Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

Nature Genetics

Volumn 50, Issue 8, 2018, Pages 1112-1121

  Lee, James J ^a   Wedow, Robbee ^b   Okbay, Aysu ^c   Kong, Edward ^d   Maghzian, Omeed ^d   Zacher, Meghan ^d   Nguyen Viet, Tuan Anh ^e   Bowers, Peter ^d   Sidorenko, Julia ^f,g   Karlsson Linnér, Richard ^c,h   Fontana, Mark Alan ^e,i   Kundu, Tushar ^e   Lee, Chanwook ^d   Li, Hui ^d   Li, Ruoxi ^e   Royer, Rebecca ^e   Timshel, Pascal N ^j,k   Walters, Raymond K ^l,m   Willoughby, Emily A ^a   Yengo, Loïc ^f   Agee, Michelle ^q   Alipanahi, Babak ^q   Auton, Adam ^q   Bell, Robert K ^q   Bryc, Katarzyna ^q   Elson, Sarah L ^q   Fontanillas, Pierre ^q   Hinds, David A ^q   McCreight, Jennifer C ^q   Huber, Karen E ^q   Litterman, Nadia K ^q   McIntyre, Matthew H ^q   Mountain, Joanna L ^q   Noblin, Elizabeth S ^q   Northover, Carrie A M ^q   Pitts, Steven J ^q   Sathirapongsasuti, J Fah ^q   Sazonova, Olga V ^q   Shelton, Janie F ^q   Shringarpure, Suyash ^q   Tian, Chao ^q   Vacic, Vladimir ^q   Wilson, Catherine H ^q   Beauchamp, Jonathan P ^ak   Pers, Tune H ^j,k   Rietveld, Cornelius A ^h,au,av   Turley, Patrick ^l,m   Chen, Guo Bo ^f   Emilsson, Valur ^aw,ax   Meddens, S Fleur W ^c,h,ay   Oskarsson, Sven ^aq   Pickrell, Joseph K ^az   Thom, Kevin ^as   Timshel, Pascal ^j,k   Vlaming, Ronald de ^h,au,av   Abdellaoui, Abdel ^c   Ahluwalia, Tarunveer S ^j,ba,bb   Bacelis, Jonas ^bc   Baumbach, Clemens ^bd   Bjornsdottir, Gyda ^be   Brandsma, Johannes H ^av   Concas, Maria Pina ^bf   Derringer, Jaime ^bg   Furlotte, Nicholas A ^q   Galesloot, Tessel E ^bh   Girotto, Giorgia ^bi   Gupta, Richa ^bj   Hall, Leanne M ^ah,bk   Harris, Sarah E ^ah   Hofer, Edith ^bl   Horikoshi, Momoko ^bm,bn   Huffman, Jennifer E ^ab   Kaasik, Kadri ^bj   Kalafati, Ioanna P ^bo   Karlsson, Robert ^ap   Kong, Augustine ^be   Lahti, Jari ^bj,bp   van der Lee, Sven J ^av   Leeuw, Christiaan de ^c,bh   Lind, Penelope A ^bq   Lindgren, Karl Oskar ^aq   Liu, Tian ^br   Mangino, Massimo ^bs,bt   Marten, Jonathan ^ab   Mihailov, Evelin ^g   Miller, Michael B ^a   van der Most, Peter J ^bu   Oldmeadow, Christopher ^bv,bw   Payton, Antony ^bx   Pervjakova, Natalia ^g,by   Peyrot, Wouter J ^bz   Qian, Yong ^ca   Raitakari, Olli ^cb   Rueedi, Rico ^ar,cc   Salvi, Erika ^cd   Schmidt, Börge ^ce   Schraut, Katharina E ^o   Shi, Jianxin ^cf   Smith, Albert V ^aw,ax   Poot, Raymond A ^av   St Pourcain, Beate ^cg   Teumer, Alexander ^ch   Thorleifsson, Gudmar ^be   Verweij, Niek ^bu   Vuckovic, Dragana ^bi   Wellmann, Juergen ^ci   Westra, Harm