ITIMs and ITAMs. The Yin and Yang of antigen and Fc receptor-linked signaling machinery

Immunologic Research

Volumn 16, Issue 1, 1997, Pages 85-100

  Isakov, Noah ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Activation motif; Inhibition motif; ITAM; ITIM; Lymphocyte activation; PTK; PTPase; SH2; Signal transduction

Indexed keywords

FC RECEPTOR; MEMBRANE ANTIGEN; RECEPTOR SUBUNIT; TYROSINE;

ARTICLE; CYTOPLASM; GENETIC CONSERVATION; HUMAN; IMMUNE RESPONSE; PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0030891713     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02786325     Document Type: Article

References (112)

1. Sun H, Tonks NK: The coordinated action of protein tyrosine phosphatases and kinases in cell signaling. TIBS 1994;19:480-485.
2. Isakov N: Tyrosine phosphorylation and dephosphorylation in T lymphocyte activation. Mol Immunol 1993;30:197-210.
3. Cambier JC: New nomenclature for the Reth motif (or ARH1/TAM/ ARAM/YXXL). Immunol Today 1995;16:110.
4. Samelson LE, Klausner RD: Tyrosine kinases and tyrosine-based activation motifs. Current research on activation via the T cell antigen receptor. J Biol Chem 1992;267:24,913-24,916.
5. Weiss A: T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases. Cell 1993;73:209-212.
6. Pleiman CM, D'Ambrosio D, Cambier JC: The B-cell antigen receptor complex: structure and signal transduction. Immunol Today 1994;15:393-399.
7. Bonnerot C, Amigorena S, Choquet D, Pavlovich R, Choukroun V, Fridman WH: Role of associated y chain in tyrosine kinase activation via murine FcγRIII. EMBO J 1992;11:2747-2757.
8. Letourneur F, Klausner RD: T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta family proteins. Proc Natl Acad Sci USA 1991;88: 8905-8909.
9. Daëron M, Latour S, Malbec O, Espinosa E, Pina P, Pasmans S, Fridman WH: The same tyrosine-based inhibition motif, in the intracytoplasmic domain of FcγRIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation. Immunity 1995; 3:635-646.
10. Van den Herik-Oudijk IE, Capel PJ, van der Bruggen T, Van de Winkel JG: Identification of signaling motifs within human FcγRIIa and FcγRIIb isoforms. Blood 1995;85:2202-2211.
11. Pani G, Kozlowski M, Cambier JC, Mills GB, Siminovitch KA: Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling. J Exp Med 1995;181:2077-2084.
12. D'Ambrosio D, Hippen KL, Minskoff SA, Mellman I, Pani G, Siminovitch KA, Cambier JC: Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by FcγRIIB1. Science 1995;268: 293-297.
13. Muta T, Kurosaki T, Misulovin Z, Sanchez M, Nussenzweig MC, Ravetch JV: A 13-amino-acid motif in the cytoplasmic domain of FcyRIIB modulates B-cell receptor signalling. Nature 1994;368:70-73.
14. Cyster JG, Goodnow CC: Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection. Immunity 1995;2:13-24.
15. Reth M: Antigen receptor tail clue. Nature 1989;338:383,384.
16. Clevers H, Alarcon B, Wileman T, Terhorst C: The T cell receptor/ CD3 complex: a dynamic protein ensemble. Annu Rev Immunol 1988;6:629-662.
17. Blumberg RS, Alarcon B, Sancho J, McDermott FV, Lopez P, Breitmeyer J, Terhorst C: Assembly and function of the T cell antigen receptor. Requirement of either the lysine or arginine residues in the transmembrane region of the alpha chain. J Biol Chem 1990; 265:14,036-14,043.
18. Koning F, Maloy WL, Coligan JE: The implication of subunit interactions for the structure of the T cell receptor-CD3 complex. Eur J Immunol 1990;20:299-305.
19. Reth M, Hombach J, Wienands J, Campbell KS, Chien N, Justement LB, Cambier JC: The B-cell antigen receptor complex. Immunol Today 1991;12:196-201.
20. Reth M: Antigen receptors on B lymphocytes. Annu Rev Immunol 1992;10:97-121.
21. Ravetch JV, Kinet JP: Fc receptors. Annu Rev Immunol 1991;9: 457-492.
22. Pfefferkorn LC, Yeaman GR: Association of IgA-Fc receptor (FcαR) with FcεRIγ2 subunits in U937 cells. Aggregation induces the tyrosine phosphorylation of γ2. J Immunol 1994;153:3228-3236.
