. J. Clin. Invest. 98: 2244-2250, 1996.
    • (1996) J. Clin. Invest. , vol.98 , pp. 2244-2250
    • Sidossis, L.S.1    Stuart, C.A.2    Shulman, G.I.3    Lopaschuk, G.D.4    Wolfe, R.R.5
  • 33
    • 0030297919 scopus 로고    scopus 로고
    • Adipogenesis and obesity: Rounding out the big picture
    • Spiegelman, B. M., and J. S. Flier. Adipogenesis and obesity: rounding out the big picture. Cell 87: 377-389, 1996.
    • (1996) Cell , vol.87 , pp. 377-389
    • Spiegelman, B.M.1    Flier, J.S.2
  • 34
    • 0029911348 scopus 로고    scopus 로고
    • Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin and troglitazone
    • Endocrinol. Metab. 34
    • Sreenan, S., J. Sturis, W. Pugh, C. F. Burant, and K. S. Polonsky. Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin and troglitazone. Am. J. Physiol. 271 (Endocrinol. Metab. 34): E742-E747, 1996.
    • (1996) Am. J. Physiol. , vol.271
    • Sreenan, S.1    Sturis, J.2    Pugh, W.3    Burant, C.F.4    Polonsky, K.S.5
  • 35
    • 0026087478 scopus 로고
    • Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid
    • Storlien, L. H., A. B. Jenkins, D. J. Chisholm, W. S. Pascoe, S. Khouri, and E. W. Kraegen. Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid. Diabetes 40: 280-289, 1991.
    • (1991) Diabetes , vol.40 , pp. 280-289
    • Storlien, L.H.1    Jenkins, A.B.2    Chisholm, D.J.3    Pascoe, W.S.4    Khouri, S.5    Kraegen, E.W.6
  • 36
    • 0028840490 scopus 로고
    • Prevention of diabetes does not completely prevent insulin secretory defects in the ZDF rat
    • Endocrinol. Metab. 32
    • Sturis, J., W. L. Pugh, J. Tang, and K. S. Polonsky. Prevention of diabetes does not completely prevent insulin secretory defects in the ZDF rat. Am. J. Physiol. 269 (Endocrinol. Metab. 32): E786-E792, 1995.
    • (1995) Am. J. Physiol. , vol.269
    • Sturis, J.1    Pugh, W.L.2    Tang, J.3    Polonsky, K.S.4
  • 37
    • 0025979358 scopus 로고
    • Multiple defects in muscle glycogen synthase activity contribute to reduced glycogen synthesis in non-insulin dependent diabetes mellitus
    • Thorburn, A. W., B. Gumbiner, F. Bulacan, G. Brechtel, and R. R. Henry. Multiple defects in muscle glycogen synthase activity contribute to reduced glycogen synthesis in non-insulin dependent diabetes mellitus. J. Clin. Invest. 87: 489-495, 1991.
    • (1991) J. Clin. Invest. , vol.87 , pp. 489-495
    • Thorburn, A.W.1    Gumbiner, B.2    Bulacan, F.3    Brechtel, G.4    Henry, R.R.5
  • 38
    • 0029151863 scopus 로고
    • Lipotoxicity in the pathogenesis of obesity-dependent NIDDM
    • Unger, R. G. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Diabetes 44: 863-870, 1995.
    • (1995) Diabetes , vol.44 , pp. 863-870
    • Unger, R.G.1
  • 39
    • 0017717091 scopus 로고
    • Mechanisms of palmityl coenzyme A inhibition of liver glycogen synthase
    • Wititsuwannakul, D., and K. H. Kim. Mechanisms of palmityl coenzyme A inhibition of liver glycogen synthase. J. Biol. Chem. 252: 7812-7817, 1977.
    • (1977) J. Biol. Chem. , vol.252 , pp. 7812-7817
    • Wititsuwannakul, D.1    Kim, K.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.