RESPIRATORY SYNCYTIAL VIRUS

Feigin and Cherry's Textbook of Pediatric Infectious Diseases, Sixth Edition

Volumn , Issue , 2009, Pages 2462-2487

  Hall, Caroline Breese ^a   Walsh, Edward E ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

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[No Author keywords available]

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EID: 85170198174     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-1-4160-4044-6.50199-0     Document Type: Chapter

References (424)

1. A. Abdallah, K.E. Rowland, S.K. Schepetiuk, et al. (2003) An outbreak of respiratory syncytial virus infection in a bone marrow transplant unit: Effect on engraftment and outcome of pneumonia without specific antiviral treatment. Bone Marrow Transplant 32 195-203.
2. J.H. Aberle, S.W. Aberle, W. Rebhandl, et al. (2004) Decreased interferon-gamma response in respiratory syncytial virus compared to other respiratory viral infections in infants. Clin. Exp. Immunol. 137 146-150.
3. J.M. Adams (1941) Primary virus pneumonitis with cytoplasmic inclusion bodies: A study of an epidemic involving thirty-two infants with nine deaths. J. Am. Med. Assoc. 116 925-933.
4. J.M. Adams, D.T. Imagawa and K. Zike (1961) Epidemic bronchiolitis and pneumonia related to respiratory syncytial virus. JAMA 176 1037-1039.
5. J.M. Adams, D.T. Imagawa and K. Zike (1961) Relationship of pneumonitis in infants to respiratory syncytial virus. Lancet 81 502-506.
6. Agency for Healthcare Research and Quality (2003) Management of Bronchiolitis in Infants and Children Rockville, MD: U.S. Department of Health and Human Services
7. Agency for Healthcare Research and Quality: Management of bronchiolitis in infants and children. Evid. Rep. Technol. Assess. 03-E009:1-5, 2003.
8. O.I. Aguinaga, P.A. Arnedo, J. Bellido, et al. (1999) The prevalence of asthma-related symptoms in 13-14-year-old children from 9 Spanish populations: The Spanish Group of the ISAAC Study (International Study of Asthma and Allergies in Childhood). Med. Clin. (Barc.) 112 171-175.
9. W. Ahere, T. Bird, S.D. Court, et al. (1970) Pathological changes in virus infections of the lower respiratory tract in children. J. Clin. Pathol. 23 7-18.
10. C.A. Altman, J.A. Englund, G. Demmler, et al. (2000) Respiratory syncytial virus in patients with congenital heart disease: A contemporary look at epidemiology and success of preoperative screening. Pediatr. Cardiol. 21 433-438.
11. W.H. Alwan, W.J. Kozlowska and P.J. Openshaw (1994) Distinct types of lung disease caused by functional subsets of antiviral T cells. J. Exp. Med. 179 81-89.
12. W.H. Alwan, F.M. Record and P.J. Openshaw (1992) CD4 + T cells clear virus but augment disease in mice infected with respiratory syncytial virus: Comparison with the effects of CD8 + T cells. Clin. Exp. Immunol. 88 527-536.
13. V. Amanatidou, G. Sourvinos, S. Apostolakis, et al. (2006) T280M variation of the CX3C receptor gene is associated with increased risk for severe respiratory syncytial virus bronchiolitis. Pediatr. Infect. Dis. J. 25 410-414.
14. American Academy of Pediatrics (2006) Respiratory syncytial virus. L. Pickering, C. Baker, G. Overturf, C. Prober (Eds) Red Book 2006: Report of the Committee on Infectious Diseases 27th ed. Elk Grove Village, IL: American Academy of Pediatrics 560-566.
15. American Academy of Pediatrics, Committee on Infectious Diseases (1998) Prevention of respiratory syncytial virus infections: Indications for use of palivizumab and update on the use of RSV-IVIG. Pediatrics 102 1211-1216.
16. American Academy of Pediatrics, Subcommittee on Diagnosis and Management of Bronchiolitis (2006) Diagnosis and management of bronchiolitis. Pediatrics 118 1774-1793.
17. N.G. Anas, C. Boettrich, C.B. Hall and J.G. Brooks (1982) The association of apnea and respiratory syncytial virus infection in infants. J. Pediatr. 101 65-68.
18. Anderson, L. J.: Burden of RSV disease in the elderly. Respiratory Syncytial Virus in the Elderly Aventis Pasteur Symposium, Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAPC) Toronto, 2000.
19. L.J. Anderson (2001) Respiratory syncytial virus vaccines for otitis media. Vaccine 19(Suppl.), S59-S65.
20. L.J. Anderson, R.M. Hendry, L.T. Pierik, et al. (1991) Multicenter study of strains of respiratory syncytial virus. J. Infect. Dis. 163 687-692.
21. L.J. Anderson, C. Tsou, C. Potter, et al. (1994) Cytokine response to respiratory syncytial virus stimulation of human peripheral blood mononuclear cells. J. Infect. Dis. 170 1201-1208.
22. J. Arbiza, M. Berois, A. Delfraro, et al. (2006) Genetic characterization of respiratory syncytial viruses isolated from consecutive acute respiratory infections in a HIV infected child. J. Clin. Virol. 35 41-45.
23. M. Arola, M. Ziegler and O. Ruuskanen (1990) Respiratory virus infection as a cause of prolonged symptoms in acute otitis media. J. Pediatr. 116 697-701.
24. V.R. Bachrach, E. Schwarz and L.R. Bachrach (2003) Breastfeeding and the risk of hospitalization for respiratory disease in infancy: A meta-analysis. Arch. Pediatr. Adolesc. Med. 157 237-243.
25. A.C. Bairan, J.D. Cherry, L.F. Fagan and J.R. Codd (1974) Complete heart block and respiratory syncytial virus. Am. J. Dis. Child. 127 264-265.
26. T.M. Ball, J.A. Castro-Rodriguez, K.A. Griffith, et al. (2000) Siblings, day-care attendance, and the risk of asthma and wheezing during childhood. N. Engl. J. Med. 343 538-543.
27. C.E. Behrendt, M.D. Decker, D.J. Burch and P.H. Watson (1998) International variation in the management of infants hospitalized with respiratory syncytial virus. Eur. J. Pediatr. 157 215-220.
28. S. Berman (1991) Epidemiology of acute respiratory infections in children of developing countries. Rev. Infect. Dis. 13(Suppl.), S454-S462.
29. M. Boeckh, J. Englund, Y. Li, et al. (2007) Randomized controlled multicenter trial of aerosolized ribavirin for respiratory syncytial virus upper respiratory tract infection in hematopoietic cell transplant recipients. Clin. Infect. Dis. 44 245-249.
30. L. Bont, C.J. Heijnen, A. Kavelaara, et al. (2000) Monocyte IL-10 production during respiratory syncytial virus bronchiolitis is associated with recurrent wheezing in a one-year follow-up study. Am. J. Respir. Crit. Care Med. 161 1518-1523.
31. L. Bont, J. Versteegh, W.T. Swelsen, et al. (2002) Natural reinfection with respiratory syncytial virus does not boost virus-specific T-cell immunity. Pediatr. Res. 52 363-367.
32. R.A. Bowden (1997) Respiratory virus infection after marrow transplant: The Fred Hutchingson Cancer Research Center experience. Am. J. Med. 102 27-30.
33. J.M. Boyce, D. Pittet, Healthcare Infection Control Practices Advisory Committee, et al. (2002) Guideline for hand hygiene in health-care settings: Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. Infect. Control. Hosp. Epidemiol. 23(Suppl.), S3-S40.
34. T.G. Boyce, B.G. Mellen, E.F. Mitchel Jr., et al. (2000) Rates of hospitalization for respiratory syncytial virus infection among children in Medicaid. J. Pediatr. 137 865-870.
35. A.H. Brandenburg, L. de Waal, H.H. Timmerman, et al. (2000) HLA class I-restricted cytotoxic T-cell epitopes of the respiratory syncytial virus fusion protein. J. Virol. 74 10240-10244.
36. A.H. Brandenburg, R. van Beek, H.A. Moll, et al. (2000) G protein variation in respiratory syncytial virus group A does not correlate with clinical severity. J. Clin. Microbiol. 38 2849-2852.
37. C.D. Brandt, H.W. Kim, J.O. Arrobio, et al. (1973) Epidemiology of respiratory syncytial virus infection in Washington, DC. III. Composite analysis of eleven consecutive yearly epidemics. Am. J. Epidemiol. 98 355-364.
38. T. Briese, G. Palacios, M. Kokoris, et al. (2005) Diagnostic system for rapid and sensitive differential detection of pathogens. Emerg. Infect. Dis. 11 310-313.
39. A.M. Brooks, J.T. McBride, K.M. McConnochie, et al. (1999) Predicting deterioration in previously healthy infants hospitalized with respiratory syncytial virus infection. Pediatrics 104 463-467.
40. F.W. Bruhn, S.T. Mokrohisky and K. McIntosh (1977) Apnea associated with respiratory syncytial virus infection in young infants. J. Pediatr. 90 382-386.
41. A. Bukreyev, I.M. Belyakov, G.A. Prince, et al. (2005) Expression of interleukin-4 by recombinant respiratory syncytial virus is associated with accelerated inflammation and a nonfunctional cytotoxic T-lymphocyte response following primary infection but not following challenge with wild-type virus. J. Virol. 79 9515-9526.
42. L.G. Byrd and G.A. Prince (1997) Animal models of respiratory syncytial virus infection. Clin. Infect. Dis. 25 1363-1368.
43. P.A. Cane, H.M. Thomas, A.F. Simpson, et al. (1996) Analysis of the human serological immune response to a variable region of the attachment (G) protein of respiratory syncytial virus during primary infection. J. Med. Virol. 48 253-261.
44. M.J. Cannon, P.J.M. Openshaw and B.A. Askonas (1988) Cytotoxic T cells clear virus but augment lung pathology in mice infected with respiratory syncytial virus. J. Exp. Med. 163 1163-1168.
45. X. Carbonell-Estrany, J. Figueras-Aloy and B.J. Law (2004) Identifying risk factors for severe respiratory syncytial virus among infants born after 33 through 35 completed weeks of gestation: Different methodologies yield consistent findings. Pediatr. Infect. Dis. J. 23(Suppl.), S193-S201.
46. Carbonell-Estrany, X., Genevieve, L., Micki, H., and Edward, C.: Phase 3 trial of motavizumab (MEDI-524), an enhanced potency repiratory syncytial virus (RSV)–specific monoclonal antibody (Mab) for the prevention of serious RSV disease in high-risk infants. 2007 PAS meeting, 2007.
47. S. Cardenas, A. Auais and G. Piedimonte (2005) Palivizumab in the prophylaxis of respiratory syncytial virus infection. Expert Rev. Anti. Infect. Ther. 3 719-726.
48. Centers for Disease Control and Prevention: The 2003 CDC Infection Control Guideline Digest. Atlanta, Centers for Disease Control and Prevention, 2003, pp. 1-66.
49. Centers for Disease Control and Prevention: National Respiratory and Enteric Virus Surveillance System (NREVSS), 2006. Available at http://www.cdc.gov/ncidod/dvrd/revb/nrevss/index.htm.
50. Centers for Disease Control and Prevention (2006) Quick stats: Percentage of infants born during 1990-1993 and 1997-2000 who were ever breastfed, by race/ethnicity of mother—United States. M. M. W. R. Morb. Mortal. Wkly. Rep. 55 1155.
