Imaging transgene expression with radionuclide imaging technologies

Neoplasia

Volumn 2, Issue 1-2, 2000, Pages 118-138

  Gambhir, S S ^a   Herschman, H R ^a   Cherry, S R ^a   Barrio, J R ^a   Satyamurthy, N ^a   Toyokuni, T ^a   Phelps, M E ^a   Larson, S M ^b   Balatoni, J ^b   Finn, R ^b   Sadelain, M ^b   Tjuvajev, J ^b   Blasberg, R ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Dopamine 2 receptor; Gene expression; Herpes simplex virus; Imaging; Marker gene; MicroPET; PET; Reporter gene; SPECT; Thymidine kinase

Indexed keywords

ACICLOVIR; DOPAMINE 2 RECEPTOR; FIALURIDINE; GANCICLOVIR; IDOXURIDINE; PENCICLOVIR; RADIOISOTOPE; THYMIDINE KINASE;

CLINICAL TRIAL; GENE EXPRESSION; GENE THERAPY; HERPES SIMPLEX VIRUS 1; HUMAN; IMAGING; LIVER TOXICITY; MARKER GENE; NEUROTOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REPORTER GENE; REVIEW; SCINTISCANNING; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TRANSGENE; WHOLE BODY AUTORADIOGRAPHY;

EID: 0034048929     PISSN: 15228002     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.neo.7900083     Document Type: Review

References (78)

