Multimodality in vivo molecular-genetic imaging

Bioconjugate Chemistry

Volumn 15, Issue 6, 2004, Pages 1376-1388

  Doubrovin, Michael ^a   Serganova, Inna ^a   Mayer Kuckuk, Philipp ^a   Ponomarev, Vladimir ^a   Blasberg, Ronald G ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; COMPUTERIZED TOMOGRAPHY; COST EFFECTIVENESS; FLUORESCENCE IMAGING; MOLECULAR IMAGING; OPTICAL IMAGE STORAGE;

GENETIC STUDIES; IN-VIVO; MOLECULAR GENETICS; MULTI-MODALITY; MULTI-MODALITY IMAGING; OPTICAL-; REPORTER GENE; REPORTER SYSTEMS; SMALL ANIMAL; TOMOGRAPHIC;

MAGNETIC RESONANCE IMAGING;

BIOLUMINESCENCE; CONFERENCE PAPER; FLUORESCENCE; IMAGING; IN VITRO STUDY; LIGHT SCATTERING; MOLECULAR GENETICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OPTICAL INSTRUMENTATION; POSITRON EMISSION TOMOGRAPHY; RAT; REPORTER GENE;

ANIMALIA;

EID: 9244250387     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc0498572     Document Type: Conference Paper

References (97)

1. Jacobs, R. E., and Cherry, S. R. (2001) Complementary emerging techniques: high-resolution PET and MRI. Curr. Opin. Neurobiol. 5, 621-9.
2. Weissleder, R. (2002) Scaling down imaging: molecular mapping of cancer in mice. Nat. Rev. Cancer 1, 11-8.
3. Cherry, S. R. (2004) In vivo molecular and genomic imaging: new challenges for imaging physics. Phys. Med. Biol. 3, R13-48.
4. Jones, T. The imaging science of positron emission tomography. (1996) Eur. J. Nucl. Med. 7, 807-13.
5. Phelps, M. E. (2000) PET: the merging of biology and imaging into molecular imaging. J. Nucl. Med. 4, 661-81.
6. Blasberg, R., and Tjuvajev, J. (1997) In Vivo Monitoring of Gene Therapy by Radiotracer Imaging, in Ernst Shering Research Foundation Workshop 22: Impact of Molecular Biology and New Technical Developments on Diagnostic Imaging, pp 161-189, Berlin-Heidelberg, Springer-Verlag,
7. Gambhir, S. S., Herschman, H. R., Cherry, S. R., Barrio, J. R., Satyamurthy, N., Toyokuni, T., Phelps, M. E., Larson, S. M., Balatoni, J., Finn, R., Sadelain, M., Tjuvajev, J., and Blasberg, R. (2000) Imaging transgene expression with radionuclide imaging technologies. Neoplasia 2, 118-138.
8. Tavitian, B. In vivo antisense imaging. (2000) Q. J. Nucl. Med. 3, 236-55.
9. Ray, P., Bauer, E., Iyer, M., Barrio, J. R., Satyamurthy, N., Phelps, M. E., Herschman, H. R., and Gambhir, S. S. (2001) Monitoring gene therapy with reporter gene imaging. Semin. Nucl. Med. 4, 312-20.
10. Blasberg, R. G., and Gelovani, J. (2002) Molecular-genetic imaging: a nuclear medicine-based perspective. Mol Imaging 3, 280-300.
11. Luker, G. D., Sharma, V., and Piwnica-Worms, D. (2003) Visualizing protein-protein interactions in living animals. Methods 1, 110-22.
12. Weissleder, R., and Ntziachristos, V. (2003) Shedding light onto live molecular targets. Nat. Med. 1, 123-8.
13. Gelovani Tjuvajev, J., and Blasberg, R. G. (2003) In vivo imaging of molecular-genetic targets for cancer therapy. Cancer Cell 4, 327-32.
14. Berger, F., and Gambhir, S. S. (2001) Recent advances in imaging endogenous or transferred gene expression utilizing radionuclide technologies in living subjects: applications to breast cancer. Breast Cancer Res. 1, 28-35.
