메뉴 건너뛰기




Volumn 6, Issue , 2015, Pages

Evaluation of candidate vaccine approaches for MERS-CoV

(30)  Wang, Lingshu a   Shi, Wei a   Joyce, M Gordon a   Modjarrad, Kayvon a,b,c   Zhang, Yi a   Leung, Kwanyee a   Lees, Christopher R a   Zhou, Tongqing a   Yassine, Hadi M a   Kanekiyo, Masaru a   Yang, Zhi Yong a,d   Chen, Xuejun a   Becker, Michelle M e   Freeman, Megan e   Vogel, Leatrice a   Johnson, Joshua C f   Olinger, Gene f   Todd, John P a   Bagci, Ulas f,g   Solomon, Jeffrey f   more..


Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS VACCINE; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; PLASMID DNA; UNCLASSIFIED DRUG; VIRUS SPIKE PROTEIN; VIRUS VACCINE; CORONAVIRUS SPIKE GLYCOPROTEIN; DNA VACCINE; IMMUNOGLOBULIN G; VIRUS ANTIBODY; VIRUS DNA;

EID: 84938149041     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms8712     Document Type: Article
Times cited : (252)

References (54)
  • 3
    • 84882598788 scopus 로고    scopus 로고
    • Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: A descriptive study
    • Assiri, A. et al. Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study. Lancet Infect. Dis. 13, 752-761 (2013).
    • (2013) Lancet Infect. Dis. , vol.13 , pp. 752-761
    • Assiri, A.1
  • 4
    • 84882918127 scopus 로고    scopus 로고
    • Interhuman transmissibility of Middle East respiratory syndrome coronavirus: Estimation of pandemic risk
    • Breban, R., Riou, J. & Fontanet, A. Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk. Lancet 382, 694-699 (2013).
    • (2013) Lancet , vol.382 , pp. 694-699
    • Breban, R.1    Riou, J.2    Fontanet, A.3
  • 5
    • 84890433761 scopus 로고    scopus 로고
    • Middle East respiratory syndrome coronavirus: Quantification of the extent of the epidemic, surveillance biases, and transmissibility
    • Cauchemez, S. et al. Middle East respiratory syndrome coronavirus: quantification of the extent of the epidemic, surveillance biases, and transmissibility. Lancet Infect. Dis. 14, 50-56 (2014).
    • (2014) Lancet Infect. Dis. , vol.14 , pp. 50-56
    • Cauchemez, S.1
  • 6
    • 84899938536 scopus 로고    scopus 로고
    • Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia, 2013
    • Memish, Z. A. et al. Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia, 2013. Emerg. Infect. Dis. 20, 1012-1015 (2014).
    • (2014) Emerg. Infect. Dis. , vol.20 , pp. 1012-1015
    • Memish, Z.A.1
  • 7
    • 84888011629 scopus 로고    scopus 로고
    • A decade after SARS: Strategies for controlling emerging coronaviruses
    • Graham, R. L., Donaldson, E. F. & Baric, R. S. A decade after SARS: strategies for controlling emerging coronaviruses. Nat. Rev. Microbiol. 11, 836-848 (2013).
    • (2013) Nat. Rev. Microbiol. , vol.11 , pp. 836-848
    • Graham, R.L.1    Donaldson, E.F.2    Baric, R.S.3
  • 8
    • 0021021580 scopus 로고
    • Coronavirus IBV: Structural characterization of the spike protein
    • Cavanagh, D. Coronavirus IBV: structural characterization of the spike protein. J. Gen. Virol. 64 Pt 12 2577-2583 (1983).
    • (1983) J. Gen. Virol. , vol.64 , pp. 2577-2583
    • Cavanagh, D.1
  • 9
    • 3042714194 scopus 로고    scopus 로고
    • Contributions of the structural proteins of severe acute respiratory syndrome coronavirus to protective immunity
    • Buchholz, U. J. et al. Contributions of the structural proteins of severe acute respiratory syndrome coronavirus to protective immunity. Proc. Natl Acad. Sci. USA 101, 9804-9809 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 9804-9809
    • Buchholz, U.J.1
  • 10
    • 84900416594 scopus 로고    scopus 로고
    • Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice
    • Coleman, C. M. et al. Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice. Vaccine 32, 3169-3174 (2014).
