메뉴 건너뛰기




Volumn 17, Issue 1, 2016, Pages

Clinical decision-making and secondary findings in systems medicine Donna Dickenson, Sandra Soo-Jin Lee, and Michael Morrison

Author keywords

Big data; Clinical decision making; Electronic health records; Epistemology; Scoring systems; Secondary findings; Systems medicine; Translation

Indexed keywords

ATTENTION; CLINICAL DECISION MAKING; CLINICAL MEDICINE; CLINICAL TRIAL; COMPARATIVE EFFECTIVENESS; CONSENSUS DEVELOPMENT; DEATH; DOCTOR PATIENT RELATION; ELECTRONIC HEALTH RECORD; EPISTEMOLOGY; ERROR; EXPERIMENTAL MEDICINE; GENOMICS; HEALTH CARE PERSONNEL; HUMAN; IMAGING; INTENSIVE CARE; JOINT; MORTALITY; PREDICTION; QUANTITATIVE STUDY; SCORING SYSTEM; ALGORITHM; DECISION MAKING; ETHICS; INCIDENTAL FINDING; INFORMATION PROCESSING; KNOWLEDGE; MEDICAL ETHICS; MEDICAL INFORMATICS; PERSONALIZED MEDICINE; PROGNOSIS; STATISTICS; SYSTEM ANALYSIS; SYSTEMS BIOLOGY; TRANSLATIONAL RESEARCH;

EID: 84969581348     PISSN: None     EISSN: 14726939     Source Type: Journal    
DOI: 10.1186/s12910-016-0113-5     Document Type: Review
Times cited : (22)

References (53)
  • 1
    • 84876144335 scopus 로고    scopus 로고
    • Ten challenges for systems medicine
    • Capobianco E. Ten challenges for systems medicine. Front Genet. 2012;3:193.
    • (2012) Front Genet , vol.3 , pp. 193
    • Capobianco, E.1
  • 2
    • 84876148983 scopus 로고    scopus 로고
    • Dynamic networks in systems medicine
    • Capobianco E. Dynamic networks in systems medicine. Front Genet. 2013;3:185.
    • (2013) Front Genet , vol.3 , pp. 185
    • Capobianco, E.1
  • 3
    • 84890050726 scopus 로고    scopus 로고
    • Systems biology and P4 Medicine: Past, Present, and Future
    • Hood L. Systems biology and P4 Medicine: Past, Present, and Future. RMMJ. 2013;4:e0012.
    • (2013) RMMJ , vol.4 , pp. e0012
    • Hood, L.1
  • 6
    • 84929609898 scopus 로고    scopus 로고
    • Risikoprädiktion: Vom Umgang mit dem Krankheitsrisiko
    • A-910/B-762/C-738
    • Schmutzler R, Huster S, Wasem J, Dabrock P. Risikoprädiktion: Vom Umgang mit dem Krankheitsrisiko. Dtsch Arztebl. 2015;112:A-910/B-762/C-738.
    • (2015) Dtsch Arztebl , vol.112
    • Schmutzler, R.1    Huster, S.2    Wasem, J.3    Dabrock, P.4
  • 7
    • 84969557539 scopus 로고    scopus 로고
    • The Meaning of "individualized Medicine": A Terminological Adjustment of a Perplexing Term
    • T. Fischer M. Langanke Marschall S. Michl (eds) Springer Cham Heidelberg New York Dordrecht London
    • Langanke M, Lieb W, Erdmann P, Dörr M, Fischer T, Kroemer H, et al. The Meaning of "Individualized Medicine": A Terminological Adjustment of a Perplexing Term. In: Fischer T, Langanke M, Marschall P, Michl S, editors. Individualized medicine, ethical, economical and historical perspectives. Cham Heidelberg New York Dordrecht London: Springer; 2015. p. 11-28.
