Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD

Cell Reports

Volumn 28, Issue 13, 2019, Pages 3395-3405.e6

  Wang, Nianshuang ^a   Rosen, Osnat ^b   Wang, Lingshu ^b   Turner, Hannah L ^c   Stevens, Laura J ^d   Corbett, Kizzmekia S ^b   Bowman, Charles A ^c   Pallesen, Jesper ^c   Shi, Wei ^b   Zhang, Yi ^b   Leung, Kwanyee ^b   Kirchdoerfer, Robert N ^c   Becker, Michelle M ^d   Denison, Mark R ^d   Chappell, James D ^d   Ward, Andrew B ^c   Graham, Barney S ^b   McLellan, Jason S ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

coronavirus; crystal structure; DPP4; electron microscopy; membrane fusion; MERS CoV; receptor binding

Indexed keywords

DIPEPTIDYL PEPTIDASE IV; EPITOPE; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G2 ANTIBODY; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG; VITRONECTIN;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CELL CYCLE G2 PHASE; CELL SURFACE; COMPLEX FORMATION; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; CRYSTAL STRUCTURE; DISULFIDE BOND; ENZYME INHIBITION; GENETIC CONSERVATION; GENETIC VARIABILITY; HEK293 CELL LINE; HUMAN; HYDROGEN BOND; IN VITRO STUDY; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SURFACE PLASMON RESONANCE; VIRUS ATTACHMENT; VIRUS CELL INTERACTION; VIRUS NEUTRALIZATION; VIRUS SPIKE; METABOLISM; PATHOGENICITY;

EPITOPES; HUMANS; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS;

EID: 85072157077     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2019.08.052     Document Type: Article

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