Oral prednisolone in the acute management of children age 6 to 35 months with viral respiratory infection-induced lower airway disease: A randomized, placebo-controlled trial

Journal of Pediatrics

Volumn 143, Issue 6, 2003, Pages 725-730

  Csonka, Péter ^a   Kaila, Minna ^b   Laippala, Pekka ^b   Iso Mustajärvi, Marja ^b   Vesikari, Timo ^b   Ashorn, Per ^b  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; PREDNISOLONE;

ARTICLE; ASTHMA; CHILD; CHILD HOSPITALIZATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; EMERGENCY WARD; FEMALE; HOSPITAL ADMISSION; HUMAN; INFANT; LENGTH OF STAY; LOWER RESPIRATORY TRACT INFECTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; RESPIRATORY DISTRESS; RESTLESSNESS; VIRUS INFECTION; VOMITING;

EID: 0344394310     PISSN: 00223476     EISSN: None     Source Type: Journal    
DOI: 10.1067/S0022-3476(03)00498-0     Document Type: Article

References (24)

1. Milner AD. The role of corticosteroids in bronchiolitis and croup. Thorax 1997;52:595-7.
2. Brunette MG, Lands L, Thibodeau LP. Childhood asthma: prevention of attacks with short-term corticosteroid treatment of upper respiratory tract infection. Pediatrics 1988;81:624-9.
3. Storr J, Barrel E, Barry W, Lenney W, Hatcher G. Effect of a single oral dose of prednisolone in acute childhood asthma. Lancet 1987;1:879-82.
4. Gleeson JG, Loftus BG, Price JF. Placebo controlled trial of systemic corticosteroids in acute childhood asthma. Acta Paediatr Scand 1990; 79:1052-8.
5. Tal A, Levy N, Bearman J. Methylprednisolone therapy for acute asthma in infants and toddlers: a controlled clinical trial. Pediatrics 1990;86:350-6.
6. Scarfone RJ, Fuchs SM, Nager AL, Shane SA. Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma. Pediatrics 1993;92:513-8.
7. Horowitz L, Zafrir O, Gilboa S, Berger I, Wolach B. Acute asthma: single dose oral steroids in paediatric community clinics. Eur J Pediatr 1994; 153:526-30.
8. Webb MS, Henry RL, Milner AD. Oral corticosteroids for wheezing attacks under 18 months. Arch Disease Child 1986;61:15-9.
9. Springer C, Bar-Yishay E, Uwayyed K, Avital A, Vilozni D, Godfrey S. Corticosteroids do not affect the clinical or physiological status of infants with bronchiolitis. Pediatr Pulmonol 1990;9:181-5.
10. Roosevelt G, Sheehan K, Grupp-Phelan J, Tanz RR, Listernick R. Dexamethasone in bronchiolitis: a randomised controlled trial. Lancet 1996; 348:292-5.
11. Klassen TP, Sutcliffe T, Watters LK, Wells GA, Allen UD, Li MM. Dexamethasone in salbutamol-treated inpatients with acute bronchiolitis: a randomised, controlled trial. J Pediatr 1997;130:191-6.
12. Bülow SM, Nir M, Levin E, Friis B, Thomsen LL, Nielsen JE, et al. Prednisolone treatment of respiratory syncytial virus infection: a randomized controlled trial of 147 infants. Pediatrics [serial online] 1999;104:e77. Available from: URL:http://www.pediatrics.org/cgi/content/full/104/6/ e77.
13. Daugbjerg P, Brenoe E, Forchhammer H, Frederiksen B, Glazowski MJ, Ibsen KK, et al. A comparison between nebulized terbutaline, nebulized corticosteroid and systemic corticosteroid for acute wheezing in children up to 18 months of age. Acta Paediatr 1993;82:547-51.
14. van Woensel JB, Wolfs TF, van Aalderen WM, Brand PL, Kimpen JL. Randomised double blind placebo controlled trial of prednisolone in children admitted to hospital with respiratory syncytial virus bronchiolitis. Thorax 1997;52:634-7.
15. Garrison MM, Christakis DA, Harvey E, Cummings P, Davis RL. Systemic corticosteroids in infant bronchiolitis: a meta-analysis. Pediatrics [serial online] 2000;105:e44. Available from: URL:http://www.pediatrics.org/ cgi/content/full/105/4/e44.
16. Schuh S, Coates AL, Binnie R, Allin T, Goia C, Corey M, et al. Efficacy of oral dexamethasone in outpatients with acute bronchiolitis. J Pediatr 2002;140:27-32.
17. Tabachnik E, Levison H. Infantile bronchial asthma. J Allergy Clin Immunol 1981;67:339-47.
18. Korppi M, Mäkelä M, Vanto T. Obstruktiivinen bronkiitti. In: Ruuskanen O, Peltola H, Vesikari T, editors. Lasten infektiosairaudet. 2nd ed. Helsinki, Finland: Pfizer, Inc; 2000. p. 142-7.
19. Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ, et al. Asthma and wheezing in the first six years of life. N Engl J Med 1995;332:133-8.
20. Martinez FD, Morgan WJ, Wright AL, Holberg CJ, Taussig LM. Diminished lung function as a predisposing factor for wheezing respiratory illness in infants. N Engl J Med 1988;319:1112-7.
21. Taussig LM. The conundrum of wheezing and airway hyperreactivity in infancy. Pediatr Pulmonol 1992;13:1-3.
22. Korppi M, Halonen P, Kleemola M, Launiala K. Viral findings in children under the age of two years with expiratory difficulties. Acta Paediatr Scand 1986;75:457-64.
23. Rakes GP, Arruda E, Ingram JM, Hoover GE, Zambrano JC, Hayden FG, et al. Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care: IgE and eosinophil analyses. Am J Respir Crit Care Med 1999;159:785-90.
24. Szefler SJ. Challenges in assessing outcomes for pediatric asthma. J Allergy Clin Immunol 2001;107:S456-64.