23. Irving BA, Weiss A: The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways. Cell 1991;64: 891-901.
24. Irving BA, Chan AC, Weiss A: Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain. J Exp Med 1993;177:1093-1103.
25. Romeo C, Seed B: Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides. Cell 1991;64:1037-1046.
26. Wegener AM, Letourneur F, Hoeveler A, Brocker T, Luton F, Malissen B: The T cell receptor/ CD3 complex is composed of at least two autonomous transduction modules. Cell 1992;68:83-95.
27. Letourneur F, Klausner RD: Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3 epsilon. Science 1992;255:79-82.
28. Romeo C, Kolanus W, Amiot M, Seed B: Activation of immune system effector function by T-cell or Fc receptor intracellular domains. Cold Spring Harb Symp Quant Biol 1992;57:117-125.
29. Kim KM, Alber G, Weiser P, Reth M: Differential signaling through the Ig-alpha and Ig-beta components of the B cell antigen receptor. Eur J Immunol 1993; 23:911-916.
30. Romeo C, Amiot M, Seed B: Sequence requirements for induction of cytolysis by the T cell antigen/Fc receptor zeta chain. Cell 1992;68:889-897.
31. Sanchez M, Misulovin Z, Burkhardt AL, Mahajan S, Costa T, Franke R, Bolen JB, Nussenzweig M: Signal transduction by immunoglobulin is mediated through Ig alpha and Ig beta. J Exp Med 1993; 178:1049-1055.
32. Cambier JC: Antigen and Fc receptor signaling. The awesome power of the immunoreceptor tyrosine-based activation motif (ITAM). J Immunol 1995;155:3281-3285.
33. Choquet D, Ku G, Cassard S, Malissen B, Korn H, Fridman WH, Bonnerot C: Different patterns of calcium signaling triggered through two components of the B lymphocyte antigen receptor. J Biol Chem 1994;269:6491-6497.
34. Hirasawa N, Scharenberg A, Yamamura H, Beaven MA, Kinet JP: A requirement for Syk in the activation of the microtubule-associated protein kinase/phospholipase A2 pathway by Fc epsilon R1 is not shared by a G protein-coupled receptor. J Biol Chem 1995;270: 10,960-10,967.
35. Wilson BS, Kapp N, Lee RJ, Pfeiffer JR, Martinez AM, Platt Y, Letourneur F, Oliver JM: Distinct functions of the Fc epsilon R1 gamma and beta subunits in the control of Fc epsilon R1-mediated tyrosine kinase activation and signaling responses in RBL-2H3 mast cells. J Biol Chem 1995;270: 4013-4022.
36. Phillips NE, Parker DC: Fc-dependent inhibition of mouse B cell activation by whole anti-μ antibodies. J Immunol 1983;130:602-606.
37. Sidman CL, Unanue ER: Requirements for mitogenic stimulation of murine B cells by soluble anti-IgM antibodies. J Immunol 1979;122: 406-413.
38. Bijsterbosch MK, Klaus GG: Crosslinking of surface immunoglobulin and Fc receptors on B lymphocytes inhibits stimulation of inositol phospholipid breakdown via the antigen receptors. J Exp Med 1985;162:1825-1836.
39. Choquet D, Partiseti M, Amigorena S, Bonnerot C, Fridman WH, Korn H: Cross-linking of IgG receptors inhibits membrane immunoglobulin-stimulated calcium influx in B lymphocytes. J Cell Biol 1993; 121:355-363.
40. Wilson HA, Greenblatt D, Taylor CW, Putney JW, Tsien RY, Finkelman FD, Chused TM: The B lymphocyte calcium response to anti-Ig is diminished by membrane immunoglobulin cross-linkage to the Fey receptor. J Immunol 1987; 138:1712-1718.
41. Hulett MD, Hogarth PM: Molecular basis of Fc receptor function. Adv Immunol 1994;57:1-127.
42. Brooks DG, Qiu WQ, Luster AD, Ravetch JV: Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes. J Exp Med 1989;170:1369-1385.
43. Daëron M, Bonnerot C, Latour S, Fridman WH: Murine recombinant FcγRIII. but not FcγRII, trigger serotonin release in rat basophilic leukemia cells. J Immunol 1992; 149:1365-1373.