15. Contag, C. H., and Ross, B. D. (2002) It's not just about anatomy: in vivo bioluminescence imaging as an eyepiece into biology J. Magn. Reson. Imaging 16, 378-87.
16. Gambhir, S. S. (2002) Molecular imaging of cancer with positron emission tomography. Nat Rev Cancer 2, 683-93.
17. Blasberg, R. G., and Tjuvajev, J. G. (2003) Molecular-genetic imaging: current and future perspectives. J. Clin. Invest. 11, 1620-9.
18. Weissleder, R., and Ntziachristos, V. (2003). Shedding light onto live molecular targets. Nat. Med. 9, 123-8.
19. Min, J. J., and Gambhir, S. S. (2004) Gene therapy progress and prospects: noninvasive imaging of gene therapy in living subjects. Gene Ther. 2, 115-25.
20. Shah, K., Jacobs, A., Breakefield, X. O., and Weissleder, R. (2004) Molecular imaging of gene therapy for cancer. Gene Ther. 11 (15), 1175-1187.
21. Jaffer, F. A., Tung, C. H., Gerszten, R. E., and Weissleder, R. (2002) In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probe. Arterioscler Thromb Vasc. Biol. 22, 1929-35.
22. Haubner, R., Wester, H. J., Weber, W. A., Mang, C., Ziegler, S. I., Goodman, S. L., Senekowitsch-Schmidtke, R., Kessler, H., and Schwaiger, M. (2001) Noninvasive imaging of alpha(v)beta3 integrin expression using 18F-labeled RGD-containing glycopeptide and positron emission tomography. Cancer Res. 61, 1781-5.
23. Demetri, G. D., von Mehren, M., Blanke, C. D., Van den Abbeele, A. D., Eisenberg, B., Roberts, P. J., Heinrich, M. C., Tuveson, D. A., Singer, S., Janicek, M., Fletcher, J. A., Silverman, S. G., Silberman, S. L., Capdeville, R., Kiese, B., Peng, B., Dimitrijevic, S., Druker, B. J., Corless, C., Fletcher, C. D. M., and Joensuu, H. (2002) Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal Tumors. N. Engl. J. Med. 347, 472-480.
24. Van den Abbeele A. D., (2001) The GIST Collaborative PET Study Group(Dana-Farber Cancer Institute, Boston, Massachusetts; OHSU, Portland, Oregon, Helsinki University Central Hospital, Turku University Central Hospital, Finland, Novartis Oncology). F18-FDG-PET provides early evidence of biological response to STI571 in patients with malignant gastrointestinal stromal tumors (GIST). Proc. Am. Soc. Clin. Oncol. 20: 362a.
25. Bogdanov, A., and Weissleder, R. (1998) The development of in vivo imaging systems to study gene expression. Trends Biotechnol. 16, 5-10.
26. Weissleder, R., and Mahmood, U. (2001) Molecular imaging. Radiology 219, 316-333.
27. Rudin, M., and Weissleder, R. (2003) Molecular imaging in drug discovery and development. Nat. Rev. Drug Discovery 2, 123-131.
28. Stegman, L. D., Rehemtulla, A., Beattie, B., Kievit, E., Lawrence, T. S., Blasberg, R. G., Tjuvajev, J. G., and Ross, B. D. (1999) Noninvasive quantitation of cytosine deaminase transgene expression in human tumor xenografts with in vivo magnetic resonance spectroscopy. Proc. Natl. Acad. Sci. U. S. A. 96, 9821-9826.
29. Hackman, T., Doubrovin, M., Balatoni, B., Beresten, T., Ponomarev, V., Beattie, B., Finn, R., Bornmann, W., Blasberg, R., and Tjuvajev, J. G. (2002) Imaging expression of cytosine deaminase-herpes virus thymidine kinase fusion gene (CD/TK) expression with [124I)FIAU and PE. Mol. Imaging 1, 36-42.
30. Tjuvajev, J. G., Stockhammer, G., Desai, R., Uehara, H., Watanabe, H., Gansbacher, B., and Blasberg, R. G. (1995) Imaging the expression of transfected genes in vivo. Cancer Res. 55, 6126-6132.
