In vivo molecular and genomic imaging: New challenges for imaging physics

Physics in Medicine and Biology

Volumn 49, Issue 3, 2004, Pages

  Cherry, Simon R ^a  

^a University of California Davis   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; GENES; HEALTH CARE; PROTEINS;

BIOLOGICAL PROCESSES; GENOMIC IMAGING; MOLECULAR IMAGING;

MEDICAL IMAGING;

1 [2 (BETA GALACTOPYRANOSYLOXY)PROPYL] 4,7,10 TRIS(CARBOXYMETHYL) 1,4,7,10 TETRAAZACYCLODECANE)GADOLINIUM; 3 (2 FLUOROETHYL)SPIPERONE F 18; 9 (4 FLUORO 3 HYDROXYMETHYLBUTYL)GUANINE; ALEXA FLUOR 700; ALEXA FLUOR 750; CONTRAST MEDIUM; COPPER 64; FIALURIDINE; FLUORESCENT DYE; FLUORINE 18; FURAN DERIVATIVE; GADOLINIUM; GADOLINIUM PENTETATE; GREEN FLUORESCENT PROTEIN; GUANINE DERIVATIVE; HELIUM; INDIUM 111; IODINE 123; IODINE 124; IODINE 125; IODINE 131; LUCIFERIN; MANGANESE; MONOCRYSTALLINE IRON OXIDE NANOPARTICLE; PENCICLOVIR; RADIOISOTOPE; TECHNETIUM 99M; UNCLASSIFIED DRUG; URACIL DERIVATIVE; XENON;

DIAGNOSTIC IMAGING; GENE FUNCTION; GENETIC ANALYSIS; HEALTH; HUMAN; IN VIVO STUDY; MOLECULAR BIOLOGY; NON INVASIVE MEASUREMENT; NUCLEAR MAGNETIC RESONANCE; OPTICAL INSTRUMENTATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RADIOGRAPHY; REVIEW; SENSITIVITY AND SPECIFICITY; SIGNAL DETECTION; SPATIAL DISCRIMINATION; TIME PERCEPTION;

ANIMALS; DIAGNOSTIC IMAGING; GENE EXPRESSION PROFILING; GENETIC MARKERS; GENOMICS; HEALTH PHYSICS; HUMANS; MAGNETIC RESONANCE IMAGING; MICROSCOPY, FLUORESCENCE; MOLECULAR BIOLOGY; NUCLEAR PHYSICS; PROTEOME; TOMOGRAPHY, EMISSION-COMPUTED; TOMOGRAPHY, X-RAY COMPUTED; ULTRASONOGRAPHY;

EID: 1142263259     PISSN: 00319155     EISSN: None     Source Type: Journal    
DOI: 10.1088/0031-9155/49/3/R01     Document Type: Review

References (137)

1. Accorsi R, Gasparini F and Lanza R C 2001 A coded aperture for high-resolution nuclear medicine planar imaging with a conventional anger camera: experimental results IEEE Trans. Nucl. Sci. 48 2411-7
2. Aime S, Cabella C, Colombatto S, Crich S G, Gianolio E and Maggioni F 2002 Insights into the use of paramagnetic Gd(III) complexes in MR-molecular imaging investigations J. Magn. Reson. Imaging 16 394-406
3. Arbeille P, Eder V, Casset D, Quillet L, Hudelo C and Herault S 2000 Real-time 3D ultrasound acquisition and display for cardiac volume and ejection fraction evaluation Ultrasound Med. Biol. 26 201-8
4. Arridge S R 1999 Optical tomography in medical imaging Inverse Probl. 15 R41-93
5. Beck B et al 2002 Progress in high field MRI at the University of Florida Magn. Reson. Mater. Phys. Biol. Med. 13 152-7
6. Beck B L and Blackband S J 2001 Phased array imaging on a 4.7 T/33 cm animal research system Rev. Sci. Instrum. 72 4292-4
7. Beekman F J, McElroy D P, Berger F, Gambhir S S, Hoffman E J and Cherry S R 2002 Towards in vivo nuclear microscopy: iodine-125 imaging in mice using micro-pinholes Eur. J. Nucl. Med. Mol. Imaging 29 933-8
8. Benveniste H and Blackband S 2002 MR microscopy and high resolution small animal MRI: applications in neuroscience research Prog. Neurobiol. 67 393-420
9. Bhattacharjee D and Ito A 2001 Deceleration of carcinogenic potential by adaptation with low dose gamma irradiation In Vivo 15 87-92
10. Blasberg R 2002a Imaging gene expression and endogenous molecular processes: molecular imaging J. Cereb. Blood Flow Metab. 22 1157-64