    • (2015) Individualized Medicine, Ethical, Economical and Historical Perspectives , pp. 11-28
    • Langanke, M.1    Lieb, W.2    Erdmann, P.3    Dörr, M.4    Fischer, T.5    Kroemer, H.6
  • 8
    • 84890516193 scopus 로고    scopus 로고
    • What is personalized medicine: Sharpening a vague term based on a systematic literature review
    • Schleidgen S, Klingler C, Bertram T, et al. What is personalized medicine: sharpening a vague term based on a systematic literature review. BMC Med Ethics. 2013;14:55.
    • (2013) BMC Med Ethics , vol.14 , pp. 55
    • Schleidgen, S.1    Klingler, C.2    Bertram, T.3
  • 9
    • 84890020495 scopus 로고    scopus 로고
    • Translational biomedical informatics and computational systems medicine
    • Zhao Z, Shen B, Lu X, Vongsangnak W. Translational biomedical informatics and computational systems medicine. Biomed Res Int. 2013;2013:237465.
    • (2013) Biomed Res Int , vol.2013 , pp. 237465
    • Zhao, Z.1    Shen, B.2    Lu, X.3    Vongsangnak, W.4
  • 10
    • 77949392495 scopus 로고    scopus 로고
    • Biomedical informatics and translational medicine
    • Sarkar IN. Biomedical informatics and translational medicine. J Transl Med. 2010;8:22.
    • (2010) J Transl Med , vol.8 , pp. 22
    • Sarkar, I.N.1
  • 11
    • 84939777684 scopus 로고    scopus 로고
    • Forschungsinfrastrukturen: Herausforderungen durch Big Data
    • A-1735/B-1497/C-1429
    • Krüger-Brand HE. 2014. Forschungsinfrastrukturen: Herausforderungen durch Big Data. Dtsch Arztebl. 2015;111:A-1735/B-1497/C-1429.
    • (2014) Dtsch Arztebl , vol.111
    • Krüger-Brand, H.E.1
  • 12
    • 84992043153 scopus 로고    scopus 로고
    • Systemmedizin: Herausforderungen eines aktuellen Ansatzes
    • A-1330/B-1116/C-1091
    • Erdmann P, Fischer T, Raths S, Flessa S, Langanke M. Systemmedizin: Herausforderungen eines aktuellen Ansatzes. Dtsch Arztebl. 2015;112:A-1330/B-1116/C-1091.
    • (2015) Dtsch Arztebl , vol.112
    • Erdmann, P.1    Fischer, T.2    Raths, S.3    Flessa, S.4    Langanke, M.5
  • 15
    • 84881411473 scopus 로고    scopus 로고
    • P4 medicine: How systems medicine will transform the healthcare sector and society
    • Flores M, Glusman G, Brogaard K, Price ND, Hood L. P4 medicine: how systems medicine will transform the healthcare sector and society. Pers Med. 2013;10(6):565-76.
    • (2013) Pers Med , vol.10 , Issue.6 , pp. 565-576
    • Flores, M.1    Glusman, G.2    Brogaard, K.3    Price, N.D.4    Hood, L.5
  • 16
    • 84924348660 scopus 로고    scopus 로고
    • Big Data in der wissenschaftlichen Medizin - Eine biostatistische Perspektive: Teil 21 der Serie zur Bewertung wissenschaftlicher Publikationen
    • Binder H, Blettner M. Big Data in der wissenschaftlichen Medizin - eine biostatistische Perspektive: Teil 21 der Serie zur Bewertung wissenschaftlicher Publikationen. Dtsch Arztebl Int. 2015;112:137-42.
    • (2015) Dtsch Arztebl Int , vol.112 , pp. 137-142
    • Binder, H.1    Blettner, M.2
  • 17
    • 84969514283 scopus 로고    scopus 로고
    • Algorithms are powerful and useful. but by themselves they are blind
    • Mainzer K. Algorithms are powerful and useful. But by themselves they are blind. Faszination Forschung. 2014;15:64-75.
