A Powerful Approach to Estimating Annotation-Stratified Genetic Covariance via GWAS Summary Statistics

American Journal of Human Genetics

Volumn 101, Issue 6, 2017, Pages 939-964

  Lu, Qiongshi ^a,f   Li, Boyang ^a   Ou, Derek ^b   Erlendsdottir, Margret ^b   Powles, Ryan L ^a   Jiang, Tony ^a   Hu, Yiming ^a   Chang, David ^a   Jin, Chentian ^a   Dai, Wei ^a   He, Qidu ^c   Liu, Zefeng ^c   Mukherjee, Shubhabrata ^d   Crane, Paul K ^d   Zhao, Hongyu ^a,e  

^a YALE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^e VA Cooperative Studies Program Coordinating Center   (United States)

^f UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Alzheimer's disease; amyotrophic lateral sclerosis; functional annotation; genetic covariance; genome wide association study; summary statistics

Indexed keywords

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; AUTOIMMUNITY; COGNITION; COVARIANCE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC COVARIANCE; GENETIC TRAIT; GENOME-WIDE ASSOCIATION STUDY; HUMAN; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL ANALYSIS; STATISTICAL MODEL; STATISTICS; SUMMARY STATISTICS; ANALYSIS OF VARIANCE; GENETIC PREDISPOSITION; GENETICS; MOLECULAR GENETICS; PROCEDURES; QUANTITATIVE TRAIT LOCUS;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ANALYSIS OF VARIANCE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LINKAGE DISEQUILIBRIUM; MOLECULAR SEQUENCE ANNOTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI;

EID: 85037353763     PISSN: 00029297     EISSN: 15376605     Source Type: Journal    
DOI: 10.1016/j.ajhg.2017.11.001     Document Type: Article

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