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Volumn 1, Issue 1, 2017, Pages 119-137

Systems Medicine—Complexity Within, Simplicity Without

Author keywords

Complexity; Simplicity; Systems medicine

Indexed keywords


EID: 85067951855     PISSN: None     EISSN: 2509498X     Source Type: Journal    
DOI: 10.1007/s41666-017-0002-9     Document Type: Note
Times cited : (19)

References (123)
  • 1
    • 80053069632 scopus 로고    scopus 로고
    • Mechanism and biological explanation
    • Bechtel W (2011) Mechanism and biological explanation. Philosophy Science 78:533–557 DOI: 10.1086/661513
    • (2011) Philosophy Science , vol.78 , pp. 533-557
    • Bechtel, W.1
  • 2
    • 84878036927 scopus 로고    scopus 로고
    • Abstraction and the organization of mechanisms
    • Levy A, Bechtel W (2013) Abstraction and the organization of mechanisms. Philosophy Science 80:241–261 DOI: 10.1086/670300
    • (2013) Philosophy Science , vol.80 , pp. 241-261
    • Levy, A.1    Bechtel, W.2
  • 3
    • 84897868480 scopus 로고    scopus 로고
    • Machine-likeness and explanation by decomposition
    • Levy A (2014) Machine-likeness and explanation by decomposition. Philosophers’ Imprint 14:1–15
    • (2014) Philosophers’ Imprint , vol.14 , pp. 1-15
    • Levy, A.1
  • 4
    • 3843081970 scopus 로고
    • The history and status of general systems theory
    • Bertalanffy L (1972) The history and status of general systems theory. Acad Mgmt J 15:407–426 DOI: 10.2307/255139
    • (1972) Acad Mgmt J , vol.15 , pp. 407-426
    • Bertalanffy, L.1
  • 5
    • 39349112675 scopus 로고    scopus 로고
    • On the making of a system theory of life: Paul A Weiss and Ludwig von Bertalanffy’s conceptual connection
    • Drack M, Apfalter W, Pouvreau D (2007) On the making of a system theory of life: Paul A Weiss and Ludwig von Bertalanffy’s conceptual connection. Q Rev Biol 82:349–373 DOI: 10.1086/522810
    • (2007) Q Rev Biol , vol.82 , pp. 349-373
    • Drack, M.1    Apfalter, W.2    Pouvreau, D.3
  • 6
    • 80655146427 scopus 로고    scopus 로고
    • Approaches to the question ‘what is life?’: reconciling theoretical biology with philosophical biology
    • Gare A (2008) Approaches to the question ‘what is life?’: reconciling theoretical biology with philosophical biology. Cosmos Hist: J Natural Social Philosophy 4:53–77
    • (2008) Cosmos Hist: J Natural Social Philosophy , vol.4 , pp. 53-77
    • Gare, A.1
  • 7
    • 85088161738 scopus 로고    scopus 로고
    • Schrodinger’s legacy: Systems and life
    • Accessed 26 Feb 2017
    • Wellstead P (2006) Schrodinger’s legacy: systems and life. Hamilton Institute. www.hamilton.ie/SystemsBiology/files/2006/schroedinger.pdf. Accessed 26 Feb 2017
    • (2006) Hamilton Institute.
    • Wellstead, P.1
  • 8
    • 84876144335 scopus 로고    scopus 로고
    • Ten challenges for systems medicine
    • Capobianco E (2012) Ten challenges for systems medicine. Front Genetics 3:1–4
    • (2012) Front Genetics , vol.3 , pp. 1-4
    • Capobianco, E.1
  • 9
    • 79951963979 scopus 로고    scopus 로고
    • Ten questions about systems biology
    • Joyner M, Pederson B (2011) Ten questions about systems biology. J Physiol. doi:10.1113/jphysiol.2010.201509
    • (2011) J Physiol
    • Joyner, M.1    Pederson, B.2
  • 10
    • 84942580956 scopus 로고    scopus 로고
    • Implementing systems medicine within healthcare
    • Kirschner M, Bauch A, Agusti A et al (2015) Implementing systems medicine within healthcare. Genome Med. doi:10.1186/s13073-015-0224-5
    • (2015) Genome Med
    • Kirschner, M.1    Bauch, A.2    Agusti, A.3
  • 11
    • 84914817486 scopus 로고    scopus 로고
    • Pushing limits by embracing complexity
    • Wolkenhauer O (2014) Pushing limits by embracing complexity. IET Syst Biol 8:244–250 DOI: 10.1049/iet-syb.2014.0031
    • (2014) IET Syst Biol , vol.8 , pp. 244-250
    • Wolkenhauer, O.1
  • 12
    • 78449283006 scopus 로고    scopus 로고
    • Stanford Encyclopedia Philosophy, Accessed 26 Feb 2017
    • Brigandt I (2008) Reductionism in biology. Stanford Encyclopedia Philosophy. https://plato.stanford.edu/entries/reduction-biology/. Accessed 26 Feb 2017
    • (2008) Reductionism in Biology
    • Brigandt, I.1
  • 13
    • 85098093305 scopus 로고    scopus 로고
    • Evolutionary developmental biology and the limits of philosophical accounts of mechanistic explanation
    • Braillard P-A, Malaterre C, (eds), Springer, Dordrecht
    • Brigandt I (2015) Evolutionary developmental biology and the limits of philosophical accounts of mechanistic explanation. In: Braillard P-A, Malaterre C (eds) Explanation in biology. Springer, Dordrecht, pp 135–174 DOI: 10.1007/978-94-017-9822-8_7
