Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

American Journal of Human Genetics

Volumn 105, Issue 2, 2019, Pages 334-350

  Lam, Max ^a,b,c   Hill, W David ^d   Trampush, Joey W ^e   Yu, Jin ^b   Knowles, Emma ^f   Davies, Gail ^d   Stahl, Eli ^g   Huckins, Laura ^g   Liewald, David C ^d   Djurovic, Srdjan ^h,i   Melle, Ingrid ^h,i   Sundet, Kjetil ^h,j   Christoforou, Andrea ^k   Reinvang, Ivar ^j   DeRosse, Pamela ^b   Lundervold, Astri J ⁱ   Steen, Vidar M ^i,k   Espeseth, Thomas ^h,j   Räikkönen, Katri ^l   Widen, Elisabeth ^l   Palotie, Aarno ^l,m,n   Eriksson, Johan G ^n,o,p   Giegling, Ina ^q   Konte, Bettina ^q   Hartmann, Annette M ^q   Roussos, Panos ^g,r   Giakoumaki, Stella ^s   Burdick, Katherine E ^g,r,t   Payton, Antony ^u   Ollier, William ^v,w   Chiba Falek, Ornit ^x   Attix, Deborah K ^x   Need, Anna C ^y   Cirulli, Elizabeth T ^z   Voineskos, Aristotle N ^aa   Stefanis, Nikos C ^ab,ac,ad   Avramopoulos, Dimitrios ^ae   Hatzimanolis, Alex ^aa,ab,ac   Arking, Dan E ^ae   Smyrnis, Nikolaos ^aa,ab   Bilder, Robert M ^ae   Freimer, Nelson A ^ae   Cannon, Tyrone D ^ag   London, Edythe ^af   Poldrack, Russell A ^ah   Sabb, Fred W ^ai   Congdon, Eliza ^af   Conley, Emily Drabant ^aj   Scult, Matthew A ^ak   Dickinson, Dwight ^al   Straub, Richard E ^am   Donohoe, Gary ^an   Morris, Derek ^an   Corvin, Aiden ^ao   Gill, Michael ^ao   Hariri, Ahmad R ^ak   Weinberger, Daniel R ^am   Pendleton, Neil ^v   Bitsios, Panos ^s   Rujescu, Dan ^q   Lahti, Jari ^l   Le Hellard, Stephanie ^i,k   Keller, Matthew C ^ap   Andreassen, Ole A ^h,i,j   Deary, Ian J ^d   Glahn, David C ^f   Malhotra, Anil K ^b,aq,ar   Lencz, Todd ^b,aq,ar   more..

^a INSTITUTE OF MENTAL HEALTH   (Singapore)

^b ZUCKER HILLSIDE HOSPITAL   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^h OSLO UNIVERSITY HOSPITAL   (Norway)

ⁱ UNIVERSITY OF BERGEN   (Norway)

^j UNIVERSITY OF OSLO   (Norway)

^k HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^l UNIVERSITY OF HELSINKI   (Finland)

^m WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

ⁿ HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^o NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^p FOLKHÄLSAN RESEARCH CENTER   (Finland)

^q MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^r VETERANS AFFAIRS MEDICAL CENTER   (United States)

^s UNIVERSITY OF CRETE   (Greece)

^t BRIGHAM AND WOMEN S HOSPITAL   (United States)

^u UNIVERSITY OF MANCHESTER   (United Kingdom)

^v UNIVERSITY OF MANCHESTER   (United Kingdom)

^w MANCHESTER METROPOLITAN UNIVERSITY   (United Kingdom)

^x DUKE UNIVERSITY MEDICAL CENTER   (United States)

^y IMPERIAL COLLEGE LONDON   (United Kingdom)

^z Helix   (United States)

^aa UNIVERSITY OF TORONTO   (Canada)

^ab NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

^ac UNIVERSITY MENTAL HEALTH RESEARCH INSTITUTE   (Greece)

^ad Theodor Theohari Cozzika Foundation   (Greece)

^ae JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^af UNIVERSITY OF CALIFORNIA   (United States)

^ag YALE UNIVERSITY   (United States)

^ah STANFORD UNIVERSITY   (United States)

^ai UNIVERSITY OF OREGON   (United States)

^aj 23andMe Inc ^*  (United States)

^ak DUKE UNIVERSITY   (United States)

^al NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^am JOHNS HOPKINS UNIVERSITY   (United States)

^an NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^ao TRINITY COLLEGE DUBLIN   (Ireland)

^ap UNIVERSITY OF COLORADO   (United States)

^aq DONALD AND BARBARA ZUCKER SCHOOL OF MEDICINE AT HOFSTRA NORTHWELL   (United States)

^ar FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

more..

Author keywords

cognitive ability; educational attainment; genetic correlation; GWAS; pathways; pleiotropy; schizophrenia

Indexed keywords

ADULT; ARTICLE; CLINICAL EVALUATION; COGNITION; DISEASE ASSOCIATION; EDUCATION; EDUCATIONAL STATUS; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENE LOCUS; GENETIC DATABASE; GENOME-WIDE ASSOCIATION STUDY; HUMAN; META ANALYSIS; NERVE CELL DIFFERENTIATION; NEUROLOGIC DISEASE ASSESSMENT; PHENOTYPE; PLEIOTROPY; PRIORITY JOURNAL; RISK FACTOR; SCHIZOPHRENIA; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SYNAPTIC TRANSMISSION; COGNITIVE DEFECT; GENETIC PREDISPOSITION; MENTAL DISEASE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADULT; COGNITION; COGNITION DISORDERS; EDUCATIONAL STATUS; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; NEURODEVELOPMENTAL DISORDERS; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA; SYNAPTIC TRANSMISSION;

EID: 85070070650     PISSN: 00029297     EISSN: 15376605     Source Type: Journal    
DOI: 10.1016/j.ajhg.2019.06.012     Document Type: Article

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