    • (2014) Faszination Forschung , vol.15 , pp. 64-75
    • Mainzer, K.1
  • 20
    • 49949093313 scopus 로고    scopus 로고
    • Development of a large-scale de-identified DNA biobank to enable personalized medicine
    • Roden DM, Pulley JM, Basford MA, et al. Development of a large-scale de-identified DNA biobank to enable personalized medicine. Clin Pharmacol Ther. 2008;84(3):362-9.
    • (2008) Clin Pharmacol Ther , vol.84 , Issue.3 , pp. 362-369
    • Roden, D.M.1    Pulley, J.M.2    Basford, M.A.3
  • 22
    • 84886447002 scopus 로고    scopus 로고
    • Cytochrome CYP2C19 polymorphism and risk of adverse clinical events in clopidogrel-treated patients: A meta-analysis based on 23,035 subjects
    • Mao L, Jian C, Changzhi L, et al. Cytochrome CYP2C19 polymorphism and risk of adverse clinical events in clopidogrel-treated patients: a meta-analysis based on 23,035 subjects. Arch Cardiovasc Dis. 2013;106(10):517-27.
    • (2013) Arch Cardiovasc Dis , vol.106 , Issue.10 , pp. 517-527
    • Mao, L.1    Jian, C.2    Changzhi, L.3
  • 23
    • 84897909928 scopus 로고    scopus 로고
    • Genetics of platelet inhibitor treatment
    • Trenk D, Hochholzer W. Genetics of platelet inhibitor treatment. Br J Clin Pharmacol. 2014;77(4):642-53.
    • (2014) Br J Clin Pharmacol , vol.77 , Issue.4 , pp. 642-653
    • Trenk, D.1    Hochholzer, W.2
  • 24
    • 84920520307 scopus 로고    scopus 로고
    • A systematic review and critical assessment of 11 discordant meta-analyses on reduced-function CYP2C19 genotype and risk of adverse clinical outcomes in clopidogrel users
    • Osnabrugge RL, Head SJ, Zijlstra F, et al. A systematic review and critical assessment of 11 discordant meta-analyses on reduced-function CYP2C19 genotype and risk of adverse clinical outcomes in clopidogrel users. Genet Med. 2015;17(1):3-11.
    • (2015) Genet Med , vol.17 , Issue.1 , pp. 3-11
    • Osnabrugge, R.L.1    Head, S.J.2    Zijlstra, F.3
  • 25
    • 85192874973 scopus 로고    scopus 로고
    • Princeton University Press Princeton, N.J
    • Hodges A. Alan Turing: The Enigma. Princeton, N.J.: Princeton University Press; 2014.
    • (2014) Alan Turing: The Enigma
    • Hodges, A.1
  • 26
    • 0002988210 scopus 로고
    • Computing machinery and intelligence
    • Turing AM. Computing machinery and intelligence. Mind. 1950;59:433-60.
    • (1950) Mind , vol.59 , pp. 433-460
    • Turing, A.M.1
  • 27
    • 0028885344 scopus 로고
    • The SUPPORT Prognostic Model. Objective Estimates of Survival for Seriously Ill Hospitalized Adults
    • Knaus WA, Harrell Jr FE, Lynn J, Goldman L, Phillips RS, Connors Jr AF, et al. The SUPPORT Prognostic Model. Objective Estimates of Survival for Seriously Ill Hospitalized Adults. Ann Intern Med. 1995;122:191-203.
    • (1995) Ann Intern Med , vol.122 , pp. 191-203
    • Knaus, W.A.1    Harrell, F.E.2    Lynn, J.3    Goldman, L.4    Phillips, R.S.5    Connors, A.F.6
  • 28
    • 33750536017 scopus 로고    scopus 로고
    • Ethical, legal and organizational issues in the ICU: Prediction of outcome
    • Moreno R, Afonso S. Ethical, legal and organizational issues in the ICU: prediction of outcome. Curr Opin Crit Care. 2006;12:619-23.