    • (2015) Explanation in biology , pp. 135-174
    • Brigandt, I.1
  • 14
    • 10044298236 scopus 로고    scopus 로고
    • Reductionism and complexity in molecular biology
    • Regenmortel M (2004) Reductionism and complexity in molecular biology. Europ Mole Biol Org EMBO reports 5:1016–1020
    • (2004) Europ Mole Biol Org EMBO reports , vol.5 , pp. 1016-1020
    • Regenmortel, M.1
  • 16
    • 33750993479 scopus 로고    scopus 로고
    • A brief history of systems biology
    • Trewavas A (2006) A brief history of systems biology. Plant Cell 18:2420–2430 DOI: 10.1105/tpc.106.042267
    • (2006) Plant Cell , vol.18 , pp. 2420-2430
    • Trewavas, A.1
  • 17
    • 33847352481 scopus 로고    scopus 로고
    • The mathematical biophysics of Nicolas Rashevsky
    • Cull P (2007) The mathematical biophysics of Nicolas Rashevsky. BioSyst 88:178–184 DOI: 10.1016/j.biosystems.2006.11.003
    • (2007) BioSyst , vol.88 , pp. 178-184
    • Cull, P.1
  • 18
    • 84929943466 scopus 로고    scopus 로고
    • On the history of Ludwid von Bertalanffy’s ‘General Systemology’, and its relationship to cybernetics – part III: convergences and divergences
    • Drack M, Pouvreau D (2015) On the history of Ludwid von Bertalanffy’s ‘General Systemology’, and its relationship to cybernetics – part III: convergences and divergences. Internat J Gen Syst 44:523–571 DOI: 10.1080/03081079.2014.1000642
    • (2015) Internat J Gen Syst , vol.44 , pp. 523-571
    • Drack, M.1    Pouvreau, D.2
  • 19
    • 85088165161 scopus 로고    scopus 로고
    • Hamilton Institute, Accessed 26 Feb 2017
    • Wellstead P (2008) Systems biology and the spirit of Tustin. Hamilton Institute. www.hamilton.ie/systemsbiology/files/2008SpiritofTustin.pdf. Accessed 26 Feb 2017
    • (2008) Systems Biology and the Spirit of Tustin
    • Wellstead, P.1
  • 20
    • 21044443402 scopus 로고    scopus 로고
    • Search for organizing principles: understanding in systems biology
    • Mesarovic M, Sreenah S, Keene J (2004) Search for organizing principles: understanding in systems biology. Syst Biol 1:19–27 DOI: 10.1049/sb:20045010
    • (2004) Syst Biol , vol.1 , pp. 19-27
    • Mesarovic, M.1    Sreenah, S.2    Keene, J.3
  • 23
    • 84878873849 scopus 로고    scopus 로고
    • Advances in systems biology: computational algorithms and applications
    • Huang Y, Zhao Z, Xu H et al (2012) Advances in systems biology: computational algorithms and applications. BMC Syst Biol 6(Suppl 3):S1 DOI: 10.1186/1752-0509-6-S3-S1
    • (2012) BMC Syst Biol , vol.6 , pp. S1
    • Huang, Y.1    Zhao, Z.2    Xu, H.3
  • 24
    • 84936971307 scopus 로고    scopus 로고
    • Systems biology, emergence and antireductionism
    • Kesic S (2016) Systems biology, emergence and antireductionism. Saudi J Biol Sci 23:584–590 DOI: 10.1016/j.sjbs.2015.06.015
    • (2016) Saudi J Biol Sci , vol.23 , pp. 584-590
    • Kesic, S.1
  • 25
    • 3442884234 scopus 로고    scopus 로고
    • Systems biology: from physiology to gene regulation
    • Khammash M, El-Samad H (2004) Systems biology: from physiology to gene regulation. IEEE Control Syst Mag 8:62–76 DOI: 10.1109/MCS.2004.1316654
    • (2004) IEEE Control Syst Mag , vol.8 , pp. 62-76
    • Khammash, M.1    El-Samad, H.2
  • 26
    • 38749148801 scopus 로고    scopus 로고
    • Why we need systems biology
    • Way J, Silver P (2007) Why we need systems biology. Complexity. doi:10.1002/cplx.20198
    • (2007) Complexity
    • Way, J.1    Silver, P.2
  • 27
    • 78049446324 scopus 로고    scopus 로고
    • Systems biology and the mechanistic framework
    • Braillard P-A (2010) Systems biology and the mechanistic framework. Hist Phil Life Sci 32:43–62
    • (2010) Hist Phil Life Sci , vol.32 , pp. 43-62
    • Braillard, P.-A.1
  • 28
    • 77949479491 scopus 로고    scopus 로고
    • So what do we really mean when we say that systems biology is holistic?
    • Gatherer D (2010) So what do we really mean when we say that systems biology is holistic? BMC Syst Biol. doi:10.1186/1752-0509-4-22
    • (2010) BMC Syst Biol
    • Gatherer, D.1
  • 29
    • 84969540507 scopus 로고    scopus 로고
    • A novel method to verify multilevel computational models of biological systems using multiscale spatio-temporal meta and model checking
    • Parvu O, Gilbert D (2016) A novel method to verify multilevel computational models of biological systems using multiscale spatio-temporal meta and model checking. PLoS One. doi:10.1371/journal.pone.0154847
    • (2016) PLoS One
    • Parvu, O.1    Gilbert, D.2
  • 30
    • 17644365470 scopus 로고    scopus 로고
    • The end of ‘naïve reductionism’: rise of systems biology or renaissance of physiology?