    • (2014) Vaccine , vol.32 , pp. 3169-3174
    • Coleman, C.M.1
  • 11
    • 84891885053 scopus 로고    scopus 로고
    • A truncated receptor-binding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses: Implication for developing therapeutics and vaccines
    • Du, L. et al. A truncated receptor-binding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses: implication for developing therapeutics and vaccines. PLoS ONE 8, e81587 (2013).
    • (2013) PLoS ONE , vol.8
    • Du, L.1
  • 12
    • 84896545485 scopus 로고    scopus 로고
    • Intranasal vaccination with recombinant receptor-binding domain of MERS-CoV spike protein induces much stronger local mucosal immune responses than subcutaneous immunization: Implication for designing novel mucosal MERS vaccines
    • Ma, C. et al. Intranasal vaccination with recombinant receptor-binding domain of MERS-CoV spike protein induces much stronger local mucosal immune responses than subcutaneous immunization: implication for designing novel mucosal MERS vaccines. Vaccine 32, 2100-2108 (2014).
    • (2014) Vaccine , vol.32 , pp. 2100-2108
    • Ma, C.1
  • 13
    • 84881232247 scopus 로고    scopus 로고
    • The receptor binding domain of the new Middle East respiratory syndrome coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodies
    • Mou, H. et al. The receptor binding domain of the new Middle East respiratory syndrome coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodies. J. Virol. 87, 9379-9383 (2013).
    • (2013) J. Virol. , vol.87 , pp. 9379-9383
    • Mou, H.1
  • 14
    • 84901303550 scopus 로고    scopus 로고
    • A conformation-dependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in middle east respiratory syndrome coronavirus spike protein
    • Du, L. et al. A conformation-dependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in middle east respiratory syndrome coronavirus spike protein. J. Virol. 88, 7045-7053 (2014).
    • (2014) J. Virol. , vol.88 , pp. 7045-7053
    • Du, L.1
  • 15
    • 84888037046 scopus 로고    scopus 로고
    • Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody
    • Ohnuma, K. et al. Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody. J. Virol. 87, 13892-13899 (2013).
    • (2013) J. Virol. , vol.87 , pp. 13892-13899
    • Ohnuma, K.1
  • 16
    • 84904663317 scopus 로고    scopus 로고
    • Exceptionally potent neutralization of middle East respiratory syndrome coronavirus by human monoclonal antibodies
    • Ying, T. et al. Exceptionally potent neutralization of middle East respiratory syndrome coronavirus by human monoclonal antibodies. J. Virol. 88, 7796-7805 (2014).
    • (2014) J. Virol. , vol.88 , pp. 7796-7805
    • Ying, T.1
  • 17
    • 84899797757 scopus 로고    scopus 로고
    • Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein
    • Jiang, L. et al. Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein. Sci. Transl. Med. 6, 234ra259 (2014).
    • (2014) Sci. Transl. Med. , vol.6 , pp. 234ra259
    • Jiang, L.1
  • 18
    • 84903737162 scopus 로고    scopus 로고
    • Middle East respiratory syndrome coronavirus quasispecies that include homologues of human isolates revealed through whole-genome analysis and virus cultured from dromedary camels in Saudi Arabia
    • Briese, T. et al. Middle East respiratory syndrome coronavirus quasispecies that include homologues of human isolates revealed through whole-genome analysis and virus cultured from dromedary camels in Saudi Arabia. mBio 5, e01146-14 (2014).
    • (2014) MBio , vol.5 , pp. e01146-e01214
    • Briese, T.1
  • 19
    • 55749111036 scopus 로고    scopus 로고
    • A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a Phase i clinical trial
    • Martin, J. E. et al. A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a Phase I clinical trial. Vaccine 26, 6338-6343 (2008).
    • (2008) Vaccine , vol.26 , pp. 6338-6343
    • Martin, J.E.1
  • 20
    • 1842589262 scopus 로고    scopus 로고
    • A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice
    • Yang, Z. Y. et al. A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice. Nature 428, 561-564 (2004).
    • (2004) Nature , vol.428 , pp. 561-564
    • Yang, Z.Y.1
  • 21
    • 0029993858 scopus 로고    scopus 로고
    • Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector
    • Naldini, L., Blomer, U., Gage, F. H., Trono, D. & Verma, I. M. Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc. Natl Acad. Sci. USA 93, 11382-11388 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 11382-11388
    • Naldini, L.1    Blomer, U.2    Gage, F.H.3    Trono, D.4    Verma, I.M.5
  • 22
    • 14144254155 scopus 로고    scopus 로고
    • Evasion of antibody neutralization in emerging severe acute respiratory syndrome coronaviruses
    • Yang, Z. Y. et al. Evasion of antibody neutralization in emerging severe acute respiratory syndrome coronaviruses. Proc. Natl Acad. Sci. USA 102, 797-801 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 797-801
    • Yang, Z.Y.1
  • 23
    • 0023733838 scopus 로고
    • Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells
    • Stevens, T. L. et al. Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells. Nature 334, 255-258 (1988).
