메뉴 건너뛰기




Volumn 16, Issue 9, 2019, Pages 563-580

Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ATEZOLIZUMAB; AVELUMAB; DURVALUMAB; IMMUNE CHECKPOINT INHIBITOR; IPILIMUMAB; NIVOLUMAB; PEMBROLIZUMAB; RITUXIMAB; UNCLASSIFIED DRUG; IMMUNOLOGIC FACTOR; IMMUNOLOGICAL ANTINEOPLASTIC AGENT;

EID: 85065986843     PISSN: 17594774     EISSN: 17594782     Source Type: Journal    
DOI: 10.1038/s41571-019-0218-0     Document Type: Review
Times cited : (1437)

References (172)
  • 1
    • 0030707866 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70
    • COI: 1:CAS:528:DyaK2sXnsVeisbY%3D, PID: 9362525
    • Calvo, C. R., Amsen, D. & Kruisbeek, A. M. Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70. J. Exp. Med. 186, 1645–1653 (1997).
    • (1997) J. Exp. Med. , vol.186 , pp. 1645-1653
    • Calvo, C.R.1    Amsen, D.2    Kruisbeek, A.M.3
  • 2
    • 0034254301 scopus 로고    scopus 로고
    • CTLA-4 (CD152) can inhibit T cell activation by two different mechanisms depending on its level of cell surface expression
    • COI: 1:STN:280:DC%2BD3cvgsFejtQ%3D%3D, PID: 10903737
    • Carreno, B. M. et al. CTLA-4 (CD152) can inhibit T cell activation by two different mechanisms depending on its level of cell surface expression. J. Immunol. 165, 1352–1356 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 1352-1356
    • Carreno, B.M.1
  • 3
    • 0034679560 scopus 로고    scopus 로고
    • + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    • COI: 1:CAS:528:DC%2BD3cXkvFGiu7c%3D, PID: 10899917
    • + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192, 303–310 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 303-310
    • Takahashi, T.1
  • 4
    • 42649125225 scopus 로고    scopus 로고
    • PD-1 and its ligands in tolerance and immunity
    • COI: 1:CAS:528:DC%2BD1cXltlWktrY%3D, PID: 18173375
    • Keir, M. E., Butte, M. J., Freeman, G. J. & Sharpe, A. H. PD-1 and its ligands in tolerance and immunity. Annu. Rev. Immunol. 26, 677–704 (2008).
    • (2008) Annu. Rev. Immunol. , vol.26 , pp. 677-704
    • Keir, M.E.1    Butte, M.J.2    Freeman, G.J.3    Sharpe, A.H.4
  • 5
    • 33645863160 scopus 로고    scopus 로고
    • The PD-1-PD-L pathway in immunological tolerance
    • COI: 1:CAS:528:DC%2BD28XjtFOkt7s%3D, PID: 16500147
    • Okazaki, T. & Honjo, T. The PD-1-PD-L pathway in immunological tolerance. Trends Immunol. 27, 195–201 (2006).
    • (2006) Trends Immunol. , vol.27 , pp. 195-201
    • Okazaki, T.1    Honjo, T.2
  • 6
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • COI: 1:CAS:528:DC%2BD3cXntFSlt7o%3D, PID: 11015443
    • Freeman, G. J. et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192, 1027–1034 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 1027-1034
    • Freeman, G.J.1
  • 7
    • 84928917822 scopus 로고    scopus 로고
    • Pooled analysis of long-term survival data from phase II and phase III trials of ipilimumab in unresectable or metastatic melanoma
    • COI: 1:CAS:528:DC%2BC2MXhsFKmt7zP, PID: 25667295
    • Schadendorf, D. et al. Pooled analysis of long-term survival data from phase II and phase III trials of ipilimumab in unresectable or metastatic melanoma. J. Clin. Oncol. 33, 1889–1894 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. 1889-1894
    • Schadendorf, D.1
  • 8
    • 84936147067 scopus 로고    scopus 로고
    • Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
    • PID: 26027431
    • Larkin, J. et al. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N. Engl. J. Med. 373, 23–34 (2015).
    • (2015) N. Engl. J. Med. , vol.373 , pp. 23-34
    • Larkin, J.1
  • 9
    • 85045136401 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab versus sunitinib in advanced renal-cell carcinoma
    • COI: 1:CAS:528:DC%2BC1cXntlGhsrY%3D, PID: 29562145
    • Motzer, R. J. et al. Nivolumab plus ipilimumab versus sunitinib in advanced renal-cell carcinoma. N. Engl. J. Med. 378, 1277–1290 (2018).
    • (2018) N. Engl. J. Med. , vol.378 , pp. 1277-1290
    • Motzer, R.J.1
  • 10
    • 85025439295 scopus 로고    scopus 로고
    • Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study
    • COI: 1:CAS:528:DC%2BC2sXht1Sls7bL, PID: 28734759
    • Overman, M. J. et al. Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study. Lancet Oncol. 18, 1182–1191 (2017).
    • (2017) Lancet Oncol. , vol.18 , pp. 1182-1191
    • Overman, M.J.1
  • 11
    • 84971620553 scopus 로고    scopus 로고
    • Nivolumab alone and nivolumab plus ipilimumab in recurrent small-cell lung cancer (CheckMate 032): a multicentre, open-label, phase 1/2 trial
    • COI: 1:CAS:528:DC%2BC28XhtFSitrnP
    • Antonia, S. J. et al. Nivolumab alone and nivolumab plus ipilimumab in recurrent small-cell lung cancer (CheckMate 032): a multicentre, open-label, phase 1/2 trial. Lancet Oncol. 17, 883–895 (2016).