    • Strange K (2005) The end of ‘naïve reductionism’: rise of systems biology or renaissance of physiology? Am J Physiol Cell Physiol 288:C968–C974 DOI: 10.1152/ajpcell.00598.2004
    • (2005) Am J Physiol Cell Physiol , vol.288 , pp. C968-C974
    • Strange, K.1
  • 31
    • 84911499901 scopus 로고    scopus 로고
    • Modeling systems-level dynamics: understanding without mechanistic explanation in integrative systems biology
    • MacLeod M, Nersessian N (2015) Modeling systems-level dynamics: understanding without mechanistic explanation in integrative systems biology. Stud Hist Phil Biol Biomed Sci 49:1–11 DOI: 10.1016/j.shpsc.2014.10.004
    • (2015) Stud Hist Phil Biol Biomed Sci , vol.49 , pp. 1-11
    • MacLeod, M.1    Nersessian, N.2
  • 32
    • 84964063309 scopus 로고    scopus 로고
    • Organizing principles as tools for bridging the gap between system theory and biological experimentation
    • Mekios C (2016) Organizing principles as tools for bridging the gap between system theory and biological experimentation. Hist Phil Life Sci 38:65–89 DOI: 10.1007/s40656-016-0095-0
    • (2016) Hist Phil Life Sci , vol.38 , pp. 65-89
    • Mekios, C.1
  • 33
    • 0036499997 scopus 로고    scopus 로고
    • Modeling the heart—from genes to cells to the whole organ
    • Noble D (2002) Modeling the heart—from genes to cells to the whole organ. Science 295:1678–1682 DOI: 10.1126/science.1069881
    • (2002) Science , vol.295 , pp. 1678-1682
    • Noble, D.1
  • 34
    • 0037336350 scopus 로고    scopus 로고
    • Integration from proteins to organs: the Physiome project
    • Hunter P, Borg T (2003) Integration from proteins to organs: the Physiome project. Nature Rev Mole Cell Biol 4:237–243 DOI: 10.1038/nrm1054
    • (2003) Nature Rev Mole Cell Biol , vol.4 , pp. 237-243
    • Hunter, P.1    Borg, T.2
  • 35
    • 85018755885 scopus 로고    scopus 로고
    • Pulse Embs, Accessed 26 Feb 2017
    • Hunter P (2016) The virtual physiological human. Pulse Embs. https://www.pulse.embs.org/july-2016/virtual-physiological-human/. Accessed 26 Feb 2017
    • (2016) The Virtual Physiological Human
    • Hunter, P.1
  • 36
    • 84958818647 scopus 로고    scopus 로고
    • The human physiome: how standards, software and innovative service infrastructure are providing the building blocks to make it achievable
    • Nickerson D, Atalag K, de Bono B et al (2016) The human physiome: how standards, software and innovative service infrastructure are providing the building blocks to make it achievable. Interface Focus 6:1–13 DOI: 10.1098/rsfs.2015.0103
    • (2016) Interface Focus , vol.6 , pp. 1-13
    • Nickerson, D.1    Atalag, K.2    de Bono, B.3
  • 37
    • 64749110869 scopus 로고    scopus 로고
    • The cardiac physiome: perspectives for the future
    • Bassingthwaighte J, Hunter P, Noble D (2009) The cardiac physiome: perspectives for the future. Exp Physiol 94:597–605 DOI: 10.1113/expphysiol.2008.044099
    • (2009) Exp Physiol , vol.94 , pp. 597-605
    • Bassingthwaighte, J.1    Hunter, P.2    Noble, D.3
  • 38
    • 84890902327 scopus 로고    scopus 로고
    • Representing physiological processes and their participants with PhysioMaps
    • Cook D (2013) Representing physiological processes and their participants with PhysioMaps. J Biomed Semantics 4(Suppl 1):1–5 DOI: 10.1186/2041-1480-4-S1-S2
    • (2013) J Biomed Semantics , vol.4 , pp. 1-5
    • Cook, D.1
  • 39
    • 84958818085 scopus 로고    scopus 로고
    • The human physiome: a necessary key for the creative destruction of medicine
    • Omholt S, Hunter P (2016) The human physiome: a necessary key for the creative destruction of medicine. Interface Focus. 6:1–4 DOI: 10.1098/rsfs.2016.0003
    • (2016) Interface Focus. , vol.6 , pp. 1-4
    • Omholt, S.1    Hunter, P.2
  • 41
    • 84962649780 scopus 로고    scopus 로고
    • Personalized cardiovascular disease prediction and treatment – a review of existing strategies and novel systems medicine tools
    • Bjornson E, Boren J, Mardinoglu A (2016) Personalized cardiovascular disease prediction and treatment – a review of existing strategies and novel systems medicine tools. Front Physiol 7:1–8 DOI: 10.3389/fphys.2016.00002
    • (2016) Front Physiol , vol.7 , pp. 1-8
    • Bjornson, E.1    Boren, J.2    Mardinoglu, A.3
  • 43
    • 32344436040 scopus 로고    scopus 로고
    • On modeling the immune system as a complex system
    • Ahmed E, Hashish A (2006) On modeling the immune system as a complex system. Theory Biosci 124:413–418 DOI: 10.1016/j.thbio.2005.07.001
    • (2006) Theory Biosci , vol.124 , pp. 413-418
    • Ahmed, E.1    Hashish, A.2
  • 44
    • 84894422309 scopus 로고    scopus 로고
    • Models and the mosaic of scientific knowledge. The case of immunology
    • Baetu T (2014) Models and the mosaic of scientific knowledge. The case of immunology. Stu Hist Philos Biol Biomed Sci 45:49–56 DOI: 10.1016/j.shpsc.2013.11.003
    • (2014) Stu Hist Philos Biol Biomed Sci , vol.45 , pp. 49-56
    • Baetu, T.1
  • 45
    • 84977616154 scopus 로고    scopus 로고
    • Using biological networks to integrate, visualize and analyze genomics data