    • (1988) Nature , vol.334 , pp. 255-258
    • Stevens, T.L.1
  • 24
    • 0028864849 scopus 로고
    • DNA-mediated immunization in mice induces a potent MHC class I-restricted cytotoxic T lymphocyte response to the hepatitis B envelope protein
    • Davis, H. L., Schirmbeck, R., Reimann, J. & Whalen, R. G. DNA-mediated immunization in mice induces a potent MHC class I-restricted cytotoxic T lymphocyte response to the hepatitis B envelope protein. Hum. Gene. Ther. 6, 1447-1456 (1995).
    • (1995) Hum. Gene. Ther. , vol.6 , pp. 1447-1456
    • Davis, H.L.1    Schirmbeck, R.2    Reimann, J.3    Whalen, R.G.4
  • 25
    • 0033664689 scopus 로고    scopus 로고
    • DNA vaccination: Antigen presentation and the induction of immunity
    • Shedlock, D. J. & Weiner, D. B. DNA vaccination: antigen presentation and the induction of immunity. J. Leukoc. Biol. 68, 793-806 (2000).
    • (2000) J. Leukoc. Biol. , vol.68 , pp. 793-806
    • Shedlock, D.J.1    Weiner, D.B.2
  • 26
    • 84878841571 scopus 로고    scopus 로고
    • Enhancement of Th1 immune responses to recombinant influenza nucleoprotein by Ribi adjuvant
    • Cargnelutti, D. E. et al. Enhancement of Th1 immune responses to recombinant influenza nucleoprotein by Ribi adjuvant. New Microbiol. 36, 145-151 (2013).
    • (2013) New Microbiol. , vol.36 , pp. 145-151
    • Cargnelutti, D.E.1
  • 27
    • 34648814055 scopus 로고    scopus 로고
    • Modulation of immune responses in mice to recombinant antigens from PE and PPE families of proteins of Mycobacterium tuberculosis by the Ribi adjuvant
    • Chaitra, M. G., Nayak, R. & Shaila, M. S. Modulation of immune responses in mice to recombinant antigens from PE and PPE families of proteins of Mycobacterium tuberculosis by the Ribi adjuvant. Vaccine 25, 7168-7176 (2007).
    • (2007) Vaccine , vol.25 , pp. 7168-7176
    • Chaitra, M.G.1    Nayak, R.2    Shaila, M.S.3
  • 28
    • 84881479703 scopus 로고    scopus 로고
    • Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26
    • Lu, G. et al. Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature 500, 227-231 (2013).
    • (2013) Nature , vol.500 , pp. 227-231
    • Lu, G.1
  • 29
    • 33744910870 scopus 로고    scopus 로고
    • Structure of severe acute respiratory syndrome coronavirus receptor-binding domain complexed with neutralizing antibody
    • Prabakaran, P. et al. Structure of severe acute respiratory syndrome coronavirus receptor-binding domain complexed with neutralizing antibody. J. Biol. Chem. 281, 15829-15836 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 15829-15836
    • Prabakaran, P.1
  • 30
    • 34547500771 scopus 로고    scopus 로고
    • Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies
    • Zhu, Z. et al. Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies. Proc. Natl Acad. Sci. USA 104, 12123-12128 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 12123-12128
    • Zhu, Z.1
  • 31
    • 84914162074 scopus 로고    scopus 로고
    • A generic approach to pathological lung segmentation
    • Mansoor, A. et al. A generic approach to pathological lung segmentation. IEEE Trans. Med. Imaging 33, 2293-2310 (2014).