31. Contag, C. H., Spilman, S. D., Contag, P. R., Oshiro, M., Eames, B., Dennery, P., Stevenson D. K., and Benaron, D. A. (1997) Visualizing gene expression in living mammals using a bioluminescent reporter. Photochem. Photobiol. 4, 523-31.
32. Liang, Q., Satyamurthy, N., Barrio, J. R., Toyokuni, T., Phelps, M. P., Gambhir, S. S., and Herschman, H. R. (2001) Noninvasive, quantitative imaging in living animals of a mutant dopamine D2 receptor reporter gene in which ligand binding is uncoupled from signal transduction. Gene Ther. 8, 1490-1498.
33. Rogers, B. E., Zinn K. R., and Buchsbaum, D. J. (2000) Gene transfer strategies for improving radiolabeled peptide imaging and therapy. Q J. Nucl. Med. 3, 208-223.
34. Haberkorn, U. (2001) Gene therapy with sodium/iodide symporter in hepatocarcinoma. Exp. Clin Endocrinol. 1, 60-62.
35. Chishima, T., Miyagi, Y., Wang, X., Yamaoka, H., Shimada, H., Moossa, A. R., and Huffman, R. M. (1997) Cancer invasion and micrometastasis visualized in live tissue by green fluorescent protein expression. Cancer Res. 10, 2042-7.
36. Tjuvajev, J. G., Finn, R., Watanabe, K., Joshi, R., Oku, T., Kennedy, J., Beattie, B., Koutcher, J., Larson, S., and Blasberg, R. G. (1996) Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: A potential method for monitoring clinical gene therapy. Cancer Res. 56, 4087-4095.
37. Tjuvajev, J. G., Avril, N., Oku, T., Sasajima, T., Miyagawa, T., Joshi, R., Safer, M., Beattie, B., DiResta, G., Daghighian, F., Augensen, F., Koutcher, J., Zweit, J., Humm, J., Larson, S. M., Finn, R., and Blasberg, R. (1998) Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography. Cancer Res. 58, 4333-4341.
38. Zhang, L., Adams, J. Y., Billick, E., Ilagan, R., Iyer, M., Le, K., Smallwood, A., Gambhir, S. S., Carey, M., and Wu, L. (2002) Molecular Engineering of a Two-Step Transcription Amplification (TSTA) System for Transgene Delivery in Prostate Cancer. Mol. Ther. 3, 223-32.
39. Green, L. A., Nguyen, K., Bauer, E., Barrio, J. R., Namavari, M., Satyamurthy, N., Tokokuni, T., Phelps, M. E., Sandgren, E. P., Herchmann, H. R., and Gambhir, S. S. (2000) Indirect Monitoring of Endogenous Gene Expression by Imaging PET Reporter Gene Expression in Transgenic Mice. J. Nucl. Med. 5, 81S.
40. Qiao, J., Doubrovin, M., Sauter, M. V., Huang, Y., Guo, Z. S., Balatoni, J., Akhurst, T., Blasberg, R., Gelovani-Tjuvajev, J., Chen S. H., and Woo, S. L. C. (2002) Tumor-Specific Transcriptional Targeting of Suicide Gene Therapy. Gene Ther. 9, 168-175.
41. Ponomarev, V., Doubrovin, M., Lyddane, C., Beresten, T., Balatoni, J., Bornmann, W., Finn, R., Akhurst, T., Larson, S., Blasberg, R., Sadelian, M., and Tjuvajev, J. G. (2001) Imaging TCR-Dependent NFAT-Mediated T-Cell Activation with Positron Emission Tomography In Vivo. Neoplasia 3, 480-488.
42. Doubrovin, M., Ponomarev, V., Beresten, T., Balatoni, J., Bornmann, W., Finn, R., Humm, J., Larson, S., Sadelain, M., Blasberg, R., and Gelovani Tjuvajev, J. (2001) Imaging transcriptional regulation of p53-dependent genes with positron emission tomography in vivo. Proc. Natl. Acad. Sci. U. S. A. 16, 9300-9305.
43. Ray, P., Pimenta, H., Paulmurugan, R., Berger, F., Phelps, M. E., Iyer, M., and Gambhir, S. S. (2002) Noninvasive quantitative imaging of protein-protein interactions in living subjects. Proc. Natl. Acad. Sci. U. S. A. 5, 3105-3110.