    • (2016) Lancet Oncol. , vol.17 , pp. 883-895
    • Antonia, S.J.1
  • 12
    • 85007425840 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab as first-line treatment for advanced non-small-cell lung cancer (CheckMate 012): results of an open-label, phase 1, multicohort study
    • COI: 1:CAS:528:DC%2BC28XitVSqs7zO, PID: 27932067
    • Hellmann, M. D. et al. Nivolumab plus ipilimumab as first-line treatment for advanced non-small-cell lung cancer (CheckMate 012): results of an open-label, phase 1, multicohort study. Lancet Oncol. 18, 31–41 (2017).
    • (2017) Lancet Oncol. , vol.18 , pp. 31-41
    • Hellmann, M.D.1
  • 13
    • 85047309884 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in lung cancer with a high tumor mutational burden
    • COI: 1:CAS:528:DC%2BC1cXhtV2rtrnL, PID: 29658845
    • Hellmann, M. D. et al. Nivolumab plus ipilimumab in lung cancer with a high tumor mutational burden. N. Engl. J. Med. 378, 2093–2104 (2018).
    • (2018) N. Engl. J. Med. , vol.378 , pp. 2093-2104
    • Hellmann, M.D.1
  • 14
    • 85053689477 scopus 로고    scopus 로고
    • Fatal toxic effects associated with immune checkpoint inhibitors: a systematic review and meta-analysis
    • PID: 30242316
    • Wang, D. Y. et al. Fatal toxic effects associated with immune checkpoint inhibitors: a systematic review and meta-analysis. JAMA Oncol. 4, 1721–1728 (2018).
    • (2018) JAMA Oncol. , vol.4 , pp. 1721-1728
    • Wang, D.Y.1
  • 15
    • 49049109683 scopus 로고    scopus 로고
    • Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE Collaborative Group
    • PID: 18506026
    • Pignon, J. P. et al. Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE Collaborative Group. J. Clin. Oncol. 26, 3552–3559 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 3552-3559
    • Pignon, J.P.1
  • 16
    • 78649429727 scopus 로고    scopus 로고
    • Reduced mortality after allogeneic hematopoietic-cell transplantation
    • COI: 1:CAS:528:DC%2BC3cXhsV2gs77P, PID: 21105791
    • Gooley, T. A. et al. Reduced mortality after allogeneic hematopoietic-cell transplantation. N. Engl. J. Med. 363, 2091–2101 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 2091-2101
    • Gooley, T.A.1
  • 17
    • 84994874924 scopus 로고    scopus 로고
    • Prolonged survival in stage III melanoma with ipilimumab adjuvant therapy
    • COI: 1:CAS:528:DC%2BC28XhvF2ksrfE, PID: 27717298
    • Eggermont, A. M. et al. Prolonged survival in stage III melanoma with ipilimumab adjuvant therapy. N. Engl. J. Med. 375, 1845–1855 (2016).
    • (2016) N. Engl. J. Med. , vol.375 , pp. 1845-1855
    • Eggermont, A.M.1
  • 18
    • 84864052441 scopus 로고    scopus 로고
    • Management of immune-related adverse events and kinetics of response with ipilimumab
    • COI: 1:CAS:528:DC%2BC38Xht1ygsr%2FK, PID: 22614989
    • Weber, J. S., Kahler, K. C. & Hauschild, A. Management of immune-related adverse events and kinetics of response with ipilimumab. J. Clin. Oncol. 30, 2691–2697 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. 2691-2697
    • Weber, J.S.1    Kahler, K.C.2    Hauschild, A.3
  • 19
    • 85008315530 scopus 로고    scopus 로고
    • Neurological adverse events associated with immune checkpoint inhibitors: review of the literature
    • COI: 1:CAS:528:DC%2BC2sXis12nug%3D%3D
    • Cuzzubbo, S. et al. Neurological adverse events associated with immune checkpoint inhibitors: review of the literature. Eur. J. Cancer 73, 1–8 (2017).
    • (2017) Eur. J. Cancer , vol.73 , pp. 1-8
    • Cuzzubbo, S.1
  • 20
    • 84897890387 scopus 로고    scopus 로고
    • Immune checkpoint blockade in cancer treatment: a double-edged sword cross-targeting the host as an “innocent bystander
    • Gelao, L., Criscitiello, C., Esposito, A., Goldhirsch, A. & Curigliano, G. Immune checkpoint blockade in cancer treatment: a double-edged sword cross-targeting the host as an “innocent bystander”. Toxins (Basel) 6, (914–933 (2014).
    • (2014) Toxins (Basel) , vol.6 , pp. 914-933
    • Gelao, L.1    Criscitiello, C.2    Esposito, A.3    Goldhirsch, A.4    Curigliano, G.5
  • 21
    • 84925222119 scopus 로고    scopus 로고
    • Nivolumab in previously untreated melanoma without BRAF mutation
    • COI: 1:CAS:528:DC%2BC2MXisFGqsLg%3D, PID: 25399552
    • Robert, C. et al. Nivolumab in previously untreated melanoma without BRAF mutation. N. Engl. J. Med. 372, 320–330 (2015).
    • (2015) N. Engl. J. Med. , vol.372 , pp. 320-330
    • Robert, C.1
  • 22
    • 85054684704 scopus 로고    scopus 로고
    • Pembrolizumab plus chemotherapy for squamous non–small-cell lung cancer
    • PID: 30280635
    • Luis Paz-Ares, M. D. et al. Pembrolizumab plus chemotherapy for squamous non–small-cell lung cancer. N. Engl. J. Med. 379, 2040–2051 (2018).
    • (2018) N. Engl. J. Med. , vol.379 , pp. 2040-2051
    • Luis Paz-Ares, M.D.1
  • 23
    • 84929481482 scopus 로고    scopus 로고
    • Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
    • PID: 25891304
    • Postow, M. A. et al. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. N. Engl. J. Med. 372, 2006–2017 (2015).
