Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets

Cell Reports

Volumn 21, Issue 9, 2017, Pages 2597-2613

  Lam, Max ^a   Trampush, Joey W ^b   Yu, Jin ^c   Knowles, Emma ^d   Davies, Gail ^e   Liewald, David C ^e   Starr, John M ^e   Djurovic, Srdjan ^f,g   Melle, Ingrid ^f,g   Sundet, Kjetil ^f,h   Christoforou, Andrea ⁱ   Reinvang, Ivar ^h   DeRosse, Pamela ^c   Lundervold, Astri J ^g   Steen, Vidar M ^g,i   Espeseth, Thomas ^f,h   Räikkönen, Katri ^j   Widen, Elisabeth ^j   Palotie, Aarno ^j,k,l   Eriksson, Johan G ^l,m,n   Giegling, Ina ^o   Konte, Bettina ^o   Roussos, Panos ^p,q   Giakoumaki, Stella ^r   Burdick, Katherine E ^p,q,s   Payton, Antony ^t   Ollier, William ^t,u   Chiba Falek, Ornit ^v   Attix, Deborah K ^v   Need, Anna C ^w   Cirulli, Elizabeth T ^x   Voineskos, Aristotle N ^y   Stefanis, Nikos C ^z,aa,ab   Avramopoulos, Dimitrios ^ac   Hatzimanolis, Alex ^z,aa,ab   Arking, Dan E ^ac   Smyrnis, Nikolaos ^z,aa   Bilder, Robert M ^ad   Freimer, Nelson A ^ad   Cannon, Tyrone D ^ae   London, Edythe ^ad   Poldrack, Russell A ^af   Sabb, Fred W ^ag   Congdon, Eliza ^ad   Conley, Emily Drabant ^ah   Scult, Matthew A ^ai   Dickinson, Dwight ^aj   Straub, Richard E ^ak   Donohoe, Gary ^al   Morris, Derek ^al   Corvin, Aiden ^am   Gill, Michael ^am   Hariri, Ahmad R ^ai   Weinberger, Daniel R ^ak   Pendleton, Neil ^an   Bitsios, Panos ^r   Rujescu, Dan ^o   Lahti, Jari ^j   Le Hellard, Stephanie ^g,i   Keller, Matthew C ^ao   Andreassen, Ole A ^f,g,h   Deary, Ian J ^e   Glahn, David C ^d   Malhotra, Anil K ^c,ap,aq   Lencz, Todd ^c,ap,aq   more..

^a INSTITUTE OF MENTAL HEALTH   (Singapore)

^b BrainWorkup LLC   (United States)

^c ZUCKER HILLSIDE HOSPITAL   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF EDINBURGH   (United Kingdom)

^f OSLO UNIVERSITY HOSPITAL   (Norway)

^g UNIVERSITY OF BERGEN   (Norway)

^h UNIVERSITY OF OSLO   (Norway)

ⁱ HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^j UNIVERSITY OF HELSINKI   (Finland)

^k WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^l HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^m NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

ⁿ FOLKHÄLSAN RESEARCH CENTER   (Finland)

^o MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^p MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^q VETERANS AFFAIRS MEDICAL CENTER   (United States)

^r UNIVERSITY OF CRETE   (Greece)

^s BRIGHAM AND WOMEN S HOSPITAL   (United States)

^t UNIVERSITY OF MANCHESTER   (United Kingdom)

^u UNIVERSITY OF MANCHESTER   (United Kingdom)

^v DUKE UNIVERSITY MEDICAL CENTER   (United States)

^w IMPERIAL COLLEGE LONDON   (United Kingdom)

^x Human Longevity Inc   (United States)

^y UNIVERSITY OF TORONTO   (Canada)

^z NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

^aa UNIVERSITY MENTAL HEALTH RESEARCH INSTITUTE   (Greece)

^ab Theodor Theohari Cozzika Foundation   (Greece)

^ac JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ad UNIVERSITY OF CALIFORNIA   (United States)

^ae YALE UNIVERSITY   (United States)

^af STANFORD UNIVERSITY   (United States)

^ag UNIVERSITY OF OREGON   (United States)

^ah University of Oregon ^*  (United States)

^ai DUKE UNIVERSITY   (United States)

^aj NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^ak JOHNS HOPKINS UNIVERSITY   (United States)

^al NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^am TRINITY COLLEGE DUBLIN   (Ireland)

^an SALFORD ROYAL NHS FOUNDATION TRUST   (United Kingdom)

^ao UNIVERSITY OF COLORADO   (United States)

^ap DONALD AND BARBARA ZUCKER SCHOOL OF MEDICINE AT HOFSTRA NORTHWELL   (United States)

^aq FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

more..

Author keywords

calcium channel; cerebellum; gene expression; general cognitive ability; GWAS; neurodevelopment; nootropics; potassium channel; synapse

Indexed keywords

CINNARIZINE; LY 97241; POTASSIUM CHANNEL BLOCKING AGENT; TRANSCRIPTOME; UNCLASSIFIED DRUG; CEFOTAXIME; LY 97962; NOOTROPIC AGENT;

ACADEMIC ACHIEVEMENT; ARTICLE; ASTROCYTE; AUTOIMMUNE DISEASE; BRAIN NERVE CELL; BRAIN REGION; CEREBELLUM; COGNITION; COMPETITIVE PATHWAY ANALYSIS; DISEASE ASSOCIATION; DRUG TARGETING; EPIGENETICS; GENE EXPRESSION; GENE IDENTIFICATION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENERAL COGNITIVE ABILITY; GENETIC CORRELATION; GENETIC DISORDER; GENOME-WIDE ASSOCIATION STUDY; HUMAN; INTELLECTUAL IMPAIRMENT; LONGEVITY; MATERNAL AGE; MENTAL DISEASE; META ANALYSIS; NERVOUS SYSTEM DEVELOPMENT; OLIGODENDROGLIA; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; SYNAPSE; SYSTEMATIC REVIEW; TRANSCRIPTOMICS; ANALOGS AND DERIVATIVES; DRUG EFFECT; FEMALE; GENETIC PREDISPOSITION; GENETICS; MALE; METABOLISM; PHYSIOLOGY; PROCEDURES; SINGLE NUCLEOTIDE POLYMORPHISM;

CEFOTAXIME; COGNITION; FEMALE; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; NOOTROPIC AGENTS; POLYMORPHISM, SINGLE NUCLEOTIDE; SYNAPSES;

EID: 85035770040     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.11.028     Document Type: Article

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