51. J.A. Cesar, C.G. Victora, F.C. Barros, et al. (1999) Impact of breast feeding on admission for pneumonia during postneonatal period in Brazil: Nested case-control study. BMJ 318 1316-1320.
52. R.E. Champlin and E. Whimbey (2001) Community respiratory virus infections in bone marrow transplant recipients: The M.D. Anderson Cancer Center experience. Biol. Blood Marrow Transplant. 7(Suppl.), 8S-10S.
53. A. Chandra, G.M. Martinez, W.D. Mosher, et al. (2005) Fertility, family planning, and reproductive health of U.S. women: Data from the 2002 National Survey of Family Growth. Vital Health Stat 23 1-160.
54. S. Chandwani, W. Borkowsky, K. Krasinski, et al. (1990) Respiratory syncytial virus infection in human immunodeficiency virus–infected children. J. Pediatr. 117 251-254.
55. J. Chang, S.Y. Choi, H.T. Jin, et al. (2004) Improved effector activity and memory CD8 T cell development by IL-2 expression during experimental respiratory syncytial virus infection. J. Immunol. 172 503-508.
56. J. Chang, A. Srikiatkhachorn and T.J. Braciale (2001) Visualization and characterization of respiratory syncytial virus F-specific CD8(+) T cells during experimental virus infection. J. Immunol. 167 4254-4260.
57. R.M. Chanock (1970) Control of acute mycoplasmal and viral respiratory tract disease. Science 169 248-256.
58. R.M. Chanock and L. Finberg (1957) Recovery from infants with respiratory illness of a virus related to chimpanzee coryza agent (CCA). II. Epidemiologic aspects of infection in infants and young children. Am. J. Hyg. 66 291-300.
59. R.M. Chanock, H.W. Kim, A.J. Vargosko, et al. (1961) Respiratory syncytial virus. I. Virus recovery and other observations during 1960 outbreak of bronchiolitis pneumonia, and minor respiratory diseases in children. JAMA 176 647-653.
60. A.H. Cherrie, K. Anderson, G.W. Wertz and P.J.M. Openshaw (1992) Human cytotoxic T cells stimulated by antigen on dendritic cells recognize the N, SH, F, M, 22K, and 1b proteins of respiratory syncytial virus. J. Virol. 66 2102-2110.
61. B. Chi, H.L. Dickensheets, K.M. Spann, et al. (2006) Alpha and lambda interferon together mediate suppression of CD4 T cells induced by respiratory syncytial virus. J. Virol. 80 5032-5040.
62. Y. Chiba, Y. Higashidato, K. Suga, et al. (1989) Development of cell-mediated cytotoxic immunity to respiratory syncytial virus in human infants following naturally acquired infection. J. Med. Virol. 28 133-139.
63. J. Chin, R.L. Magoffin and L.A. Shearer (1969) Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a pediatric population. Am. J. Epidemiol. 89 449-463.
64. E.H. Choi, H.J. Lee, T. Yoo and S.J. Chanock (2002) A common haplotype of interleukin-4 gene IL4 is associated with severe respiratory syncytial virus disease in Korean children. J. Infect. Dis. 186 1207-1211.
65. K.S. Choi, D.G. Scorpio and J.S. Dumler (2004) Anaplasma phagocytophilum ligation to Toll-like receptor (TLR) 2, but not to TLR4, activates macrophages for nuclear factor-kappa B nuclear translocation. J. Infect. Dis. 189 1921-1925.
66. N.R. Church, N.G. Anas, C.B. Hall and JG. Brooks (1984) Respiratory syncytial virus–related apnea in infants: Demographics and outcome. Am. J. Dis. Child. 138 247-250.
67. G. Cilla, A. Sarasua, M. Montes, et al. (2006) Risk factors for hospitalization due to respiratory syncytial virus infection among infants in the Basque Country, Spain. Epidemiol. Infect. 134 506-513.
68. Cincinnati Children's Hospital Medical Center: Evidence Based Clinical Practice Guideline for Bronchiolitis in Infants 1 Year of Age or Less, 2001. Available at http://www.cincinnatichildrens.org/NR/rdonlyres/FAC539F9-07B2-4FE4-A9DD-EC1013BBE64B/0/BronchGL.pdf.
69. S.E. Coffin, K.L. Gest and A. Shimamura (1993) Respiratory syncytial virus as a cause of fever and petechiae in infants. Clin. Pediatr. 32 355-356.
70. P.L. Collins, R.M. Chanock, B.R. Murphy (2006) Respiratory syncytial virus and metapneumoviruses. D. Knipe, P. Howley, D. Griffin, et al., (Eds) Fields Virology 5th ed. Philadelphia: Lippincott Williams & Wilkins 1601-1646.
71. S. Cooper, H. Lyall, S. Walters, et al. (2004) Children with human immunodeficiency virus admitted to a paediatric intensive care unit in the United Kingdom over a 10-year period. Intensive Care Med. 30 113-118.
72. H.M. Corneli, J.J. Zorc, P. Mahajan, et al. (2007) A multicenter, randomized, controlled trial of dexamethasone for bronchiolitis. N. Engl. J. Med. 357 331-339.
73. R.B. Couch, J.A. Englund and E. Whimbey (1997) Respiratory viral infections in immunocompetent and immunocompromised persons. Am. J. Med. 102 2-9.
74. B.N. Crooks, C.E. Taylor, A.J. Turner, et al. (2000) Respiratory viral infections in primary immune deficiencies: Significance and relevance to clinical outcome in a single BMT unit. Bone Marrow Transplant 26 1097-1102.
75. J.E. Crowe (2002) Respiratory syncytial virus vaccine development. Vaccine 20(Suppl.), S32-S37.
76. J.E. Crowe Jr., C.Y. Firestone and B.R. Murphy (2001) Passively acquired antibodies suppress humoral but not cell-mediated immunity in mice immunized with live attenuated respiratory syncytial virus vaccines. J. Immunol. 167 3910-3918.
77. P. Csonka, M. Kaila, P. Laippala, et al. (2003) Oral prednisolone in the acute management of children age 6 to 35 months with viral respiratory infection-induced lower airway disease: A randomized, placebo-controlled trial. J. Pediatr. 143 725-730.
78. F.J. Culley, A.M. Pennycook, J.S. Tregoning, et al. (2006) Differential chemokine expression following respiratory virus infection reflects Th1- or Th2-biased immunopathology. J. Virol. 80 4521-4527.
79. P.M. de Graaff, E.C. de Jong, T.M. van Capel, et al. (2005) Respiratory syncytial virus infection of monocyte-derived dendritic cells decreases their capacity to activate CD4 T cells. J. Immunol. 175 5904-5911.
80. J.P. DeVincenzo (2000) Pre-emptive ribavirin for “RSV” in BMT. Bone Marrow Transplant 26 113.
81. J.P. DeVincenzo (2005) Factors predicting childhood respiratory syncytial virus severity: What they indicate about pathogenesis. Pediatr. Infect. Dis. J. 24(Suppl.), S177-S183.
82. J.P. DeVincenzo, C.B. Hall, D.W. Kimberlin, et al. (2004) Surveillance of clinical isolates of respiratory syncytial virus for palivizumab (Synagis)–resistant mutants. J. Infect. Dis. 190 975-978.
83. J.P. DeVincenzo, C.M. El Saleeby and A.J. Bush (2005) Respiratory syncytial virus load predicts disease severity in previously healthy infants. J. Infect. Dis. 191 1861-1868.
84. R.K. Ditchburn, J. McQuillin, P.S. Gardner and S.D. Court (1971) Respiratory syncytial virus infection in hospital cross-infection. Br. Med. J. 3 671-673.
85. J.B. Domachowske, C.A. Bonville and H.F. Rosenberg (2004) Animal models for studying respiratory syncytial virus infection and its long term effects on lung function. Pediatr. Infect. Dis. J. 23(Suppl.), S228-S234.
86. S.F. Dowell, L.J. Anderson, H.E. Gary, et al. (1996) Respiratory syncytial virus is an important cause of community-acquired lower respiratory infection among hospitalized adults. J. Infect. Dis. 174 456-462.
87. J.E. Durbin and R.K. Durbin (2004) Respiratory syncytial virus–induced immunoprotection and immunopathology. Viral Immunol. 17 370-380.
88. D. Edell, V. Khoshoo, G. Ross and K. Salter (2002) Early ribavirin treatment of bronchiolitis: Effect on long-term respiratory morbidity. Chest 122 935-939.
89. W. Eder, M.J. Ege and E. von Mutius (2006) The asthma epidemic. N. Engl. J. Med. 355 2226-2235.
90. N.O. Elhassan, M.E. Sorbero, C.B. Hall, et al. (2006) Cost-effectiveness analysis of palivizumab in premature infants without chronic lung disease. Arch. Pediatr. Adolesc. Med. 160 1070-1076.
91. J.A. Englund, L.J. Anderson and F.S. Rhame (1991) Nosocomial transmission of respiratory syncytial virus in immunocompromised adults. J. Clin. Microbiol. 29 115-119.
92. J.A. Englund, J.A. Englund, P.A. Piedra, L.S. Jefferson, et al. (1990) High-dose, short-duration ribavirin aerosol therapy in children with suspected respiratory syncytial virus infection. J. Pediatr. 117 313-320.
93. J.A. Englund, P.A. Piedra and E. Whimbey (1997) Prevention and treatment of respiratory syncytial virus and parainfluenza viruses in immunocompromised patient. Am. J. Med. 102 61-70.
94. V. Erard, J.W. Chien, H.W. Kim, et al. (2006) Airflow decline after myeloablative allogeneic hematopoietic cell transplantation: The role of community respiratory viruses. J. Infect. Dis. 193 1619-1625.
95. M. Eriksson, R. Bennet, M. Rotzen-Ostlund, et al. (2002) Population-based rates of severe respiratory syncytial virus infection in children with and without risk factors, and outcome in a tertiary care setting. Acta Paediatr. 91 593-598.
96. M.L. Everard (2006) The relationship between respiratory syncytial virus infections and the development of wheezing and asthma in children. Curr. Opin. Allergy Clin. Immunol. 6 56-61.
97. A.R. Falsey and E.E. Walsh (1997) Safety and immunogenicity of a respiratory syncytial virus subunit vaccine (PFP-2) in the institutionalized elderly. Vaccine 15 1130-1132.
98. A.R. Falsey and E.E. Walsh (2000) Respiratory syncytial virus infections in adults. Clin. Microbiol. Rev. 13 371-384.
99. A.R. Falsey and E.E. Walsh (2006) Respiratory syncytial virus infection in elderly adults. Drugs Aging 22 577-587.
100. A.R. Falsey, M.A. Formica, J.J. Treanor and E.E. Walsh (2003) Comparison of quantitative reverse transcription-PCR to viral culture for assessment of respiratory syncytial virus shedding. J. Clin. Microbiol. 41 4160-4165.
101. A.R. Falsey, P.A. Hennessey, M.A. Formica, et al. (2005) Respiratory syncytial virus infection in elderly and high-risk adults. N. Engl. J. Med. 352 1749-1759.
102. T. Farha and A.H. Thomson (2005) The burden of pneumonia in children in the developed world. Paediatr. Respir. Rev. 6 76-82.