1. Culver KW, and Blaese RM (1994). Gene therapy for cancer. Trends Genet 10, 174-178.
2. Jolly D (1994). Viral vector systems for gene delivery. Cancer Gene Ther 1, 51-64.
3. List CP (1995). Cancer Gene Ther 2, 225.
4. Moolten FL (1986). Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for prospective cancer control strategy. Cancer Res 46, 5276-5281.
5. Tjuvajev JG, Stockhammer G, Desai R, Uehara H, Watanabe H, Gansbacher B, and Blasberg RG (1995). Imaging the expression of transfected genes in vivo. Cancer Res 55, 6126-6132.
6. Gambhir SS, Barrio JR, Herschman HR, and Phelps ME (1999). Assays for noninvasive imaging of reporter gene expression. Nucl Med Biol 26, 481-490.
7. Contag PR, Olomu IN, Stevenson DK, and Contag CH (1998). Bioluminescent indicators in living mammals. Nat Med 4, 245-247.
8. Bogdanov A, and Weissleder R (1998). The development of in vivo imaging systems to study gene expression. Trends Biotechnol 16, 5-10.
9. Huang SC, and Phelps ME (1986). In Positron Emission Tomography and Autoradiography, Principles and Applications for the Brain and Heart (Chapter 7). Raven Press, New York.
10. Weber DA, and Ivanovic M (1999). Ultra-high-resolution imaging of small animals: implications for preclinical and research studies. J Nucl Cardiol 6, 332-344.
11. Lear JL (1986). In Principles of Single and Multiple Radionuclide Autoradiography. Raven Press, New York.
12. Gambhir SS, Barrio JR, Phelps ME, Iyer M, Namavari M, Satyamurthy N, Wu L, Green LA, Bauer E, MacLaren DC, Nguyen K, Berk AJ, Cherry SR, and Herschman HR (1999). Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography. Proc Natl Acad Sci USA 96, 2333-2338.
13. Kastis GK, Barber HB, Barrett HH, Gifford HC, Pang IW, Patton DD, Sain JD, Stevenson G, and Wilson DW (1998). High resolution SPECT imager for three-dimensional imaging of small animals (abstract) J Nucl Med 39, 9 pp.
14. Weber DA, and Ivanovic M (1995). Pinhole SPECT: ultra-high resolution imaging for small animal studies. J Nucl Med 36, 2287-2289.
15. Bloomfield PM, Rajeswaran S, Spinks TJ, Hume SP, Myers R, Ashworth S, Clifford KM, Jones WF, Byars LG, Young J, Andreaco M, Williams CW, Lammertsma AA, and Jones T (1995). The design and physical characteristics of a small animal positron emission tomograph. Phys Med Biol 40, 1105-1126.
16. Fricker RA, Torres EM, Hume SP, Myers R, Opacka-Juffrey J, Ashworth S, Brooks DJ, and Dunnett SB (1997). The effects of donor stage on the survival and function of embryonic striatal grafts in the adult rat brain: II. Correlation between positron emission tomography and reaching behaviour. Neuroscience 79, 711-721.
17. Hume SP, Lammertsma AA, Myers R, Rajeswaran S, Bloomfield PM, Ashworth S, Fricker RA, Torres EM, Watson I, and Jones T (1996). The potential of high-resolution positron emission tomography to monitor striatal dopaminergic function in rat models of disease. J Neurosci Methods 67, 103-112.
18. Cherry SR, Shao Y, Silverman RW, Meadors K, Siegel S, Chatziioannou A, Young JW, Jones WF, Moyers JC, Newport D, Boutefnouchet A, Farquhar TH, Andreaco M, Paulus MJ, Binkley DM, Nutt R, and Phelps ME (1997). MicroPET: a high resolution PET scanner for imaging small animals. IEEE Trans Nucl Sci 44, 1161-1166.
19. Jeavons AP, Chandler RA, and Dettmmar CAR (1999). A3D HIDAC-PET camera with sub-millimetre resolution for imaging small animals. IEEE Trans Nucl Sci 46, 468-473.
20. Marriott CJ, Cadorette JE, Lecomete R, Scasnar V, Rousseau J, and van Lier JE (1994). High-resolution PET imaging and quantitation of pharmaceutical biodistributions in a small animal using avalance photodiode detectors. J Nucl Med 35, 1390-1396.
21. Weber S, Terstegge A, Herzon H, Reinartz R, Reinhart P, Rongen F, Muller-Gartner HW, and Halling H (1997). The design of an animal PET: flexible geometry for achieving optimal spatial resolution or high sensitivity. IEEE Trans Med Imaging 16, 684-689.