    • (2014) IEEE Trans. Med. Imaging , vol.33 , pp. 2293-2310
    • Mansoor, A.1
  • 32
    • 84897480727 scopus 로고    scopus 로고
    • Rapid generation of a mouse model for Middle East respiratory syndrome
    • Zhao, J. et al. Rapid generation of a mouse model for Middle East respiratory syndrome. Proc. Natl Acad. Sci. USA 111, 4970-4975 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 4970-4975
    • Zhao, J.1
  • 33
    • 84879760362 scopus 로고    scopus 로고
    • The Middle East respiratory syndrome coronavirus (MERS-CoV) does not replicate in Syrian hamsters
    • de Wit, E. et al. The Middle East respiratory syndrome coronavirus (MERS-CoV) does not replicate in Syrian hamsters. PLoS ONE 8, e69127 (2013).
    • (2013) PLoS ONE , vol.8
    • De Wit, E.1
  • 34
    • 84900515662 scopus 로고    scopus 로고
    • Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution
    • Tang, X. C. et al. Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution. Proc. Natl Acad. Sci. USA 111, E2018-E2026 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. E2018-E2026
    • Tang, X.C.1
  • 35
    • 0036776650 scopus 로고    scopus 로고
    • Sustained peptide-specific gamma interferon T-cell response in rhesus macaques immunized with human immunodeficiency virus gag DNA vaccines
    • Caulfield, M. J. et al. Sustained peptide-specific gamma interferon T-cell response in rhesus macaques immunized with human immunodeficiency virus gag DNA vaccines. J. Virol. 76, 10038-10043 (2002).
    • (2002) J. Virol. , vol.76 , pp. 10038-10043
    • Caulfield, M.J.1
  • 36
    • 27644584129 scopus 로고    scopus 로고
    • Modulation of the immune response to the severe acute respiratory syndrome spike glycoprotein by gene-based and inactivated virus immunization
    • Kong, W. P. et al. Modulation of the immune response to the severe acute respiratory syndrome spike glycoprotein by gene-based and inactivated virus immunization. J. Virol. 79, 13915-13923 (2005).
    • (2005) J. Virol. , vol.79 , pp. 13915-13923
    • Kong, W.P.1
  • 37
    • 81855182191 scopus 로고    scopus 로고
    • DNA priming and influenza vaccine immunogenicity: Two phase 1 open label randomised clinical trials
    • Ledgerwood, J. E. et al. DNA priming and influenza vaccine immunogenicity: two phase 1 open label randomised clinical trials. Lancet Infect. Dis. 11, 916-924 (2011).
    • (2011) Lancet Infect. Dis. , vol.11 , pp. 916-924
    • Ledgerwood, J.E.1
  • 38
    • 84880191764 scopus 로고    scopus 로고
    • Prime-boost interval matters: A randomized phase 1 study to identify the minimum interval necessary to observe the H5 DNA influenza vaccine priming effect
    • Ledgerwood, J. E. et al. Prime-boost interval matters: a randomized phase 1 study to identify the minimum interval necessary to observe the H5 DNA influenza vaccine priming effect. J. Infect. Dis. 208, 418-422 (2013).
    • (2013) J. Infect. Dis. , vol.208 , pp. 418-422
    • Ledgerwood, J.E.1
  • 39
    • 84880206390 scopus 로고    scopus 로고
    • DNA priming prior to inactivated influenza A(H5N1) vaccination expands the antibody epitope repertoire and increases affinity maturation in a boost-interval-dependent manner in adults
    • Khurana, S. et al. DNA priming prior to inactivated influenza A(H5N1) vaccination expands the antibody epitope repertoire and increases affinity maturation in a boost-interval-dependent manner in adults. J. Infect. Dis. 208, 413-417 (2013).
    • (2013) J. Infect. Dis. , vol.208 , pp. 413-417
    • Khurana, S.1
  • 40
    • 84911383558 scopus 로고    scopus 로고
    • Effects of human anti-spike protein receptor binding domain antibodies on SARS-coronavirus neutralization escape and fitness
    • Sui, J. et al. Effects of human anti-spike protein receptor binding domain antibodies on SARS-coronavirus neutralization escape and fitness. J. Virol. 88, 13769-13780 (2014).
    • (2014) J. Virol. , vol.88 , pp. 13769-13780
    • Sui, J.1
  • 41
    • 84887277978 scopus 로고    scopus 로고
    • Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus
    • McLellan, J. S. et al. Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus. Science 342, 592-598 (2013).
    • (2013) Science , vol.342 , pp. 592-598
    • McLellan, J.S.1
  • 42
    • 84878349946 scopus 로고    scopus 로고
    • Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody
    • McLellan, J. S. et al. Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody. Science 340, 1113-1117 (2013).
