PECAM-1, apoptosis and CD34+ precursors

Leukemia and Lymphoma

Volumn 45, Issue 11, 2004, Pages 2205-2213

  Zocchi, Maria R ^a   Poggi, A ^b  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

T lymphocytes; B CLL; IFN ; MIC A; TNF ; ULBP

Indexed keywords

B LYMPHOCYTE RECEPTOR; CASPASE; CD31 ANTIGEN; CD34 ANTIGEN; CELL ADHESION MOLECULE; CHEMOKINE; CHEMOKINE RECEPTOR CXCR4; DEATH RECEPTOR 5; GROWTH FACTOR; HORMONE; IMMUNOGLOBULIN; INHIBITOR OF APOPTOSIS PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN KINASE; PROTEIN KINASE B; SCLEROPROTEIN; STROMAL CELL DERIVED FACTOR 1; T LYMPHOCYTE RECEPTOR; TYROSINE; VASCULAR CELL ADHESION MOLECULE 1;

ANTIGEN FUNCTION; ANTIGEN STRUCTURE; APOPTOSIS; BINDING KINETICS; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CELL ADHESION; CELL MATURATION; CELL POPULATION; CELL SURVIVAL; CYTOPLASM; ENDOTHELIUM CELL; ENZYME ACTIVATION; GENETIC TRANSCRIPTION; HEMATOPOIETIC STEM CELL; HOMEOSTASIS; HUMAN; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; STROMA CELL; UPREGULATION;

ANIMALS; ANTIGENS, CD31; ANTIGENS, CD34; APOPTOSIS; BCL-X PROTEIN; CELL SURVIVAL; CYTOPLASM; DNA-BINDING PROTEINS; ENDOTHELIUM, VASCULAR; EXTRACELLULAR MATRIX; HEMATOPOIETIC STEM CELLS; HOMEOSTASIS; HUMANS; IMMUNOGLOBULINS; MODELS, BIOLOGICAL; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; REPLICATION PROTEIN C; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 8644263171     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/10428190410001724312     Document Type: Review

References (71)