103. B.F. Fernie and J.L. Gerin (1980) The stabilization and purification of respiratory syncytial virus using MgSO 4. Virology 106 141-144.
104. C.M. Field, J.H. Connolly, G. Murtagh, et al. (1966) Antibiotic treatment of epidemic bronchiolitis: A double-blind trial. Br. Med. J. 1 83-85.
105. H.O. Fjaerli, T. Farstad and D. Bratlid (2004) Hospitalisations for respiratory syncytial virus bronchiolitis in Akershus, Norway, 1993-2000: A population-based retrospective study. BMC Pediatr. 25 1-7.
106. D.M. Fleming, R.S. Pannell and K.W. Cross (2005) Mortality in children from influenza and respiratory syncytial virus. J. Epidemiol. Community Health 59 586-590.
107. J. Forster, G. Ihorst, C.H. Rieger, et al. (2004) Prospective population-based study of viral lower respiratory tract infections in children under 3 years of age (the PRIDE study). Eur. J. Pediatr. 163 709-716.
108. B. Friis, P. Andersen, E. Brenoe, et al. (1984) Antibiotic treatment of pneumonia and bronchiolitis: A prospective randomised study. Arch. Dis. Child. 59 1038-1045.
109. B. Friis, M. Eiken, A. Hornsleth and A. Jensen (1990) Chest x-ray appearances in pneumonia and bronchiolitis. Acta Paediatr. Scand. 79 219-225.
110. V.A. Fulginiti, J.J. Eller, O.F. Sieber, et al. (1969) Respiratory virus immunization. I. A field trial of two inactivated respiratory virus vaccines, an aqueous trivalent parainfluenza virus vaccine, and an alum-precipitated respiratory syncytial virus vaccine. Am. J. Epidemiol. 89 435-448.
111. D.G. Fuller, G. Davie, D. Lamb, et al. (2005) Analysis of respiratory viral coinfection and cytomegalovirus coisolation in pediatric inpatients. Pediatr. Infect. Dis. J. 24 195-200.
112. C.L. Gala, C.B. Hall, K.C. Schnabel, et al. (1986) The use of eye-nose goggles to control nosocomial respiratory syncytial virus infection. JAMA 256 2706-2708.
113. M.C. Galiano, C. Palomo, C.M. Videla, et al. (2005) Genetic and antigenic variability of human respiratory syncytial virus (groups a and b) isolated over seven consecutive seasons in Argentina (1995 to 2001). J. Clin. Microbiol. 43 2266-2273.
114. P.S. Gardner, S.D.M. Court, J.T. Brocklebank, et al. (1973) Virus cross-infection in paediatric wards. Br. Med. J. 2 571-575.
115. R.P. Garofalo, J. Patti, K.A. Hintz, et al. (2001) Macrophage inflammatory protein-1a (not T helper type 2 cytokines) is associated with severe forms of respiratory syncytial virus bronchiolitis. J. Infect. Dis. 184 393-399.
116. M. Garrison, D.A. Christakis, E. Harvey, et al. (2000) Systemic corticosteroids in infant bronchiolitis: A meta-analysis. Pediatrics 105 e44.
117. L.M. Gartner, J. Morton, R.A. Lawrence, et al. (2005) Breastfeeding and the use of human milk. Pediatrics 115 496-506.
118. E.L. Gasparetto, D.L. Escuissato, E. Marchiori, et al. (2004) High-resolution CT findings of respiratory syncytial virus pneumonia after bone marrow transplantation. A. J. R. Am. J. Roentgenol. 182 1133-1137.
119. D.A. Gentile, W.J. Doyle, A. Zeevi, et al. (2003) Cytokine gene polymorphisms moderate illness severity in infants with respiratory syncytial virus infection. Hum. Immunol. 64 338-344.
120. J.E. Gern, L.A. Rosenthal, R.L. Sorkness and R.F. Lemanske Jr. (2005) Effects of viral respiratory infections on lung development and childhood asthma. J. Allergy Clin. Immunol. 115 668-674.
121. B.D. Gessner (2000) The cost-effectiveness of a hypothetical respiratory syncytial virus vaccine in the elderly. Vaccine 18 1485-1494.
122. T.D. Giles and R.S. Gohd (1976) Respiratory syncytial virus and heart disease. JAMA 236 1128-1130.
123. W.P. Glezen (1983) Viral pneumonia as a cause and result of hospitalization. J. Infect. Dis. 4 765-770.
124. W.P. Glezen (2004) The changing epidemiology of respiratory syncytial virus and influenza: Impetus for new control measures. Pediatr. Infect. Dis. J. 23(Suppl.), S202-S206.
125. W.P. Glezen and F.W. Denny (1973) Epidemiology of acute lower respiratory disease in children. N. Engl. J. Med. 288 498-505.
126. W.P. Glezen, S.B. Greenberg, R.L. Atmar, et al. (2000) Impact of respiratory virus infections on persons with chronic underlying conditions. JAMA 283 499-505.
127. W.P. Glezen, A. Paredes, J.E. Allison, et al. (1981) Risk of respiratory syncytial virus infection for infants from low-income families in relationship to age, sex, ethnic group, and maternal antibody level. J. Pediatr. 98 708-715.
128. W.P. Glezen, L.H. Taber, A.L. Frank and J.A. Kasel (1986) Risk of primary infection and reinfection with respiratory syncytial virus. Am. J. Dis. Child. 140 543-546.
129. D.A. Goldmann (1992) Transmission of infectious diseases in children. Pediatr. Rev. 13 283-294.
130. D.A. Goldmann (2000) Transmission of viral respiratory infections in the home. Pediatr. Infect. Dis. J. 19(Suppl.), S97-S102.
131. D.A. Goldmann (2001) Epidemiology and prevention of pediatric viral respiratory infections in health-care institutions. Emerg. Infect. Dis. 7 249-253.
132. B.S. Graham, L.A. Bunton, P.F. Wright and D.T. Karzon (1991) Reinfection of mice with respiratory syncytial virus. J. Med. Virol. 34 7-13.
133. B.S. Graham, L.A. Bunton, P.F. Wright and D.T. Karzon (1991) Role of T lymphocyte subsets in the pathogenesis of primary infection and rechallenge with respiratory syncytial virus in mice. J. Clin. Invest. 88 1026-1033.
134. B.S. Graham, G.S. Henderson, Y.W. Tang, et al. (1993) Priming immunization determines T helper cytokine mRNA expression patterns in lungs of mice challenged with respiratory syncytial virus. J. Immunol. 151 2032-2040.
135. B.S. Graham, T.R. Johnson and R.S. Peebles (2000) Immune-mediated disease pathogenesis in respiratory syncytial virus infection. Immunopharmacology 48 237-247.
136. B.S. Graham, M.D. Perkins, P.F. Wright and D.T. Karzon (1988) Primary respiratory syncytial virus infection in mice. J. Med. Virol. 26 153-162.
137. H.B. Greenberg and P.A. Piedra (2004) Immunization against viral respiratory disease: A review. Pediatr. Infect. Dis. J. 23(Suppl.), S254-S261.
138. D.S. Greenes and M.B. Harper (1999) Low risk of bacteremia in febrile children with recognizable viral syndromes. Pediatr. Infect. Dis. J. 18 258-261.
139. J.R. Groothuis, S.J. King, DA Hogerman, et al. (1998) Safety and immunogenicity of a purified F protein respiratory syncytial virus (PFP-2) vaccine in seropositive children with bronchopulmonary dysplasia. J. Infect. Dis. 177 467-469.
140. J.R. Groothuis, E.A.F. Simoes, M.J. Levin, et al. (1993) Prophylactic administration of respiratory syncytial virus immune globulin to high-risk infants and young children. N. Engl. J. Med. 329 1524-1530.
141. D.J. Groskreutz, M.M. Monick, L.S. Powers, et al. (2006) Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double-stranded RNA responsiveness in airway epithelial cells. J. Immunol. 176 1733-1740.
142. A. Guerrero-Plata, A. Casola, G. Suarez, et al. (2006) Differential response of dendritic cells to human metapneumovirus and respiratory syncytial virus. Am. J. Respir. Cell Mol. Biol. 34 320-329.
143. H.A. Haeberle, R. Takizawa, A. Casola, et al. (2002) Respiratory syncytial virus–induced activation of nuclear factor-κ B in the lung involves alveolar macrophages and Toll-like receptor 4–dependent pathways. J. Infect. Dis. 186 1199-1206.
144. N.B. Halasa, J.V. Williams, G.J. Wilson, et al. (2005) Medical and economic impact of a respiratory syncytial virus outbreak in a neonatal intensive care unit. Pediatr. Infect. Dis. J. 24 1040-1044.
145. C.B. Hall (1977) The shedding and spreading of respiratory syncytial virus. Pediatr. Res. 11 236-239.
146. C.B. Hall (2000) Nosocomial respiratory syncytial virus infections: The “cold war” has not ended. Clin. Infect. Dis. 31 590-596.
147. C.B. Hall (2000) Respiratory syncytial virus: Microbe for all ages, mimic of maladies many. W. Scheld, W. Craig, J. Hughes (Eds) Emerging Infections 4 Washington, D.C.: ASM Press 1-15.
148. C.B. Hall (2000) Respiratory syncytial viral infections: Pathology and pathogenicity. L. Weisman, J. Groothuis (Eds) Contemporary Diagnosis and Management of Respiratory Syncytial Virus Infection 5th ed. Newtown, PA: Handbooks in Health Care 72-93.
149. C.B. Hall (2001) Respiratory syncytial virus and parainfluenza virus. N. Engl. J. Med. 344 1917-1928.
150. C.B. Hall (2001) Respiratory syncytial virus infections in previously healthy working adults. Clin. Infect. Dis. 33 792-796.
151. C.B. Hall and R.G. Douglas Jr. (1975) Clinically useful method for the isolation of respiratory syncytial virus. J. Infect. Dis. 131 1-5.
152. C.B. Hall and R.G. Douglas Jr. (1976) Respiratory syncytial virus and influenza: Practical community surveillance. Am. J. Dis. Child. 130 615-620.
153. C.B. Hall and R.G. Douglas Jr. (1981) Modes of transmission of respiratory syncytial virus. J. Pediatr. 99 100-103.
154. C.B. Hall and R.G. Douglas Jr. (1981) Nosocomial respiratory syncytial virus infections: The role of gowns and masks on prevention. Am. J. Dis. Child. 135 512-516.
155. C.B. Hall, R.G. Douglas Jr., J.M. Geiman and M.K. Messner (1975) Nosocomial respiratory syncytial virus infections. N. Engl. J. Med. 293 1343-1346.
156. C.B. Hall, R.G. Douglas Jr. and J.M. Geiman (1975) Quantitative shedding patterns of respiratory syncytial virus in infants. J. Infect. Dis. 132 151-156.
157. C.B. Hall, R.G. Douglas Jr. and J.M. Geiman (1976) Respiratory syncytial virus infections in infants: Quantitation and duration of shedding. J. Pediatr. 89 11-15.
158. C.B. Hall, R.G. Douglas Jr., K.C. Schnabel and J.M. Geiman (1981) Infectivity of respiratory syncytial virus by various routes of inoculation. Infect. Immun. 33 779-783.
159. C.B. Hall, R.G. Douglas Jr., R.L. Simons and J.M. Geiman (1978) Interferon production in children with respiratory syncytial, influenza, and parainfluenza virus infections. J. Pediatr. 93 28-32.
