Noninvasive, quantitative imaging in living animals of a mutant dopamine D2 receptor reporter gene in which ligand binding is uncoupled from signal transduction

Gene Therapy

Volumn 8, Issue 19, 2001, Pages 1490-1498

  Liang, Q ^a   Satyamurthy, N ^a   Barrio, J R ^a   Toyokuni, T ^a   Phelps, M P ^a   Gambhir, S S ^a   Herschman, H R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Dopamine receptor; Positron emission tomography; Reporter gene

Indexed keywords

3 (2 FLUOROETHYL)SPIPERONE; ASPARTIC ACID DERIVATIVE; CYCLIC AMP; DOPAMINE; DOPAMINE 2 RECEPTOR; FORSKOLIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; MUTANT PROTEIN; SERINE DERIVATIVE; SPIPERONE DERIVATIVE; TRITIUM;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CELL CULTURE; CONTROLLED STUDY; CYCLIC AMP BLOOD LEVEL; DRUG ACTIVITY; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; GENE EXPRESSION; GENE MUTATION; GENE TARGETING; GENETIC TRANSFECTION; IMAGING SYSTEM; IN VIVO STUDY; LIGAND BINDING; MALE; MODULATION; MOUSE; NONHUMAN; PLASMID; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RAT; RECEPTOR BINDING; REPORTER GENE; REPRODUCIBILITY; SIGNAL TRANSDUCTION; TUMOR CELL; TUMOR XENOGRAFT; VIRUS REPLICATION;

ADENOVIRIDAE; ANIMALS; CELL LINE; CYCLIC AMP; DOPAMINE; FORSKOLIN; GENES, REPORTER; GENETIC VECTORS; INJECTIONS, INTRAVENOUS; LIVER; MICE; POINT MUTATION; PROTEIN BINDING; RATS; RECEPTORS, DOPAMINE D2; SIGNAL TRANSDUCTION; SPIPERONE; TOMOGRAPHY, EMISSION-COMPUTED; TUMOR CELLS, CULTURED;

ADENOVIRIDAE; ANIMALIA; TRITIUM;

EID: 0034772465     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301542     Document Type: Article

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