44. Luker, G. D., Sharma, V., Pica, C. M., Dahlheimer, J. L., Li, W., Ochesky, J., Ryan, C. E., Piwnica-Worms, H., and Piwnica-Worms, D. (2002) Noninvasive imaging of protein-protein interactions in living animals. Proc. Natl. Acad. Sci. U. S. A. 10, 6961-6.
45. Mayer Kuckuk, P., Banerjee, D., Malhotra, S., Doubrovin, M., Iwamoto, M., Akhurst, T., Balatoni, J., Bornmann, W., Finn, R., Larson, S., Fong, Y., Gelovani Tjuvajev, J., Blasberg, R., and Bertino, J. R. (2002) Cells exposed to antifolates show increased cellular levels of proteins fused to dihydrofolate reductase: a method to modulate gene expression. Proc. Natl. Acad. Sci. U. S. A. 6, 3400-3405.
46. Ponomarev, V., Doubrovin, M., Serganova, I., Beresten, T., Vider, J., Sharvin, A., Ageyeva, L., Balatoni, J., Blasberg, R., and Tjuvajev, J. G. (2003) Cytoplasmically retargeted HSV1-tk/GFP reporter gene mutants for optimization of noninvasive molecular-genetic imaging. Neoplasia 3, 245-54.
47. Pelletier, S. (1988) Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature 334, 320-5.
48. Sachs, A. B., Sarnow, P., and Hentze, M. W. (1997) Starting at the Beginning, Middle, and End: Translation Initiation in Eukaryotes. Cell 89, 831-838.
49. Yaghoubi, S. S., Wu, L., Liang, Q., Toyokuni, T., Barrio, J. R., Namavari, M., Satyamurthy, N., Phelps, M. E., Herschman, H. R., and Gambhir, S. S. (2001) Direct correlation between positron emission tomographic images of two reporter genes delivered by two distinct adenoviral vectors. Gene Ther. 14, 1072-80.
50. Gambhir, S. S., Bauer, E., Black, M. E., Liang, Q., Kokoris, M. S., Barrio, J. R., Iyer, M., Namavari, M., Phelps, M. E., and Herschman, H. R. (2000) A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography. Proc. Natl. Acad. Sci. U. S. A. 97, 2785-2790.
51. Wang, J., Su, C., Neuhard, J., and Eriksson, S. (2000) "Expression of human mitochondrial thymidine kinase in Escherichia coli: correlation between the enzymatic activity of pyrimidine nucleoside analogues and their inhibitory effect on bacterial growth. Biochem Pharmacol. 53, 1583-1588.
52. Tjuvajev, J. G., Doubrovin, M., Akhurst, T., Cai, S., Balatoni, J., Alauddin, M. M., Finn, R., Bornmann, W., Thaler, H., Conti, P. S., and Blasberg, R. G. (2002) Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression. J. Nucl. Med. 43, 1072-1083.
53. Min, J. J., Iyer, M., and Gambhir, S. S. (2003) Comparison of [18F] FHBG and [14C] FIAU for imaging of HSV1-tk reporter gene expression: adenoviral infection vs stable transfection. Eur. J. Nucl. Med. Mol. Imaging 30, 1547-1560.
54. Jacobs, J., Voges, R., Reszka, M., Lercher, A., Gossmann, L., Kracht, C., Kaestle, R., Wagner, K., Wienhard, and Heiss, W. D. (2001) Positron-emission tomography of vector-mediated gene expression in gene therapy for gliomas. Lancet 358, 727-729.
55. 18F]FHBG: a reporter probe for imaging herpes simplex virus type-1 thymidine kinase reporter gene expression. J. Nucl. Med. 42, 1225-1234.
56. Yu, Y. A., Timiryasova, T. Zhang, Q., Beltz, R., and Szalay, A. A. (2003) Optical imaging: bacteria, viruses, and mammalian cells encoding light-emitting proteins reveal the locations of primary tumors and metastases in animals. Anal. Bioanal. Chem. 377, 964-972.