Jan ^m,cj,ck   Yang, Jingyun ^cl,cm   Zhao, Wei ^cn   Zhu, Zhihong ^f   Alizadeh, Behrooz Z ^bu   Amin, Najaf ^av   Bakshi, Andrew ^f   Baumeister, Sebastian E ^ch,co   Biino, Ginevra ^cp   Bønnelykke, Klaus ^ba   Boyle, Patricia A ^cl,cm   Campbell, Harry ^o   Cappuccio, Francesco P ^cq   Davies, Gail ^ah   De Neve, Jan Emmanuel ^cr   Deloukas, Panos ^cs,ct   Demuth, Ilja ^cu   Ding, Jun ^ca   Eibich, Peter ^bm,cv   Eisele, Lewin ^ce   Eklund, Niina ^by   Evans, David M ^f,cg   Faul, Jessica D ^cn   Feitosa, Mary F ^cw   Forstner, Andreas J ^cx   Gandin, Ilaria ^bi   Gunnarsson, Bjarni ^be   Halldórsson, Bjarni V ^be,cy   Harris, Tamara B ^ca   Heath, Andrew C ^cw   Hocking, Lynne J ^cz   Holliday, Elizabeth G ^bv,bw   Homuth, Georg ^ch   Horan, Michael A ^da   Hottenga, Jouke Jan ^c   de Jager, Philip L ^m,cj,db   Joshi, Peter K ^o,r   Jugessur, Astanand ^dc   Kaakinen, Marika A ^dd   Kähönen, Mika ^de,df   Kanoni, Stavroula ^cs   Keltigangas Järvinen, Liisa ^bj   Kiemeney, Lambertus A L M ^bh   Kolcic, Ivana ^dg   Koskinen, Seppo ^by   Kraja, Aldi T ^cw   Kroh, Martin ^cv   Kutalik, Zoltan ^r,ar,cc   Latvala, Antti ^bj   Launer, Lenore J ^ca   Lebreton, Maël P ^ay   Levinson, Douglas F ^y   Lichtenstein, Paul ^ap   Lichtner, Peter ^bd   Liewald, David C M ^ah   Loukola, LifeLines Cohort Study, Anu ^bj   Madden, Pamela A ^cw   Mägi, Reedik ^g   Mäki Opas, Tomi ^by   Marioni, Riccardo E ^ah,ak   Marques Vidal, Pedro ^dh   Meddens, Gerardus A ^di   McMahon, George ^cg   Meisinger, Christa ^bd   Meitinger, Thomas ^bd   Milaneschi, Yusplitri ^bz   Milani, Lili ^g   Montgomery, Grant W ^bq   Myhre, Ronny ^dc   Nelson, Christopher P ^bk,dj   Nyholt, Dale R ^bq,dk   Ollier, William E R ^bx   Palotie, Aarno ^l,m,bj   Paternoster, Lavinia ^cg   Pedersen, Nancy L ^ap   Petrovic, Katja E ^bl   Porteous, David J ^ah   Räikkönen, Katri ^bj,bp   Ring, Susan M ^cg   Robino, Antonietta ^dl   Rostapshova, Olga ^d,dm   Rudan, Igor ^o   Rustichini, Aldo ^a   Salomaa, Veikko ^by   Sanders, Alan R ^dn,do   Sarin, Antti Pekka ^bj,by   Schmidt, Helena ^bl   Scott, Rodney J ^bv,bw   Smith, Blair H ^ai,aj   Smith, Jennifer A ^bu   Staessen, Jan A ^dp,dq   Steinhagen Thiessen, Elisabeth ^cu   Strauch, Konstantin ^bd,dr   Terracciano, Antonio ^ds   Tobin, Martin D ^bk   Ulivi, Sheila ^dl   Vaccargiu, Simona ^bf   Quaye, Lydia ^bs   van Rooij, Frank J A ^av   Venturini, Cristina ^bs,bt   Vinkhuyzen, Anna A E ^f   Völker, Uwe ^ch   Völzke, Henry ^ch   Vonk, Judith M ^bu   Vozzi, Diego ^dl   Waage, Johannes ^ba,bb   Ware, Erin B ^cn   Willemsen, Gonneke ^c   