    • (2015) N. Engl. J. Med. , vol.372 , pp. 2006-2017
    • Postow, M.A.1
  • 24
    • 85061988861 scopus 로고    scopus 로고
    • Toxicity of checkpoint inhibition in advanced RCC: a systematic review
    • PID: 30334015
    • Ornstein, M. C. & Garcia, J. A. Toxicity of checkpoint inhibition in advanced RCC: a systematic review. Kidney Cancer 1, 133–141 (2017).
    • (2017) Kidney Cancer , vol.1 , pp. 133-141
    • Ornstein, M.C.1    Garcia, J.A.2
  • 25
    • 85032035687 scopus 로고    scopus 로고
    • Safety and efficacy of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma: the CheckMate 016 study
    • COI: 1:CAS:528:DC%2BC1cXitFemt7rO, PID: 28678668
    • Hammers, H. J. et al. Safety and efficacy of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma: the CheckMate 016 study. J. Clin. Oncol. 35, 3851–3858 (2017).
    • (2017) J. Clin. Oncol. , vol.35 , pp. 3851-3858
    • Hammers, H.J.1
  • 26
    • 85030551079 scopus 로고    scopus 로고
    • Tumour- and class-specific patterns of immune-related adverse events of immune checkpoint inhibitors: a systematic review
    • COI: 1:STN:280:DC%2BC1M%2FitV2ktg%3D%3D, PID: 28945858
    • Khoja, L., Day, D., Wei-Wu Chen, T., Siu, L. L. & Hansen, A. R. Tumour- and class-specific patterns of immune-related adverse events of immune checkpoint inhibitors: a systematic review. Ann. Oncol. 28, 2377–2385 (2017).
    • (2017) Ann. Oncol. , vol.28 , pp. 2377-2385
    • Khoja, L.1    Day, D.2    Wei-Wu Chen, T.3    Siu, L.L.4    Hansen, A.R.5
  • 27
    • 85032727826 scopus 로고    scopus 로고
    • Not all immune-checkpoint inhibitors are created equal: meta-analysis and systematic review of immune-related adverse events in cancer trials
    • COI: 1:STN:280:DC%2BC1M7ktVymtQ%3D%3D, PID: 29065979
    • El Osta, B., Hu, F., Sadek, R., Chintalapally, R. & Tang, S. C. Not all immune-checkpoint inhibitors are created equal: meta-analysis and systematic review of immune-related adverse events in cancer trials. Crit. Rev. Oncol. Hematol. 119, 1–12 (2017).
    • (2017) Crit. Rev. Oncol. Hematol. , vol.119 , pp. 1-12
    • El Osta, B.1    Hu, F.2    Sadek, R.3    Chintalapally, R.4    Tang, S.C.5
  • 28
    • 85027510221 scopus 로고    scopus 로고
    • Incidence of pneumonitis with use of programmed death 1 and programmed death-ligand 1 inhibitors in non-small cell lung cancer: a systematic review and meta-analysis of trials
    • PID: 28499515
    • Khunger, M. et al. Incidence of pneumonitis with use of programmed death 1 and programmed death-ligand 1 inhibitors in non-small cell lung cancer: a systematic review and meta-analysis of trials. Chest 152, 271–281 (2017).
    • (2017) Chest , vol.152 , pp. 271-281
    • Khunger, M.1
  • 29
    • 85030650022 scopus 로고    scopus 로고
    • Comparison of the toxicity profile of PD-1 versus PD-L1 inhibitors in non-small cell lung cancer: a systematic analysis of the literature
    • COI: 1:CAS:528:DC%2BC1cXnt1WhtA%3D%3D, PID: 28960263
    • Pillai, R. N. et al. Comparison of the toxicity profile of PD-1 versus PD-L1 inhibitors in non-small cell lung cancer: a systematic analysis of the literature. Cancer 124, 271–277 (2018).
    • (2018) Cancer , vol.124 , pp. 271-277
    • Pillai, R.N.1
  • 30
    • 85056330383 scopus 로고    scopus 로고
    • Comparative safety of immune checkpoint inhibitors in cancer: systematic review and network meta-analysis
    • PID: 30409774
    • Xu, C. et al. Comparative safety of immune checkpoint inhibitors in cancer: systematic review and network meta-analysis. BMJ 363, k4226 (2018).
    • (2018) BMJ , vol.363 , pp. k4226
    • Xu, C.1
  • 31
    • 85042387648 scopus 로고    scopus 로고
    • Safety profile of avelumab in patients with advanced solid tumors: a pooled analysis of data from the phase 1 JAVELIN solid tumor and phase 2 JAVELIN Merkel 200 clinical trials
    • COI: 1:CAS:528:DC%2BC1cXotlCmsbY%3D, PID: 29469949
    • Kelly, K. et al. Safety profile of avelumab in patients with advanced solid tumors: a pooled analysis of data from the phase 1 JAVELIN solid tumor and phase 2 JAVELIN Merkel 200 clinical trials. Cancer 124, 2010–2017 (2018).
    • (2018) Cancer , vol.124 , pp. 2010-2017
    • Kelly, K.1
  • 32
    • 85014010627 scopus 로고    scopus 로고
    • Pneumonitis in patients treated with anti-programmed death-1/programmed death ligand 1 therapy
    • COI: 1:CAS:528:DC%2BC1cXktFGrtbc%3D, PID: 27646942
    • Naidoo, J. et al. Pneumonitis in patients treated with anti-programmed death-1/programmed death ligand 1 therapy. J. Clin. Oncol. 35, 709–717 (2017).
