Optical imaging of cardiac reporter gene expression in living rats

Circulation

Volumn 105, Issue 14, 2002, Pages 1631-1634

  Wu, Joseph C ^a   Inubushi, Masayuki ^a   Sundaresan, Gobalakrishnan ^a   Schelbert, Heinrich R ^a   Gambhir, Sanjiv S ^a  

^a NONE   (United States)

Author keywords

Gene therapy; Heart diseases; Maging; Pharmacokinetics; Viruses

Indexed keywords

LUCIFERASE; LUCIFERIN;

ACCURACY; ADENOVIRUS; ANIMAL EXPERIMENT; ARTICLE; CAMERA; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; HISTOPATHOLOGY; IMAGE ANALYSIS; IMAGING; NONHUMAN; OPTICAL IMAGING; PRIORITY JOURNAL; RAT; REPORTER GENE;

ADENOVIRIDAE; ANIMALS; DIAGNOSTIC IMAGING; DRUG ADMINISTRATION ROUTES; FEASIBILITY STUDIES; FIREFLY LUCIFERIN; GENE EXPRESSION; GENES, REPORTER; GENETIC VECTORS; IMAGE PROCESSING, COMPUTER-ASSISTED; LUCIFERASES; LUMINESCENT MEASUREMENTS; MYOCARDIUM; OPTICS; RATS; RATS, SPRAGUE-DAWLEY; REGRESSION ANALYSIS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TRANSDUCTION, GENETIC;

EID: 0037046190     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000014984.95520.AD     Document Type: Article

References (10)

1. Direct gene transfer into mouse muscle in vivo
2. Efficient gene transfer into myocardium by direct injection of adenovirus vectors
3. The route of administration is a major determinant of the transduction efficiency of rat tissues by adenoviral recombinants
4. Monitoring gene therapy with reporter gene expression
5. Noninvasive optical imaging of firefly luciferase reporter gene expression in skeletal muscles of living mice
6. A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography
7. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses
8. Analysis of tissue-specific gene delivery by recombinant adenoviruses containing cardiac-specific promoters
9. Use of positron emission tomography in animal research
10. Quantification of target gene expression by imaging reporter gene expression in living animals