    • Charitou T, Bryan K, Lynn D (2016) Using biological networks to integrate, visualize and analyze genomics data. Genet Sel Evol. doi:10.1186/s12711-016-0205-1
    • (2016) Genet Sel Evol
    • Charitou, T.1    Bryan, K.2    Lynn, D.3
  • 47
    • 84861199459 scopus 로고    scopus 로고
    • Sepsis: something old, something new, and a systems view
    • Namas R, Zamora R, Namas R et al (2012) Sepsis: something old, something new, and a systems view. J Crit Care 27:1–19 DOI: 10.1016/j.jcrc.2011.05.025
    • (2012) J Crit Care , vol.27 , pp. 1-19
    • Namas, R.1    Zamora, R.2    Namas, R.3
  • 48
    • 84880960789 scopus 로고    scopus 로고
    • In silico modeling: methods and applications to trauma and sepsis
    • Vodovotz Y, Billar T (2013) In silico modeling: methods and applications to trauma and sepsis. Crit Care Med 41:2008–2014 DOI: 10.1097/CCM.0b013e31829a6eb4
    • (2013) Crit Care Med , vol.41 , pp. 2008-2014
    • Vodovotz, Y.1    Billar, T.2
  • 49
    • 85088167206 scopus 로고    scopus 로고
    • Towards integrative physiological monitoring of the critically ill: from cardiovascular to microcirculatory and cellular function monitoring at the bedside
    • Donati A, Tibboel D, Ince C (2013) Towards integrative physiological monitoring of the critically ill: from cardiovascular to microcirculatory and cellular function monitoring at the bedside. Crit Care 17(Suppl 1):1–7 DOI: 10.1186/cc11499
    • (2013) Crit Care , vol.17 , pp. 1-7
    • Donati, A.1    Tibboel, D.2    Ince, C.3
  • 50
    • 84915781135 scopus 로고    scopus 로고
    • Using what you get: dynamic physiologic signatures of critical illness
    • Holder A, Clermont G (2015) Using what you get: dynamic physiologic signatures of critical illness. Crit Care Clin 31:133–164 DOI: 10.1016/j.ccc.2014.08.007
    • (2015) Crit Care Clin , vol.31 , pp. 133-164
    • Holder, A.1    Clermont, G.2
  • 51
    • 84962886304 scopus 로고    scopus 로고
    • Predicting cardiorespiratory instability
    • Pinsky M, Clermont G, Hravnak M (2016) Predicting cardiorespiratory instability. Crit Care 20:1–9
    • (2016) Crit Care , vol.20 , pp. 1-9
    • Pinsky, M.1    Clermont, G.2    Hravnak, M.3
  • 52
    • 85019098644 scopus 로고    scopus 로고
    • Generalizing mechanistic explanation using graph-theoretic representations
    • Braillard P-A, Malaterre C, (eds), Springer, Dordrecht
    • Bechtel W (2015) Generalizing mechanistic explanation using graph-theoretic representations. In: Braillard P-A, Malaterre C (eds) Explanation in biology. Springer, Dordrecht, pp 199–228 DOI: 10.1007/978-94-017-9822-8_9
    • (2015) Explanation in biology , pp. 199-228
    • Bechtel, W.1
  • 53
    • 84940572649 scopus 로고    scopus 로고
    • Circadian rhythms and mood disorders: are the phenomena and mechanisms causally related?
    • Bechtel W (2015) Circadian rhythms and mood disorders: are the phenomena and mechanisms causally related? Front Psychiatry. doi:10.3389/fpsyt.2015.00118
    • (2015) Front Psychiatry
    • Bechtel, W.1
  • 54
    • 84930333298 scopus 로고    scopus 로고
    • Systems biology for biologists
    • Accessed 26 Feb 2017
    • Hillmer R (2015) Systems biology for biologists. PLOS Pathog doi:10.1371/journal.ppat.1004786. Accessed 26 Feb 2017 DOI: 10.1371/journal.ppat.1004786
    • (2015) PLOS Pathog
    • Hillmer, R.1
  • 55
    • 69849085965 scopus 로고    scopus 로고
    • Evolving from reductionism to holism
    • Federoff H, Gostin L (2009) Evolving from reductionism to holism. JAMA 302:994–996 DOI: 10.1001/jama.2009.1264
    • (2009) JAMA , vol.302 , pp. 994-996
    • Federoff, H.1    Gostin, L.2
  • 57
    • 84900410255 scopus 로고    scopus 로고
    • Tracing organizing principles: learning from the history of systems biology
    • Green S, Wolkenhauer O (2013) Tracing organizing principles: learning from the history of systems biology. Hist Philos Life 35:553–576
    • (2013) Hist Philos Life , vol.35 , pp. 553-576
    • Green, S.1    Wolkenhauer, O.2
  • 58
    • 84888295655 scopus 로고    scopus 로고
    • The search for organizing principles as a cure against reductionism in systems medicine
    • Wolkenhauer O (2013) The search for organizing principles as a cure against reductionism in systems medicine. FEBS J 280:5938–5948 DOI: 10.1111/febs.12311
    • (2013) FEBS J , vol.280 , pp. 5938-5948
    • Wolkenhauer, O.1
  • 59
    • 84898808114 scopus 로고    scopus 로고
    • Enabling multiscale modeling in systems medicine
    • Wolkenhauer O, Auffray C, Brass O et al (2014) Enabling multiscale modeling in systems medicine. Genome Med 6:1–3 DOI: 10.1186/gm538
    • (2014) Genome Med , vol.6 , pp. 1-3
    • Wolkenhauer, O.1    Auffray, C.2    Brass, O.3
  • 60
    • 84963957174 scopus 로고    scopus 로고
    • Multi-class and multi-scale models of complex biological phenomena
    • Yu J, Bagheri N (2016) Multi-class and multi-scale models of complex biological phenomena. Curr Opin Biotech 39:167–173 DOI: 10.1016/j.copbio.2016.04.002
    • (2016) Curr Opin Biotech , vol.39 , pp. 167-173
    • Yu, J.1    Bagheri, N.2
  • 61