11. Blasberg R 2002b PET imaging of gene expression Eur. J. Cancer 38 2137-46
12. Boerman O C, Laverman P, Oyen W J G, Corstens F H M and Storm G 2000 Radiolabeled liposomes for scintigraphic imaging Prog. Lipid Res. 39 461-75
13. Bremer C, Ntziachristos V and Weissleder R 2003 Optical-based molecular imaging: contrast agents and potential medical applications Eur. Radiol. 13 231-43
14. Bremer C, Tung C H and Weissleder R 2001 In vivo molecular target assessment of matrix metalloproteinase inhibition Nat. Med. 7 743-8
15. Brown P O and Botstein D 1999 Exploring the new world of the genome with DNA microarrays Nat. Genet. 21 33-7
16. 2 crystals and a photo sensitive wire chamber Nucl. Instrum. Methods A 392 407-13
17. Callaghan P T 1991 Principles of Nuclear Magnetic Resonance Microscopy (Oxford: Clarendon)
18. Campbell R E, Tour O, Palmer A E, Steinbach P A, Baird G S, Zacharias D A and Tsien R Y 2002 A monomeric red fluorescent protein Proc. Natl Acad. Sci. USA 99 7877-82
19. Chan W C W, Maxwell D J, Gao X H, Bailey R E, Han M Y and Nie S M 2002 Luminescent quantum dots for multiplexed biological detection and imaging Curr. Opin. Biotechnol. 13 40-6
20. Chance B 1998 Near-infrared images using continuous, phase-modulated, and pulsed light with quantitation of blood and blood oxygenation Ann. New York Acad. Sci. 838 29-45
21. Charon Y, Laniece P and Tricoire H 1998 Radio-imaging for quantitative autoradiography in biology Nucl. Med. Biol. 25 699-704
22. Cherry S R and Gambhir S S 2001 Use of positron emission tomography in animal research ILAR J 42 219-32
23. Cherry S R et al 1997 MicroPET: A high resolution PET scanner for imaging small animals IEEE Trans. Nucl. Sci. 44 1161-6
24. Cherry S R, Sorenson J A and Phelps M E 2003 Physics in Nuclear Medicine (Philadelphia: Saunders)
25. Contag C H and Bachmann M H 2002 Advances in in vivo bioluminescence imaging of gene expression Annu. Rev. Biomed. Eng. 4 235-60
26. Contag P R, Olomu I N, Stevenson D K and Contag C H 1998 Bioluminescent indicators in living mammals Nat. Med. 4 245-7
27. Correia J A, Burnham C A, Kaufman D and Fischman A J 1999 Development of a small animal PET imaging device with resolution approaching 1 mm IEEE Trans. Nucl. Sci. 46 631-5
28. Dayton P A, Allen J S and Ferrara K W 2002 The magnitude of radiation force on ultrasound contrast agents J. Acoust. Soc. Am. 112 2183-92
29. Dayton P A and Ferrara K W 2002 Targeted imaging using ultrasound J. Magn. Reson. Imaging 16 362-77
30. Del Guerra A, Di Domenico G, Scandola M and Zavattini G 1998 High spatial resolution small animal YAP-PET Nucl. Instrum. Methods A 409 508-10
31. Derenzo S 1979 Precision measurement of annihilation point spread distributions for medically important positron emitters Positron Annihilation ed R R Hasiguti and K Fujiwara (Sendai, Japan: The Japan Institute of Metals) pp 819-23
32. Early P J 1995 Use of diagnostic radionuclides in medicine Health Phys. 69 649-61
33. Feinendegen L E and Pollycove M 2001 Biologic responses to low doses of ionizing radiation: detriment versus hormesis J. Nucl. Med. 42 17N-27N
34. Feldkamp L, Davis L and Kress J 1984 Practical cone beam algorithm J. Opt. Soc. Am. A1 612-9
35. Flannery B P, Deckman H W, Roberge W G and D'Amico K L 1987 Three-dimensional x-ray microtomography Science 237 1439-44