160. C.B. Hall, R.G. Douglas Jr. and R.L. Simons (1981) Interferon production in adults with respiratory syncytial viral infection. Ann. Intern. Med. 94 53-55.
161. C.B. Hall, J.M. Geiman, R. Biggar, et al. (1976) Respiratory syncytial virus infections within families. N. Engl. J. Med. 294 414-419.
162. C.B. Hall, J.M. Geiman and R.G. Douglas Jr. (1980) Possible transmission by fomites of respiratory syncytial virus. J. Infect. Dis. 141 98-102.
163. C.B. Hall, W.J. Hall and D.M. Speers (1979) Clinical and physiological manifestations of bronchiolitis and pneumonia: Outcome of respiratory syncytial virus. Am. J. Dis. Child. 133 798-802.
164. C.B. Hall, A. Kopelman and R.G. Douglas (1979) Neonatal respiratory syncytial viral infections. N. Engl. J. Med. 300 393-396.
165. C.B. Hall, K.R. Powell, N.E. MacDonald, et al. (1986) Respiratory syncytial virus infection in children with compromised immune function. N. Engl. J. Med. 315 77-81.
166. C.B. Hall, K.R. Powell, K.C. Schnabel, et al. (1988) Risk of secondary bacterial infection in infants hospitalized with respiratory syncytial viral infection. J. Pediatr. 113 266-271.
167. C.B. Hall, E.E. Walsh, C.E. Long and K.C. Schnabel (1991) Immunity to and frequency of reinfection with respiratory syncytial virus. J. Infect. Dis. 163 693-698.
168. C.B. Hall, E.E. Walsh, K.C. Schnabel, et al. (1990) Occurrence of groups A and B of respiratory syncytial virus over 15 years: Associated epidemiologic and clinical characteristics in hospitalized and ambulatory children. J. Infect. Dis. 162 1283-1290.
169. Hall, C. B., Weinberg, G. A., Iwane, M. K., et al.: The burden of respiratory syncytial virus infection among healthy children. N. Engl. J. Med. In Press.
170. W.J. Hall, C.B. Hall and D.M. Speers (1978) Respiratory syncytial virus infections in adults: Clinical, virologic, and serial pulmonary function studies. Ann. Intern. Med. 88 203-205.
171. M.H. Hambling (1964) Survival of the respiratory syncytial virus during storage under various conditions. Br. J. Exp. Pathol. 45 647-655.
172. B. Hammond, Y. Ali, E. Fendler, et al. (2000) Effect of hand sanitizer use on elementary school absenteeism. Am. J. Infect. Control 28 340-346.
173. L.L. Han, J.P. Alexander and L.J. Anderson (1999) Respiratory syncytial virus pneumonia among the elderly: An assessment of disease burden. J. Infect. Dis. 179 25-30.
174. J. Harcourt, R. Alvarez, L.P. Jones, et al. (2006) Respiratory syncytial virus G protein and G protein CX3C motif adversely affect CX3CR1 + T cell responses. J. Immunol. 176 1600-1608.
175. L.M. Haynes, D.D. Moore, E. Kurt-Jones, et al. (2001) Involvement of Toll-like receptor 4 in innate immunity to respiratory syncytial virus. J. Virol. 75 10730-10737.
176. A.T. Heerens, D.D. Marshall and C.L. Bose (2002) Nosocomial respiratory syncytial virus: A threat in the modern neonatal intensive care unit. J. Perinatol. 22 306-307.
177. J. Heidema, G.J. de Bree, P.M. De Graaff, et al. (2004) Human CD8(+) T cell responses against five newly identified respiratory syncytial virus–derived epitopes. J. Gen. Virol. 85 2365-2374.
178. T. Heikkinen and T. Chonmaitree (2003) Importance of respiratory viruses in acute otitis media. Clin. Microbiol. Rev. 16 230-241.
179. T. Heikkinen, J. Marttila, A.A. Salmi and O. Ruuskanen (2002) Nasal swab versus nasopharyngeal aspirate for isolation of respiratory viruses. J. Clin. Microbiol. 40 4337-4339.
180. C.A. Heilman (1990) Respiratory syncytial and parainfluenza viruses. J. Infect. Dis. 161 402-406.
181. A. Heinzmann, I. Ahlert, T. Kurz, et al. (2004) Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma and respiratory syncytial virus bronchiolitis. J. Allergy Clin. Immunol. 114 671-676.
182. F.W. Henderson, W.A. Clyde Jr., A.M. Collier, et al. (1979) The etiologic and epidemiologic spectrum of bronchiolitis in pediatric practice. J. Pediatr. 95 183-190.
183. F.W. Henderson, A.M. Collier, W.A. Clyde and F.W. Denny (1979) Respiratory syncytial virus infections, reinfections and immunity: A prospective, longitudinal study in young children. N. Engl. J. Med. 300 530-534.
184. J. Henderson, T.N. Hilliard, A. Sherriff, et al. (2005) Hospitalization for RSV bronchiolitis before 12 months of age and subsequent asthma, atopy and wheeze: A longitudinal birth cohort study. Pediatr. Allergy Immunol. 16 386-392.
185. R.M. Hendry, J.C. Burns, E.E. Walsh, et al. (1988) Strain-specific serum antibody responses in infants undergoing primary infection with respiratory syncytial virus. J. Infect. Dis. 157 640-647.
186. K.J. Henrickson (2004) Advances in the laboratory diagnosis of viral respiratory disease. Pediatr. Infect. Dis. J. 23(Suppl.), S6-S10.
187. P.W. Heymann, T.A. Platts-Mills and S.L. Johnston (2005) Role of viral infections, atopy and antiviral immunity in the etiology of wheezing exacerbations among children and young adults. Pediatr. Infect. Dis. J. 24(Suppl.), S217-S222.
188. B. Hoebee, L. Bont, E. Rietveld, et al. (2004) Influence of promoter variants of interleukin-10, interleukin-9, and tumor necrosis factor-alpha genes on respiratory syncytial virus bronchiolitis. J. Infect. Dis. 189 239-247.
189. C.J. Holberg, A.L. Wright, F.D. Martinez, et al. (1991) Risk factors for respiratory syncytial virus–associated lower respiratory illnesses in the first year of life. Am. J. Epidemiol. 133 1135-1151.
190. R.C. Holman, D.K. Shay, A.T. Curns, et al. (2003) Risk factors for bronchiolitis-associated deaths among infants in the United States. Pediatr. Infect. Dis. J. 22 483-490.
191. A. Hornsleth, L. Loland and L.B. Larsen (2001) Cytokines and chemokines in respiratory secretion and severity of disease in infants with respiratory syncytial virus (RSV) infection. J. Clin. Virol. 21 163-170.
192. T.S. Howard, L.H. Hoffman, P.E. Stang and E.A.F. Simoes (2000) Respiratory syncytial virus pneumonia in the hospital setting: Length of stay, charges, and mortality. J. Pediatr. 137 227-232.
193. J. Hull, K. Rowlands, E. Lockhart, et al. (2003) Variants of the chemokine receptor CCR5 are associated with severe bronchiolitis caused by respiratory syncytial virus. J. Infect. Dis. 188 904-907.
194. J. Hull, K. Rowlands, E. Lockhart, et al. (2004) Haplotype mapping of the bronchiolitis susceptibility locus near IL8. Hum. Genet. 114 272-279.
195. T. Hussell, L.C. Spender, A. Gerogiou, et al. (1996) Th1 and Th2 cytokine induction in pulmonary T cells during infection with respiratory syncytial virus. J. Gen. Virol. 77 2447-2455.
196. M. Hyvarinen, E. Piippo-Savolainen, K. Korhonen and M. Korppi (2005) Teenage asthma after severe infantile bronchiolitis or pneumonia. Acta Paediatr. 94 1378-1383.
197. Impact RSV Study Group (1998) Palivizumab, a humanized respiratory syncytial virus monoclonal antibody, reduces hospitalization from respiratory syncytial virus infection in high-risk infants. Pediatrics 102 531-537.
198. Institute of Medicine (1986) The Prospects for Immunizing against Respiratory Syncytial Virus: Institute of Medicine Committee on Issues and Priorities for New Vaccine Development Washington, D.C.: National Academies Press 299-308.
199. D. Isaacs, C.R.M. Bangham and A.J. McMichael (1987) Cell-mediated cytotoxic response to respiratory syncytial virus in infants with bronchiolitis. Lancet 2 769-771.
200. M.K. Iwane, K.M. Edwards, P.G. Szilagyi, et al. (2004) Population-based surveillance for hospitalizations associated with respiratory syncytial virus, influenza virus, and parainfluenza viruses among young children. Pediatrics 113 1758-1764.
201. H.S. Jafri, S. Chavez-Bueno, A. Mejias, et al. (2004) Respiratory syncytial virus induces pneumonia, cytokine response, airway obstruction, and chronic inflammatory infiltrates associated with long-term airway hyperresponsiveness in mice. J. Infect. Dis. 189 1856-1865.
202. A.E. John, C.J. Gerard, M. Schaller, et al. (2005) Respiratory syncytial virus–induced exaggeration of allergic airway disease is dependent upon CCR1-associated immune responses. Eur. J. Immunol. 35 108-116.
203. K.M. Johnson, R.M. Chanock, D. Rifkind, et al. (1961) Respiratory syncytial virus. IV. Correlation of virus shedding, serologic response, and illness in adult volunteer. JAMA 176 663-667.
204. T.R. Johnson, S. Hong, L. Van Kaer, et al. (2002) NK T cells contribute to expansion of CD8(+) T cells and amplification of antiviral immune responses to respiratory syncytial virus. J. Virol. 76 4294-4303.
205. T.R. Johnson, S.E. Mertz, N. Gitiban, et al. (2005) Role for innate IFNs in determining respiratory syncytial virus immunopathology. J. Immunol. 174 7234-7241.
206. T.R. Johnson, S.M. Varga, T.J. Braciale and B.S. Graham (2004) Vbeta14(+) T cells mediate the vaccine-enhanced disease induced by immunization with respiratory syncytial virus (RSV) G glycoprotein but not with formalin-inactivated RSV. J. Virol. 78 8753-8760.
207. C. Johnstone, P. de Leon, F. Medina, et al. (2004) Shifting immunodominance pattern of two cytotoxic T-lymphocyte epitopes in the F glycoprotein of the Long strain of respiratory syncytial virus. J. Gen. Virol. 85 3229-3238.
208. J.S. Kahn (2003) Human metapneumovirus: A newly emerging respiratory pathogen. Curr. Opin. Infect. Dis. 16 255-258.
209. G. Kampf, D. Grotheer and J. Steinmann (2005) Efficacy of three ethanol-based hand rubs against feline calicivirus, a surrogate virus for norovirus. J. Hosp. Infect. 60 144-149.
210. A.Z. Kapikian, R.H. Mitchell, R.M. Chanock, et al. (1969) An epidemiologic study of altered clinical reactivity to respiratory syncytial (RS) virus infection in children previously vaccinated with an inactivated RS virus vaccine. Am. J. Epidemiol. 89 405-421.
211. W. Karmaus and C. Botezan (2002) Does a higher number of siblings protect against the development of allergy and asthma? A review. J. Epidemiol. Community Health 56 209-217.