Attia, John R ^bv,bw   Bennett, David A ^cl,cm   Berger, Klaus ^bu   Bertram, Lars ^dd,dt   Bisgaard, Hans ^ba   Boomsma, Dorret I ^c   Borecki, Ingrid B ^cw   Bültmann, Ute ^bu   Chabris, Christopher F ^u   Cucca, Francesco ^bf   Cusi, Daniele ^cd,du   Deary, Ian J ^ah   Dedoussis, George V ^bo   van Duijn, Cornelia M ^av   Eriksson, Johan G ^bj,bp   Franke, Barbara ^dv   Franke, Lude ^bu   Gasparini, Paolo ^bi,dl,dw   Gejman, Pablo V ^dn,do   Gieger, Christian ^bd   Grabe, Hans Jörgen ^ch,dx   Gratten, Jacob ^f   Groenen, Patrick J F ^dy   Gudnason, Vilmundur ^aw,ax   van der Harst, Pim ^bu,dz   Hayward, Caroline ^ab   Hoffmann, Wolfgang ^ch   Hyppönen, Elina ^ea,eb,ec   Iacono, William G ^a   Jacobsson, Bo ^bc,dc   Järvelin, Marjo Riitta ^dd,ed,ee,ef   Jöckel, Karl Heinz ^ce   Kaprio, Jaakko ^bj,by   Kardia, Sharon L R ^cn   Lehtimäki, Terho ^df,eg   Lehrer, Steven F ^am,an,ao   Magnusson, Patrik K E ^ap   Martin, Nicholas G ^bq   McGue, Matt ^a   Metspalu, Andres ^g,ag   Pendleton, Neil ^bx,eh   Penninx, Brenda W J H ^bz   Perola, Markus ^g,by   Pirastu, Nicola ^bi   Pirastu, Mario ^bf   Polasek, Ozren ^o,dg   Posthuma, Danielle ^c,bz   Power, Christine ^eb   Province, Michael A ^cw   Samani, Nilesh J ^bk,dj   Schlessinger, David ^ca   Schmidt, Reinhold ^bl   Sørensen, Thorkild I A ^j,cg,ei   Spector, Tim D ^bs   Stefansson, Kari ^ax,be   Thorsteinsdottir, Unnur ^ax,be   Thurik, A Roy ^h,au,ej,ek   Timpson, Nicholas J ^cg   Tiemeier, Henning ^av   Tung, Joyce Y ^q   Uitterlinden, André G ^av   Vitart, Veronique ^ab   Vollenweider, Peter ^dh   Weir, David R ^cn   Wilson, James F ^o,ab   Wright, Alan F ^ab   Conley, Dalton C ^al   Krueger, Robert F ^a   Smith, George Davey ^cg   Hofman, Albert ^av   Laibson, David I ^d   Medland, Sarah E ^bq   Meyer, Michelle N ^u   Yang, Jian ^f   Johannesson, Magnus ^at   Visscher, Peter M ^f   Esko, Tõnu ^g   Koellinger, Philipp D ^c,h   Cesarini, David ^ao,as   Benjamin, Daniel J ^e,ao   Alver, Maris ^g   Bao, Yanchun ⁿ   Clark, David W ^o   Day, Felix R ^p   Kemper, Kathryn E ^f   Kleinman, Aaron ^q   Langenberg, Claudia ^p   Trampush, Joey W ^s,t   Verma, Shefali Setia ^u   Wu, Yang ^f   Lam, Max ^v,w   Zhao, Jing Hua ^p   Zheng, Zhili ^f,x   Boardman, Jason D ^b   Freese, Jeremy ^y   Harris, Kathleen Mullan ^z,aa   Herd, Pamela ^n,ac   Kumari, Meena ⁿ   Lencz, Todd ^ad,ae,af   Luan, Jian’an ^p   Malhotra, Anil K ^ad,ae,af   Ong, Ken K ^p   Perry, John R B ^p   Ritchie, Marylyn D ^u   Smart, Melissa C ^o   Wareham, Nicholas J ^p   Robinson, Matthew R ^f,ar   Watson, Chelsea ^e   more..