57. Wilson, T., and Hastings, J. W. (1998) Bioluminescence. Annu. Rev. Cell. Dev. Biol. 14, 197-230.
58. Wu, J. C., Inubushi, M., Sundaresan, G., Schelbert, H. R., and Gambhir, S. S. (2002) Optical imaging of cardiac reporter gene expression in living rats. Circulation 105, 1631-1634.
59. Bhaumik, S., and Gambhir, S. (2002) Optical imaging of renilla luciferase reporter gene expression in living mice. Proc. Natl. Acad. Sci. U.S.A. 99, 377-382.
60. Pichler, A., Prior, J. L., and Piwnica-Worms, D. (2004) Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine. Proc. Natl. Acad. Sci. U. S. A. 6, 1702-7.
61. Levy, J. P., Muldoon, R. R., Zolotukhin, S., and Link, C. J., Jr. (1996) Retroviral transfer and expression of a humanized, red-shifted green fluorescent protein gene into human tumor cells. Nat. Biotechnol. 14, 610-614.
62. Lalwani, A. K., Han, J. J., Walsh, B. J., Zolotukhin, S., Muzyczka, N., and Mhatre, A. N. (1997) Green fluorescent protein as a reporter for gene transfer studies in the cochlea. Hear. Res. 114, 139-147.
63. Ellenberg, J., Lippincott Schwartz, J., and Presley, J. F. (1999) Dual-colour imaging with GFP variants. Trends Cell Biol. 9, 52-56.
64. Matz, M., Matz, M. V., Fradkov, A. F., Labas, Y. A., Savitsky, A. P., Zaraisky, A. G., Markelov, M. L., and Lukyanov SA. (1999) Fluorescent proteins from nonbioluminescent Anthozoa species. Nat. Biotechnol. 17, 969-973; Erratum in: Nat. Biotechnol. 17, 1227.
65. Matz, M., Matz, M. V., Fradkov, A. F., Labas, Y. A., Savitsky, A. P., Zaraisky, A. G., Markelov, M. L., and Lukyanov SA. (1999) Fluorescent proteins from nonbioluminescent Anthozoa species. Nat. Biotechnol. 17, 969-973; Erratum in: Nat. Biotechnol. 17, 1227.
66. Falk, M. M., and Lauf, U. (2001) High resolution, fluorescence deconvolution microscopy and tagging with the autofluorescent tracers CFP, GFP, and YFP to study the structural composition of gap junctions in living cells. Microsc. Res. Technol. 52, 251-262.
67. Hadjantonakis, A. K., and Nagy, A. (2001) The color of mice: in the light of GFP-variant reporters. Histochem Cell Biol. 115, 49-58.
68. Labas, Y. A., Gurskaya, N. G., Yanushevich, Y. G., Fradkov, A. F., Lukyanov, K. A., Lukyanov, S. A., and Matz, M. V. (2002) Diversity and evolution of the green fluorescent protein family. Proc. Natl. Acad. Sci. U. S. A. 99, 4256-4261.
69. Campbell, R. E., Tour, O., Palmer, A. E., Steinbach, P. A., Baird, G. S., Zacharias, D. A., and Tsien, R. Y. (2002) A monomeric red fluorescent protein. Proc. Natl. Acad. Sci. U.S.A. 99, 7877-7882.
70. S. Mathieu, S., and El-Battari, A. (2003) "Monitoring E-selectin-mediated adhesion using green and red fluorescent proteins. J. Immunol Methods 272, 81-92.
71. Gurskaya, N. G., Fradkov, A. F., Terskikh, A., Matz, M. V., Labas, Y. A., Martynov, V. I., Yanushevich, Y. G., Lukyanov, K. A., and Lukyanov, S. A. (2001) GFP-like chromoproteins as a source of far-red fluorescent proteins. FEBS Lett. 507, 16-20.
72. Yang, M., Baranov, E., Jiang, P., Sun, F., Li, X. M., Li, L. N., Hasegawa, S., Bouvet, M., Al Tuwaijri, M., Chishima, T., Shimada, H., Moossa, A. R., Penman, S., and Hoffman, R. M. (2000) Whole-body optical imaging of green fluorescent protein expressing tumors and metastases. PNAS 97, 1206-1211.