212. R.A. Karron, D.A. Buonagurio, A.F. Georgiu, et al. (1997) Respiratory syncytial virus (RSV) SH and G proteins are not essential for viral replication in vitro: Clinical evaluation and molecular characterization of a cold-passaged, attenuated RSV subgroup B mutant. Proc. Natl. Acad. Sci. U. S. A. 94 13961-13966.
213. R.A. Karron, P.F. Wright, R.B. Belshe, et al. (2005) Identification of a recombinant live attenuated respiratory syncytial virus vaccine candidate that is highly attenuated in infants. J. Infect. Dis. 191 1093-1104.
214. M. Kattan (1999) Epidemiologic evidence of increased airway reactivity in children with a history of bronchiolitis. J. Pediatr. 135(Suppl.), S8-S13.
215. J.D. Kellner, A. Ohlsson, A.M. Gadomski and E.E. Wang (2000) Bronchodilators for bronchiolitis. Cochrane Database Syst. Rev. 3 CD001266.
216. C.R. Kennedy, K. Chrzanowska, R.O. Robinson, et al. (1986) A major role for viruses in acute childhood encephalopathy. Lancet 1 989-991.
217. D. Kesebir, M. Vazquez, C. Weibel, et al. (2006) Human bocavirus infection in young children in the United States: Molecular epidemiological profile and clinical characteristics of a newly emerging respiratory virus. J. Infect. Dis. 194 1276-1282.
218. V. Khoshoo and D. Edell (1999) Previously healthy infants may have increased risk of aspiration during respiratory syncytial viral bronchiolitis. Pediatrics 104 1389-1390.
219. V. Khoshoo, G. Ross and D. Edell (2002) Effect of interventions during acute respiratory syncytial virus bronchiolitis on subsequent long term respiratory morbidity. Pediatr. Infect. Dis. J. 21 468-472.
220. V. Khoshoo, G. Ross, B. Kelly, et al. (2001) Benefits of thickened feeds in previously healthy infants with respiratory syncytial virus bronchiolitis. Pediatr. Pulmonol. 31 301-302.
221. H.W. Kim, J.O. Arrobio, C.D. Brandt, et al. (1973) Epidemiology of respiratory syncytial virus infection in Washington, D.C. I. Importance of the virus in different respiratory tract disease syndromes and temporal distribution of infection. Am. J. Epidemiol. 98 216-225.
222. H.W. Kim, J.G. Canchola, C.D. Brandt, et al. (1969) Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am. J. Epidemiol. 89 422-434.
223. H.W. Kim, S.L. Leikin, J. Arrobio, et al. (1976) Cell-mediated immunity to respiratory syncytial virus induced by inactivated vaccine or by infection. Pediatr. Res. 10 75-78.
224. J.C. King (1997) Community respiratory viruses in individuals with human immunodeficiency virus infection. Am. J. Med. 102 19-26.
225. V.J. King, M. Viswanathan, W.C. Bordley, et al. (2004) Pharmacologic treatment of bronchiolitis in infants and children: A systematic review. Arch. Pediatr. Adolesc. Med. 158 127-137.
226. M.C. Kneyber, A.H. Brandenburg, R. de Groot, et al. (1998) Risk factors for respiratory syncytial virus associated apnoea. Eur. J. Pediatr. 157 331-335.
227. B. Konig, W. Konig, R. Arnold, et al. (2004) Prospective study of human metapneumovirus infection in children less than 3 years of age. J. Clin. Microbiol. 42 4632-4635.
228. S. Krishnan, M. Halonen and R.C. Welliver (2004) Innate immune responses in respiratory syncytial virus infections. Viral Immunol. 17 220-223.
229. S. Kristjansson, S.P. Bjarnarson, G. Wennergren, et al. (2005) Respiratory syncytial virus and other respiratory viruses during the first 3 months of life promote a local TH2-like response. J. Allergy Clin. Immunol. 116 805-811.
230. A.B. Kulkarni, P.L. Collins, I. Bacik, et al. (1995) Cytotoxic T cells specific for a single peptide on the M2 protein of respiratory syncytial virus are the sole mediators of resistance induced by immunization with M2 encoded by a recombinant vaccinia virus. J. Virol. 69 1261-1264.
231. N. Kuppermann, D.E. Bank, E.A. Walton, et al. (1997) Risks for bacteremia and urinary tract infections in young febrile children with bronchiolitis. Arch. Pediatr. Adolesc. Med. 151 1207-1214.
232. E.A. Kurt-Jones, L. Popova, L. Kwinn, et al. (2000) Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat. Immunol. 1 398-401.
233. A. Laegreid, A.B. Kolsto Otnaess, I. Orstavik and K.H. Carlsen (1986) Neutralizing activity in human milk fractions against respiratory syncytial virus. Acta Paediatr. Scand. 75 696-701.
234. M. Lahti, J. Lofgren, R. Marttila, et al. (2002) Surfactant protein D gene polymorphism associated with severe respiratory syncytial virus infection. Pediatr. Res. 51 696-699.
235. C.D. Lapin, P.W. Hiatt, C. Langston, et al. (1993) A lamb model for human respiratory syncytial virus infection. Pediatr. Pulmonol. 15 151-156.
236. L.E. Larsen (2000) Bovine respiratory syncytial virus (BRSV): A review. Acta Vet. Scand. 41 1-24.
237. S. Leader and K. Kohlhase (2002) Respiratory syncytial virus–coded pediatric hospitalizations, 1997-1999. Pediatr. Infect. Dis. J. 21 629-632.
238. S. Leader and K. Kohlhase (2003) Recent trends in severe respiratory syncytial virus (RSV) among US infants, 1997 to 2000. J. Pediatr. 143(Suppl.), S127-S132.
239. J.M. Leclair, J. Freeman, B.F. Sullivan, et al. (1987) Prevention of nosocomial respiratory syncytial virus infections through compliance with glove and gown isolation precautions. N. Engl. J. Med. 317 329-334.
240. F.E. Lee, E.E. Walsh, A.R. Falsey, et al. (2004) Experimental infection of humans with A2 respiratory syncytial virus. Antiviral Res. 63 191-196.
241. G.M. Lee, J.A. Salomon, J.F. Friedman, et al. (2005) Illness transmission in the home: A possible role for alcohol-based hand gels. Pediatrics 115 852-860.
242. J.P. Legg, I.R. Hussain, J.A. Warner, et al. (2003) Type 1 and type 2 cytokine imbalance in acute respiratory syncytial virus bronchiolitis. Am. J. Respir. Crit. Care Med. 168 633-639.
243. J.P. Legg, J.A. Warner, S.L. Johnston and J.O. Warner (2005) Frequency of detection of picornaviruses and seven other respiratory pathogens in infants. Pediatr. Infect. Dis. J. 24 611-616.
244. R.F. Lemanske (2003) Viruses and asthma: Inception, exacerbation, and possible prevention. J. Pediatr. 142(Suppl.), S3-S8.
245. D.A. Levine, S.L. Platt, P.S. Dayan, et al. (2004) Risk of serious bacterial infection in young febrile infants with respiratory syncytial virus infections. Pediatrics 113 1728-1734.
246. P. Ljungman (1997) Respiratory virus infections in bone marrow transplant recipients: The European perspective. Am. J. Med. 102 44-47.
247. P. Ljungman (2001) Respiratory virus infections in stem cell transplant patients: The European experience. Biol. Blood Marrow Transplant. 7(Suppl.), 5S-7S.
248. M.S. Lo, R.M. Brazas and M.J. Holtzman (2005) Respiratory syncytial virus nonstructural proteins NS1 and NS2 mediate inhibition of Stat2 expression and alpha/beta interferon responsiveness. J. Virol. 79 9315-9319.
249. J. Lofgren, M. Ramet, M. Renko, et al. (2002) Association between surfactant protein A gene locus and severe respiratory syncytial virus infection in infants. J. Infect. Dis. 185 283-289.
250. M.P. Loscertales, A. Roca, P.J. Ventura, et al. (2002) Epidemiology and clinical presentation of respiratory syncytial virus infection in a rural area of southern Mozambique. Pediatr. Infect. Dis. J. 21 148-155.
251. J.K. Louie, J.K. Hacker, R. Gonzales, et al. (2005) Characterization of viral agents causing acute respiratory infection in a San Francisco University Medical Center Clinic during the influenza season. Clin. Infect. Dis. 41 822-828.
252. D.I. Lowell, G. Lister, H. Von Koss and P. McCarthy (1987) Wheezing in infants: The response to epinephrine. Pediatrics 79 939-945.
253. S.A. Lowther, D.K. Shay, R.C. Holman, et al. (2000) Bronchiolitis-associated hospitalizations among American Indian and Alaska Native children. Pediatr. Infect. Dis. J. 19 11-17.
254. M.V. Lukens, E.A. Claassen, P.M. de Graaff, et al. (2006) Characterization of the CD8 + T cell responses directed against respiratory syncytial virus during primary and secondary infection in C57BL/6 mice. Virology 352 157-168.
255. N.E. MacDonald, C.B. Hall, S.C. Suffin, et al. (1982) Respiratory syncytial viral infection in infants with congenital heart disease. N. Engl. J. Med. 307 397-400.
256. S.A. Madhi, L. Kuwanda, C. Cutland and K.P. Klugman (2006) Five-year cohort study of hospitalization for respiratory syncytial virus associated lower respiratory tract infection in African children. J. Clin. Virol. 36 215-221.
257. E.M. Mahabee-Gittens, J. Grupp-Phelan, A.S. Brody, et al. (2005) Identifying children with pneumonia in the emergency department. Clin. Pediatr. (Phila.) 44 427-435.
258. P. Mangtani, S. Hajat, S. Kovats, et al. (2006) The association of respiratory syncytial virus infection and influenza with emergency admissions for respiratory disease in London: An analysis of routine surveillance data. Clin. Infect. Dis. 42 640-646.
259. A. Manning, V. Russell, K. Eastick, et al. (2006) Epidemiological profile and clinical associations of human bocavirus and other human parvoviruses. J. Infect. Dis. 194 1283-1290.
260. P. Margolis and A. Gadomski (1998) The rational clinical examination Does this infant have pneumonia? JAMA 279 308-313.
261. F.D. Martinez (2005) Heterogeneity of the association between lower respiratory illness in infancy and subsequent asthma. Proc. Am. Thorac. Soc. 2 157-161.
262. R. Martino, E. Rámila, N. Rabella, et al. (2003) Respiratory virus infections in adults with hematologic malignancies: A prospective study. Clin. Infect. Dis. 36 1-8.
263. J.G. Mastronarde, B. He, M.M. Monick, et al. (1996) Induction of interleukin (IL)-8 gene expression by respiratory syncytial virus involves activation of nuclear factor (NF)–IL-6. J. Infect. Dis. 174 262-267.
264. J.W. Matheson, F.J. Rich, C. Cohet, et al. (2006) Distinct patterns of evolution between respiratory syncytial virus subgroups A and B from New Zealand isolates collected over thirty-seven years. J. Med. Virol. 78 1354-1364.
265. S.P. Matthews, J.S. Tregoning, A.J. Coyle, et al. (2005) Role of CCL11 in eosinophilic lung disease during respiratory syncytial virus infection. J. Virol. 79 2050-2057.
266. T. Mazzulli, T.C. Peret, A. McGeer, et al. (1999) Molecular characterization of a nosocomial outbreak of human respiratory syncytial virus on an adult leukemia/lymphoma ward. J. Infect. Dis. 180 1686-1689.