1. Hengartner, M.O. (2000) "The biochemistry of apoptosis", Nature, 407, 770-776.
2. Frisch, S.M. and Ruoslahti, E. (1997) "Integrins and anoikis", Curr. Opin. Cell. Biol., 9, 701-706.
3. Ashkenazi, A. and Dixit, V.M. (1998) "Death receptors: signalling and modulation", Science, 281, 1305-1308.
4. Zamzami, N. and Kroemer, G. (2001) "The mitochondrion in apoptosis: how Pandora's box opens", Nat. Rev. Mol. Cell. Biol., 2, 67-71.
5. Chao, D.T. and Korsmeyer, S.J. (1998) "Bcl-2 family: regulators of cell death", Annu. Rev. Immunol., 16, 395-419.
6. Cheng, E.H., Wie, M.C., Weiler, S., Flavell, R.A., Mak, T.W., Lindsten, T., et al. (2001) "BCL-2, BCL-XL sequester BH3 domain-only molecules preventing Bax- and Bak-mediated mitochondrial apoptosis", Mol. Cell, 8, 705-711.
7. Hsu, Y.T., Wolter, K.G. and Joule, R.J. (1997) "Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis", Proc. Natl. Acad. Sci. USA, 94, 3668-3672.
8. Antonsson, B., Montessuit, S., Sanchez, B. and Martinou, J.C. (2001) "Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells", J. Biol. Chem., 276, 11615-11623.
9. Rodriguez, J. and Lazebnik, Y. (1999) "Caspase-9 and APAF-1 for an active holoenzyme", Genes Dev., 13, 3179-3184.
10. Deveraux, Q.L. and Reed, J.C. (1999) "IAP family proteins-suppressors of apoptosis", Genes Dev., 13, 239-252.
11. Ardeshna, K.M., Pizzey, A.R., Devereux, S. and Khwaja, A. (2000) "The PI3 kinase, p38 SAP kinase, and NF-kB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells", Blood, 96, 1039-1046.
12. Chan, T.O., Rittenhouse, S.E. and Tsichlis, P.N. (1999) "AKT/PKB and other D3phosphoinositide-regulated kinases: kinase activation-by phosphoinositide-dependent phosphorylation", Annu. Rev. Biochem., 6, 965-1014.
13. Pugazhenti, S., Nesterova, A., Sable, C., Heidenreich, K.A., Boxer,L.M., Heasley, L.E., et al. (2000) "Akt/Protein kinase B upregulates Bcl-2 expression through cAMP-response element-binding protein", J. Biol. Chem., 275, 10761-10766.
14. Zhou, H., Li, X.M., Meinkoth, J. and Pittman, R.N. (2000) "Akt regulates cell survival and apoptosis at a postmitochondrial level", J. Cell. Biol., 151, 483-494.
15. Wang, J.F., Park, I.W. and Groopman, J.E. (2000) "Stromal cell-derived factor-1 alpha stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: roles of phopshoinositide-3 kinase and protein kinase C", Blood, 95, 2505-2513.
16. + cells, myeloblasts, erythroblasts and megacarioblasts and regulate normal hemopoiesis in an autocrine/paracrine manner", Blood, 97, 3075-3085.
17. Zeuner, A., Pedini, F., Signore, M., Testa, U., Pelosi, E., Peschle, C., et al. (2003) "Stem cell factor protects erythroid precursor cells from chemotherapeutic agents via up-regulation of BCL-2 family proteins", Blood, 102, 87-93.
18. + cells mobilized into peripheral blood of healthy donors by recombinant human granulocyte colony-stimulating factor", Blood, 89, 1189-1196.
19. + progenitors to peripheral blood", J. Exp. Med., 185, 111-120.
20. Kim, C.H. and Broxmeyer, H.E. (1998) "In vitro behaviour of hematopoietic progenitor cells under the influence of chemoattractants: stromal cell-derived factor-1, steel factor, and the bone marrow environment", Blood, 91, 100-110.
21. Imhof, B.A. and Dunon, D. (1995) "Leukocyte migration and adhesion", Adv. Immunol., 58, 345-416.
22. Kinashi, T. and Springer, T.A. (1994) "Adhesion molecules in hemopoietic cells", Blood Cells, 20, 25-44.
23. Schweitzer, C.M., Drager, A.M., van der Walk, P., Thijsen, S.F.T., Zevenbergen, A., Theijmeijer, A.P., et al. (1996) "Constitutive expression of E-selectin and vascular cell adhesion molecule-1 on endothelial cells of hemopoietic tissues", Am. J. Pathol., 148, 165-175.
24. + cells across specialized and nonspecialized endothelium requires prior activation by growth factors and is mediated by PECAM-1 (CD31)", Blood, 91, 1196-1205.
25. + hematopoietic precursor cells with early myeloid and B-lymphoid cell phenotypes", Blood, 82, 2649-2663.
26. Williams, D.A., Rios, M., Stephens, C. and Patel, V.P. (1991) "Fibronectin and VLA-4 in haematopoietic stem cell-microenvironment interactions", Nature, 352, 438-441.
27. Miyake, K., Medina, K.L., Hayshi, S.-Y., Ono, S., Hamaoka, T. and Kincade, T.W. (1990) "Monoclonal antibodies to Pgp-1/CD44 block lympho-hemopoiesis in long-term bone marrow cultures", J. Exp. Med. 17, 477-488.
28. Bruno, E., Luikart, S.D., Long, M.F. and Hoffman, R. (1995) "Marrow-derived heparan sulphate proteoglycan mediates the adhesion of hemopoietic, progenitor cells to cytokines", Exp. Hematol., 23 1212-1217.
29. Stossel, T.P. (1994) "The machinery of cell movement", Blood, 84, 367-379.