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

^d HARVARD UNIVERSITY   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f UNIVERSITY OF QUEENSLAND   (Australia)

^g UNIVERSITY OF TARTU   (Estonia)

^h ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

ⁱ HOSPITAL FOR SPECIAL SURGERY   (United States)

^j Capital Region   (Denmark)

^k STATENS SERUM INSTITUT   (Denmark)

^l MASSACHUSETTS GENERAL HOSPITAL   (United States)

^m BROAD INSTITUTE OF MIT AND HARVARD   (United States)

ⁿ UNIVERSITY OF ESSEX   (United Kingdom)

^o UNIVERSITY OF EDINBURGH   (United Kingdom)

^p UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^q 23andMe Inc ^*  (United States)

^r UNIVERSITY OF LAUSANNE   (Switzerland)

^s BrainWorkup   (United States)

^t UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^u GEISINGER HEALTH SYSTEM   (United States)

^v INSTITUTE OF MENTAL HEALTH   (Singapore)

^w GENOME INSTITUTE OF SINGAPORE   (Singapore)

^x WENZHOU MEDICAL UNIVERSITY   (China)

^y STANFORD UNIVERSITY   (United States)

^z UNIVERSITY OF NORTH CAROLINA   (United States)

^aa UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL   (United States)

^ab UNIVERSITY OF EDINBURGH   (United Kingdom)

^ac UNIVERSITY OF WISCONSIN MADISON   (United States)

^ad DONALD AND BARBARA ZUCKER SCHOOL OF MEDICINE AT HOFSTRA NORTHWELL   (United States)

^ae FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^af ZUCKER HILLSIDE HOSPITAL   (United States)

^ag UNIVERSITY OF TARTU   (Estonia)

^ah UNIVERSITY OF EDINBURGH   (United Kingdom)

^ai UNIVERSITY OF DUNDEE   (United Kingdom)

^aj UNIVERSITY OF DUNDEE   (United Kingdom)

^ak UNIVERSITY OF TORONTO   (Canada)

^al PRINCETON UNIVERSITY   (United States)

^am QUEEN S UNIVERSITY   (Canada)

^an NEW YORK UNIVERSITY SHANGHAI   (China)

^ao NATIONAL BUREAU OF ECONOMIC RESEARCH   (United States)

^ap KAROLINSKA INSTITUTE   (Sweden)

^aq UPPSALA UNIVERSITY   (Sweden)

^ar UNIVERSITY OF LAUSANNE   (Switzerland)

^as NEW YORK UNIVERSITY   (United States)

^at STOCKHOLM SCHOOL OF ECONOMICS   (Sweden)

^au ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^av ERASMUS MEDICAL CENTER   (Netherlands)

^aw ICELANDIC HEART ASSOCIATION   (Iceland)

^ax UNIVERSITY OF ICELAND   (Iceland)

^ay UNIVERSITY OF AMSTERDAM   (Netherlands)

^az NEW YORK GENOME CENTER   (United States)

^ba UNIVERSITY OF COPENHAGEN   (Denmark)

^bb STENO DIABETES CENTER   (Denmark)

^bc SAHLGRENSKA ACADEMY AT UNIVERSITY OF GOTHENBURG   (Sweden)

^bd INSTITUTE OF EPIDEMIOLOGY   (Germany)

^be DECODE GENETICS   (Iceland)

^bf Milan Unit   (Italy)

^bg UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^bh RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^bi UNIVERSITY OF TRIESTE   (Italy)

^bj UNIVERSITY OF HELSINKI   (Finland)

^bk UNIVERSITY OF LEICESTER   (United Kingdom)

^bl MEDICAL UNIVERSITY OF GRAZ   (Austria)

^bm UNIVERSITY OF OXFORD   (United Kingdom)

^bn UNIVERSITY OF OXFORD   (United Kingdom)

^bo HAROKOPIO UNIVERSITY   (Greece)

^bp FOLKHÄLSAN RESEARCH CENTER   (Finland)

^bq QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^br MAX PLANCK INSTITUTE FOR HUMAN DEVELOPMENT   (Germany)

^bs KING'S COLLEGE LONDON   (United Kingdom)

^bt GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^bu UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^bv HUNTER MEDICAL RESEARCH INSTITUTE   (Australia)

^bw UNIVERSITY OF NEWCASTLE   (Australia)

^bx UNIVERSITY OF MANCHESTER   (United Kingdom)