22. Fries O, Bradbury SM, Gebauer J, Holl I, Lorenz E, Renker D, and Ziegler SI (1997). A small animal PET prototype based on LSO crystals read out by avalanche photodiodes. Nucl Instrum Methods A387, 220-224.
23. Chatziioannou AF, Cherry SR, Shao Y, Silverman RW, Meadors K, Farquhar TH, Pedarsani M, and Phelps ME (1999). Performance evaluation of microPET: a high resolution LSO PET scanner for animal imaging. J Nucl Med 40, 1164-1175.
24. Kinahan PE, and Rogers JG (1989). Analytic 3D image reconstruction using all detected events. IEEE Trans Nucl Sci 36, 964-968.
25. Qi J, Leahy RM, Cherry SR, Chatziioannou A, and Farquhar TH (1998). High-resolution 3D Bayesian image reconstruction using the microPET small-animal scanner. Phys Med Biol 43, 1001-1013.
26. Borrelli E, Heyman R, Hsi M, and Evans RM (1988). Targeting of an inducible toxic phenotype in animal cells. Proc Natl Acad Sci USA 85, 7572-7576.
27. Moolten FL, and Wells JM (1990). Curability of tumors bearing herpes thymidine kinase genes transfected by retroviral vectors. J Natl Cancer Inst 82, 297-300.
28. Culver KW, Ram Z, Walbridge S, Ishii H, Oldfield EH, and Blaise RM (1992). In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 256, 1550-1552.
29. Moolten FL (1997). Suicide genes for cancer therapy. Sci Med 4, 16-25.
30. Iwashina T, Tovell DR, Xu LI, Tyrrell DL, Knaus EE, and Wiebe LI (1988). Synthesis and antiviral activity of IVFRU, a potential probe for non-invasive diagnosis of herpes simplex encephalitis. Drug Res Delivery 3, 309-321.
31. Saito Y, Price RW, Rottenberg DA, Fox JJ, Su T-L, Watanabe KA, and Philips FA (1982). Quantitative autoradiographic mapping of herpes simplex virus encephalitis with radiolabeled antiviral drug. Science 217, 1151-1153.
32. Saito Y, Rubenstein R, Price R, Fox JJ, and Watanabe KA (1984). Diagnostic imaging of herpes simplex virus encephalitis using antiviral drug: autoradiographic assessment in animal model. Ann Neurol 15, 548-558.
33. Price R, Cardle K, and Watanabe K (1983). The use of antiviral drugs to image herpes encephalitis. Cancer Res 43, 3619-3627.
34. 131-I-labeled 5-iodo-2′-fluoro-2′-deoxy-1-β-D-arabino-furanosyl-uracil in herpes infected cells. J Med Virol 22, 183-188.
35. Blasberg RG, Gazendam J, Patlak CS, and Fenstenmacher JD (1980). Quantitative Autoradiographic Studies of Brain Edema and a Comparison of Multi-Isotope Autoradiographic Techniques. Raven Press, New York. pp. 255-270.
36. Blasberg RG, Groothius D, and Molnar P (1981). Application of quantitative autoradiographic measurements in experimental brain tumor models. Semin Neurol 1, 203-223.
37. Tjuvajev JG, Finn R, Watanabe K, Joshi R, Oku T, Kennedy J, Beattie B, Koutcher J, Larson S, and Blasberg RG (1996). Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy. Cancer Res 56, 4087-4095.
38. Tjuvajev JG, Avril N, Oku T, Sasajima T, Miyagawa T, Joshi R, Safer M, Beattie B, DiResta G, Daghighian F, Augensen F, Koutcher J, Zweit J, Humm J, Larson SM, Finn R, and Blasberg R (1998). Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography. Cancer Res 58, 4333-4341.
39. Patlak CS, and Blasberg RG (1985). Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Generalizations. J Cereb Blood Flow Metab 5, 584-590.
40. Patlak CS, Blasberg RG, and Fenstermacher JD (1983). Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 3, 1-7.
41. McKenzie R, Fried MW, Sallie R, Conjeevaram H, Di Bisceglie AM, Park Y, Savarese B, Kleiner D, Tsokos M, Luciano C, Pruett T, Stotka JL, Straus SE, and Hoofnagle JH (1995). Hepatic failure and lactic acidosis due to fialuridine (FIAU), and investigational nucleoside analogue for chronic hepatitis B. N Engl J Med 333, 1099-1105.
42. 82Br labelled 5-halo-1-(2-deoxy-2-fluoro-b-D-arabinofuranosyl) uracils. Appl Radiat Isot 37, 901-905.