    • 84862173365 scopus 로고
    • University Utah, Accessed 26 Feb 2017
    • Keller E (1993) Rethinking the meaning of genetic determinism. University Utah. https://www.tannerlectures.utah.edu/_documents/a-to-z/keller94.pdf. Accessed 26 Feb 2017
    • (1993) Rethinking the Meaning of Genetic Determinism
    • Keller, E.1
  • 62
    • 33947494924 scopus 로고    scopus 로고
    • Oxford University Press, Oxford
    • Noble D (2006) The music of life. Oxford University Press, Oxford
    • (2006) The music of life
    • Noble, D.1
  • 63
    • 84901483188 scopus 로고    scopus 로고
    • The concept of function in modern physiology
    • Roux E (2014) The concept of function in modern physiology. J Physiol. doi:10.1113/jphysiol.2014.272062
    • (2014) J Physiol
    • Roux, E.1
  • 64
    • 0003089738 scopus 로고
    • On the mismatch between systems and their models
    • Ackoff R, Gharajedaghi J (1966) On the mismatch between systems and their models. Syst Research 13:13–23 DOI: 10.1002/(SICI)1099-1735(199603)13:1<13::AID-SRES66>3.0.CO;2-O
    • (1966) Syst Research , vol.13 , pp. 13-23
    • Ackoff, R.1    Gharajedaghi, J.2
  • 65
    • 85088168556 scopus 로고    scopus 로고
    • The trouble with theories of everything
    • Accessed 26 Feb 2017
    • Krauss L (2015) The trouble with theories of everything. Nautilus. https://www.nautil.us/issue/29/scaling/the-trouble-with-theories-of-everything. Accessed 26 Feb 2017
    • (2015) Nautilus
    • Krauss, L.1
  • 66
    • 81855167619 scopus 로고    scopus 로고
    • Information in biology: a fictionalist account
    • Levy A (2011) Information in biology: a fictionalist account. Nous 45:640–657 DOI: 10.1111/j.1468-0068.2010.00792.x
    • (2011) Nous , vol.45 , pp. 640-657
    • Levy, A.1
  • 67
    • 84867713167 scopus 로고    scopus 로고
    • Systems approaches to biology and disease enable translational systems medicine
    • Hood L, Tian Q (2012) Systems approaches to biology and disease enable translational systems medicine. Genom Proteom Bioinform 10:181–185 DOI: 10.1016/j.gpb.2012.08.004
    • (2012) Genom Proteom Bioinform , vol.10 , pp. 181-185
    • Hood, L.1    Tian, Q.2
  • 68
    • 77953469815 scopus 로고    scopus 로고
    • Systems medicine: the future of medicine genomics and healthcare
    • Auffray C, Chen Z, Hood L (2009) Systems medicine: the future of medicine genomics and healthcare. Genome Med. 1:1–11 DOI: 10.1186/gm1
    • (2009) Genome Med. , vol.1 , pp. 1-11
    • Auffray, C.1    Chen, Z.2    Hood, L.3
  • 69
    • 84872045007 scopus 로고    scopus 로고
    • Chapter 4: protein interactions and disease
    • Gonzalez M, Kann M (2012) Chapter 4: protein interactions and disease. PLOS Computat Biol 8:1–11 DOI: 10.1371/journal.pcbi.1002819
    • (2012) PLOS Computat Biol , vol.8 , pp. 1-11
    • Gonzalez, M.1    Kann, M.2
  • 70
    • 84890050726 scopus 로고    scopus 로고
    • Systems biology and P4 medicine: past, present, and future
    • Hood L (2013) Systems biology and P4 medicine: past, present, and future. Rambam Maimon Med J 4:1–15 DOI: 10.5041/RMMJ.10112
    • (2013) Rambam Maimon Med J , vol.4 , pp. 1-15
    • Hood, L.1
  • 71
    • 0035775725 scopus 로고    scopus 로고
    • A new approach to decoding life: systems biology
    • Ideker T, Galitski T, Hood L (2001) A new approach to decoding life: systems biology. Ann Rev Genom Human Genet 2:343–372 DOI: 10.1146/annurev.genom.2.1.343
    • (2001) Ann Rev Genom Human Genet , vol.2 , pp. 343-372
    • Ideker, T.1    Galitski, T.2    Hood, L.3
  • 72
    • 84978829495 scopus 로고    scopus 로고
    • Systems medicine—evolution of a new era in health care
    • Kudva P (2016) Systems medicine—evolution of a new era in health care. J Indian Soc Periodontol 20:232–233
    • (2016) J Indian Soc Periodontol , vol.20 , pp. 232-233
    • Kudva, P.1
  • 73
    • 85023782689 scopus 로고    scopus 로고
    • Big data science and its applications in healthcare and medical research: challenges and opportunities
    • Liang L, Kelemen A (2016) Big data science and its applications in healthcare and medical research: challenges and opportunities. Austin Biom and Biostat 3:1–9
    • (2016) Austin Biom and Biostat , vol.3 , pp. 1-9
    • Liang, L.1    Kelemen, A.2
  • 74
    • 4644335402 scopus 로고    scopus 로고
    • Systems biology, proteomics, and the future of health care: toward predictive, preventive, and personalized medicine
    • Weston A, Hood L (2004) Systems biology, proteomics, and the future of health care: toward predictive, preventive, and personalized medicine. J Proteome Res 3:179–196 DOI: 10.1021/pr0499693
    • (2004) J Proteome Res , vol.3 , pp. 179-196
    • Weston, A.1    Hood, L.2
  • 75
    • 84999971472 scopus 로고    scopus 로고
    • Systems medicine: The application of systems biology approaches for modern medical research and drug development
    • Accessed 26 Feb 2017
    • Ayers D, Day P (2015) Systems medicine: the application of systems biology approaches for modern medical research and drug development. Molec Bio Int (Hindawi Pub). doi:10.1155/2015/698169. Accessed 26 Feb 2017 DOI: 10.1155/2015/698169.