    • (2017) J. Clin. Oncol. , vol.35 , pp. 709-717
    • Naidoo, J.1
  • 33
    • 85054447575 scopus 로고    scopus 로고
    • Pre-existing pulmonary fibrosis is a risk factor for anti-PD-1-related pneumonitis in patients with non-small cell lung cancer: a retrospective analysis
    • PID: 30429022
    • Yamaguchi, T. et al. Pre-existing pulmonary fibrosis is a risk factor for anti-PD-1-related pneumonitis in patients with non-small cell lung cancer: a retrospective analysis. Lung Cancer 125, 212–217 (2018).
    • (2018) Lung Cancer , vol.125 , pp. 212-217
    • Yamaguchi, T.1
  • 34
    • 85032668718 scopus 로고    scopus 로고
    • Prognostic value of smoking status in non-small-cell lung cancer patients treated with immune checkpoint inhibitors: a meta-analysis
    • PID: 29190984
    • Kim, J. H., Kim, H. S. & Kim, B. J. Prognostic value of smoking status in non-small-cell lung cancer patients treated with immune checkpoint inhibitors: a meta-analysis. Oncotarget 8, 93149–93155 (2017).
    • (2017) Oncotarget , vol.8 , pp. 93149-93155
    • Kim, J.H.1    Kim, H.S.2    Kim, B.J.3
  • 35
    • 85046022431 scopus 로고    scopus 로고
    • Association of immune-related adverse events with nivolumab efficacy in non-small-cell lung cancer
    • PID: 28975219
    • Haratani, K. et al. Association of immune-related adverse events with nivolumab efficacy in non-small-cell lung cancer. JAMA Oncol. 4, 374–378 (2018).
    • (2018) JAMA Oncol. , vol.4 , pp. 374-378
    • Haratani, K.1
  • 36
    • 84958181736 scopus 로고    scopus 로고
    • Immune checkpoint inhibitors in clinical practice: update on management of immune-related toxicities
    • COI: 1:CAS:528:DC%2BC28XntV2msrc%3D, PID: 26629425
    • Villadolid, J. & Amin, A. Immune checkpoint inhibitors in clinical practice: update on management of immune-related toxicities. Transl Lung Cancer Res. 4, 560–575 (2015).
    • (2015) Transl Lung Cancer Res. , vol.4 , pp. 560-575
    • Villadolid, J.1    Amin, A.2
  • 37
    • 84962144656 scopus 로고    scopus 로고
    • Characterisation and management of dermatologic adverse events to agents targeting the PD-1 receptor
    • COI: 1:CAS:528:DC%2BC28XksFKjsrk%3D, PID: 27043866
    • Belum, V. R. et al. Characterisation and management of dermatologic adverse events to agents targeting the PD-1 receptor. Eur. J. Cancer 60, 12–25 (2016).
    • (2016) Eur. J. Cancer , vol.60 , pp. 12-25
    • Belum, V.R.1
  • 38
    • 84925326818 scopus 로고    scopus 로고
    • Vitiligo-like depigmentation in patients with stage III-IV melanoma receiving immunotherapy and its association with survival: a systematic review and meta-analysis
    • COI: 1:CAS:528:DC%2BC2MXhtVWgsrvK, PID: 25605840
    • Teulings, H. E. et al. Vitiligo-like depigmentation in patients with stage III-IV melanoma receiving immunotherapy and its association with survival: a systematic review and meta-analysis. J. Clin. Oncol. 33, 773–781 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. 773-781
    • Teulings, H.E.1
  • 39
    • 85050862025 scopus 로고    scopus 로고
    • Characterization of dermatitis after PD-1/PD-L1 inhibitor therapy and association with multiple oncologic outcomes: a retrospective case-control study
    • COI: 1:CAS:528:DC%2BC1cXhsVers7bP, PID: 29857011
    • Min Lee, C. K. et al. Characterization of dermatitis after PD-1/PD-L1 inhibitor therapy and association with multiple oncologic outcomes: a retrospective case-control study. J. Am. Acad. Dermatol. 79, 1047–1052 (2018).
    • (2018) J. Am. Acad. Dermatol. , vol.79 , pp. 1047-1052
    • Min Lee, C.K.1
  • 40
    • 85048707368 scopus 로고    scopus 로고
    • Dermatologic toxicity from immune checkpoint blockade therapy with an interstitial granulomatous pattern
    • PID: 29633300
    • Trinidad, C. et al. Dermatologic toxicity from immune checkpoint blockade therapy with an interstitial granulomatous pattern. J. Cutan. Pathol. 45, 504–507 (2018).
    • (2018) J. Cutan. Pathol. , vol.45 , pp. 504-507
    • Trinidad, C.1
  • 41
    • 84903269067 scopus 로고    scopus 로고
    • Ipilimumab in patients with cancer and the management of dermatologic adverse events
    • COI: 1:CAS:528:DC%2BC2cXmvVWqt7g%3D, PID: 24767731
    • Lacouture, M. E. et al. Ipilimumab in patients with cancer and the management of dermatologic adverse events. J. Am. Acad. Dermatol. 71, 161–169 (2014).
    • (2014) J. Am. Acad. Dermatol. , vol.71 , pp. 161-169
    • Lacouture, M.E.1
  • 42
    • 84876678621 scopus 로고    scopus 로고
    • Patterns of onset and resolution of immune-related adverse events of special interest with ipilimumab: detailed safety analysis from a phase 3 trial in patients with advanced melanoma
    • COI: 1:CAS:528:DC%2BC3sXmsFWmsr4%3D, PID: 23400564
    • Weber, J. S. et al. Patterns of onset and resolution of immune-related adverse events of special interest with ipilimumab: detailed safety analysis from a phase 3 trial in patients with advanced melanoma. Cancer 119, 1675–1682 (2013).
