Cytoplasmically retargeted HSV1-tk/GFP reporter gene mutants for optimization of noninvasive molecular-genetic imaging

Neoplasia

Volumn 5, Issue 3, 2003, Pages 245-254

  Ponomarev, Vladimir ^a   Doubrovin, Michael ^a   Serganova, Inna ^a   Beresten, Tatiana ^a   Vider, Jelena ^a   Shavrin, Aleksander ^a   Ageyeva, Ludmila ^a   Balatoni, Julius ^a   Blasberg, Ronald ^a   Gelovani Tjuvajev, Juri ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

FIAU; Green fluorescent protein; Herpes virus type one thymidine kinase; Molecular imaging; PET

Indexed keywords

FIALURIDINE; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; IODINE 131; RETROVIRUS VECTOR; THYMIDINE KINASE;

ARTICLE; BIOAVAILABILITY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE MUTATION; GENE TARGETING; HERPES SIMPLEX VIRUS 1; IMAGING; ISOTOPE LABELING; MOLECULAR GENETICS; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; REPORTER GENE; SCINTILLATION CAMERA; XENOGRAFT;

EID: 10744233241     PISSN: 15228002     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1476-5586(03)80056-8     Document Type: Article

References (49)

1. Bengel FM, Anton M, Avril N, Brill T, Nguyen N, Haubner R, Gleiter E, Gansbacher B, and Schwaiger M (2000). Uptake of radiolabeled 2′-fluoro-2′-deoxy-5-iodo-1-beta-D-arabinofuranosyluracil in cardiac cells after adenoviral transfer of the herpesvirus thymidine kinase gene: the cellular basis for cardiac gene imaging, Circulation 102, 948-50.
2. Bhaumik S, and Gambhir SS (2002). Optical imaging of Renilla luciferase reporter gene expression in living mice. Proc Natl Acad Sci USA 99, 377-82.
3. Black ME, Kokoris MS, and Sabo P (2001). Herpes simplex virus-1 thymidine kinase mutants created by semi-random sequence mutagenesis improve prodrug-mediated tumor cell killing. Cancer Res 61, 3022-26.
4. Black ME, Rechtin TM, and Drake RR (1996). Effect on substrate binding of an alteration at the conserved aspartic acid-162 in herpes simplex virus type 1 thymidine kinase, J Gen Virol 77 (Pt 7), 1521-27.
5. Brown DG, Visse R, Sandhu G, Davies A, Rizkallah P, Melitz C, Summers W, and Sanderson MR (1995). Crystal structures of the thymidine kinase from herpes simplex virus type-1 in complex with deoxythymidine and ganciclovir. Nat Struct Biol 2, 876-81.
6. 124/125I]FIAU for imaging herpes simplex virus type 1 thymidine kinase gene expression. Eur J Nucl Med 28, 721-29.
7. Campbell RE, Tour O, Palmer AE, Steinbach PA, Baird GS, Zacharias DA, and Tsien RY (2002). A monomeric red fluorescent protein. Proc Natl Acad Sci USA 99, 7877-82.
8. Champness JN, Bennett MS, Wien F, Visse R, Summers WC, Herdewijn P, de Clerq E, Ostrowski T, Jarvest RL, and Sanderson MR (1998). Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands. Proteins 32, 350-61.
9. Cohen JL, Boyer O, Salomon B, Onclerco R, Depetris D, Lejeune L, Dubus-Bonnet V, Bruel S, Charlotte F, Mattei MG, and Klatzmann D (1998). Fertile homozygous transgenic mice expressing a functional truncated herpes simplex thymidine kinase delta TK gene. Transgenic Res 7, 321-30.
10. Contag CH, and Bachmann MH (2002). Advances in in vivo bioluminescence imaging of gene expression. Annu Rev Biomed Eng 4, 235-60.
11. Contag CH, Jenkins D, Contag PR, and Negrin RS (2000). Use of reporter genes for optical measurements of neoplastic disease in vivo. Neoplasia 2, 41-52.
12. Cowsill C, Southgate TD, Morrissey G, Dewey RA, Morelli AE, Maleniak TC, Forrest Z, Klatzmann D, Wilkinson GW, Lowenstein PR, and Castro MG (2000). Central nervous system toxicity of two adenoviral vectors encoding variants of the herpes simplex virus type 1 thymidine kinase: reduced cytotoxicity of a truncated HSV1-TK. Gene Ther 7, 679-85.
13. Degreve B, Esnouf R, De Clercq E, and Balzarini J (1999). Characterization of multiple nuclear localization signals in herpes simplex virus type 1 thymidine kinase. Biochem Biophys Res Commun 264, 338-42.