36. Flynn M J, Hames S M, Reimann D A and Wilderman S J 1994 Microfocus x-ray sources for 3D microtomography Nucl. Instrum. Methods Phys. Res. A 353 312-5
37. Foster F S et al 2002 A new ultrasound instrument for in vivo microimaging of mice Ultrasound Med. Biol. 28 1165-72
38. Gambhir S S et al 2000 Imaging transgene expression with radionuclide imaging technologies Neoplasia 2 118-38
39. Garlick P B, Marsden P K, Cave A C, Parkes H G, Slates R, Shao Y, Silverman R W and Cherry S R 1997 PET and NMR dual acquisition (PANDA): applications to isolated, perfused rat hearts NMR Biomed. 10 138-42
40. Garnett E S, Firnau G and Nahmias C 1983 Dopamine visualized in the basal ganglia of living man Nature 305 137-8
41. Gillies R J 2002 In vivo molecular imaging J. Cell. Biochem. 87 231-8
42. Goertzen A L 2003 Development of a combined microPET and microCT system for mouse imaging PhD Dissertation University of California, Los Angeles
43. Goertzen A L, Meadors A K, Silverman R W and Cherry S R 2002 Simultaneous molecular and anatomical imaging of the mouse in vivo Phys. Med. Biol. 47 4315-28
44. Graves E E, Ripoll J, Weissleder R and Ntziachristos V 2003 A submillimeter resolution fluorescence molecular imaging system for small animal imaging Med. Phys. 30 901-11
45. Greer L F and Szalay A A 2002 Imaging of light emission from the expression of luciferases in living cells and organisms: a review Luminescence 17 43-74
46. Hanahan D and Weinberg R A 2000 The hallmarks of cancer Cell 100 57-70
47. Hasegawa B H, Iwata K, Wong K H, Wu M C, Da Silva A J, Tang H R, Barber W C, Hwang A H and Sakdinawat A E 2002 Dual-modality imaging of function and physiology Acad. Radiol. 9 1305-21
48. Hashimoto S, Shirato H, Hosokawa M, Nishioka T, Kuramitsu Y, Matushita K, Kobayashi M and Miyasaka K 1999 The suppression of metastases and the change in host immune response after low-dose total-body irradiation in tumor-bearing rats Radiat. Res. 151 717-24
49. Hedlund L W, Cofer G P, Owen S J and Johnson G A 2000 MR-compatible ventilator for small animals: computer-controlled ventilation for proton and noble gas imaging Magn. Reson. Imaging 18 753-9
50. Herschman H R et al 2000 Seeing is believing: non-invasive, quantitative and repetitive imaging of reporter gene expression in living animals, using positron emission tomography J. Neurosci. Res. 59 699-705
51. Hill D L G, Batchelor P G, Holden M and Hawkes D J 2001 Medical image registration Phys. Med. Biol. 46 R1-45
52. Hogemann D and Basilion J P 2002 Seeing inside the body: MR imaging of gene expression Eur. J. Nucl. Med. Mol. Imaging 29 400-8
53. Huber J S and Moses W W 1999 Conceptual design of a high-sensitivity small animal PET camera with 4 pi coverage IEEE Trans. Nucl. Sci. 46 498-502
54. Idee J M, Nachman I, Port M, Petta M, Le Lem G, Le'Greneur S, Dencausse A, Meyer D and Corot C 2002 Iodinated contrast media: from non-specific to blood-pool agents Contrast Agents II : Optical, Ultrasound, X-Ray and Radiopharmaceutical Imaging ed W Krause (Berlin: Springer) pp 151-71
55. Iwata K, Wu M C and Hasegawa B H 1999 Design of combined X-ray CT and SPECT systems for small animals 1999 IEEE Nuclear Science Symp. Conf. Record vol 3 pp 1608-12