30. 2+ and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils", Nature, 377, 75-79.
31. Bleul, C.C., Fuhlbrigge, R.C., Casasnovas, J.M., Aiuti, A. and Springer, T.A. (1996) "A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor-1 (SDF-1)", J. Exp. Med. 184, 1101-1109.
32. + hematopoietic progenitor cells" , Blood, 89, 3522-3528.
33. Zhou, Y.-R., Kottmann, A.H., Kudora, M., Taniuchi, I. and Littman, D.R. (1998) "Function of the chemokine receptor CXCR-4 in hematopoiesis and in cerebellar development", Nature, 393, 595-599.
34. Peled, A., Petit, I., Kollet, O., Magid, M., Ponomaryov, T., Byk, T., et al. (1999) "Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR-4", Science, 283, 845-848.
35. + cells is related to hematopoietic recovery after autologous stem cells transplantation", Blood, 97, 799-804.
36. Williams, A.F. and Barclay, A.N. (1988) "The immunoglobulin superfamily. Domains for cell surface recognition", Annu. Rev. Immunol., 6, 381-405.
37. Kirschbaum, N.E., Gumina, R.J. and Newman, P.J. (1994) "Organization of the gene for human platelet endothelial cell adhesion moilecule-1 shows alternatively spliced isoforms and a functionally complex cytoplasmic domain", Blood, 84, 4828-4837.
38. Muller, W.A., Weigl, S.A., Deng, X. and Phillips, D.M. (1993) "PECAM-1 is required for transendothelial migration of leukocytes", J. Exp. Med., 178, 449-460.
39. Newman, P.J. (1997) "The biology of PECAM-1", J. Clin. Invest., 99, 3-8.
40. Liao, F., Huynh, H.K., Eiroa, A., Greene, T., Polizzi, E. and Muller, W.A. (1995) "Migration of monocytes across endothelium and passage through extracellular matrix involve separate molecular domains of PECAM-1", J. Exp. Med., 182, 1337-1342.
41. Piali, L., Hammel, P., Uherek, C., Bachmann, F., Gisler, R.H., Dunon, D., et al. (1995) "CD31/PECAM-1 is a a ligand for αvβ3 integrin involved in adhesion of leukocytes to endothelium", J. Cell. Biol., 130, 451-460.
42. Zehnder, J.L., Shatsky, M., Leung, L.L.K., Butcher, E.C., McGregor, J.L. and Levitt, L. (1995) "Involvement of CD31 in lymphocyte-mediated immune responses: importance of the membrene-proximal immunoglobulin domain and identification of an inhibiting CD31 peptide", Blood, 85, 1282-1288.
43. Wong, C.W., Wiedle, G., Ballestrem, C., Wehrle-Haller, B., Etteldorf, S., Bruckner, M., et al. (2000) "PECAM-1/CD31 trans-homophilic binding at the intercellular junctions is independent of ist cytoplasmic domain; evidence for heterophilic interaction with integrin alphavbeta3 in Cis", Mol. Biol. Cell., 11, 3109-3121.
44. Poggi, A., Panzeri, M.C., Moretta, L. and Zocchi, M.R. (1996) "CD31-triggered rearrangement of the actin cytoskeleton in human natural killer cells", Eur. J. Immunol., 26, 817-824.
45. Fawcett, J., Buckley, C., Holness, C.L., Bird, I.N., Spragg, J.H., Saunders, J., et al. (1995) "Mapping of the homotypic binding sites in CD31 and the role of CD31 adhesion in the formation of interendothelial cell contacts", J. Cell. Biol., 128, 1229-1241.
46. Sun, Q.-H., DeLisser, H.M., Zukowski, M.M., Paddock, C., Albelda, S.M. and Newman, P.J. (1996) "Individually distinct Ig homology domains in PECAM-1 regulate homophilic binding and modulate receptor activity", J. Biol. Chem., 271, 11090-11098.
47. Tanaka, Y., Albelda, S.M., Horgan, K.J., van Seventer, G.A., Shimizu, Y., Newman, W., et al. (1992) "CD31 expressed on distinctive T cell subsets is a preferential amplifier of β1 integrin-mediated adhesion", J. Exp. Med., 176, 245-253.
48. Zehnder, J.L., Hirai, K., Shatsky, M., McGregor, J.L., Levitt, L.J. and Leung, L.L.K. (1992) "The cell adhesion molecule CD31 is phosphorylated after cell activation. Down-regulation of CD31 after T cell activation", J. Biol. Chem., 287, 5243-5249.
49. Ferrero, E., Villa, A., Ferrero, M.E., Toninelli, E., Bender, J.F., Pardi, R., et al. (1996) "Tumor necrosis factor alpha-induced vascular leakage involves PECAM1 phosphorylation", Cancer Res., 56, 3211-3215.
50. Zocchi, M.R., Ferrero, E., Leone, B.E., Rovere, P., Bianchi, E., Toninelli, E., et al. (1996) "CD31/PECAM-1-driven chemokine-independent transmigration of human T lymphocytes", Eur. J. Immunol., 26, 759-767.
51. DeLisser, H.M., Chilkotowski, J., Yan, H.C., Daise, M.L., Buck, C.A. and Albelda, S.M. (1994) "Deletions in the cytoplasmic domain of platelet-endothelial cell adhesion molecule-1 (PECAM-1, CD31) results in changes in ligand binding properties", J. Cell. Biol., 124 195-203.
52. Sun, J., Williams, J., Yan, H.C., Amin, K.M., Albelda, S.M. and DeLisser, H.M. (1996) "Platelet endothelial cell adhesion molecule-1 (PECAM-1) homophilic adhesion is mediated by immunoglobulin-like domains 1 and 2 and depends on the cytoplasmic domain and on the level of surface expression", J. Biol. Chem., 271, 18561-18570.