73. Kolb, V. A., Makeyev, E. V., and Spirin, A. S. (2000) Co-translational folding of an eukaryotic multidomain protein in a prokaryotic translation system. J. Biol. Chem. 275, 16597-601.
74. Thompson, J. F., Hayes, L. S., and Lloyd, D. B. (1991) Modulation of firefly luciferase stability and impact on studies of gene regulation. Gene 103, 171-177.
75. Day, R. N., Kawecki, M., and Berry, D. (1998) Dual function reporter protein for analysis of gene expression in living cells. Biotechnology 25, 852-854.
76. Jacobs, A., Doubrovin, M., Hewett, J., Sena-Esteves, M., Tan, C. W., Slack, M., Sadelain, M., Breakefield, X. O., and Tjuvajev, J. G. (1999) Functional coexpression of HSV-1 thymidine kinase and green fluorescent protein: implications for noninvasive imaging of transgene expression. Neoplasia 1, 154-161.
77. Ray, P., Wu, A. M., and Gambhir, S. S. (2003) Optical bioluminescence and positron emission tomography imaging of a novel fusion reporter gene in tumor xenografts of living mice. Cancer Res. 63, 1160-1165.
78. Ponomarev, V., Doubrovin, M., Serganova, I., Vider, J., Shavrin, A., Beresten, T., Ivanova, A., Ageyeva, L., Tourkova, V., Balatoni, J., Bornmann, W., Blasberg, R., and Gelovani Tjuvajev, J. (2004) A Novel Triple Modality Reporter Gene for Whole Body Fluorescent, Bioluminescent and Nuclear Noninvasive Imaging. Eur. J. Nucl. Med. 5, 740-51.
79. Ray, P., De, A., Min, J. J., Tsien, R. Y., and Gambhir, S. S. (2004) Imaging tri-fusion multimodality reporter gene expression in living subjects. Cancer Res. 64, 1323-30.
80. Luker, G. D., Sharma, V., Pica, C. M., Prior, J. L., Li, W., and Piwnica-Worms, D. (2003) Molecular imaging of protein-protein interactions: controlled expression of p53 and large T-antigen fusion proteins in vivo. Cancer Res. 63, 1780-1788.
81. Luker, G. D., Pica, C. M., Song, J., Luker, K. E., and Piwnica-Worms, D. (2003) Imaging 26S proteasome activity and inhibition in living mice. Nat. Med. 9, 969-973.
82. Laxman, B., Hall, D. E., Bhojani, M. S., Hamstra, D. A., Chenevert, T. L., Ross, B. D., and Rehemtulla, A. (2002) Noninvasive real-time imaging of apoptosis. Proc. Natl. Acad. Sci. U. S. A. 99, 16551-16555.
83. Gambhir, S. S., Barrio, J. R., Phelps, M. E., Iyer, M., Namavari, M., Satyamurthy, N., Wu, L., Green, L. A., Bauer, E., MacLaren, D. C., Nguyen, K., Berk, A. J., Cherry, S. R., and Herschman, H. R. (1999) Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography. Proc. Natl. Acad. Sci. U. S. A. 96, 2333-2338.
84. Tjuvajev, J. G., Chen, S. H., Joshi, A., Joshi, R., Guo, Z. S., Balatoni, J., Ballon, D., Koutcher, J., Finn, R., Woo, S. L., and Blasberg, R. G. (1999) Imaging adenoviral-mediated herpes virus thymidine kinase gene transfer and expression in vivo. Cancer Res. 59, 5186-5193.
85. Tjuvajev, J., Blasberg, R., Luo, X., Zheng, L. M., King, I., and Bermudes D. (2001) Salmonella-based tumor-targeted cancer therapy: tumor amplified protein expression therapy (TAPET) for diagnostic imaging. J. Controlled Release 74, 313-315.
86. Koehne, G., Doubrovin, M., Doubrovina, E., Zanzonico, P., Gallardo, H. F., Ivanova, A., Balatoni, J., Teruya-Feldstein, J., Heller, G., May, C., Ponomarev, V., Ruan, S., Finn, R., Blasberg, R. G., Bornmann, W., Riviere, I., Sadelain, M., O'Reilly, R. J., Larson, S. M., and Tjuvajev, J. G. (2003) Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytes. Nat. Biotechnol. 21, 405-413.