    • (2013) Cancer , vol.119 , pp. 1675-1682
    • Weber, J.S.1
  • 43
    • 85033690916 scopus 로고    scopus 로고
    • Anti-PD1/PDL1 induced psoriasis
    • PID: 29096940
    • Voudouri, D. et al. Anti-PD1/PDL1 induced psoriasis. Curr. Probl. Cancer 41, 407–412 (2017).
    • (2017) Curr. Probl. Cancer , vol.41 , pp. 407-412
    • Voudouri, D.1
  • 44
    • 85033564743 scopus 로고    scopus 로고
    • Lupus-like cutaneous reaction following pembrolizumab: an immune-related adverse event associated with anti-PD-1 therapy
    • PID: 29028121
    • Shao, K., McGettigan, S., Elenitsas, R. & Chu, E. Y. Lupus-like cutaneous reaction following pembrolizumab: an immune-related adverse event associated with anti-PD-1 therapy. J. Cutan. Pathol. 45, 74–77 (2018).
    • (2018) J. Cutan. Pathol. , vol.45 , pp. 74-77
    • Shao, K.1    McGettigan, S.2    Elenitsas, R.3    Chu, E.Y.4
  • 45
    • 84962113288 scopus 로고    scopus 로고
    • Bullous pemphigoid, an autoantibody-mediated disease, is a novel immune-related adverse event in patients treated with anti-programmed cell death 1 antibodies
    • COI: 1:CAS:528:DC%2BC28XhtVyitb%2FE, PID: 27031539
    • Hwang, S. J. et al. Bullous pemphigoid, an autoantibody-mediated disease, is a novel immune-related adverse event in patients treated with anti-programmed cell death 1 antibodies. Melanoma Res. 26, 413–416 (2016).
    • (2016) Melanoma Res. , vol.26 , pp. 413-416
    • Hwang, S.J.1
  • 46
    • 85046621752 scopus 로고    scopus 로고
    • Dermatologic reactions to immune checkpoint inhibitors: skin toxicities and immunotherapy
    • PID: 29256113
    • Sibaud, V. Dermatologic reactions to immune checkpoint inhibitors: skin toxicities and immunotherapy. Am. J. Clin. Dermatol. 19, 345–361 (2018).
    • (2018) Am. J. Clin. Dermatol. , vol.19 , pp. 345-361
    • Sibaud, V.1
  • 47
    • 85034015225 scopus 로고    scopus 로고
    • Checkpoint blockade toxicity and immune homeostasis in the gastrointestinal tract
    • PID: 29230210
    • Dougan, M. Checkpoint blockade toxicity and immune homeostasis in the gastrointestinal tract. Front. Immunol. 8, 1547 (2017).
    • (2017) Front. Immunol. , vol.8 , pp. 1547
    • Dougan, M.1
  • 48
    • 84994691339 scopus 로고    scopus 로고
    • Ipilimumab-induced enteritis without colitis: a new challenge
    • PID: 27920706
    • Messmer, M. et al. Ipilimumab-induced enteritis without colitis: a new challenge. Case Rep. Oncol. 9, 705–713 (2016).
    • (2016) Case Rep. Oncol. , vol.9 , pp. 705-713
    • Messmer, M.1
  • 49
    • 85073836799 scopus 로고    scopus 로고
    • Microscopic colonic inflammation in immune check point inhibitor-induced diarrhoea/colitis [abstract PWE-025]
    • (Suppl. 1
    • Ibraheim, H. et al. Microscopic colonic inflammation in immune check point inhibitor-induced diarrhoea/colitis [abstract PWE-025]. Gut 67 (Suppl. 1), A80 (2018).
    • (2018) Gut , vol.67 , pp. A80
    • Ibraheim, H.1
  • 50
    • 85054012525 scopus 로고    scopus 로고
    • Importance of endoscopic and histological evaluation in the management of immune checkpoint inhibitor-induced colitis
    • PID: 30253811
    • Abu-Sbeih, H. et al. Importance of endoscopic and histological evaluation in the management of immune checkpoint inhibitor-induced colitis. J. Immunother. Cancer 6, 95 (2018).
    • (2018) J. Immunother. Cancer , vol.6 , pp. 95
    • Abu-Sbeih, H.1
  • 51
    • 85054779229 scopus 로고    scopus 로고
    • Infliximab associated with faster symptom resolution compared with corticosteroids alone for the management of immune-related enterocolitis
    • PID: 30305177
    • Johnson, D. H. et al. Infliximab associated with faster symptom resolution compared with corticosteroids alone for the management of immune-related enterocolitis. J. Immunother. Cancer 6, 103 (2018).
    • (2018) J. Immunother. Cancer , vol.6 , pp. 103
    • Johnson, D.H.1
  • 52
    • 0034679567 scopus 로고    scopus 로고
    • + regulatory cells that control intestinal inflammation
    • COI: 1:CAS:528:DC%2BD3cXkvFGiu7Y%3D, PID: 10899916
    • + regulatory cells that control intestinal inflammation. J. Exp. Med. 192, 295–302 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 295-302
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 53
    • 84953427271 scopus 로고    scopus 로고
    • Early-onset Crohn’s disease and autoimmunity associated with a variant in CTLA-4
    • COI: 1:CAS:528:DC%2BC28XmvVWitbk%3D, PID: 25367873
    • Zeissig, S. et al. Early-onset Crohn’s disease and autoimmunity associated with a variant in CTLA-4. Gut 64, 1889–1897 (2015).
    • (2015) Gut , vol.64 , pp. 1889-1897
    • Zeissig, S.1
  • 54
    • 85019259316 scopus 로고    scopus 로고
    • Enhancing the clinical coverage and anticancer efficacy of immune checkpoint blockade through manipulation of the gut microbiota
    • PID: 28197360
    • Pitt, J. M. et al. Enhancing the clinical coverage and anticancer efficacy of immune checkpoint blockade through manipulation of the gut microbiota. Oncoimmunology 6, e1132137 (2017).