43. Balatoni JA, Finn RD, Tjuvajev JG, Larson SM, and Blasberg RG (1997). Synthesis and quality assurance of radioiodinated 2′-fluoro-2′-deoxy-1-b-D-arabinofuranosyl-5-[*1]iodo-uracil. J Labelled Compd Radiopharm 40, 103.
44. Manning FJ, and Swartz M (1995). Review of Fialurdine (FIAU) Clinical Trials. Institute of Medicine, Washington, DC.
45. Blasberg R, and Tjuvajev J (1997). In Vivo Monitoring of Gene Therapy by Radiotracer Imaging. In Ernst Shering Research Foundation Workshop 22: impact of molecular biology and new technical developments on diagnostic imaging. Springer Verlag, Berlin-Heidelberg. pp. 161-189.
46. Gambhir SS, Barrio J, Wu L, Iyer M, Namavari M, Satyamurthy N, Bauer E, Parrish C, MacLaren D, Borghei A, Berk A, Cherry S, Phelps ME, and Herschman H (1998). Imaging of adenoviral directed herpes simplex virus type 1 thymidine kinase gene expression in mice with ganciclovir. J Nucl Med 39, 2003-2011.
47. Srinivasan A, Gambhir SS, Green LA, Cherry SR, Sharfstein S, Barrio JR, Satyamurthy N, Namavari M, Wu L, Berk AJ, Phelps ME, and Herschman H (1996). A PET reporter gene (PRG)/PET reporter probe (PRP) technology for repeatedly imaging gene expression in living animals. J Nucl Med 37, 107 p.
48. Barrio JB, Namavari M, Phelps ME, and Satyamurthy N (1996). Regioselective fluorination of substituted guanines with dilute F2: a facile entry of 8-fluoroguanine derivatives. J Org Chem 61, 6084-6085.
49. 18F] fluoroguanine derivatives: in-vivo probes imaging gene expression with PET. Nucl Med Biol.
50. Gambhir SS, Barrio JR, Bauer E, Iyer M, Namavari M, Satyamurthy N, Shah P, Toyokuni T, Wu L, Berk AJ, Phelps ME, and Herschman H (1998). Radiolabeled penciclovir: a new reporter probe with improved imaging properties over ganciclovir for imaging herpes-simplex virus type 1 thymidine kinase reporter gene expression (abstract). J Nucl Med 39, 53 p.
51. Boyd MR, Safrin S, and Kern ER (1993). Penciclovir: a review of its spectrum of activity, selectivity, and cross-resistance pattern. Antiviral Chem Chemother 4, 3-11.
52. 18F]Fluoro-1-hydroxy-2-propoxy)methyl)guanine. Bioorg Med Chem Lett 7, 1879-1882.
53. 18F]FHPG): a potential imaging agent of viral infection and gene therapy using PET. Nucl Med Biol 23, 787-792.
54. 18F]FHBG): a new potential imaging agent for viral infection and gene therapy using PET. Nucl Med Biol 25, 175-180.
55. Bading JR, Alauddin MM, Fissekis JD, Kirkman E, Raman RK, and Conti PS (1997). Pharmacokinetics of F-18 fluorohydroxy-propoxymethylguanina (FHPG). J Nucl Med 38, 43 p.
56. Green LA, Gambhir SS, Barrio JR, Bauer E, Nguyen K, Namavari M, Cherry SR, Herschman H, and Phelps ME (1998). Tracer kinetic modeling of 8-(F18)-fluoroganciclovir PET data: a new tracer for measuring reporter gene expression. J Nucl Med 39 (suppl), 10 p.
57. Gambhir SS, Bauer E, Black M, Liang Q, Kokoris MS, Barrio JR, Iyer M, Namavari M, Satyamurthy N, Green LA, Nguyen K, Cherry SR, Phelps ME, and Herschman HR (in press). A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography. Proc Natl Acad Sci USA.
58. Black ME, Newcomb TG, Wilson H-MP, and Loeb LA (1996). Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutant for gene therapy. Proc Natl Acad Sci USA 93, 3525-3529.
59. 18F]fluoroethyl)spiperone: in vivo biochemical and kinetic characterization in rodents, nonhuman primates, and humans. J Cereb Blood Flow Metab 9, 830-839.
60. 18F]fluoroethyl)spiperone, a potent dopamine antagonist: synthesis, structural analysis and in vivo utilization in human. Appl Radiat Isot 41, 113-129.
61. MacLaren DC, Gambhir SS, Satyamurthy N, Barrio JR, Sharfstein S, Toyokuni T, Wu L, Berk AJ, Cherry SR, Phelps ME, and Herschman HR (1999). Repetitive, non-invasive imaging of the dopamine D2 receptor as a reporter gene in living animals. Gene Ther 6, 785-791.