56. Jacobs A, Voges J, Reszka R, Lercher M, Gossmann A, Kracht L, Kaestle C, Wagner R, Wienhard K and Heiss W D 2001 Positron-emission tomography of vector-mediated gene expression in gene therapy for gliomas Lancet 358 727-9
57. Jacobs R E, Ahrens E T, Meade T J and Fraser S E 1999 Looking deeper into vertebrate development Trends Cell Biol. 9 73-6
58. Jacobs R E and Cherry S R 2001 Complementary emerging techniques: high-resolution PET and MRI Curr. Opin. Neurobiol. 11 621-9
59. Jeavons A P, Chandler R A and Dettmar C A R 1999 A 3D HIDAC-PET camera with sub-millimetre resolution for imaging small animals IEEE Trans. Nucl. Sci. 46 468-73
60. Johnson G A, Cofer G P, Fubara B, Gewalt S L, Hedlund L W and Maronpot R R 2002 Magnetic resonance histology for morphologic phenotyping J. Magn. Reson. Imaging 16 423-9
61. Johnson G A and Hedlund L W 1996 Functional imaging of the lung Nat. Med. 2 1192
62. Johnson C A, Seidel J, Carson R E, Gandler W R, Sofer A, Green M V and Daube-Witherspoon M E 1997 Evaluation of 3D reconstruction algorithms for a small animal PET camera IEEE Trans. Nucl. Sci. 44 1303-8
63. Kastis G A et al 2002 Tomographic small-animal imaging using a high-resolution semiconductor camera IEEE Trans. Nucl. Sci. 49 172-5
64. Klimas M T 2002 Positron emission tomography and drug discovery: contributions to the understanding of pharmacokinetics, mechanism of action and disease state characterization Mol. Imag. Biol. 4 311-37
65. Kruse D E and Ferrara K W 2002 A new high resolution color flow system using an eigendecomposition-based adaptive filter for clutter rejection IEEE Trans. Ultrason. Ferroelectr. Freq. Control 49 1739-54
66. Lanza G M and Wickline S A 2001 Targeted ultrasonic contrast agents for molecular imaging and therapy Prog. Cardiovast. Dis. 44 13-31
67. Lecomte R, Cadorette J, Rodrigue S, Lapointe D, Rouleau D, Bentourkia M, Yao R and Msaki P 1996 Initial results from the Sherbrooke avalanche photodiode positron tomograph IEEE Trans. Nucl. Sci. 43 1952-7
68. Leong-Poi H, Christiansen J, Klibanov A L, Kaul S and Lindner J R 2003 Noninvasive assessment of angiogenesis by ultrasound and microbubbles targeted to alpha(v)-integrins Circulation 107 455-60
69. Levin C S and Hoffman E J 1999 Calculation of positron range and its effect on the fundamental limit of positron emission tomography system spatial resolution Phys. Med. Biol. 44 781-99
70. Lindner J R, Song J, Christiansen J, Klibanov A L, Xu F and Ley K 2001 Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to p-selectin Circulation 104 2107-12
71. Liu Z, Kastis G A, Stevenson G D, Barrett H H, Furenlid L R, Kupinski M A, Patton D D and Wilson D W 2002 Quantitative analysis of acute myocardial infarct in rat hearts with ischemia-reperfusion using a high-resolution stationary SPECT system J. Nucl. Med. 43 933-9
72. Louie A Y, Huber M M, Ahrens E T, Rothbacher U, Moats R, Jacobs R E, Fraser S E and Meade T J 2000 In vivo visualization of gene expression using magnetic resonance imaging Nat. Biotechnol. 18 321-5
73. Louie A Y and Meade T J 2000 Recent advances in MRI: novel contrast agents shed light on in vivo biochemistry Trends Biochem. Sci. Dec 2000 7-11
74. Machin K and Webb S 1994 Cone-beam x-ray microtomography of small specimens Phys. Med. Biol. 39 1639-57
75. Maclean D 2002 PET imaging as a tool for post-genomic drug discovery Mol. Imag. Biol. 4 S15