44. Latour S, Bonnerot C, Fridman WH, Daeron M: Induction of tumor necrosis factor-α production by mast cells via FcgR. Role of the FcgRIIIγ subunit. J Immunol 1992;149:2155-2162.
45. AmigorenaS, Bonnerot C, Choquet D, Fridman WH, Teillaud JL: FcγRII expression in resting and activated B lymphocytes. Eur J Immunol 1989;19:1379-1385.
46. Amigorena S, Bonnerot C, Drake JR, Choquet D, Hunziker W, Guillet J, Webster P, Sautes C, Mellman I, Fridman WH: Cytoplasmic domain heterogeneity and functions of IgG Fc receptors in B lymphocytes. Science 1992;256: 1808-1812.
47. Van den Herik-Oudijk IE, Westerdaal NA, Henriquez NV, Capel PJ, Van de Winkel JG: Functional analysis of human FcγRII (CD32) isoforms expressed in B lymphocytes. J Immunol 1994; 152:574-585.
48. Koyasu S, Tse AGD, Moingeon P, Hussey RE, Mildonian A, Hannisian J, Clayton LK, Reinherz EL: Delineation of a T-cell activation motif required for binding of protein tyrosine kinases containing tandem SH2 domains. Proc Natl Acad Sci USA 1994;91: 6693-6697.
49. Shaw AS, Timson Gauen LK, Zhu Y: Interactions of TCR tyrosine based activation motifs with tyrosine kinases. Semin Immunol 1995;7:13-20.
50. Songyang Z, Blechner S, Hoagland N, Hoekstra MF, Piwnica WH, Cantley LC: Use of an oriented peptide library to determine the optimal substrates of protein kinases. Curr Biol 1994;4:973-982.
51. Isakov N, Wange RL, Watts JD, Aebersold R, Samelson LE: Purification and characterization of human ZAP-70 from a baculo-virus expression system. J Biol Chem 1996;271:15,753-15,761.
52. Flaswinkel H, Barner M, Reth M: The tyrosine activation motif as a target of protein tyrosine kinases and SH2 domains. Semin Immunol 1995;7:21-27.
53. Flaswinkel H, Reth M: Dual role of the tyrosine activation motif of the Ig-alpha protein during signal transduction via the B cell antigen receptor. EMBO J 1994;13:83-89.
54. Wange RL, Kong AN, Samelson LE: A tyrosine-phosphorylated 70-kDa protein binds a photo-affinity analogue of ATP and associates with both the zeta chain and CD3 components of the activated T cell antigen receptor. J Biol Chem 1992;267:11,685-11,688.
55. Chan AC, Irving BA, Fraser JD, Weiss A: The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein. Proc Natl Acad Sci USA 1991;88: 9166-9170.
56. Chan AC, Iwashima M, Turck CW, Weiss A: ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain. Cell 1992;71:649-662.
57. Clark MR, Campbell KS, Kazlauskas A, Johnson SA, Hertz M, Potter TA, Pleiman C, Cambier JC: The B cell antigen receptor complex: association of Ig-alpha and Ig-beta with distinct cytoplasmic effectors. Science 1992;258:123-126.
58. Hutchcroft JE, Harrison ML, Geahlen RL: B lymphocyte activation is accompanied by phosphorylation of a 72-kDa protein tyrosine kinase. J Biol Chem 1991; 266:14,846-14,849.
59. Hutchcroft JE, Harrison ML, Geahlen RL: Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor. J Biol Chem 1992;267: 8613-8619.
60. Isakov N, Wange RL, Burgess WH, Watts JD, Aebersold R, Samelson LE: ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity. J Exp Med 1995;181:375-380.
61. Iwashima M, Irving BA, van Oers NSC, Chan AC, Weiss A: Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science 1994;263:1136-1139.
62. fyn and ZAP-70 with T-cell receptor activation motifs: Defining the nature of a signalling motif. Mol Cell Biol 1994;14: 3729-3741.
63. Wange RL, Malek SN, Desiderio S, Samelson LE: Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells. J Biol Chem 1993;268: 19,797-19,801.
64. Hatada MH, Lu X, Laird ER, Green J, Morgenstern JP, Lou M, Marr CS, Phillips TB, Ram MK, Theriault K, Zoller MK, Karas JL: Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor. Nature 1995;376:32-38.