53. Newman, P.J. (1999) "Switched at birth: a new family for PECAM-1", J. Clin. Invest., 103, 5-9.
54. Wilkinson, R., Lyons, A.B., Roberts, D., Wong, M.-X., Bartley, P.A. and Jackson, D.E. (2002) "Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) acts as a regulator of B-cell development, B-cell antigen receptor (BCR)-mediated activation, and autoimmune disease", Blood, 100, 184-193.
55. Newman, D.K., Hamilton, C. and Newman, P.J. (2001) "Inhibition of antigen receptor signalling by platelet endothelial cell adhesion molecule-1 (CD31) requires functional ITIMs, SHP2, and p561ck", Blood, 97, 2351-2357.
56. Goldberger, A., Middleton, K.A., Oliver, J.A., Paddock, C., Yan, H.-C., DeLisser, H.M., et al. (1994) "Biosynthesis and processing of the cell adhesion molecule PECAM-1 includes production of a soluble form", J. Biol. Chem., 269, 17183-17191.
57. Sagawa, K., Kimura, T., Swieter, M. and Siraganian, R.P. (1997) "The proteintyrosine phosphatase SHP-2 associates with tyrosine-phosphorylated adhesion molecule PECAM-1 (CD31)", J. Biol. Chem., 272, 31086-31091.
58. Jackson, D.E., Ward, C.M., Wang, R. and Newman, P.J. (1996) "The protein-tyrosine phosphatase SHP2 binds to platelet/endothelial cell adhesion molecule-1 (PECAM-1) and forms a distinct signalling complex during platelet aggregation. Evidence for a mechanistic link between PECAM-1 and integrin-mediated cellular signalling", J. Biol. Chem., 272, 6986-6993.
59. Hua, C.T., Gamble, J.R., Vadas, M.A. and Jackson, D.E. (1998) "Recruitment and activation of SHP-1 protein-tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1). Identification of immunoreceptor tyrosine-based inhibitory motif-like binding motifs and substrates", J. Biol. Chem., 273, 28332-28340.
60. Hof, P., Pluskey, S., Dhe-Paganon, S. and Shoelson, S.E. (1998) "Crystal structure of the tyrosine phosphatase SHP-2", Cell 92, 441-450.
61. Isakov, N. (1997) "ITIMs and ITAMs. The Yin and Yang of antigen and Fc receptor-linked signalling machinery", Immunol. Res. 16, 85-100.
62. Henshall, T.L., Jones, K.L., Wilkinson, R. and Jackson, D.E. (2001) "Src homology 2 domain-containing protein-tyrosine phosphatases, shp-1 and shp-2, are required for platelet endothelial cell adhesion molecule-1/CD31-mediated inhibitory signalling", J. Immunol., 166, 3098-3106.
63. Cao, M.Y., Huber, M., Beauchemin, N., Famiglietti, J., Albelda, S.M. and Veillette, A. (1998) "Regulation of mouse PECAM-1 tyrosine phosphorylation by the Src and Csk families of protein-tyrosine kinases", J. Biol. Chem., 273, 15765-15772.
64. Ilan, N., Cheung, L., Pinter, E. and Madri, J.A. (2000) "Platelet endothelial cell adhesion molecule-1 (CD31), a scaffolding molecule for selected catenin family members whose binding is mediated by different tyrosine and serine/threonine phosphorylation", J. Biol. Chem., 14, 21435-21443.
65. Noble, K.E., Wickremasinghe, R.G., DeComet, C., Panayiotidis, P. and Yong, K.L. (1999) "Monocytes stimulate expression of the Bcl-2 family member, A1, in endothelial cells and confers protection from apoptosis", J. Immunol., 162, 1376-1383.
66. Bird, I.N., Taylor, V., Newton, J.P., Spragg, J.H., Simmons, D.L., Salmon, M., et al. (1999) "Homophilic PECAM-1(CD31) interactions prevent endothelial cell apoptosis but do not support cell spreading or migration", J. Cell Sci., 112, 1989-1997.
67. Ferrero, E., Belloni, D., Contini, P., Foglieni, C., Ferrero, M.E., Fabbri, M., et al. (2003) "Transendothelial migration leads to protection from starvation-induced apoptosis in CD34 + CD14 + circulating precursors: evidence for PECAM-1 involvement through Akt/PKB activation", Blood, 101, 186-193.
68. Pellegatta, F., Chierchia, S.L. and Zocchi, M.R. (1998) "Functional association of platelet endothelial cell adhesion molecule-1 and phosphoinositide-3 kinase in human neutrophils", J. Biol. Chem. 273, 27768-27771.
69. Gao, C., Sun, W., Christofidou-Solomidou, M., Sawada, M., Newman, D.K., Bergom, C., et al. (2003) "PECAM-1 functions as a specific and potent inhibitor of mitochondrial-dependent apoptosis", Blood, 102, 169-179.
70. Pumphrey, N.J., Taylor, V., Freeman, S., Douglas, M.R., Bradfield, P.F., Young, S.P., et al. (1999) "Differential association of cytoplasmic signalling molecules SHP-1, SHP-2 and SHIP and phospholipase C-gamma 1 with PECAM-1/CD31", FEBS Lett., 450, 77-83.
71. Lu, T.T., Barreuther, M., Davis, S. and Madri, J.A. (1997) "Platelet endothelial cell adhesion molecule-1 is phosphorylatable by c-Src, binds Src-Src homology 2 domain, and exhibits immunoreceptor tyrosine-based activation motif-like properties", J. Biol. Chem., 272, 14442-14446.