    • (2017) Oncoimmunology , vol.6
    • Pitt, J.M.1
  • 55
    • 84948461699 scopus 로고    scopus 로고
    • Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
    • COI: 1:CAS:528:DC%2BC2MXhvFamtL3J, PID: 26541610
    • Vetizou, M. et al. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science 350, 1079–1084 (2015).
    • (2015) Science , vol.350 , pp. 1079-1084
    • Vetizou, M.1
  • 56
    • 85021170776 scopus 로고    scopus 로고
    • Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab
    • COI: 1:STN:280:DC%2BC1cvjsleiug%3D%3D, PID: 28368458
    • Chaput, N. et al. Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab. Ann. Oncol. 28, 1368–1379 (2017).
    • (2017) Ann. Oncol. , vol.28 , pp. 1368-1379
    • Chaput, N.1
  • 57
    • 84957565779 scopus 로고    scopus 로고
    • Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis
    • COI: 1:CAS:528:DC%2BC28XitVOlur0%3D, PID: 26837003
    • Dubin, K. et al. Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis. Nat. Commun. 7, 10391 (2016).
    • (2016) Nat. Commun. , vol.7
    • Dubin, K.1
  • 58
    • 85056460979 scopus 로고    scopus 로고
    • Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis
    • COI: 1:CAS:528:DC%2BC1cXit1Sgur%2FE, PID: 30420754
    • Wang, Y. et al. Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis. Nat. Med. 24, 1804–1808 (2018).
    • (2018) Nat. Med. , vol.24 , pp. 1804-1808
    • Wang, Y.1
  • 59
    • 84997771368 scopus 로고    scopus 로고
    • Baseline circulating IL-17 predicts toxicity while TGF-beta1 and IL-10 are prognostic of relapse in ipilimumab neoadjuvant therapy of melanoma
    • PID: 26380086
    • Tarhini, A. A. et al. Baseline circulating IL-17 predicts toxicity while TGF-beta1 and IL-10 are prognostic of relapse in ipilimumab neoadjuvant therapy of melanoma. J. Immunother. Cancer 3, 39 (2015).
    • (2015) J. Immunother. Cancer , vol.3 , pp. 39
    • Tarhini, A.A.1
  • 60
    • 0141889125 scopus 로고    scopus 로고
    • Blockade of B7-H1 suppresses the development of chronic intestinal inflammation
    • COI: 1:CAS:528:DC%2BD3sXnvVOktr8%3D, PID: 14530338
    • Kanai, T. et al. Blockade of B7-H1 suppresses the development of chronic intestinal inflammation. J. Immunol. 171, 4156–4163 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 4156-4163
    • Kanai, T.1
  • 61
    • 61449267507 scopus 로고    scopus 로고
    • Intestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockade
    • COI: 1:CAS:528:DC%2BD1MXhsFKku70%3D, PID: 19201863
    • Reynoso, E. D. et al. Intestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockade. J. Immunol. 182, 2102–2112 (2009).
    • (2009) J. Immunol. , vol.182 , pp. 2102-2112
    • Reynoso, E.D.1
  • 62
    • 85021387287 scopus 로고    scopus 로고
    • Clinical features, diagnostic challenges, and management strategies in checkpoint inhibitor-related pneumonitis
    • COI: 1:CAS:528:DC%2BC1cXit1SksbrN, PID: 28652812
    • Chuzi, S. et al. Clinical features, diagnostic challenges, and management strategies in checkpoint inhibitor-related pneumonitis. Cancer Manag. Res. 9, 207–213 (2017).
    • (2017) Cancer Manag. Res. , vol.9 , pp. 207-213
    • Chuzi, S.1
  • 63
    • 85013156149 scopus 로고    scopus 로고
    • Incidence of programmed cell death 1 inhibitor-related pneumonitis in patients with advanced cancer: a systematic review and meta-analysis
    • PID: 27540850
    • Nishino, M., Giobbie-Hurder, A., Hatabu, H., Ramaiya, N. H. & Hodi, F. S. Incidence of programmed cell death 1 inhibitor-related pneumonitis in patients with advanced cancer: a systematic review and meta-analysis. JAMA Oncol. 2, 1607–1616 (2016).
    • (2016) JAMA Oncol. , vol.2 , pp. 1607-1616
    • Nishino, M.1    Giobbie-Hurder, A.2    Hatabu, H.3    Ramaiya, N.H.4    Hodi, F.S.5
  • 64
    • 84997418743 scopus 로고    scopus 로고
    • Systemic inflammation in a melanoma patient treated with immune checkpoint inhibitors-an autopsy study
    • PID: 26981243
    • Koelzer, V. H. et al. Systemic inflammation in a melanoma patient treated with immune checkpoint inhibitors-an autopsy study. J. Immunother. Cancer 4, 13 (2016).
    • (2016) J. Immunother. Cancer , vol.4 , pp. 13
    • Koelzer, V.H.1
  • 65
    • 85081978436 scopus 로고    scopus 로고
    • Pembrolizumab-induced pneumonitis
    • Leroy, V. et al. Pembrolizumab-induced pneumonitis. ERJ Open Res. 10.1183/23120541.00081-2016 (2017).
    • (2017) ERJ Open Res.
    • Leroy, V.1
  • 66
    • 85006982967 scopus 로고    scopus 로고
    • Pulmonary sarcoid-like granulomatosis induced by nivolumab
    • COI: 1:CAS:528:DC%2BC2sXmtFCltLk%3D, PID: 27291635
    • Montaudie, H., Pradelli, J., Passeron, T., Lacour, J. P. & Leroy, S. Pulmonary sarcoid-like granulomatosis induced by nivolumab. Br. J. Dermatol. 176, 1060–1063 (2017).
