Mutations in the spike protein of Middle East respiratory syndrome coronavirus transmitted in Korea increase resistance to antibody-mediated neutralization

Journal of Virology

Volumn 93, Issue 2, 2019, Pages

  Kleine Weber, Hannah ^a,b   Elzayat, Mahmoud Tarek ^a   Wang, Lingshu ^c   Graham, Barney S ^c   Müller, Marcel A ^d   Drosten, Christian ^d   Pöhlmann, Stefan ^a,b   Hoffmann, Markus ^a  

^a GERMAN PRIMATE CENTER   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL PEPTIDASE IV; INTERFERON; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; PROTEINASE; SIALIC ACID; VIRUS SPIKE PROTEIN; VITRONECTIN; CORONAVIRUS SPIKE GLYCOPROTEIN; DPP4 PROTEIN, HUMAN; NEUTRALIZING ANTIBODY; PROTEIN BINDING; SIALIC ACID DERIVATIVE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MIDDLE EAST RESPIRATORY SYNDROME; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; SERUM; SOUTH KOREA; TRAVEL; VIRUS ENTRY; VIRUS MUTATION; VIRUS NEUTRALIZATION; VIRUS TRANSMISSION; AGED; ANTIVIRAL RESISTANCE; BINDING SITE; CHEMISTRY; CORONAVIRUS INFECTION; DOWN REGULATION; GENETICS; MALE; METABOLISM; MIDDLE AGED; MUTATION; PATHOGENICITY;

AGED; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; BINDING SITES; CORONAVIRUS INFECTIONS; DIPEPTIDYL PEPTIDASE 4; DOWN-REGULATION; DRUG RESISTANCE, VIRAL; HUMANS; MALE; MIDDLE AGED; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MUTATION; PROTEIN BINDING; REPUBLIC OF KOREA; SIALIC ACIDS; SPIKE GLYCOPROTEIN, CORONAVIRUS; VIRUS INTERNALIZATION;

EID: 85059494347     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01381-18     Document Type: Article

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