76. Martin D B and Nelson P S 2001 From genomics to proteomics: techniques and applications in cancer research Trends Cell Biol. 11 S60-65
77. Matz M V, Fradkov A F, Labas Y A, Savitsky A P, Zaraisky A G, Markelov M L and Lukyanov S A 1999 Fluorescent proteins from nonbioluminescent anthozoa species Nat. Biotechnol. 17 969-73
78. McElroy D P, MacDonald L R, Beekman F J, Wang Y C, Patt B E, Iwanczyk J S, Tsui B M W and Hoffman E J 2002 Performance evaluation of A-SPECT: a high resolution desktop pinhole SPECT system for imaging small animals IEEE Trans. Nucl. Sci. 49 2139-47
79. Meier D et al 2002 Silicon detector for a compton camera in nuclear medical imaging IEEE Trans. Nucl. Sci. 49 812-6
80. Meikle S R, Kench P, Weisenberger A G, Wojcik R, Smith M F, Majewski S, Eberl S, Fulton R R, Rosenfeld A B and Fulham M J 2002 A prototype coded aperture detector for small animal SPECT IEEE Trans. Nucl. Sci. 49 2167-71
81. Meyer F and Finer M 2001 Gene therapy: progress and challenges Cell. Mol. Biol. 47 1277-94
82. Miyaoka R S, Kohlmyer S G and Lewellen T K 2001 Performance characteristics of micro crystal element (MICE) detectors IEEE Trans. Nucl. Sci. 48 1403-7
83. Moller H E, Chen X J, Chawla M S, Cofer G P, Driehuys B, Hedlund L W, Suddarth S A and Johnson G A 1999 Sensitivity and resolution in 3D NMR microscopy of the lung with hyperpolarized noble gases Magn. Reson. Med. 41 800-8
84. Nagarkar V V, Gupta T K, Miller S R, Klugerman Y, Squillante M R and Entine G 1998 Structured CsI(TI) scintillators for x-ray imaging applications IEEE Trans. Nucl. Sci. 45 492-6
85. Ntziachristos V, Bremer C and Weissleder R 2003 Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging Eur. Radiol. 13 195-208
86. Ntziachristos V and Weissleder R 2001 Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized born approximation Opt. Lett. 26 893-5
87. Ntziachristos V and Weissleder R 2002 Charge-coupled-device based scanner for tomography of fluorescent near-infrared probes in turbid media Med. Phys. 29 803-9
88. Ochoa A V, Ploux L, Mastrippolito R, Charon Y, Laniece P, Pinot L and Valentin L 1997 An original emission tomograph for in vivo brain imaging of small animals IEEE Trans. Nucl. Sci. 44 1533-7
89. Pardridge W M 1998 CNS drug design based on principles of blood-brain barrier transport J. Neurochem. 70 1781-92
90. Paulus M J, Gleason S S, Kennel S J, Hunsicker P R and Johnson D K 2000a High resolution x-ray computed tomography: an emerging tool for small animal cancer research Neoplasia 2 62-70
91. Paulus M J et al 2000b High-resolution X-ray CT screening of mutant mouse models Optical Diagnostics of Living Cells III (San Jose, CA: SPIE) pp 270-9
92. Paulus M J, Sari-Sarraf H, Gleason S S, Bobrek M, Hicks J S, Johnson D K, Behel J K, Thompson L H and Allen W C 1999 A new x-ray computed tomography system for laboratory mouse imaging IEEE Trans. Nucl. Sci. 46 558-64
93. Pautler R G, Silva A C and Koretsky A P 1998 In vivo neuronal tract tracing using manganese-enhanced magnetic resonance imaging Magn. Reson. Med. 40 740-8
94. Phizicky E, Bastiaens P I H, Zhu H, Snyder M and Fields S 2003 Protein analysis on a proteomic scale Nature 422 208-15
95. Qi J, Leahy R M, Cherry S R, Chatziioannou A and Farquhar T H 1998 High-resolution 3D Bayesian image reconstruction using the microPET small-animal scanner Phys. Med. Biol. 43 1001-13