14. Degreve B, Johansson M, De Clercq E, Karlsson A, and Balzarini J (1998). Differential intracellular compartmentalization of herpetic thymidine kinases (TKs) in TK gene-transfected tumor cells: molecular characterization of the nuclear localization signal of herpes simplex virus type 1 TK. J Virol 72, 9535-43.
15. Doubrovin M, Ponomarev V, Beresten T, Balatoni J, Bornmann W, Finn R, Humm J, Larson S, Sadelain M, Blasberg R, and Gelovani Tjuvajev J (2001). Imaging transcriptional regulation of p53-dependent genes with positron emission tomography in vivo. Proc Natl Acad Sci USA 98, 9300-05.
16. 19F Nuclear Magnetic Resonance Measurements of Enhanced 5FU Conversion to Fluoronucleotides after UPRT Gene Transduction. Abstract, 3rd Annual Meeting of the ASGT, Denver, CO, May 31-June 4, 2000.
17. Ellenberg J, Lippincott-Schwartz J, and Presley JF (1999). Dual-colour imaging with GFP variants. Trends Cell Biol 9, 52-56.
18. Falk MM, and Lauf U (2001). High resolution, fluorescence deconvolution microscopy and tagging with the autofluorescent tracers CFP, GFP, and YFP to study the structural composition of gap junctions in living cells. Microsc Res Tech 52, 251-62.
19. Gallardo HF, Tan C, Ory D, and Sadelain M (1997). Recombinant retroviruses pseudotyped with the vesicular stomatitis virus G glycoprotein mediate both stable gene transfer and pseudotransduction in human peripheral blood lymphocytes. Blood 90, 952-57.
20. Gambhir SS, Barrio JR, Wu L, Iyer M, Namavari M, Satyamurthy N, Bauer E, Parrish C, MacLaren DC, Borghei AR, Green LA, Sharfstein S, Berk AJ, Cherry SR, Phelps ME, and Herschman HR (1998). Imaging of adenoviral-directed herpes simplex virus type 1 thymidine kinase reporter gene expression in mice with radiolabeled ganciclovir. J Nucl Med 39, 2003-11.
21. Gambhir SS, Herschman HR, Cherry SR, Barrio JR, Satyamurthy N, Toyokuni T, Phelps ME, Larson SM, Balatoni J, Finn R, Sadelain M, Tjuvajev J, and Blasberg R (2000). Imaging transgene expression with radionuclide imaging technologies. Neoplasia 2, 118-38.
22. Green L, Yap C, Nguyen N, Barrio J, Namavari M, Satyamurthy N, Phelps M, Sandgren E, Herschman H, and Gambhir S (2002). Indirect monitoring of endogenous gene expression by positron emission tomography (PET) imaging of reporter gene expression in transgenic mice. Mol Imaging Biol 4, 71-81.
23. Haberkorn U (2001). Gene therapy with sodium/iodide symporter in hepatocarcinoma. Exp Clin Endocrinol 1, 60-62.
24. 124I]FIAU and PET. Mol Imaging 1, 36-42.
25. Hadjantonakis AK, and Nagy A (2001). The color of mice: in the light of GFP-variant reporters. Histochem Cell Biol 115, 49-58.
26. Jacobs A, Dubrovin M, Hewett J, Sena-Esteves M, Tan CW, Slack M, Sadelain M, Breakefield XO, and Tjuvajev JG (1999). Functional coexpression of HSV-1 thymidine kinase and green fluorescent protein: implications for noninvasive imaging of transgene expression. Neoplasia 1, 154-61,
27. Kokoris MS, and Black ME (2002). Characterization of herpes simplex virus type 1 thymidine kinase mutants engineered for improved ganciclovir or acyclovir activity. Protein Sci 11, 2267-72.
28. Kokoris MS, Sabo P, Adman ET, and Black ME (1999). Enhancement of tumor ablation by a selected HSV-1 thymidine kinase mutant. Gene Ther 6, 1415-26.
29. Kokoris MS, Sabo P, and Black ME (2000). In vitro evaluation of mutant HSV-1 thymidine kinases for suicide gene therapy. Anticancer Res 20, 959-63.
30. Kussmann-Gerber S, Kuonen O, Folkers G, Pilger BD, and Scapozza L (1998). Drug resistance of herpes simplex virus type 1-structural considerations at the molecular level of the thymidine kinase. Eur J Biochem 255, 472-81.
31. Lalwani AK, Han JJ, Walsh BJ, Zolotukhin S, Muzyczka N, and Mhatre AN (1997). Green fluorescent protein as a reporter for gene transfer studies in the cochlea. Hear Res 114, 139-47.
32. Levy JP, Muldoon RR, Zolotukhin S, and Link Jr, CJ 1996. Retroviral transfer and expression of a humanized, red-shifted green fluorescent protein gene into human tumor cells. Nat Biotechnol 14, 610-14.