87. Rehemtulla, A., Stegman, L. D., Cardozo, S. J., Gupta, S., Hall, D. E., Contag, C. H., and Ross, B. D. (2000) Rapid and quantitative assessment of cancer treatment response using in vivo bioluminescence imaging. Neoplasia 2, 491-495.
88. Wang, X., Rosol, M., Ge, S., Peterson, D., McNamara, G., Pollack, H., Kohn, D. B., Nelson, M. D., and Crooks, G. M. (2003) Dynamic tracking of human hematopoietic stem cell engraftment using in vivo bioluminescence imaging. Blood 102, 3478-82.
89. Hill, J. M., Dick, A. J., Raman, V. K., Thompson, R. B., Yu, Z. X., Hinds, K. A., Pessanha, B. S., Guttman, M. A., Varney, T. R., Martin, B. J., Dunbar, C. E., McVeigh, E. R., and Lederman, R. J. (2003) Serial cardiac magnetic resonance imaging of injected mesenchymal stem cells. Circulation 108, 1009-1014.
90. Vose, J. M., Bierman, P. J., Anderson, J. R., Harrison, K. A., Dalrymple, G. V., Byar, K., Kessinger, A., and Armitage, J. O. (1996) Single-photon emission computed tomography gallium imaging versus computed tomography: predictive value in patients undergoing high-dose chemotherapy and autologous stem-cell transplantation for non-Hodgkin's lymphoma. J. Clin. Oncol. 14, 2473-2479.
91. Gardner, S. F., Lazarus, H. M., Bednarczyk, E. M., Creger, R. J., Miraldi, F. D., Leisure, G., and Green, J. A. (1993) High-dose cyclophosphamide-induced myocardial damage during BMT: assessment by positron emission tomography. Bone Marrow Transplant 12, 139-144.
92. Olasz, E. B., Lang, L., Seidel, J., Green, M. V., Eckelman, W. C., and Katz, S. I. (2002) Fluorine-18 labeled mouse bone marrow-derived dendritic cells can be detected in vivo by high-resolution projection imaging. J Immunol. Methods 260, 137-48.
93. Cao, Y. A., Wagers, A. J., Beilhack, A., Dusich, J.; Bachmann, M. H., Negrin, R. S., Weissman, I. L., and Contag, C. H. (2004) Shifting foci of hematopoiesis during reconstitution from single stem cells. Proc. Natl. Acad. Sci. U.S.A. 101 (1), 221-226.
94. Wang, X., Rosol, M., Ge, S., Peterson, D., McNamara, G., Pollack, H., Kohn, D. B., Nelson, M. D., and Crooks, G. M. (2003) Dynamic tracking of human hematopoietic stem cell engraftment using in vivo bioluminscence imaging. Blood 102 (10), 3478-3482.
95. Mayer-Kuckuk, P., Doubrovin, M., Budak-Alpdogan, T., Ponomarev, V., Blasberg, R., D. Banerjee, D., and Gelovani Tjuvajev, J. (2003) Noninvasive imaging of the transplanted bone marrow progenitor cells transfected with a triple gene reporter system in fusion with methotrexate resistant DHFR in vivo. (Presented at the 50th Annual Meeting of The Society of Nuclear Medicine, New Orleans, LA, Abstract no. 93) J. Nucl. Med. 44, 29p.
96. Tomita, S., Mickle, D. A., Weisel, R. D., Jia, Z. Q., Tumiati, L. C., Allidina, Y., Liu, P., and Li, R. K. (2002) Improved heart function with myogenesis and angiogenesis following autologous porcine bone marrow stromal cell transplantation. J. Thorac. Cardiovasc. Surg. 123, 1132-1140.
97. Stamm, C., Westphal, B., Kleine, H. D., Petzsch, M., Kittner, C., Klinge, H., Schumichen, C. Nienaber, C. A., Freund, M., and Steinhoff, G. (2003) Autologous bone-marrow stem-cell transplantation for myocardial infarction. Lancet 361, 45-46.