65. Shiue L, Zoller MJ, Brugge JS: Syk is activated by phosphotyrosine-containing peptides representing the tyrosine-based activation motifs of the high affinity receptor for IgE. J Biol Chem 1995;270:10,498-10,502.
66. Rowley RB, Burkhardt AL, Chao HG, Matsueda GR, Bolen JB: Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation. J Biol Chem 1995;270:11,590-11,594.
67. Neumeister EN, Zhu Y, Richard S, Terhorst C, Chan AC, Shaw AS: Binding of ZAP-70 to phosphorylated T-cell receptor ζ and η enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins. Mol Cell Biol 1995;15: 3171-3178.
68. Madrenas J, Wange RL, Wang JL, Isakov N, Samelson LE, Germain RN: ζ phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science 1995;267:515-518.
69. van Oers NSC, Killeen N, Weiss A: ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells. Immunity 1994;1:675-685.
70. lck. Immunity 1996;4:495-504.
71. Chan AC, Dalton M, Johnson R, Kong GH, Wang T, Thoma R, Kurosaki T: Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function. EMBO J 1995;14:2499-2508.
72. Wange RL, Guitian R, Isakov N, Watts JD, Aebersold R, Samelson LE: Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70. J Biol Chem 1995;270:18,730-18,733.
73. Hall CG, Sancho J, Terhorst C: Reconstitution of T cell receptor ζ-mediated calcium mobilization in nonlymphoid cells. Science 1993;261:915-918.
74. Kolanus W, Romeo C, Seed B: T cell activation by clustered tyrosine kinases. Cell 1993;74:171-183.
75. Adachi M, Fischer EH, Ihle J, Imai K, Jirik F, Neel B, Pawson T, Shen S, Thomas M, Ullrich A, Zhao Z: Mammalian SH2-containing protein tyrosine phosphatases. Cell 1996;85:15.
76. Vogel W, Lammers R, Huang J, Ullrich A: Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation. Science 1993; 259:1611-1614.
77. Lechleider RJ, Sugimoto S, Bennett AM, Kashishian AS, Cooper JA, Shoelson SE, Walsh CT, Neel BG: Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor. J Biol Chem 1993;268: 21,478-21,481.
78. Pluskey S, Wandless TJ, Walsh CT, Shoelson SE: Potent stimulation of SH-PTP2 phosphatase activity by simultaneous occupancy of both SH2 domains. J Biol Chem 1995;270:2897-2900.
79. Paolini R, Numerof R, Kinet JP: Phosphorylation/dephosphorylation of high-affinity IgE receptors: a mechanism for coupling/uncoupling a large signaling complex. Proc Natl Acad Sci USA 1992;89: 10,733-10,737.
80. Gold MR, Matsuuchi L, Kelly RB, DeFranco AL: Tyrosine phosphorylation of components of the B-cell antigen receptors following receptor crosslinking. Proc Natl Acad Sci USA 1991;88:3436-3440.
81. Samelson LE, Patel MD, Weissman AM, Harford JB, Klausner RD: Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor. Cell 1986;46:1083-1090.
82. Samelson LE, O'Shea JJ, Luong H, Ross P, Urdahl KB, Klausner RD, Bluestone J: T cell antigen receptor phosphorylation induced by an anti-receptor antibody. J Immunol 1987;139:2708-2714.
83. Baniyash M, Garcia MP, Luong E, Samelson LE, Klausner RD: The T cell antigen receptor zeta chain is tyrosine phosphorylated upon activation. J Biol Chem 1988;263: 18,225-18,230.
84. Bu JY, Shaw AS, Chan AC: Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance. Proc Natl Acad Sci USA 1995;92:5106-5110.
85. 3, a novel competitive inhibitor of the binding of ZAP-70 to the T cell antigen receptor, blocks early T cell signaling. J Biol Chem 1995;270:944-948.
86. + thymic selection in humans lacking Zap-70 kinase. Cell 1994;76: 947-958.
87. Elder ME, Lin D, Clever J, Chan AC, Hope TJ, Weiss A, Parslow TG: Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. Science 1994;264:1596-1599.
88. Chan AC, Kadlecek TA, Elder ME, Filipovich AH, Kuo WL, Iwashima M, Parslow TG, Weiss A: ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency. Science 1994;264:1599-1601.