267. I.N. Mbawuike, J.M. Wells, R.P. Byrd, et al. (2001) HLA-restricted CD8 + cytotoxic T lymphocyte, interferon-γ, and interleukin-4 responses to respiratory syncytial virus infection in infants and children. J. Infect. Dis. 183 687-696.
268. K. McIntosh (1978) Interferon in nasal secretions from infants with viral respiratory tract infections. J. Pediatr. 93 33-36.
269. K. McIntosh (1991) Pathogenesis of severe acute respiratory infections in the developing world: Respiratory syncytial virus and parainfluenza virus. Rev. Infect. Dis. 13(Suppl.), S492-S500.
270. K. McIntosh (2006) Human bocavirus: Developing evidence for pathogenicity. J. Infect. Dis. 194 1197-1199.
271. K. McIntosh, H.B. Master, I. Orr, et al. (1978) The immunologic response to infection with respiratory syncytial virus in infants. J. Infect. Dis. 138 24-32.
272. J.A. McMillan, D.A. Tristram, L.B. Weiner, et al. (1988) Prediction of the duration of hospitalization in patients with respiratory syncytial virus: Use of clinical parameters. Pediatrics 81 22-26.
273. P.S. McNamara, B.F. Flanagan, C.A. Hart and R.L. Smyth (2005) Production of chemokines in the lungs of infants with severe respiratory syncytial virus bronchiolitis. J. Infect. Dis. 191 1225-1232.
274. H.C. Meissner (2003) Selected populations at increased risk from respiratory syncytial virus infection. Pediatr. Infect. Dis. J. 22(Suppl.), S40-S45.
275. H.C. Meissner, L.J. Anderson and L.K. Pickering (2004) Annual variation in respiratory syncytial virus season and decisions regarding immunoprophylaxis with palivizumab. Pediatrics 114 1082-1084.
276. H.C. Meissner, S.A. Murray, M.A. Kiernan, et al. (1984) A simultaneous outbreak of respiratory syncytial virus and parainfluenza virus type 3 in a newborn nursery. J. Pediatr. 104 680-684.
277. A. Mejias, S. Chavez-Bueno and O. Ramilo (2005) Respiratory syncytial virus pneumonia: Mechanisms of inflammation and prolonged airway hyperresponsiveness. Curr. Opin. Infect. Dis. 18 199-204.
278. E. Melendez and M.B. Harper (2003) Utility of sepsis evaluation in infants 90 days of age or younger with fever and clinical bronchiolitis. Pediatr. Infect. Dis. J. 22 1053-1056.
279. M.C. Mendoza Sanchez, J. Ruiz-Contreras, J.L. Vivanco, et al. (2006) Respiratory virus infections in children with cancer or HIV infection. J. Pediatr. Hematol. Oncol. 28 154-159.
280. I.C. Michelow, K. Olsen, J. Lozano, et al. (2004) Epidemiology and clinical characteristics of community-acquired pneumonia in hospitalized children. Pediatrics 113 701-707.
281. A.L. Miller, T.L. Bowlin and N.W. Lukacs (2004) Respiratory syncytial virus–induced chemokine production: Linking viral replication to chemokine production in vitro and in vivo. J. Infect. Dis. 189 1419-1430.
282. F.W. Moler, A.S. Khan, J.N. Meliones, et al. (1992) Respiratory syncytial virus morbidity and mortality estimates in congenital heart disease patients: A recent experience. Crit. Care Med. 20 1406-1413.
283. A.S. Monto and J.J. Cavallaro (1971) The Tecumseh study of respiratory illness. II. Patterns of occurrence of infection with respiratory pathogens, 1965-1969. Am. J. Epidemiol. 94 280-289.
284. M.L. Moore and R.S. Peebles Jr. (2006) Respiratory syncytial virus disease mechanisms implicated by human, animal model, and in vitro data facilitate vaccine strategies and new therapeutics. Pharmacol. Ther. 112 405-424.
285. J.A. Morris, R.E. Blount and R.E. Savage (1956) Recovery of cytopathogenic agent from chimpanzees with coryza. Proc. Soc. Exp. Biol. Med. 92 544-549.
286. P.M. Muelenaer, F.W. Henderson, V.G. Hemming, et al. (1991) Group-specific serum antibody responses in children with primary and recurrent respiratory syncytial virus infections. J. Infect. Dis. 164 15-21.
287. J.A. Mullins, A.C. LaMonte, J.S. Bresee and L.J. Anderson (2003) Substantial variability in community respiratory syncytial virus season timing. Pediatr. Infect. Dis. J. 22 857-862.
288. F.M. Munoz and J.A. Englund (2001) Vaccines in pregnancy. Infect. Dis. Clin. North Am. 15 253-271.
289. B.R. Murphy and E.E. Walsh (1988) Formalin-inactivated respiratory syncytial virus vaccine induces antibodies to the fusion glycoprotein that are deficient in fusion-inhibiting activity. J. Clin. Microbiol. 26 1595-1597.
290. B.R. Murphy, D.W. Alling, M.H. Snyder, et al. (1986) Effect of age and preexisting antibody on serum antibody response of infants and children to the F and G glycoproteins during respiratory syncytial viral infection. J. Clin. Microbiol. 24 894-898.
291. B.R. Murphy, B.S. Graham, G.A. Prince, et al. (1986) Serum and nasal-wash immunoglobulin G and A antibody response of infants and children to respiratory syncytial virus F and G glycoproteins following primary infection. J. Clin. Microbiol. 23 1009-1014.
292. B.R. Murphy, G.A. Prince, E.E. Walsh, et al. (1986) Dissociation between serum neutralizing antibody responses of infants and children who received inactivated respiratory syncytial virus vaccine. J. Clin. Microbiol. 24 197-202.
293. D. Murphy, J.K. Todd, R.K. Chao, et al. (1981) The use of gowns and masks to control respiratory illness in pediatric personnel. J. Pediatr. 99 746.
294. N. Nandapalan, C. Taylor, R. Scott and G.L. Toms (1987) Mammary immunity in mothers of infants with respiratory syncytial virus infection. J. Med. Virol. 22 277-287.
295. L. Navas, E. Wang, V. de Carvalho and J. Robinson (1992) Improved outcome of respiratory syncytial virus infection in a high-risk hospitalized population of Canadian children. J. Pediatr. 121 348-354.
296. D.S. Newburg and W.A. Walker (2007) Protection of the neonate by the innate immune system of developing gut and of human milk. Pediatr. Res. 61 2-8.
297. Y. Ng, C. Cox, J. Atkins and I.J. Butler (2001) Encephalopathy associated with respiratory syncytial virus bronchiolitis. J. Child Neurol. 16 105-108.
298. J.A. Nicholas, K.L. Rubino, M.E. Levely, et al. (1990) Cytolytic T-lymphocyte responses to respiratory syncytial virus: Effector cell phenotype and target proteins. J. Virol. 64 4232-4241.
299. K.J. Nicholas, M.O. Dhouieb, T.G. Marshal, et al. (1999) An evaluation of chest physiotherapy in the management of acute bronchiolitis: Changing clinical practice. Physiotherapy 85 669-674.
300. W.G. Nichols, T. Gooley and M. Boeckh (2001) Community-acquired respiratory syncytial virus and parainfluenza virus infections after hematopoietic stem cell transplantation: The Fred Hutchinson Cancer Research Center experience. Biol. Blood Marrow Transplant. 7(Suppl.), 11S-15S.
301. K.G. Nicholson, T. McNally, M. Silverman, et al. (2006) Rates of hospitalisation for influenza, respiratory syncytial virus and human metapneumovirus among infants and young children. Vaccine 24 102-108.
302. T.L. Noah, S.S. Ivins, P.M. Murphy, et al. (2002) Chemokines and inflammation in the nasal passages of infants with respiratory syncytial virus bronchiolitis. Clin. Immunol. 104 86-95.
303. D.J. Nokes, E.A. Okiro, M. Ngama, et al. (2004) Respiratory syncytial virus epidemiology in a birth cohort from Kilifi district, Kenya: Infection during the first year of life. J. Infect. Dis. 190 1828-1832.
304. M.M. Ogilvie, S. Vatheneo, M. Radford, et al. (1981) Maternal antibody and respiratory syncytial virus infection in infancy. J. Med. Virol. 7 263-271.
305. P.L. Ogra (2004) Respiratory syncytial virus: The virus, the disease and the immune response. Paediatr. Respir. Rev. 5(Suppl. A), S119-S128.
306. P.J. Openshaw (2005) Antiviral immune responses and lung inflammation after respiratory syncytial virus infection. Proc. Am. Thorac. Soc. 2 121-125.
307. P.J. Openshaw and JS Tregoning (2005) Immune responses and disease enhancement during respiratory syncytial virus infection. Clin. Microbiol. Rev. 18 541-555.
308. P.J. Openshaw, G.S. Dean and F.J. Culley (2003) Links between respiratory syncytial virus bronchiolitis and childhood asthma: Clinical and research approaches. Pediatr. Infect. Dis. J. 22(Suppl.), S58-S65.
309. J. Ordas, J.A. Boga, M. Alvarez-Arguelles, et al. (2006) Role of metapneumovirus in viral respiratory infections in young children. J. Clin. Microbiol. 44 2739-2742.
310. D. Osborne (1978) Radiologic appearance of viral disease of the lower respiratory tract in infants and children. A. J. R. Am. J. Roentgenol. 130 29-33.
311. M.K. O'Shea, M.A. Ryan, A.W. Hawksworth, et al. (2005) Symptomatic respiratory syncytial virus infection among previously healthy young adults living in a crowded military environment. Clin. Infect. Dis. 41 311-317.
312. D.R. Ownby and C.C. Johnson (2003) Does exposure to dogs and cats in the first year of life influence the development of allergic sensitization? Curr. Opin. Allergy Clin. Immunol. 3 517-522.
313. Palivizumab Outcomes Registry Study Group (2003) Palivizumab prophylaxis of respiratory syncytial virus disease in 2000-2001: Results from the palivizumab outcomes registry. Pediatr. Pulmonol. 35 484-489.
314. M.A. Palomino, C. Larranaga, E. Villagra, et al. (2004) Adenovirus and respiratory syncytial virus–adenovirus mixed acute lower respiratory infections in Chilean infants. Pediatr. Infect. Dis. J. 23 337-341.
315. J.R. Panuska, R. Merolla, N.A. Rebert, et al. (1995) Respiratory syncytial virus induces interleukin-10 by human alveolar macrophages: Suppression of early cytokine production and implications for incomplete immunity. J. Clin. Invest. 96 2445-2453.
316. N.G. Papadopoulos, D. Gourgiotis, A. Javadyan, et al. (2004) Does respiratory syncytial virus subtype influences the severity of acute bronchiolitis in hospitalized infants? Respir. Med. 98 879-882.
317. P.R. Paradiso, S.W. Hildreth, D.A. Hogerman, et al. (1994) Safety and immunogenicity of a subunit respiratory syncytial virus vaccine in children 24 to 48 months old. Pediatr. Infect. Dis. J. 13 792-798.
318. J.M. Paricio Talayero, M. Lizan-Garcia, A. Otero Puime, et al. (2006) Full breastfeeding and hospitalization as a result of infections in the first year of life. Pediatrics 118 e92-e99.