62. Neve KA, Cox BA, Henningsen RA, Spanoyannis A, and Neve RL (1991). Pivotal role for aspartate-80 in the regulation of dopamine D2 receptor affinity for drugs and inhibition of adenylyl cyclase. Mol Pharmacol 39, 733-739.
63. Cox BA, Henningsen RA, Spanoyannis A, Neve RL, and Neve KA (1992). Contributions of conserved serine residues to the interactions of ligands with dopamine D2 receptors. J Neurochem 59, 627-635.
64. Woodward R, Roley C, Daniell S, Naylor LH, and Strange PG (1996). Investigation of the role of conserved serine residues in the long form of the rat D2 dopamine receptor using site-directed mutagenesis. J Neurochem 66, 394-402.
65. Gambhir SS, MacLaren DC, Barrio JR, Toyokuni T, Satyamurthy N, Nguyen K, Berk A, Wu L, Cherry SR, Phelps ME, and Herschman HR (1999). Noninvasive and Repeated Imaging of Reporter Gene Expression in Living Mice Utilizing Positron Emission Tomography. American Society of Gene Therapy, Washington, DC.
66. Herschman HR, MacLaren DC, Satyamurthy N, Barrio JR, Sharfstein S, Green LA, Iyer M, Namavari M, Toyokuni T, Wu L, Berk AJ, Cherry SR, Phelps ME, Sandgren EP, and Gambhir SS (in press). Seeing is believing: non-invasive, quantitative and repetitive imaging of reporter gene expression in living animals, using positron emission tomography. J Neurosci Res.
67. Braun RE, Lo D, Pinkert CA, Widera G, Flavell RA, Palmiter RD, and Brinster RL (1990). Infertility in male transgenic mice: disruption of sperm development by HSV-tk expression in postmeiotic germ cells. Biol Reprod 43, 684-693.
68. Gambhir SS, Barrio JR, Herschman HR, and Phelps ME (1999). Imaging gene expression: principles and assays. J Nucl Cardiol 6, 219-233.
69. Tjuvajev JG, Joshi R, Lindsley L, Balatoni J, Finn R, Larson S, Sadelain M, and Blasberg R (1998). Noninvasive imaging of HSV1-tk marker gene with FIAU for monitoring transfer and expression of other therapeutic genes by multi-gene delivery vectors. J Nucl Med 39, 130 p.
70. Tjuvajev JG, Chen SH, Joshi A, Joshi R, Guo ZS, Balatoni J, Ballon D, Koutcher J, Finn R, Woo SL, and Blasberg RG (1999). Imaging adenoviral-mediated herpes virus thymidine kinase gene transfer expression in vivo. Cancer Res 59, 5186-5193.
71. Tjuvajev J, Joshi A, Callegari J, Lindsley L, Joshi R, Balatoni J, Finn R, Larson S, Sadelain M, and Blasberg R (1999). A general approach to the non-invasive imaging of transgenes using cis-linked herpes simplex virus thymidine kinase. Neoplasia 1, 315-320.
72. Yu Y, Annala AJ, Barrio JR, Toyokuni T, Satyamurthy N, Namavari M, Cherry SR, Phelps ME, Herschman HR, and Gambhir SS (in press). Quantitation of target gene expression by imaging reporter gene expression in living animals. Nat Med.
73. Pelletier S (1988). Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature 334, 320.
74. Jackson RJ, and Kaminski A (1995). Internal initiation of translation in eukaryotes: the picomovirus paradigm and beyond. RNA 1985.
75. Sachs AB, Sarnow P, and Hentze MW (1997). Starting at the beginning, middle, and end: translation initiation in eukaryotes. Cell 89, 831-838.
76. Ghattas SAM (1991). The encephalomyocarditis virus internal ribosomal entry site allows efficient coexpression of two genes from a recombinant provirus in cultured cells and in embryos. Mol Cell Biol 11, 5848.
77. Tjuvajev JG, Gallardo H, Joshi A, Joshi R, Blasberg R, and Sadelain M (1997). Bi-cistronic co-expression of a cell surface marker gene and the HSV1-tk gene in jurkat cells: implications for noninvasive imaging in vivo. Cancer Gene Ther 4, S44.
78. Tjuvajev JG, Avril N, Lindsley L, Safer M, Joshi R, Beattie B, Larson S, Sadelain M, and Blasberg R (1997). Monitoring the expression of therapeutic genes by noninvasive imaging of the HSV1-tk marker gene using double-gene vector constructs. Cancer Gene Ther 4, S43-S44.