    • (2015) Molec Bio Int (Hindawi Pub)
    • Ayers, D.1    Day, P.2
  • 76
    • 84872037912 scopus 로고    scopus 로고
    • Chapter 5: network biology approach to complex diseases
    • Cho D-Y, Kim Y-A, Przytycka T (2012) Chapter 5: network biology approach to complex diseases. PLoS Comput Biol 8:1–11 DOI: 10.1371/journal.pcbi.1002820
    • (2012) PLoS Comput Biol , vol.8 , pp. 1-11
    • Cho, D.-Y.1    Kim, Y.-A.2    Przytycka, T.3
  • 77
    • 77953381289 scopus 로고    scopus 로고
    • Bridging the gap between systems biology and medicine
    • Clermont G, Auffray C, Moreau Y et al (2009) Bridging the gap between systems biology and medicine. Genome Med. 1:1–6 DOI: 10.1186/gm88
    • (2009) Genome Med. , vol.1 , pp. 1-6
    • Clermont, G.1    Auffray, C.2    Moreau, Y.3
  • 78
    • 84923762812 scopus 로고    scopus 로고
    • A new initiative on precision medicine
    • Collins F, Varmus H (2015) A new initiative on precision medicine. NEJM 372:793–795 DOI: 10.1056/NEJMp1500523
    • (2015) NEJM , vol.372 , pp. 793-795
    • Collins, F.1    Varmus, H.2
  • 79
    • 84856796565 scopus 로고    scopus 로고
    • Preparing for precision medicine
    • Mirnezami R, Nicholson J, Darzi A (2012) Preparing for precision medicine. NEJM 366:489–491 DOI: 10.1056/NEJMp1114866
    • (2012) NEJM , vol.366 , pp. 489-491
    • Mirnezami, R.1    Nicholson, J.2    Darzi, A.3
  • 80
    • 84950288016 scopus 로고    scopus 로고
    • Systems medicine in pharmaceutical research and development
    • Schmitz U, Wolkenhauer O, (eds), Humana Press Springer, New York
    • Kueper L, Schuppert A (2016) Systems medicine in pharmaceutical research and development. In: Schmitz U, Wolkenhauer O (eds) Systems medicine. Humana Press Springer, New York, pp 87–106 DOI: 10.1007/978-1-4939-3283-2_6
    • (2016) Systems medicine , pp. 87-106
    • Kueper, L.1    Schuppert, A.2
  • 81
    • 84923011094 scopus 로고    scopus 로고
    • Getting personal: can systems medicine intergrate scientific and humanistic conceptions of the patient
    • Vogt H, Ulvestad E, Eriksen T et al (2014) Getting personal: can systems medicine intergrate scientific and humanistic conceptions of the patient. J Eval Clin Pract 20:942–952 DOI: 10.1111/jep.12251
    • (2014) J Eval Clin Pract , vol.20 , pp. 942-952
    • Vogt, H.1    Ulvestad, E.2    Eriksen, T.3
  • 82
    • 49949099252 scopus 로고    scopus 로고
    • Top-down causation by information control: from a philosophical problem to a scientific research programme
    • Auletta G, Ellis G, Jaeger L (2008) Top-down causation by information control: from a philosophical problem to a scientific research programme. J R Soc Interface 5:1159–1172 DOI: 10.1098/rsif.2008.0018
    • (2008) J R Soc Interface , vol.5 , pp. 1159-1172
    • Auletta, G.1    Ellis, G.2    Jaeger, L.3
  • 83
    • 84860910544 scopus 로고    scopus 로고
    • Laws, causation and dynamics at different levels
    • Butterfield J (2012) Laws, causation and dynamics at different levels. Interface Focus. 2:101–114 DOI: 10.1098/rsfs.2011.0052
    • (2012) Interface Focus. , vol.2 , pp. 101-114
    • Butterfield, J.1
  • 84
    • 84855951317 scopus 로고    scopus 로고
    • A review of causal inference for biomedical informatics
    • Kleinberg S, Hripcsak G (2011) A review of causal inference for biomedical informatics. J Biomed Inform 44:1102–1112 DOI: 10.1016/j.jbi.2011.07.001
    • (2011) J Biomed Inform , vol.44 , pp. 1102-1112
    • Kleinberg, S.1    Hripcsak, G.2
  • 85
    • 84951936230 scopus 로고    scopus 로고
    • The idealization of causation in mechanistic explanation
    • Accessed 26 Feb 2017
    • Love A, Nathan M (2015) The idealization of causation in mechanistic explanation. Phil Sci 2015 us www.du.edu/ahss/philosophy/media/documents/mnathan/theidealizationofcausationinmechanisticexplanation.pdf. Accessed 26 Feb 2017
    • (2015) Phil Sci 2015 Us
    • Love, A.1    Nathan, M.2
  • 86
    • 84860897260 scopus 로고    scopus 로고
    • Hierarchy, causation and explanation: ubiquity, locality and pluralism
    • Love A (2012) Hierarchy, causation and explanation: ubiquity, locality and pluralism. Interface Focus. 2:115–125 DOI: 10.1098/rsfs.2011.0064
    • (2012) Interface Focus. , vol.2 , pp. 115-125
    • Love, A.1
  • 87
    • 85006137985 scopus 로고    scopus 로고
    • Top-down models in biology: explanation and control of complex living systems above the molecular level
    • Pezzulo G, Levin M (2016) Top-down models in biology: explanation and control of complex living systems above the molecular level. J R Soc Interface. doi:10.1098/rsif.2016.0555
    • (2016) J R Soc Interface
    • Pezzulo, G.1    Levin, M.2
  • 88
    • 0029004440 scopus 로고
    • Toward a theory of situation awareness in dynamic systems
    • Endsley M (1995) Toward a theory of situation awareness in dynamic systems. Hum Factors 37:32–64 DOI: 10.1518/001872095779049543
    • (1995) Hum Factors , vol.37 , pp. 32-64
    • Endsley, M.1
  • 89
    • 6344293994 scopus 로고    scopus 로고
    • Objective measures of situation awareness in a simulated medical environment