319. R.H. Parrott, H.W. Kim, J.O. Arrobio, et al. (1973) Epidemiology of respiratory syncytial virus infection in Washington, DC. II. Infection and disease with respect to age, immunologic status, race, and sex. Am. J. Epidemiol. 98 289-300.
320. S. Parveen, W.M. Sullender, K. Fowler, et al. (2006) Genetic variability in the G protein gene of group A and B respiratory syncytial viruses from India. J. Clin. Microbiol. 44 3055-3064.
321. H. Patel, R. Platt, J.M. Lozano and E.E.L. Wang (2004) Glucocorticoids for acute viral bronchiolitis in infants and young children. Cochrane Database Syst. Rev. 4 1-63.
322. R.S. Peebles Jr. (2004) Viral infections, atopy, and asthma: Is there a causal relationship? J. Allergy Clin. Immunol. 113(Suppl.), S15-S18.
323. R.S. Peebles Jr. and B.S. Graham (2005) Pathogenesis of respiratory syncytial virus infection in the murine model. Proc. Am. Thorac. Soc. 2 110-115.
324. A.J. Pelletier, J.M. Mansbach and C.A. Camargo Jr. (2006) Direct medical costs of bronchiolitis hospitalizations in the United States. Pediatrics 118 2418-2423.
325. T.C.T. Peret, C.B. Hall, K.C. Schnabel, et al. (1998) Circulation patterns of genetically distinct group A and B strains of human respiratory syncytial virus in a community. J. Gen. Virol. 79 2221-2229.
326. S.M. Perkins, D.L. Webb, S.A. Torrance, et al. (2005) Comparison of a real-time reverse transcriptase PCR assay and a culture technique for quantitative assessment of viral load in children naturally infected with respiratory syncytial virus. J. Clin. Microbiol. 43 2356-2362.
327. A. Pitkaranta, A. Virolainen, J. Jero, et al. (1998) Detection of rhinovirus, respiratory syncytial virus, and coronavirus infections in acute otitis media by reverse transcriptase polymerase chain reaction. Pediatrics 102 291-295.
328. H. Plotnicky-Gilquin, T. Huss, J.P. Aubry, et al. (1999) Absence of lung immunopathology following respiratory syncytial virus (RSV) challenge in mice immunized with a recombinant RSV G protein fragment. Virology 258 128-140.
329. F.M. Preston, P.L. Beier and J.H. Pope (1995) Identification of the respiratory syncytial virus–induced immunosuppressive factor produced by human peripheral blood mononuclear cells in vitro as interferon-α. J. Infect. Dis. 172 919-926.
330. PREVENT Study Group (1997) Reduction of respiratory syncytial virus hospitalization among premature infants and infants with bronchopulmonary dysplasia using respiratory syncytial virus immune globulin prophylaxis. Pediatrics 99 93-99.
331. G.A. Prince and D.D. Porter (1976) The pathogenesis of respiratory syncytial virus infection in infant ferrets. Am. J. Pathol. 82 339-352.
332. G.A. Prince, R.L. Horswood, E. Camargo, et al. (1983) Mechanisms of immunity to respiratory syncytial virus in cotton rats. Infect. Immun. 42 81-87.
333. G.A. Prince, R.L. Horswood and R.M. Chanock (1985) Quantitative aspects of passive immunity to respiratory syncytial virus infection in infant cotton rats. J. Virol. 55 517-520.
334. G.A. Prince, A.B. Jenson, R.L. Horswood, et al. (1978) The pathogenesis of respiratory syncytial virus infection in cotton rats. Am. J. Pathol. 93 771-791.
335. G.A. Prince, J.P. Prieels, M. Slaoui and D.D. Porter (1999) Pulmonary lesions in primary respiratory syncytial virus infection, reinfection, and vaccine-enhanced disease in the cotton rat (Sigmodon hispidus). Lab. Invest. 79 1385-1392.
336. C.R. Pringle (1991) The order Mononegavirales. Arch. Virol. 117 137-140.
337. K. Purcell and J. Fergie (2002) Concurrent serious bacterial infections in 2396 infants and children hospitalized with respiratory syncytial virus lower respiratory tract infections. Arch. Pediatr. Adolesc. Med. 156 322-324.
338. K. Purcell and J. Fergie (2004) Concurrent serious bacterial infections in 912 infants and children hospitalized for treatment of respiratory syncytial virus lower respiratory tract infection. Pediatr. Infect. Dis. J. 3 267-269.
339. K. Purcell and J. Fergie (2004) Driscoll Children's Hospital respiratory syncytial virus database: Risk factors, treatment and hospital course in 3308 infants and young children, 1991 to 2002. Pediatr. Infect. Dis. J. 23 418-423.
340. S.M. Raboni, M.B. Nogueira, L.R. Tsuchiya, et al. (2003) Respiratory tract viral infections in bone marrow transplant patients. Transplantation 76 142-146.
341. J. Rechsteiner and K.C. Winkler (1969) Inactivation of respiratory syncytial virus in aerosol. J. Gen. Virol. 5 405-410.
342. C.A. Reeve, J.S. Whitehall, P.G. Buettner, et al. (2006) Cost-effectiveness of respiratory syncytial virus prophylaxis with palivizumab. J. Paediatr. Child Health 42 248-252.
343. C.A. Reeve, J.S. Whitehall, P.G. Buettner, et al. (2006) Predicting respiratory syncytial virus hospitalisation in Australian children. J. Paediatr. Child Health 42 248-252.
344. S.T. Remes, J.A. Castro-Rodriguez, C.J. Holberg, et al. (2001) Dog exposure in infancy decreases the subsequent risk of frequent wheeze but not of atopy. J. Allergy Clin. Immunol. 108 509-515.
345. R.P. Rice and F. Loda (1966) A roentgenographic analysis of respiratory syncytial virus pneumonia in infants. Radiology 87 1021-1027.
346. L.S. Richardson-Wyatt, R.B. Belshe, W.T. London, et al. (1981) Respiratory syncytial virus antibodies in nonhuman primates and domestic animals. Lab. Anim. Sci. 31 413-415.
347. B.W. Richter, J.M. Onuska, S. Niewiesk, et al. (2005) Antigen-dependent proliferation and cytokine induction in respiratory syncytial virus–infected cotton rats reflect the presence of effector-memory T cells. Virology 337 102-110.
348. M.G. Roback and M.N. Baskin (1997) Failure of oxygen saturation and clinical assessment to predict which patients with bronchiolitis discharged from the emergency department will return requiring admission. Pediatr. Emerg. Care 13 9-11.
349. N.J. Roberts, A.H. Prill and T.N. Mann (1986) Interleukin 1 and interleukin 1 inhibitor production by human macrophages exposed to influenza virus or respiratory syncytial virus. J. Exp. Med. 163 511-519.
350. A. Rohwedder, O. Keminer, J. Forster, et al. (1998) Detection of respiratory syncytial virus RNA in blood of neonates by polymerase chain reaction. J. Med. Virol. 54 320-327.
351. J.R. Romero (2003) Palivizumab prophylaxis of respiratory syncytial virus disease from 1998 to 2002: Results from four years of palivizumab usage. Pediatr. Infect. Dis. J. 22(Suppl.), S46-S54.
352. B.D. Rudd, E. Burstein, C.S. Duckett, et al. (2005) Differential role for TLR3 in respiratory syncytial virus–induced chemokine expression. J. Virol. 79 3350-3357.
353. B.D. Rudd, J.J. Smit, R.A. Flavell, et al. (2006) Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory syncytial virus infection. J. Immunol. 176 1937-1942.
354. J.A. Rutigliano, M.T. Rock, A.K. Johnson, et al. (2005) Identification of an H-2D(b)-restricted CD8 + cytotoxic T lymphocyte epitope in the matrix protein of respiratory syncytial virus. Virology 337 335-343.
355. T. Saito, R.W. Deskin, A. Casola, et al. (1997) Respiratory syncytial virus induces selective production of the chemokine RANTES by upper airway epithelial cells. J. Infect. Dis. 175 497-504.
356. A.R. Salkind, D.O. McCarthy, J.E. Nichols, et al. (1991) Interleukin-1-inhibitor activity induced by respiratory syncytial virus: Abrogation of virus-specific and alternate human lymphocyte proliferative responses. J. Infect. Dis. 163 71-77.
357. L. Sangare, M.P. Curtis and S. Ahmad (2006) Hospitalization for respiratory syncytial virus among California infants: Disparities related to race, insurance, and geography. J. Pediatr. 149 373-377.
358. M. Sato, R. Saito, T. Sakai, et al. (2005) Molecular epidemiology of respiratory syncytial virus infections among children with acute respiratory symptoms in a community over three seasons. J. Clin. Microbiol. 43 36-40.
359. M. Schaller, C.M. Hogaboam, N. Lukacs and S.L. Kunkel (2006) Respiratory viral infections drive chemokine expression and exacerbate the asthmatic response. J. Allergy Clin. Immunol. 118 295-302.
360. U. Schauer, S. Hoffjan, T. Rothoeft, et al. (2004) Severe respiratory syncytial virus infections and reduced interferon-gamma generation in vitro. Clin. Exp. Immunol. 138 102-109.
361. J. Schlender, V. Hornung, S. Finke, et al. (2005) Inhibition of Toll-like receptor 7- and 9-mediated alpha/beta interferon production in human plasmacytoid dendritic cells by respiratory syncytial virus and measles virus. J. Virol. 79 5507-5515.
362. S. Schuh, A.L. Coates, R. Binnie, et al. (2002) Efficacy of oral dexamethasone in outpatients with acute bronchiolitis. J. Pediatr. 140 27-32.
363. P.D. Scott, R. Ochola, M. Ngama, et al. (2004) Molecular epidemiology of respiratory syncytial virus in Kilifi district, Kenya. J. Med. Virol. 74 344-354.
364. K.N. Shaw, L.M. Bell and N.H. Sherman (1991) Outpatient assessment of infants with bronchiolitis. Am. J. Dis. Child. 145 151-155.
365. D.K. Shay, R.C. Holman, R.D. Newman, et al. (1999) Bronchiolitis-associated hospitalizations among US children, 1980-1996. JAMA 282 1440-1446.
366. D.K. Shay, R.C. Holman, G.E. Roosevelt, et al. (2001) Bronchiolitis-associated mortality and estimates of respiratory syncytial virus–associated deaths among US children, 1979-1997. J. Infect. Dis. 183 16-22.
367. P. Sheeran, H. Jafri, C. Carubelli, et al. (1999) Elevated cytokine concentrations in the nasopharyngeal and tracheal secretions of children with respiratory syncytial virus disease. Pediatr. Infect. Dis. J. 18 115-122.
368. R.W. Sidwell and D.L. Barnard (2006) Respiratory syncytial virus infections: Recent prospects for control. Antiviral Res. 71 379-390.
369. C.A. Siegrist, H. Plotnicky-Gilquin, M. Cordova, et al. (1999) Protective efficacy against respiratory syncytial virus following murine neonatal immunization with BBG2Na vaccine: Influence of adjuvants and maternal antibodies. J. Infect. Dis. 179 1326-1333.
370. N. Sigurs, R. Bjarnason, F. Sigurbergsson and B. Kjellman (2000) Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. Am. J. Respir. Crit. Care Med. 161 1501-1507.
371. N. Sigurs, P.M. Gustafsson, R. Bjarnason, et al. (2005) Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13. Am. J. Respir. Crit. Care Med. 171 137-141.