    • (2006) Curr Opin Crit Care , vol.12 , pp. 619-623
    • Moreno, R.1    Afonso, S.2
  • 29
    • 0029750157 scopus 로고    scopus 로고
    • Die Bedeutung von Score-Systemen für die Voraussage von Behandlungsergebnissen in der Intensivmedizin
    • Schuster HP. Die Bedeutung von Score-Systemen für die Voraussage von Behandlungsergebnissen in der Intensivmedizin. Internist. 1996;37:1237-43.
    • (1996) Internist , vol.37 , pp. 1237-1243
    • Schuster, H.P.1
  • 30
    • 0027721918 scopus 로고
    • Predictions in the intensive care unit - In search of an "unholy grail"!
    • Murdoch IA, Bihari DJ. Predictions in the intensive care unit - in search of an "unholy grail"! Pediatr Nephrol. 1993;7:708-10.
    • (1993) Pediatr Nephrol , vol.7 , pp. 708-710
    • Murdoch, I.A.1    Bihari, D.J.2
  • 31
    • 4344673260 scopus 로고    scopus 로고
    • Limitations of score-based daily outcome predictions in the individual intensive care patient. An example of the RIAHDH algorithm
    • Lefering R, Wolfrum B, Wauer H, Neugebauer EA. Limitations of score-based daily outcome predictions in the individual intensive care patient. An example of the RIAHDH algorithm. Inflamm Res. 2004;53 Suppl 2:169-74.
    • (2004) Inflamm Res , vol.53 , pp. 169-174
    • Lefering, R.1    Wolfrum, B.2    Wauer, H.3    Neugebauer, E.A.4
  • 32
    • 0023679154 scopus 로고
    • Predicting outcome among intensive care unit patients using computerized trend analysis of daily Apache II scores corrected for organ system failure
    • Chang RW, Jacobs S, Lee B. Predicting outcome among intensive care unit patients using computerized trend analysis of daily Apache II scores corrected for organ system failure. Intensive Care Med. 1988;14:558-66.
    • (1988) Intensive Care Med , vol.14 , pp. 558-566
    • Chang, R.W.1    Jacobs, S.2    Lee, B.3
  • 33
    • 0024372162 scopus 로고
    • Individual outcome prediction models for intensive care units
    • Chang RW. Individual outcome prediction models for intensive care units. Lancet. 1989;2:143-6.
    • (1989) Lancet , vol.2 , pp. 143-146
    • Chang, R.W.1
  • 34
    • 0028223397 scopus 로고
    • Outcome prediction for the individual patient in the ICU
    • Chang RW, Bihari DJ. Outcome prediction for the individual patient in the ICU. Unfallchirurg. 1994;97:199-204.
    • (1994) Unfallchirurg , vol.97 , pp. 199-204
    • Chang, R.W.1    Bihari, D.J.2
  • 35
    • 84969512256 scopus 로고    scopus 로고
    • Computerprognose - Ärztliche Entscheidungen zwischen Statistik und Intuition. Juristische Aspekte von Prognose und Behandlungspflicht
    • Weber R, Vogt-Weber B. Computerprognose - Ärztliche Entscheidungen zwischen Statistik und Intuition. Juristische Aspekte von Prognose und Behandlungspflicht. MedR. 1999;5:204-9.
    • (1999) MedR , vol.5 , pp. 204-209
    • Weber, R.1    Vogt-Weber, B.2
  • 36
    • 4243536170 scopus 로고    scopus 로고
    • Todescomputer: Risikobewertung von Intensivpatienten
    • A-621/B-523/C-499
    • Zylka-Menhorn V."Todescomputer": Risikobewertung von Intensivpatienten. Dtsch Arztebl. 1997;94:A-621/B-523/C-499.
    • (1997) Dtsch Arztebl , vol.94
    • Zylka-Menhorn, V.1
  • 37
    • 0026758946 scopus 로고
    • The Riyadh Intensive Care Program applied to a mortality analysis of a teaching hospital intensive care unit
    • Jacobs S, Arnold A, Clyburn PA, Willis BA. The Riyadh Intensive Care Program applied to a mortality analysis of a teaching hospital intensive care unit. Anaesthesia. 1992;47:775-80.