    • Wright M, Taekman J, Endsley M (2004) Objective measures of situation awareness in a simulated medical environment. Qual Safety in Health Care 13(Suppl 1):i65–i71 DOI: 10.1136/qshc.2004.009951
    • (2004) Qual Safety in Health Care , vol.13 , pp. i65-i71
    • Wright, M.1    Taekman, J.2    Endsley, M.3
  • 90
    • 79551553754 scopus 로고    scopus 로고
    • Toward optimal display of physiologic status in critical care: I. Recreating bedside displays from archived physiologic data
    • Burykin A, Peck T, Krejci V et al (2011) Toward optimal display of physiologic status in critical care: I. Recreating bedside displays from archived physiologic data. J Crit Care. doi:10.1016/j.crc.2010.06.013
    • (2011) J Crit Care
    • Burykin, A.1    Peck, T.2    Krejci, V.3
  • 91
    • 79952938697 scopus 로고    scopus 로고
    • Integrated information displays for ICU nurses: Field observations, display design, and display evaluation
    • Accessed 26 Feb 2017
    • th Ann. Meeting. https://www.journals.sagepub.com/doi/abs/10.1177/154193121005401227. Accessed 26 Feb 2017
    • (2010) th Ann. Meeting
    • Koch, S.1    Staggers, N.2    Weir, C.3
  • 93
    • 84904580437 scopus 로고    scopus 로고
    • Situation awareness: a new model for predicting and preventing patient deterioration
    • Brady P, Wheeler D, Muething S et al (2014) Situation awareness: a new model for predicting and preventing patient deterioration. Hosp Peds 4:143–145 DOI: 10.1542/hpeds.2013-0119
    • (2014) Hosp Peds , vol.4 , pp. 143-145
    • Brady, P.1    Wheeler, D.2    Muething, S.3
  • 94
    • 84886945776 scopus 로고    scopus 로고
    • Patient monitors in critical care: lessons for improvement
    • Henriksen K, (ed), Agency for Healthcare Research and Quality, Washington, DC
    • Drews F (2008) Patient monitors in critical care: lessons for improvement. In: Henriksen K (ed) Advances in patient safety: new directions and alternative approaches, vol 3. Agency for Healthcare Research and Quality, Washington, DC
    • (2008) Advances in patient safety: new directions and alternative approaches , vol.3
    • Drews, F.1
  • 95
    • 84946034319 scopus 로고    scopus 로고
    • Error producing conditions in the intensive care unit
    • Henriksen K, (ed), Agency for Healthcare Research and Quality, Washington, DC
    • Drews F (2008) Error producing conditions in the intensive care unit. In: Henriksen K (ed) Advances in patient safety: new directions and alternative approaches, vol 3. Agency for Healthcare Research and Quality, Washington, DC
    • (2008) Advances in patient safety: new directions and alternative approaches , vol.3
    • Drews, F.1
  • 96
    • 84925746570 scopus 로고    scopus 로고
    • Interruptions of nurses’ activities and patient safety: an integrative literature review
    • Monteiro C, Avelar A, Pedreira M (2015) Interruptions of nurses’ activities and patient safety: an integrative literature review. Rev Lat Am Enfermagem 23:169–179 DOI: 10.1590/0104-1169.0251.2539
    • (2015) Rev Lat Am Enfermagem , vol.23 , pp. 169-179
    • Monteiro, C.1    Avelar, A.2    Pedreira, M.3
  • 97
    • 33745250092 scopus 로고    scopus 로고
    • Understanding diagnostic errors in medicine: a lesson from aviation
    • Singh H, Peterson L, Thomas E (2006) Understanding diagnostic errors in medicine: a lesson from aviation. Qual Saf Health Care 15:159–164 DOI: 10.1136/qshc.2005.016444
    • (2006) Qual Saf Health Care , vol.15 , pp. 159-164
    • Singh, H.1    Peterson, L.2    Thomas, E.3
  • 98
    • 85088164779 scopus 로고    scopus 로고
    • Modeling shared situation awareness
    • Accessed 26 Feb 2017
    • Bolstad C, Cuevas H, Gonzalez C, et al (2005) Modeling shared situation awareness. SA Tech. www.cc.ist.psu.edu/BRIMS/archives/2005/papers/05-BRIMS-047.pdf. Accessed 26 Feb 2017
    • (2005) SA Tech.
    • Bolstad, C.1    Cuevas, H.2    Gonzalez, C.3
  • 99
    • 84891048554 scopus 로고    scopus 로고
    • Measuring situation awareness in emergency settings: a systematic review of tools and outcomes
    • dovepress
    • Cooper S, Porter J, Peach L (2013) Measuring situation awareness in emergency settings: a systematic review of tools and outcomes. Open Access Emergency Medicine. doi:10.2147/OAEM.S53679 dovepress
    • (2013) Open Access Emergency Medicine
    • Cooper, S.1    Porter, J.2    Peach, L.3
  • 100
    • 84902546204 scopus 로고    scopus 로고
    • How do physicians decide to treat: an empirical evaluation of the threshold model
    • Djulbegovic B, Elqayam S, Reljic T et al (2014) How do physicians decide to treat: an empirical evaluation of the threshold model. BMC Med Inform Decis Mak. doi:10.1186/1472-6947-14-47
    • (2014) BMC Med Inform Decis Mak
    • Djulbegovic, B.1    Elqayam, S.2    Reljic, T.3
  • 102
    • 85088165455 scopus 로고    scopus 로고
    • Building a framework for situation awareness
    • Accessed 26 Feb 2017
    • Salerno J, Hinman M, Boulware D (2004) Building a framework for situation awareness. Air Force Res. Lab. https://www.citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.63.1633&rep=rep1&type=pdf. Accessed 26 Feb 2017
    • (2004) Air Force Res. Lab.