372. E.A.F. Simoes, D.H.S. Tan, A. Ohlsson, et al. (2002) Respiratory syncytial virus vaccine: A systematic overview with emphasis on respiratory syncytial virus subunit vaccines. Vaccine 20 954-960.
373. R. Singleton, N. Etchart, S. Hou and L. Hyland (2003) Inability to evoke a long-lasting protective immune response to respiratory syncytial virus infection in mice correlates with ineffective nasal antibody responses. J. Virol. 77 11303-11311.
374. K.M. Spann, K.C. Tran and P.L. Collins (2005) Effects of nonstructural proteins NS1 and NS2 of human respiratory syncytial virus on interferon regulatory factor 3, NF-kappaB, and proinflammatory cytokines. J. Virol. 79 5353-5362.
375. A. Srikiatkhachorn and T.J. Braciale (1997) Virus-specific memory and effector T lymphocytes exhibit different cytokine responses to antigens during experimental murine respiratory syncytial virus infection. J. Virol. 71 678-685.
376. R.T. Stein, D. Sherrill, W.J. Morgan, et al. (1999) Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet 354 541-545.
377. T.P. Stevens, R.A. Sinkin, C.B. Hall, et al. (2000) Respiratory syncytial virus and premature infants born at 32 weeks' gestation or earlier: Hospitalization and economic implications of prophylaxis. Arch. Pediatr. Adolesc. Med. 54 55-61.
378. G.A. Storch, C.B. Hall, L.J. Anderson, et al. (1993) Antigenic and nucleic acid analysis of nosocomial isolates of respiratory syncytial virus. J. Infect. Dis. 167 562-566.
379. C.H. Takimoto, D.L. Cram and R.K. Root (1991) Respiratory syncytial virus infections on an adult medical ward. Arch. Intern. Med. 151 706-708.
380. G. Tal, A. Mandelberg, I. Dalal, et al. (2004) Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease. J. Infect. Dis. 189 2057-2063.
381. L.M. Taussig, A.L. Wright, C.J. Holberg, et al. (2003) Tucson Children's Respiratory Study: 1980 to present. J. Allergy Clin. Immunol. 111 661-675.
382. B. Tian, Y. Zhang, B.A. Luxon, et al. (2002) Identification of NF-κB–dependent gene networks in respiratory syncytial virus–infected cells. J. Virol. 76 6800-6814.
383. M.O. Titus and S.W. Wright (2003) Prevalence of serious bacterial infections in febrile infants with respiratory syncytial virus infection. Pediatrics 112 282-284.
384. G.L. Toms, M.S.C. Web, P.D. Milner, et al. (1989) IgG and IgM antibodies to viral glycoproteins in respiratory syncytial virus infections of graded severity. Arch. Dis. Child. 64 1661-1665.
385. R.A. Tripp, D. Moore, A. Barskey, et al. (2002) Peripheral blood mononuclear cells from infants hospitalized because of respiratory syncytial virus infection express T helper-1 and T helper-2 cytokines and CC chemokine messenger RNA. J. Infect. Dis. 185 1388-1394.
386. R.A. Tripp, C. Oshansky and R. Alvarez (2005) Cytokines and respiratory syncytial virus infection. Proc. Am. Thorac. Soc. 2 147-149.
387. H. Tsutsumi, K. Matsuda, H. Yamazaki, et al. (1995) Different kinetics of antibody responses between IgA and IgG classes in nasopharyngeal secretion in infants and children during primary respiratory syncytial virus infection. Acta Paediatr. Jpn. 37 464-468.
388. B.G. van den Hoogen, J.C. de Jong, J. Groen, et al. (2001) A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat. Med. 7 719-724.
389. S.M. van Schaik, G. Enhorning, I. Vargas and R.C. Welliver (1998) Respiratory syncytial virus affects pulmonary function in BALB/c mice. J. Infect. Dis. 177 269-276.
390. M.P. Venkatesh and L.E. Weisman (2006) Prevention and treatment of respiratory syncytial virus infection in infants: An update. Expert Rev. Vaccines 5 261-268.
391. D.W. Visscher and J.L. Myers (2006) Bronchiolitis: The pathologist's perspective. Proc. Am. Thorac. Soc. 3 41-47.
392. E. von Mutius (2001) Infection: Friend or foe in the development of atopy and asthma?. The epidemiological evidence. Eur. Respir. J. 18 872-881.
393. D.K. Wagner, P. Muelenaer, F.W. Henderson, et al. (1989) Serum immunoglobulin G antibody subclass response to respiratory syncytial virus F and G glycoproteins after first, second, and third infections. J. Clin. Microbiol. 27 589-599.
394. E.E. Walsh and A.R. Falsey (2004) Age related differences in humoral immune response to respiratory syncytial virus infection in adults. J. Med. Virol. 73 295-299.
395. E.E. Walsh and A.R. Falsey (2004) Humoral and mucosal immunity in protection from natural respiratory syncytial virus infection in adults. J. Infect. Dis. 190 373-378.
396. E.E. Walsh, D.R. Peterson and A.R. Falsey (2004) Risk factors for severe respiratory syncytial virus infection in elderly persons. J. Infect. Dis. 189 233-238.
397. E.E. Wang, B.J. Law, F.D. Boucher, et al. (1996) Pediatric investigators collaborative network on infections in Canada (PICNIC) study of admission and management variation in patients hospitalized with respiratory syncytial viral lower respiratory tract infection. J. Pediatr. 129 390-395.
398. E.E. Wang, B.J. Law and D. Stephens (1995) Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) prospective study of risk factors and outcomes in patients hospitalized with respiratory syncytial viral lower respiratory tract infection. J. Pediatr. 126 212-219.
399. E.E. Wang, R. Milner, U. Allen and H. Maj (1992) Bronchodilators for treatment of mild bronchiolitis: A factorial randomised trial. Arch. Dis. Child. 67 289-293.
400. M. Waris, C. Tsou, D. Erdman, et al. (1996) Respiratory syncytial virus infection in BALB/c mice previously immunized with formalin-inactivated virus induces enhanced pulmonary inflammatory response with a predominant Th2-like cytokine pattern. J. Virol. 70 2852-2860.
401. M.W. Wathen, T.J. Kakuk, R.J. Brideau, et al. (1991) Vaccination of cotton rats with a chimeric FG glycoprotein of human respiratory syncytial virus induces minimal pulmonary pathology on challenge. J. Infect. Dis. 163 477-482.
402. P.J. Watt, M. Zardis and P.R. Lambden (1986) Age related IgG subclass response to respiratory syncytial virus fusion protein in infected infants. Clin. Exp. Immunol. 64 503-509.
403. M.S. Webb, G.A. Martin, P.H. Cartlidge, et al. (1985) Chest physiotherapy in acute bronchiolitis. Arch. Dis. Child. 60 1078-1079.
404. J.A. Weigl, W. Puppe and H.J. Schmitt (2001) Incidence of respiratory syncytial virus–positive hospitalizations in Germany. Eur. J. Clin. Microbiol. Infect. Dis. 20 452-459.
405. G.A. Weinberg, D.D. Erdman, K.M. Edwards, et al. (2004) Superiority of reverse-transcription polymerase chain reaction to conventional viral culture in the diagnosis of acute respiratory tract infections in children. J. Infect. Dis. 189 706-710.
406. L.E. Weisman (2003) Populations at risk for developing respiratory syncytial virus and risk factors for respiratory syncytial virus severity: Infants with predisposing conditions. Pediatr. Infect. Dis. J. 22(Suppl.), S33-S39.
407. R.C. Welliver (2003) Respiratory syncytial virus and other respiratory viruses. Pediatr. Infect. Dis. J. 22(Suppl.), S6-S12.
408. R.C. Welliver and L. Duffy (1993) The relationship of RSV-specific immunoglobulin E antibody responses in infancy, recurrent wheezing, and pulmonary function at age 7-8 years. Pediatr. Pulmonol. 15 19-27.
409. R.C. Welliver, R.P. Garofalo and P.L. Ogra (2002) Beta-chemokines, but neither T helper type 1 nor T helper type 2 cytokines, correlate with severity of illness during respiratory syncytial virus infection. Pediatr. Infect. Dis. J. 21 457-561.
410. R.C. Welliver, T.N. Kaul and P.L. Ogra (1980) The appearance of cell-bound IgE in respiratory-tract epithelium after respiratory syncytial virus infection. N. Engl. J. Med. 303 1198-1202.
411. R.C. Welliver, T.N. Kaul, T.I. Putnam, et al. (1980) The antibody response to primary and secondary infection with respiratory syncytial virus: Kinetics of class-specific responses. J. Pediatr. 96 808-813.
412. R.C. Welliver, D.T. Wong, M. Sun, et al. (1981) The development of respiratory syncytial virus–specific IgE and the release of histamine in naso-pharyngeal secretions after infection. N. Engl. J. Med. 305 841-846.
413. R. Weltzin and T.P. Monath (1999) Intranasal antibody prophylaxis for protection against viral disease. Clin. Microbiol. Rev. 12 383-393.
414. G.W. Wertz and R.M. Moudy (2004) Antigenic and genetic variation in human respiratory syncytial virus. Pediatr. Infect. Dis. J. 23(Suppl.), S19-S24.
415. E. Whimbey and S. Ghosh (2000) Respiratory syncytial virus infections in immunocompromised adults. Curr. Clin. Top. Infect. Dis. 20 232-255.
416. C. White, R. Kolble, R. Carlson, et al. (2003) The effect of hand hygiene on illness rate among students in university residence halls. Am. J. Infect. Control 31 364-370.
417. S.R. Wildin, T. Chonmaitree and L.E. Swischuk (1988) Roentgenographic features of common pediatric viral respiratory tract infections. Am. J. Dis. Child. 142 43-46.
418. T.M. Wilkinson, G.C. Donaldson, S.L. Johnston, et al. (2006) Respiratory syncytial virus, airway inflammation, and FEV 1 decline in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 173 871-876.
419. J.V. Williams, C.K. Wang, C.F. Yang, et al. (2006) The role of human metapneumovirus in upper respiratory tract infections in children: A 20-year experience. J. Infect. Dis. 193 387-395.
420. J. Wilson, K. Rowlands, K. Rockett, et al. (2005) Genetic variation at the IL10 gene locus is associated with severity of respiratory syncytial virus bronchiolitis. J. Infect. Dis. 191 1705-1709.
421. P.F. Wright, W.C. Gruber, M. Peters, et al. (2002) Illness severity, viral shedding, and antibody responses in infants hospitalized with bronchiolitis caused by respiratory syncytial virus. J. Infect. Dis. 185 1011-1018.
422. P.F. Wright, R.A. Karron, R.B. Belshe, et al. (2000) Evaluation of a live, cold-passaged, temperature sensitive, respiratory syncytial virus vaccine candidate in infancy. J. Infect. Dis. 182 1331-1342.
423. H. Wu, D.S. Pfarr, Y. Tang, et al. (2005) Ultra-potent antibodies against respiratory syncytial virus: Effects of binding kinetics and binding valence on viral neutralization. J. Mol. Biol. 350 126-144.
424. Y. Zhang, B.A. Luxon, A. Casola, et al. (2001) Expression of respiratory syncytial virus–induced chemokine gene networks in lower airway epithelial cells revealed by cDNA microarrays. J. Virol. 75 9044-9058.