    • (2017) Br. J. Dermatol. , vol.176 , pp. 1060-1063
    • Montaudie, H.1    Pradelli, J.2    Passeron, T.3    Lacour, J.P.4    Leroy, S.5
  • 67
    • 85041076967 scopus 로고    scopus 로고
    • Endocrine side effects of cancer immunotherapy
    • COI: 1:CAS:528:DC%2BC1cXitFOlurbM, PID: 29025857
    • Cukier, P., Santini, F. C., Scaranti, M. & Hoff, A. O. Endocrine side effects of cancer immunotherapy. Endocr. Relat. Cancer 24, T331–T347 (2017).
    • (2017) Endocr. Relat. Cancer , vol.24 , pp. T331-T347
    • Cukier, P.1    Santini, F.C.2    Scaranti, M.3    Hoff, A.O.4
  • 68
    • 84954389695 scopus 로고    scopus 로고
    • Immunotherapy and hypophysitis: clinical presentation, treatment, and biologic insights
    • COI: 1:CAS:528:DC%2BC2MXht1SqsrjN, PID: 26186958
    • Faje, A. Immunotherapy and hypophysitis: clinical presentation, treatment, and biologic insights. Pituitary 19, 82–92 (2016).
    • (2016) Pituitary , vol.19 , pp. 82-92
    • Faje, A.1
  • 69
    • 27444440093 scopus 로고    scopus 로고
    • Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer
    • COI: 1:CAS:528:DC%2BD2MXhtFSis7rO, PID: 16224277
    • Blansfield, J. A. et al. Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer. J. Immunother. 28, 593–598 (2005).
    • (2005) J. Immunother. , vol.28 , pp. 593-598
    • Blansfield, J.A.1
  • 70
    • 84876248304 scopus 로고    scopus 로고
    • Endocrine side effects induced by immune checkpoint inhibitors
    • COI: 1:CAS:528:DC%2BC3sXmtFehsb4%3D, PID: 23471977
    • Corsello, S. M. et al. Endocrine side effects induced by immune checkpoint inhibitors. J. Clin. Endocrinol. Metab. 98, 1361–1375 (2013).
    • (2013) J. Clin. Endocrinol. Metab. , vol.98 , pp. 1361-1375
    • Corsello, S.M.1
  • 71
    • 84899071058 scopus 로고    scopus 로고
    • Pituitary expression of CTLA-4 mediates hypophysitis secondary to administration of CTLA-4 blocking antibody
    • Iwama, S. et al. Pituitary expression of CTLA-4 mediates hypophysitis secondary to administration of CTLA-4 blocking antibody. Sci. Transl Med. 6, 230ra245 (2014).
    • (2014) Sci. Transl Med. , vol.6 , pp. 230ra245
    • Iwama, S.1
  • 72
    • 84995906230 scopus 로고    scopus 로고
    • Hypophysitis secondary to cytotoxic T-lymphocyte-associated protein 4 blockade: insights into pathogenesis from an autopsy series
    • COI: 1:CAS:528:DC%2BC28XhslWjt73L, PID: 27750046
    • Caturegli, P. et al. Hypophysitis secondary to cytotoxic T-lymphocyte-associated protein 4 blockade: insights into pathogenesis from an autopsy series. Am. J. Pathol. 186, 3225–3235 (2016).
    • (2016) Am. J. Pathol. , vol.186 , pp. 3225-3235
    • Caturegli, P.1
  • 73
    • 84874605864 scopus 로고    scopus 로고
    • Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma
    • COI: 1:CAS:528:DC%2BC3sXjvVart74%3D, PID: 23295794
    • Ribas, A. et al. Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma. J. Clin. Oncol. 31, 616–622 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. 616-622
    • Ribas, A.1
  • 74
    • 84993971904 scopus 로고    scopus 로고
    • Nivolumab-induced hypophysitis in a patient with advanced malignant melanoma
    • PID: 27440480
    • Okano, Y. et al. Nivolumab-induced hypophysitis in a patient with advanced malignant melanoma. Endocr. J. 63, 905–912 (2016).
    • (2016) Endocr. J. , vol.63 , pp. 905-912
    • Okano, Y.1
  • 75
    • 84978523049 scopus 로고    scopus 로고
    • & Spanish Group for Cancer Immuno-Biotherapy (GETICA). Immune checkpoint inhibitors: review and management of endocrine adverse events
    • PID: 27306911
    • Gonzalez-Rodriguez, E. & Rodriguez-Abreu, D. & Spanish Group for Cancer Immuno-Biotherapy (GETICA). Immune checkpoint inhibitors: review and management of endocrine adverse events. Oncologist 21, 804–816 (2016).
    • (2016) Oncologist , vol.21 , pp. 804-816
    • Gonzalez-Rodriguez, E.1    Rodriguez-Abreu, D.2
  • 76
    • 84994852309 scopus 로고    scopus 로고
    • Incidence of thyroid-related adverse events in melanoma patients treated with pembrolizumab
    • PID: 27571185
    • de Filette, J. et al. Incidence of thyroid-related adverse events in melanoma patients treated with pembrolizumab. J. Clin. Endocrinol. Metab. 101, 4431–4439 (2016).
    • (2016) J. Clin. Endocrinol. Metab. , vol.101 , pp. 4431-4439
    • de Filette, J.1
  • 77
    • 85037606593 scopus 로고    scopus 로고
    • Characterization of thyroid disorders in patients receiving immune checkpoint inhibition therapy
    • COI: 1:CAS:528:DC%2BC2sXhvFWhsbrK, PID: 29079654
    • Lee, H. et al. Characterization of thyroid disorders in patients receiving immune checkpoint inhibition therapy. Cancer Immunol. Res. 5, 1133–1140 (2017).