    • Salerno, J.1    Hinman, M.2    Boulware, D.3
  • 103
    • 33044506498 scopus 로고    scopus 로고
    • Modeling biological complexity: a physical scientist’s perspective
    • Coveney P, Fowler P (2005) Modeling biological complexity: a physical scientist’s perspective. J R Soc Interface 2:267–280 DOI: 10.1098/rsif.2005.0045
    • (2005) J R Soc Interface , vol.2 , pp. 267-280
    • Coveney, P.1    Fowler, P.2
  • 104
    • 84969581348 scopus 로고    scopus 로고
    • Clinical decision-making and secondary findings in systems medicine
    • Fischer T, Brother K, Erdmann P et al (2016) Clinical decision-making and secondary findings in systems medicine. BMC Med Ethics. doi:10.1186/s12910-016-0113-5
    • (2016) BMC Med Ethics
    • Fischer, T.1    Brother, K.2    Erdmann, P.3
  • 105
    • 84988615962 scopus 로고    scopus 로고
    • Personalizing medicine: Disease prevention in silico and in socio
    • Accessed 26 Feb 2017
    • Green S, Vogt H (2016) Personalizing medicine: disease prevention in silico and in socio. Humana. Mente J Phil. Studies. http://philsci-archive.pitt.edu/id/eprint/12274. Accessed 26 Feb 2017
    • (2016) Humana. Mente J Phil. Studies.
    • Green, S.1    Vogt, H.2
  • 106
    • 84939186066 scopus 로고    scopus 로고
    • One mechanism, many models: a distributed theory of mechanistic explanation
    • Hochstein E (2016) One mechanism, many models: a distributed theory of mechanistic explanation. Synthese 193:1387–1407 DOI: 10.1007/s11229-015-0844-8
    • (2016) Synthese , vol.193 , pp. 1387-1407
    • Hochstein, E.1
  • 107
    • 84870878892 scopus 로고    scopus 로고
    • A review of human factors challenges of complex adaptive systems: discovering and understanding chaos in human performance
    • Karwowski W (2012) A review of human factors challenges of complex adaptive systems: discovering and understanding chaos in human performance. Hum Factors 54:983–995 DOI: 10.1177/0018720812467459
    • (2012) Hum Factors , vol.54 , pp. 983-995
    • Karwowski, W.1
  • 108
    • 84888288827 scopus 로고    scopus 로고
    • Systems medicine: opportunities and challenges for system biology approaches
    • Kolch W, Kholodenko B (2013) Systems medicine: opportunities and challenges for system biology approaches. FEBS J. doi:10.1111/febs.12560
    • (2013) FEBS J
    • Kolch, W.1    Kholodenko, B.2
  • 109
    • 84940602448 scopus 로고    scopus 로고
    • Revisiting generality in biology: systems biology and the quest for design principles
    • Green S (2015) Revisiting generality in biology: systems biology and the quest for design principles. Biol and Phil. doi:10.1007/s10539=-15-9496-9
    • (2015) Biol and Phil
    • Green, S.1
  • 112
    • 84906346349 scopus 로고    scopus 로고
    • Superior pattern processing is the essence of the evolved human brain
    • Mattson M (2014) Superior pattern processing is the essence of the evolved human brain. Front Neurosci 8:1–17 DOI: 10.3389/fnins.2014.00265
    • (2014) Front Neurosci , vol.8 , pp. 1-17
    • Mattson, M.1
  • 113
    • 85015886887 scopus 로고    scopus 로고
    • Translational bioinformatics in the era of real-time biomedical, health care and wellness data streams
    • Shameer K, Badgeley M, Miotto R et al (2016) Translational bioinformatics in the era of real-time biomedical, health care and wellness data streams. Brief in Bioinform 18:105–124 DOI: 10.1093/bib/bbv118
    • (2016) Brief in Bioinform , vol.18 , pp. 105-124
    • Shameer, K.1    Badgeley, M.2    Miotto, R.3
  • 115
    • 84958763741 scopus 로고    scopus 로고
    • A method to select human-system interfaces for nuclear power plants
    • Hugo J, Gertman D (2016) A method to select human-system interfaces for nuclear power plants. Nuclear Engineering Technology 48:87–97 DOI: 10.1016/j.net.2015.10.004
    • (2016) Nuclear Engineering Technology , vol.48 , pp. 87-97
    • Hugo, J.1    Gertman, D.2
  • 116
    • 84876361111 scopus 로고    scopus 로고
    • Tech Report DKS-03-03/ICE 03, Accessed 10 Apr 2017
    • Mouthaan Q (2003) Towards an intelligent cockpit environment. Tech Report DKS-03-03/ICE 03. www.kbs.twi.tudelft.nl/docs/report/DKS03-03.pdf. Accessed 10 Apr 2017
    • (2003) Towards an Intelligent Cockpit Environment
    • Mouthaan, Q.1
  • 117
    • 0027610491 scopus 로고
    • Cockpit checklists: concepts, design, and use
    • Degani A, Wiener E (1993) Cockpit checklists: concepts, design, and use. Hum Factors 35:28–43
    • (1993) Hum Factors , vol.35 , pp. 28-43
    • Degani, A.1    Wiener, E.2
  • 120
    • 85088162360 scopus 로고    scopus 로고
    • Instit Defense Anal. IDA Document D-4313, Accessed 10 Apr 2017
    • Green K (2011) Complex adaptive systems in military analysis. Instit Defense Anal. IDA Document D-4313. www.ida.org/idamedia/Corporate/Files/Publications/IDA_Documents/JAWD/ida-document-d-4313.pdf. Accessed 10 Apr 2017
    • (2011) Complex adaptive systems in military analysis
    • Green, K.1
  • 121
    • 84906346349 scopus 로고    scopus 로고
    • Superior pattern processing is the essence of the evolved human brain
    • Mattson M (2014) Superior pattern processing is the essence of the evolved human brain. Front Neurosci 8:1–17 DOI: 10.3389/fnins.2014.00265
    • (2014) Front Neurosci , vol.8 , pp. 1-17
    • Mattson, M.1
  • 123
    • 84908456801 scopus 로고    scopus 로고
    • Systems biology—the broader perspective
    • Bard J (2013) Systems biology—the broader perspective. Cell 2:414–431 DOI: 10.3390/cells2020414
    • (2013) Cell , vol.2 , pp. 414-431
    • Bard, J.1


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