33. Liang Q, Satyamurthy N, Barrio JR, Toyokuni T, Phelps MP, Gambhir SS, and Herschman HR (2001). Noninvasive, quantitative imaging in living animals of a mutant dopamine D2 receptor reporter gene in which ligand binding is uncoupled from signal transduction. Gene Ther 8, 1490-98.
34. Luker GD, Sharma V, Pica CM, Dahlheimer JL, Li W, Ochesky J, Ryan CE, Piwnica-Worms H, and Piwnica-Worms D (2002). Noninvasive imaging of protein-protein interactions in living animals. Proc Natl Acad Sci USA 99, 6961-66.
35. Mathieu S, and El-Battari (2003). Monitoring E-selectin-mediated adhesion using green and red fluorescent proteins. J Immunol Methods 272, 81-92.
36. Ponomarev V, Doubrovin M, Lyddane C, Beresten T, Balatoni J, Bornman W, Finn R, Akhurst T, Larson S, Blasberg R, Sadelain M, and Tjuvajev JG (2001). Imaging TCR-dependent NFAT-mediated T-cell activation with positron emission tomography in vivo. Neoplasia 3, 480-88.
37. Ponomarev VDM, Beresten T, Balatoni J, Blasberg R, and Tjuvajev JG (2000). Functional coexpression of HSV1-tk and GFP and generation of mutants with different subcellular localization of TK/GFP fusion protein for gene therapy of gliomas. J Nucl Med 41, 81.
38. Ponomarev VDM, Serganova I, Ageyeva L, Beresten T, Sagomonyan S, Balatoni J, Finn R, Blasberg R, and Gelovani Tjuvajev JG (2002), Human Thymidine Kinase Type 2 - A Novel Non-Immunogenic Reporter Gene For Non-Invasive Imaging In Humans. AACR Meeting, Molecular Imaging in Cancer, Orlando, FL January 23-27, 2002.
39. Ponomarev VSIALBT, Doubrovin M, and Gelovani Tjuvajev JG (2001). Xanthine Phosphoribosyl Transferase and Red Fluorescent Protein Fusion - A Novel Reporter Gene for Multi-Modality Imaging. Abstract, 9th Annual Meeting of the ESGT Antalya, Turkey, November 2-4, 2001.
40. Qiao J, Doubrovin M, Sauter BV, Huang Y, Guo ZS, Balatoni J, Akhurst T, Blasberg RG, Tjuvajev JG, Chen SH, and Woo SL (2002). Tumor-specific transcriptional targeting of suicide gene therapy. Gene Ther 9, 168-75.
41. Ray P, Bauer E, Iyer M, Barrio JR, Satyamurthy N, Phelps ME, Herschman HR, and Gambhir SS (2001). Monitoring gene therapy with reporter gene imaging. Semin Nucl Med 31, 312-20.
42. Rogers BE, Zinn KR, and Buchsbaum DJ (2000). Gene transfer strategies for improving radiolabeled peptide imaging and therapy. Q J Nucl Med 3, 208-23.
43. Salomon B, Maury S, Loubiere L, Caruso M, Onclercq R, and Klatzmann D (1995). A truncated herpes simplex virus thymidine kinase phosphorylates thymidine and nucleoside analogs and does not cause sterility in transgenic mice. Mol Cell Biol 15, 5322-28.
44. Stegman LD, Rehemtulla A, Beattie B, Kievit E, Lawrence TS, Blasberg RG, Tjuvajev JG, and Ross BD (1999). Noninvasive quantitation of cytosine deaminase transgene expression in human tumor xenografts with in vivo magnetic resonance spectroscopy. Proc Natl Acad Sci USA 96, 9821-26.
45. Tjuvajev JG, Avrit N, Oku T, Sasajima T, Miyagawa T, Joshi R, Safer M, Beattie B, DiResta G, Daghighian F, Augensen F, Koutcher J, Zweit J, Humm J, Larson SM, Finn R, and Blasberg R (1998). Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography. Cancer Res 58, 4333-41.
46. Tjuvajev JG, Doubrovin M, Akhurst T, Cai S, Balatoni J, Alauddin MM, Finn R, Bornmann W, Thaler H, Conti PS, and Blasberg RG (2002). Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression. J Nucl Med 43, 1072-83.
47. Tjuvajev JG, Stockhammer G, Desai R, Uehara H, Watanabe K, Gansbacher B, and Blasberg RG (1995). Imaging the expression of transfected genes in vivo. Cancer Res 55, 6126-32.
48. Wild K, Bohner T, Aubry A, Folkers G, and Schulz GE (1995). The three-dimensional structure of thymidine kinase from herpes simplex virus type 1. FEBS Lett 368, 289-92.
49. Yaghoubi S, Barrio JR, Dahlbom M, Iyer M, Namavari M, Satyamurthy N, Goldman R, Herschman HR, Phelps ME, and Gambhir SS (2001).1 Human pharmacokinetic and dosimetry studies of [(18)F]FHBG: a reporter probe for imaging herpes simplex virus type-1 thymidine kinase reporter gene expression. J Nucl Med 42, 1225-34.