    • (1992) Anaesthesia , vol.47 , pp. 775-780
    • Jacobs, S.1    Arnold, A.2    Clyburn, P.A.3    Willis, B.A.4
  • 38
    • 84869591206 scopus 로고    scopus 로고
    • Prognostizierbarkeit des Todes - Ärztliche Beurteilung oder Scores?
    • T. Junginger A. Perneczky C.-F. Vahl C. Werner (eds) Springer Berlin Heidelberg
    • Grundmann RT. Prognostizierbarkeit des Todes - Ärztliche Beurteilung oder Scores? In: Junginger T, Perneczky A, Vahl C-F, Werner C, editors. Grenzsituationen in der Intensivmedizin. Berlin Heidelberg: Springer; 2008. p. 153-63.
    • (2008) Grenzsituationen in der Intensivmedizin , pp. 153-163
    • Grundmann, R.T.1
  • 39
    • 75549090412 scopus 로고    scopus 로고
    • Even without our biases, the outlook for prognostication is grim
    • Downar J. Even without our biases, the outlook for prognostication is grim. Crit Care. 2009;13:168.
    • (2009) Crit Care , vol.13 , pp. 168
    • Downar, J.1
  • 40
    • 0026775637 scopus 로고
    • Evidence-based medicine. A new approach to teaching the practice of medicine
    • Evidence-Based Medicine Working Group
    • Evidence-Based Medicine Working Group. Evidence-based medicine. A new approach to teaching the practice of medicine. JAMA. 1992;268:2420-5.
    • (1992) JAMA , vol.268 , pp. 2420-2425
  • 41
    • 0027156371 scopus 로고
    • The Riyadh Intensive Care Programme
    • Chang RW, Bihari DJ. The Riyadh Intensive Care Programme. Anaesthesia. 1993;48(4):345-6.
    • (1993) Anaesthesia , vol.48 , Issue.4 , pp. 345-346
    • Chang, R.W.1    Bihari, D.J.2
  • 43
    • 85075809384 scopus 로고    scopus 로고
    • Handling Incidental Findings from Imaging within im related Research - Results from an Empirical-Ethical Study
    • T. Fischer M. Langanke Marschall S. Michl (eds) Springer Cham Heidelberg New York Dordrecht London
    • Erdmann P. Handling Incidental Findings from Imaging within IM related Research - Results from an Empirical-Ethical Study. In: Fischer T, Langanke M, Marschall P, Michl S, editors. Individualized medicine, ethical, economical and historical perspectives. Cham Heidelberg New York Dordrecht London: Springer; 2015. p. 231-50.
    • (2015) Individualized Medicine, Ethical, Economical and Historical Perspectives , pp. 231-250
    • Erdmann, P.1
  • 44
    • 84901253165 scopus 로고    scopus 로고
    • Ethische und rechtliche Aspekte im Umgang mit genetischen Zufallsbefunden - Herausforderungen und Lösungsansätze
    • Rudnik-Schöneborn S, Langanke M, Erdmann P, Robienski J. Ethische und rechtliche Aspekte im Umgang mit genetischen Zufallsbefunden - Herausforderungen und Lösungsansätze. Ethik Med. 2014;26:105-19.
    • (2014) Ethik Med , vol.26 , pp. 105-119
    • Rudnik-Schöneborn, S.1    Langanke, M.2    Erdmann, P.3    Robienski, J.4
  • 45
    • 84969524241 scopus 로고    scopus 로고
    • Zufallsbefunde bei molekulargenetischen Untersuchungen. Medizinische, juristische und ethische Perspektiven
    • Langanke M, Erdmann P, Robienski J, Rudnik-Schöneborn S, editors. Zufallsbefunde bei molekulargenetischen Untersuchungen. Medizinische, juristische und ethische Perspektiven. Heidelberg Berlin: Springer-Verlag; 2015.
