Identification of nafamostat as a potent inhibitor of middle east respiratory syndrome Coronavirus s protein-mediated membrane fusion using the split-protein-based cell-cell fusion assay

Antimicrobial Agents and Chemotherapy

Volumn 60, Issue 11, 2016, Pages 6532-6539

  Yamamoto, Mizuki ^a   Matsuyama, Shutoku ^b   Li, Xiao ^a   Takeda, Makoto ^b   Kawaguchi, Yasushi ^a,b   Inoue, Jun Ichiro ^a   Matsuda, Zene ^a,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^c INSTITUTE OF BIOPHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL PEPTIDASE IV; NAFAMSTAT; PROTEINASE; RENILLA LUCIFERIN 2 MONOOXYGENASE; TRANSMEMBRANE PROTEASE SERINE 2; UNCLASSIFIED DRUG; VITRONECTIN; CATHEPSIN; CORONAVIRUS SPIKE GLYCOPROTEIN; DPP4 PROTEIN, HUMAN; FURIN; GUANIDINE DERIVATIVE; LUCIFERASE; SERINE PROTEINASE; TMPRSS2 PROTEIN, HUMAN; VIRUS FUSION INHIBITOR;

ARTICLE; CELL ASSAY; CELL FUSION; CELL MEMBRANE; EFFECTOR CELL; HUMAN; HUMAN CELL; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEK293 CELL LINE; HIGH THROUGHPUT SCREENING; HOST PATHOGEN INTERACTION; INTRACELLULAR MEMBRANE; MEMBRANE FUSION; METABOLISM; PROTEIN DEGRADATION; REPORTER GENE; VIROLOGY;

CATHEPSINS; CELL FUSION; CELL MEMBRANE; DIPEPTIDYL PEPTIDASE 4; FURIN; GENE EXPRESSION REGULATION; GENES, REPORTER; GUANIDINES; HEK293 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HOST-PATHOGEN INTERACTIONS; HUMANS; INTRACELLULAR MEMBRANES; LUCIFERASES; MEMBRANE FUSION; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; PROTEOLYSIS; SERINE ENDOPEPTIDASES; SPIKE GLYCOPROTEIN, CORONAVIRUS; VIRAL FUSION PROTEIN INHIBITORS;

EID: 84994850983     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01043-16     Document Type: Article

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