Crystal structure of anti-polysialic acid antibody single chain Fv fragment complexed with octasialic acid: Insight into the binding preference for Polysialic acid

Journal of Biological Chemistry

Volumn 288, Issue 47, 2013, Pages 33784-33796

  Nagae, Masamichi ^a   Ikeda, Akemi ^a   Hane, Masaya ^b   Hanashima, Shinya ^a,c   Kitajima, Ken ^b   Sato, Chihiro ^b   Yamaguchi, Yoshiki ^a  

^a RIKEN   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ASYMMETRIC UNIT; BIOLOGICAL STUDIES; COMPLEMENTARITY-DETERMINING REGIONS; DEGREE OF POLYMERIZATION; HELICAL CONFORMATION; MURINE MONOCLONAL ANTIBODY; POLYSIALIC ACID; SINGLE CHAIN VARIABLE FRAGMENTS;

CARBOXYLIC ACIDS; CELL ADHESION; CELL MEMBRANES; CHAINS; LIGANDS; MOLECULES;

ANTIBODIES;

ANTIBODY; DIVALENT CATION; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 735; MONOVALENT CATION; OCTASIALIC ACID; OLIGOSIALIC ACID; POLYSIALIC ACID; POLYSIALIC ACID ANTIBODY; SIALIC ACID; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG; WATER;

ANIMAL CELL; ANTIBODY AFFINITY; ANTIGEN BINDING; ANTIGEN SPECIFICITY; ARTICLE; CONFORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA BINDING; LIGAND BINDING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS; THERMODYNAMICS;

ANTIBODIES; CRYSTAL STRUCTURE; OLIGOSACCHARIDE; SIALIC ACID; SITE-DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; ANTIBODY SPECIFICITY; BINDING SITES, ANTIBODY; CRYSTALLOGRAPHY, X-RAY; MICE; MOLECULAR SEQUENCE DATA; N-ACETYLNEURAMINIC ACID; PROTEIN STRUCTURE, SECONDARY; SINGLE-CHAIN ANTIBODIES;

EID: 84888384303     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.496224     Document Type: Article

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