^by NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^bz VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^ca NATIONAL INSTITUTE ON AGING   (United States)

^cb UNIVERSITY OF TURKU   (Finland)

^cc SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^cd UNIVERSITY OF MILAN   (Italy)

^ce UNIVERSITY HOSPITAL ESSEN   (Germany)

^cf NATIONAL CANCER INSTITUTE   (United States)

^cg UNIVERSITY OF BRISTOL   (United Kingdom)

^ch UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^ci UNIVERSITY OF MÜNSTER   (Germany)

^cj HARVARD MEDICAL SCHOOL   (United States)

^ck LABORATORY FOR MOLECULAR MEDICINE   (United States)

^cl RUSH UNIVERSITY MEDICAL CENTER   (United States)

^cm RUSH UNIVERSITY MEDICAL CENTER   (United States)

^cn UNIVERSITY OF MICHIGAN   (United States)

^co UNIVERSITY OF REGENSBURG   (Germany)

^cp CNR   (Italy)

^cq UNIVERSITY OF WARWICK   (United Kingdom)

^cr UNIVERSITY OF OXFORD   (United Kingdom)

^cs QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^ct KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^cu CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^cv DIW BERLIN   (Germany)

^cw WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^cx UNIVERSITY OF BONN   (Germany)

^cy REYKJAVIK UNIVERSITY   (Iceland)

^cz UNIVERSITY OF ABERDEEN   (United Kingdom)

^da UNIVERSITY OF MANCHESTER   (United Kingdom)

^db BRIGHAM AND WOMEN S HOSPITAL   (United States)

^dc NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^dd IMPERIAL COLLEGE LONDON   (United Kingdom)

^de TAMPERE UNIVERSITY HOSPITAL   (Finland)

^df TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^dg UNIVERSITY OF SPLIT   (Croatia)

^dh LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^di Tema BV   (Netherlands)

^dj GLENFIELD HOSPITAL   (United Kingdom)

^dk QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^dl INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

^dm Social Impact Inc   (United States)

^dn NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

^do UNIVERSITY OF CHICAGO   (United States)

^dp UNIVERSITY OF LEUVEN   (Belgium)

^dq MAASTRICHT UNIVERSITY   (Netherlands)

^dr UNIVERSITY OF MUNICH   (Germany)

^ds FLORIDA STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^dt UNIVERSITY OF LÜBECK   (Germany)

^du INSTITUTE OF BIOMEDICAL TECHNOLOGIES   (Italy)

^dv RADBOUD UNIVERSITY   (Netherlands)

^dw Sidra Hospital   (Qatar)

^dx Department of Psychiatry and Psychotherapy   (Germany)

^dy Erasmus University Rotterdam   (Netherlands)

^dz INTERUNIVERSITY CARDIOLOGY INSTITUTE OF THE NETHERLANDS   (Netherlands)

^ea UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^eb SOUTH AUSTRALIAN HEALTH AND MEDICAL RESEARCH INSTITUTE   (Australia)

^ec UNIVERSITY COLLEGE LONDON   (United Kingdom)

^ed UNIVERSITY OF OULU   (Finland)

^ee OULU UNIVERSITY HOSPITAL   (Finland)

^ef UNIVERSITY OF OULU   (Finland)

^eg FIMLAB LABORATORIES   (Finland)

^eh HOPE HOSPITAL   (United Kingdom)

^ei The Capital Region   (Denmark)

^ej MONTPELLIER BUSINESS SCHOOL   (France)

^ek Panteia   (Netherlands)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BRAIN DEVELOPMENT; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HERITABILITY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; JOINT; MAJOR CLINICAL STUDY; MALE; MENTAL CAPACITY; NERVE CELL; PHENOTYPE; PREDICTION; X CHROMOSOME; AGED; COHORT ANALYSIS; EDUCATIONAL STATUS; META ANALYSIS; MIDDLE AGED; MULTIFACTORIAL INHERITANCE; PROCEDURES; SINGLE NUCLEOTIDE POLYMORPHISM; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; COHORT STUDIES; EDUCATIONAL STATUS; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MIDDLE AGED; MULTIFACTORIAL INHERITANCE; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 85050543338     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/s41588-018-0147-3     Document Type: Article

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