    • (2015) Heidelberg Berlin: Springer-Verlag
    • Langanke M, E.1
  • 46
    • 84877120914 scopus 로고    scopus 로고
    • Psychosocial consequences and severity of disclosed incidental findings from whole-body MRI in a general population study
    • Schmidt CO, Hegenscheid K, Erdmann P, Kohlmann T, Langanke M, Völzke H, et al. Psychosocial consequences and severity of disclosed incidental findings from whole-body MRI in a general population study. Eur Radiol. 2013;23:1343-51.
    • (2013) Eur Radiol , vol.23 , pp. 1343-1351
    • Schmidt, C.O.1    Hegenscheid, K.2    Erdmann, P.3    Kohlmann, T.4    Langanke, M.5    Völzke, H.6
  • 47
    • 84882287816 scopus 로고    scopus 로고
    • Implications of the incidentalome for clinical pharmacogenomics
    • Brothers KB, Langanke M, Erdmann P. Implications of the incidentalome for clinical pharmacogenomics. Pharmacogenomics. 2013;14:1353-62.
    • (2013) Pharmacogenomics , vol.14 , pp. 1353-1362
    • Brothers, K.B.1    Langanke, M.2    Erdmann, P.3
  • 48
    • 34547111031 scopus 로고    scopus 로고
    • Zufallsbefunde bei bildgebenden Verfahren in der Hirnforschung. Ethische Überlegungen und Lösungsvorschläge
    • A-1982/B-1748/C-1684
    • Heinemann T, Hoppe C, Listl S, Spickhoff A, Elger CE. Zufallsbefunde bei bildgebenden Verfahren in der Hirnforschung. Ethische Überlegungen und Lösungsvorschläge. Dtsch Arztebl. 2007;104:A-1982/B-1748/C-1684.
    • (2007) Dtsch Arztebl , vol.104
    • Heinemann, T.1    Hoppe, C.2    Listl, S.3    Spickhoff, A.4    Elger, C.E.5
  • 49
    • 84901914041 scopus 로고    scopus 로고
    • Cohort profile: Greifswald approach to individualized medicine (GANI-MED)
    • Grabe H, Assel H, Bahls T, Dörr M, Endlich K, Endlich N, et al. Cohort profile: Greifswald approach to individualized medicine (GANI-MED). J Transl Med. 2014;12:144.
    • (2014) J Transl Med , vol.12 , pp. 144
    • Grabe, H.1    Assel, H.2    Bahls, T.3    Dörr, M.4    Endlich, K.5    Endlich, N.6
  • 51
    • 84948956196 scopus 로고    scopus 로고
    • Alarming symptoms of a paradigm shift? An approach to bridge the gap between hypothetical ethics and the current status of im research
    • J. Vollmann J. Schildmann (eds) Ashgate Publishing Limited Fulham
    • Fischer T, Dörr M, Haring R, Langanke M. Alarming symptoms of a paradigm shift? An approach to bridge the gap between hypothetical ethics and the current status of IM research. In: Vollmann J, Schildmann J, editors. Personalised Medicine: Ethical, Medical, Economic and Legal Critical Perspectives. Fulham: Ashgate Publishing Limited; 2015. p. 25-40.
    • (2015) Personalised Medicine: Ethical, Medical, Economic and Legal Critical Perspectives , pp. 25-40
    • Fischer, T.1    Dörr, M.2    Haring, R.3    Langanke, M.4
  • 52
    • 33344456886 scopus 로고    scopus 로고
    • Public Health Genetics and Social Justice
    • Dabrock P. Public Health Genetics and Social Justice. Community Genet. 2006;9:34-9.
    • (2006) Community Genet , vol.9 , pp. 34-39
    • Dabrock, P.1
  • 53
    • 85001012004 scopus 로고    scopus 로고
    • The Ethics of Big Data: Current and Foreseeable Issues in Biomedical Contexts
    • Mittelstadt BD, Luciano F. The Ethics of Big Data: Current and Foreseeable Issues in Biomedical Contexts. Sci Eng Ethics. 2015;29:1-39.
    • (2015) Sci Eng Ethics , vol.29 , pp. 1-39
    • Mittelstadt, B.D.1    Luciano, F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.