    • (2013) Science , vol.340 , pp. 1113-1117
    • McLellan, J.S.1
  • 43
    • 21644475386 scopus 로고    scopus 로고
    • A human T-cell leukemia virus type 1 regulatory element enhances the immunogenicity of human immunodeficiency virus type 1 DNA vaccines in mice and nonhuman primates
    • Barouch, D. H. et al. A human T-cell leukemia virus type 1 regulatory element enhances the immunogenicity of human immunodeficiency virus type 1 DNA vaccines in mice and nonhuman primates. J. Virol. 79, 8828-8834 (2005).
    • (2005) J. Virol. , vol.79 , pp. 8828-8834
    • Barouch, D.H.1
  • 44
    • 34247201441 scopus 로고    scopus 로고
    • Phase i clinical evaluation of a six-plasmid multiclade HIV-1 DNA candidate vaccine
    • Catanzaro, A. T. et al. Phase I clinical evaluation of a six-plasmid multiclade HIV-1 DNA candidate vaccine. Vaccine 25, 4085-4092 (2007).
    • (2007) Vaccine , vol.25 , pp. 4085-4092
    • Catanzaro, A.T.1
  • 45
    • 33745158157 scopus 로고
    • A simple method of estimating fifty per cent endpoints
    • Reed, L. J. & Muench, H. A simple method of estimating fifty per cent endpoints. Am. J. Epidemiol. 27, 493-497 (1938).
    • (1938) Am. J. Epidemiol. , vol.27 , pp. 493-497
    • Reed, L.J.1    Muench, H.2
  • 46
    • 0031059866 scopus 로고    scopus 로고
    • Processing of X-ray diffraction data collected in oscillation mode
    • Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307-326 (1997).
    • (1997) Methods Enzymol. , vol.276 , pp. 307-326
    • Otwinowski, Z.1    Minor, W.2
  • 47
    • 34447508216 scopus 로고    scopus 로고
    • Phaser crystallographic software
    • McCoy, A. J. et al. Phaser crystallographic software. J. Appl. Crystallogr. 40, 658-674 (2007).
    • (2007) J. Appl. Crystallogr. , vol.40 , pp. 658-674
    • McCoy, A.J.1
  • 49
    • 14844321328 scopus 로고    scopus 로고
    • Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT
    • Blanc, E. et al. Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT. Acta Crystallogr. D Biol. Crystallogr. 60, 2210-2221 (2004).
    • (2004) Acta Crystallogr. D Biol. Crystallogr. , vol.60 , pp. 2210-2221
    • Blanc, E.1
  • 50
    • 0026468883 scopus 로고
    • Three-dimensional structure of an Fv from a human IgM immunoglobulin
    • Fan, Z. C. et al. Three-dimensional structure of an Fv from a human IgM immunoglobulin. J. Mol. Biol. 228, 188-207 (1992).
    • (1992) J. Mol. Biol. , vol.228 , pp. 188-207
    • Fan, Z.C.1
  • 51
    • 67349103859 scopus 로고    scopus 로고
    • Structural insights into immune recognition of the severe acute respiratory syndrome coronavirus S protein receptor binding domain
    • Pak, J. E. et al. Structural insights into immune recognition of the severe acute respiratory syndrome coronavirus S protein receptor binding domain. J. Mol. Biol. 388, 815-823 (2009).
    • (2009) J. Mol. Biol. , vol.388 , pp. 815-823
    • Pak, J.E.1
  • 52
    • 76449098262 scopus 로고    scopus 로고
    • PHENIX: A comprehensive Python-based system for macromolecular structure solution
    • Adams, P. D. et al. PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta. Crystallogr. D Biol. Crystallogr. 66, 213-221 (2010).
    • (2010) Acta. Crystallogr. D Biol. Crystallogr. , vol.66 , pp. 213-221
    • Adams, P.D.1
  • 53
    • 74549178560 scopus 로고    scopus 로고
    • MolProbity: All-atom structure validation for macromolecular crystallography
    • Chen, V. B. et al. MolProbity: all-atom structure validation for macromolecular crystallography. Acta. Crystallogr. D Biol. Crystallogr. 66, 12-21 (2010).
    • (2010) Acta. Crystallogr. D Biol. Crystallogr. , vol.66 , pp. 12-21
    • Chen, V.B.1
  • 54
    • 84885038468 scopus 로고    scopus 로고
    • Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus
    • Scobey, T. et al. Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus. Proc. Natl Acad. Sci. USA 110, 16157-16162 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 16157-16162
    • Scobey, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.