89. Negishi I, Motoyama N, Nakayama K-I, Nakayama K, Senju S, Hatakeyama S, Zhang Q, Chan AC, Loh DY: Essential role for ZAP-70 in both positive and negative selection of thymosytes. Nature 1995;376:435-438.
90. Taniguchi T, Kobayashi T, Kondo J, Takahashi K, Nakamura H, Susuki J, Nagai K, Yamada T, Nakamura S-I, Yamamura H: Molecular cloning of a porcine gene syk that encodes a 72-kDa protein tyrosine kinase showing high susceptibility to proteolysis. J Biol Chem 1991;266:15,790-15,796.
91. 2+ mobilization through distinct pathways. EMBO J 1994;13:1341-1349.
92. Oliver JM, Burg DL, Wilson BS, McLaughlin JL, Geahlen RL: Inhibition of mast cell FceR1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol. J Biol Chem 1994;269:29,697-29,703.
93. Turner M, Mee PJ, Costello PS, Williams O, Price AA, Duddy LP, Furlong MT, Geahlen RL, Tybulewicz VL: Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 1995;378:298-302.
94. Cheng AM, Rowley B, Pao W, Hayday A, Bolen JB, Pawson T: Syk tyrosine kinase required for mouse viability and B-cell development. Nature 1995;378:303-306.
95. Shultz LD, Green MC: Motheaten, an immunodeficient mutant of the mouse. II. Depressed immune competence and elevated serum immunoglobulins. J Immunol 1976;116:936-943.
96. Shultz LD, Coman DR, Bailey CL, Beamer WG, Sidman CL: "Viable motheaten," a new allele at the motheaten locus. I. Pathology. Am J Pathol 1984;116:179-192.
97. Sidman CL, Shultz LD, Unanue ER: The mouse mutant "motheaten." II. Functional studies of the immune system. J Immunol 1978;121:2399-2404.
98. Sidman CL, Shultz LD, Unanue ER: The mouse mutant "motheaten". I. Development of lymphocyte populations. J Immunol 1978; 121:2392-2398.
99. Davidson WF, Morse HC, Sharrow SO, Chused TM: Phenotypic and functional effects of the motheaten gene on murine B and T lymphocytes. J Immunol 1979; 122:884-891.
100. Shultz LD, Schweitzer PA, Rajan TV, Yi T, Ihle JN, Matthews RJ, Thomas ML, Beier DR: Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell 1993;73:1445-1454.
101. Tsui HW, Siminovitch KA, de Souza L, Tsui FW: Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene. Nature Genet 1993;4:124-129.
102. Kozlowski M, Mlinaric RI, Feng GS, Shen R, Pawson T, Siminovitch KA: Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice. J Exp Med 1993;178: 2157-2163.
103. Matthews RJ, Bowne DB, Flores E, Thomas ML: Characterization of hemalopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences. Mol Cell Biol 1992;12:2396-2405.
104. Plutzky J, Neel BG, Rosenberg RD: Isolation of a src homology 2-containing tyrosine phosphatase. Proc Natl Acad Sci USA 1992; 89:1123-1127.
105. Shen SH, Bastien L, Posner BI, Chretien P: A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases. Nature 1991;352:736-739.
106. Daëron M, Malbec O, Latour S, Arock M, Fridman WH: Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors. J Clin Invest 1995;95:577-585.
107. Doody GM, Justement LB, Delibrias CC, Matthews RJ, Lin J, Thomas ML, Fearon DT: A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP. Science 1995;269:242-244.
108. Burshtyn DN, Scharenberg AM, Wagtmann N, Rajagopalan S, Berrada K, Yi T, Kinet J, Jong EO: Recruitment of tyrosine phosphatase HCP by killer cell inhibitory receptor. Immunity 1996;4:77-85.
109. Olcese L, Lang P, Vely F, Cambiaggi A, Marguet D, Blery M, Hippen K, Biassoni R, Moretta A, Moretta L, Cambier JC, Vivier E: Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases. J Immunol 1996;156: 4531-4534.
110. Yi T, Zhang J, Miura O, Ihle JN: Hematopoietic cell phosphatase associates with erythropoietin (Epo) receptor after Epo-induced receptor tyrosine phosphorylation: identification of potential binding sites. Blood 1995;85:87-95.
111. Yi T, Ihle JN: Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand. Mol Cell Biol 1993; 13:3350-3358.
112. Yi T, Mui AL, Krystal G, Ihle JN: Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis. Mol Cell Biol 1993; 13:7577-7586.