96. Ray P, Wu A M and Gambhir S S 2003 Optical bioluminescence and positron emission tomography imaging of a novel fusion reporter gene in tumor xenografts of living mice Cancer Res. 63 1160-5
97. Reader A J, Ally S, Bakatselos F, Manavaki R, Walledge R J, Jeavons A P, Julyan P J, Zhao S, Hastings D L and Zweit J 2002 One-pass list-mode EM algorithm for high-resolution 3-D PET image reconstruction into large arrays IEEE Trans. Nucl. Sci. 49 693-9
98. Rice B W, Cable M D and Nelson M B 2001 In vivo imaging of light-emitting probes J. Biomed. Opt. 6 432-40
99. Ritman E L 2002 Molecular imaging in small animals - roles for micro-CT J. Cell. Biochem. 87 116-24
100. Seidel J, Vacquero J J and Green M V 2003 Resolution uniformity and sensitivity of the NIH ATLAS small animal PET scanner IEEE Trans. Nucl. Sci. 50 1347-56
101. Sevick-Muraca E M, Houston J P and Gurfinkel M 2002 Fluorescence-enhanced, near infrared diagnostic imaging with contrast agents Curr. Opin. Chem. Biol. 6 642-50
102. Sharma V and Piwnica-Worms D 2002 Molecular imaging of gene expression and protein function in vivo with PET and SPECT J. Magn. Reson. Imaging 16 336-51
103. Shohet R V, Chen S Y, Zhou Y T, Wang Z W, Meidell R S, Unger T H and Grayburn P A 2000 Echocardiographic destruction of albumin microbubbles directs gene delivery to the myocardium Circulation 101 2554-6
104. Slates R B, Farahani K, Shao, Y, Marsden P K, Taylor J, Summers P E, Williams S, Beech J and Cherry S R 1999 A study of artefacts in simultaneous PET and MR imaging using a prototype MR compatible PET scanner Phys. Med. Biol. 44 2015-27
105. Song X, Frey E C and Tsui B M W 2001 Development and evaluation of a MicroCT system for small animal imaging IEEE Nuclear Science Symp. Medical Imaging Conf. Record vol 3 pp 1600-4
106. Stith A, Zagar B G, Fournaris R and Ferrara K 1996 3D ultrasonic mapping of the microvasculature IEEE Ultrason Symp. Proc. 2 1473-6
107. 2 for direct detection active matrix x-ray image sensors J. Appl. Phys. 91 3345-55
108. 13C MR angiography using trueFISP Magn. Reson. Med. 50 256-62
109. Tai Y-C, Chatziioannou A, Siegel S, Young J, Newport D, Goble R N, Nutt R E and Cherry S R 2001 Performance evaluation of the microPET P4: a PET system dedicated to animal imaging Phys. Med. Biol. 46 1845-62
110. Tai Y-C, Chatziioannou A F, Yang Y, Silverman R W, Meadors K, Siegel S, Newport D F, Stickel J R and Cherry S R 2003 MicroPET II: design, development and initial performance of an improved microPET scanner for small-animal imaging Phys. Med. Biol. 48 1519-37
111. Takahashi M, Kojima S, Yamaoka K and Niki E 2000 Prevention of type I diabetes by low-dose gamma irradiation in nod mice Radiat. Res. 154 680-5
112. Tavitian B et al 1998 In vivo imaging of oligonucleotides with positron emission tomography Nat. Med. 4 467-71
113. Townsend D W and Cherry S R 2001 Combining anatomy and function: the path to true image fusion Eur. Radiol. 11 1968-74
114. Tsien R Y 1998 The green fluorescent protein Annu. Rev. Biochem. 67 509-44
115. Tung C H, Mahmood U, Bredow S and Weissleder R 2000 In vivo imaging of proteolytic enzyme activity using a novel molecular reporter Cancer Res. 60 4953-8
116. Turnbull D H 1999 In utero ultrasound backscatter microscopy of early stage mouse embryos Comput. Med. Imaging Graph. 23 25-31
117. Venter J C, Levy S, Stockwell T, Remington K and Halpern A 2003 Massive parallelism, randomness and genomic advances Nat. Gen. 33 219-27
118. Wagner H N et al 1983 Imaging dopamine receptors in the human brain by positron tomography Science 22 1264-6
119. Wang Y, Yu Y A, Shabahang S, Wang G and Szalay A A 2002 Renilla luciferase-aequorea gfp (ruc-gfp) fusion protein, a novel dual reporter for real-time imaging of gene expression in cell cultures and in live animals Mol. Gen. Genomics 268 160-8
120. Weber B L 2002 Cancer genomics Cancer Cell 1 37-47
121. Weber D and Ivanovic M 1999 Ultra-high-resolution imaging of small animals: implications for preclinical and research studies J. Nucl. Cardiol. 6 332-44
122. Weber S et al 1999 Evaluation of the TierPET system IEEE Trans. Nucl. Sci. 46 1177-83
123. Weisenberger A G, Kross B, Majewski S, Wojick R, Bradley E L and Saba M S 1998 Design features and performance of a CsI(Na) array based gamma camera for small animal gene research IEEE Trans. Nucl. Sci. 45 3053-8
124. Weissleder R 2002 Scaling down imaging: molecular mapping of cancer in mice Nat. Rev. Cancer 2 11-8
125. Weissleder R and Mahmood U 2001 Molecular imaging Radiology 219 316-33
126. Weissleder R, Moore A, Mahmood U, Bhorade R, Benveniste H, Chiocca E A and Basilion J P 2000 In vivo magnetic resonance imaging of transgene expression Nat. Med. 6 351-5
127. Weissleder R, Tung C H, Mahmood U and Bogdanov A 1999 In vivo imaging of tumors with protease-activated near-infrared fluorescent probes Nat. Biotechnol. 17 375-8
128. Welch M J and Redvanly C S (eds) 2002 Handbook of Radiopharmaceuticals (New York: Wiley)
129. Williams M B et al 2000 Integrated CT-SPECT system for small-animal imaging Penetrating Radiation Systems and Applications II (San Diego, CA: SPIE) pp 265-74
130. Yang M, Baranov E, Moossa A R, Penman S and Hoffman R M 2000 Visualizing gene expression by whole-body fluorescence imaging Proc. Natl Acad. Sci. USA 97 12278-82
131. Yarmush M L and Jayaraman A 2002 Advances in proteomic technologies Annu. Rev. Biomed. Eng. 4 349-73
132. Younes C K, Boisgard R and Tavitian B 2002 Labelled oligonucleotides as radiopharmaceuticals: pitfalls, problems and perspectives Curr. Pharma. Design 8 1451-66
133. Yuhas J M 1974 Recovery from radiation-carcinogenic injury to the mouse ovary Radiat. Res. 60 321-32
134. Zavattini G, Vecchi S, Leahy R M, Smith D J and Cherry S R 2003 A hyperspectral fluorescence imaging system for biological applications Conference Record of the 2003 IEEE Medical Imaging Conference (Portland, OR)
135. Zhang J, Campbell R E, Ting A Y and Tsien R Y 2002a Creating new fluorescent probes for cell biology Nat. Rev. Mol. Cell Biol. 3 906-18
136. Zhang L Q, Adams J Y, Billick E, Ilagan R, Iyer M, Le K, Smallwood A, Gambhir S S, Carey M and Wu L L 2002b Molecular engineering of a two-step transcription amplification (TSTA) system for transgene delivery in prostate cancer Mol. Ther. J. Am. Soc. Gene Ther. 5 223-32
137. Ziegler S I, Pichler B J, Boening G, Rafecas M, Pimpl W, Lorenz E, Schmitz N and Schwaiger M 2001 A prototype high-resolution animal positron tomograph with avalanche photodiode arrays and LSO crystals Eur. J. Nucl. Med. 28 136-43