    • (2017) Cancer Immunol. Res. , vol.5 , pp. 1133-1140
    • Lee, H.1
  • 78
    • 85022190469 scopus 로고    scopus 로고
    • Clinical features of nivolumab-induced thyroiditis: a case series study
    • COI: 1:CAS:528:DC%2BC2sXhtFemtb%2FL, PID: 28537531
    • Yamauchi, I. et al. Clinical features of nivolumab-induced thyroiditis: a case series study. Thyroid 27, 894–901 (2017).
    • (2017) Thyroid , vol.27 , pp. 894-901
    • Yamauchi, I.1
  • 79
    • 84929481481 scopus 로고    scopus 로고
    • Pembrolizumab versus ipilimumab in advanced melanoma
    • COI: 1:CAS:528:DC%2BC2MXhtFyrsbrF, PID: 25891173
    • Robert, C. et al. Pembrolizumab versus ipilimumab in advanced melanoma. N. Engl. J. Med. 372, 2521–2532 (2015).
    • (2015) N. Engl. J. Med. , vol.372 , pp. 2521-2532
    • Robert, C.1
  • 80
    • 85020635231 scopus 로고    scopus 로고
    • Risk of hepatotoxicity in cancer patients treated with immune checkpoint inhibitors: A systematic review and meta-analysis of published data
    • COI: 1:CAS:528:DC%2BC2sXhtFSmu77F, PID: 28263392
    • Wang, W., Lie, P., Guo, M. & He, J. Risk of hepatotoxicity in cancer patients treated with immune checkpoint inhibitors: A systematic review and meta-analysis of published data. Int. J. Cancer 141, 1018–1028 (2017).
    • (2017) Int. J. Cancer , vol.141 , pp. 1018-1028
    • Wang, W.1    Lie, P.2    Guo, M.3    He, J.4
  • 81
    • 85048293934 scopus 로고    scopus 로고
    • Hepatotoxicity of immune checkpoint inhibitors: an evolving picture of risk associated with a vital class of immunotherapy agents
    • PID: 29603856
    • Suzman, D. L., Pelosof, L., Rosenberg, A. & Avigan, M. I. Hepatotoxicity of immune checkpoint inhibitors: an evolving picture of risk associated with a vital class of immunotherapy agents. Liver Int. 38, 976–987 (2018).
    • (2018) Liver Int. , vol.38 , pp. 976-987
    • Suzman, D.L.1    Pelosof, L.2    Rosenberg, A.3    Avigan, M.I.4
  • 82
    • 85049222937 scopus 로고    scopus 로고
    • Immune checkpoint inhibitor-induced gastrointestinal and hepatic injury: pathologists’ perspective
    • COI: 1:CAS:528:DC%2BC1cXisFWnsLfJ, PID: 29703758
    • Karamchandani, D. M. & Chetty, R. Immune checkpoint inhibitor-induced gastrointestinal and hepatic injury: pathologists’ perspective. J. Clin. Pathol. 71, 665–671 (2018).
    • (2018) J. Clin. Pathol. , vol.71 , pp. 665-671
    • Karamchandani, D.M.1    Chetty, R.2
  • 83
    • 84938085491 scopus 로고    scopus 로고
    • Ipilimumab-associated hepatitis: clinicopathologic characterization in a series of 11 cases
    • PID: 26034866
    • Johncilla, M. et al. Ipilimumab-associated hepatitis: clinicopathologic characterization in a series of 11 cases. Am. J. Surg. Pathol. 39, 1075–1084 (2015).
    • (2015) Am. J. Surg. Pathol. , vol.39 , pp. 1075-1084
    • Johncilla, M.1
  • 84
    • 84992692374 scopus 로고    scopus 로고
    • Fibrin ring granulomas in checkpoint inhibitor-induced hepatitis
    • PID: 27792061
    • Everett, J., Srivastava, A. & Misdraji, J. Fibrin ring granulomas in checkpoint inhibitor-induced hepatitis. Am. J. Surg. Pathol. 41, 134–137 (2017).
    • (2017) Am. J. Surg. Pathol. , vol.41 , pp. 134-137
    • Everett, J.1    Srivastava, A.2    Misdraji, J.3
  • 85
    • 85043452821 scopus 로고    scopus 로고
    • Myocarditis in patients treated with immune checkpoint inhibitors
    • COI: 1:CAS:528:DC%2BC1cXltFWqtrs%3D, PID: 29567210
    • Mahmood, S. S. et al. Myocarditis in patients treated with immune checkpoint inhibitors. J. Am. Coll. Cardiol. 71, 1755–1764 (2018).
    • (2018) J. Am. Coll. Cardiol. , vol.71 , pp. 1755-1764
    • Mahmood, S.S.1
  • 86
    • 84994144982 scopus 로고    scopus 로고
    • Fulminant myocarditis with combination immune checkpoint blockade
    • PID: 27806233
    • Johnson, D. B. et al. Fulminant myocarditis with combination immune checkpoint blockade. N. Engl. J. Med. 375, 1749–1755 (2016).
    • (2016) N. Engl. J. Med. , vol.375 , pp. 1749-1755
    • Johnson, D.B.1
  • 87
    • 85042943560 scopus 로고    scopus 로고
    • Increased reporting of fatal immune checkpoint inhibitor-associated myocarditis
    • PID: 29536852
    • Moslehi, J. J., Salem, J. E., Sosman, J. A., Lebrun-Vignes, B. & Johnson, D. B. Increased reporting of fatal immune checkpoint inhibitor-associated myocarditis. Lancet 391, 933 (2018).
    • (2018) Lancet , vol.391 , pp. 933
    • Moslehi, J.J.1    Salem, J.E.2    Sosman, J.A.3    Lebrun-Vignes, B.4    Johnson, D.B.5
  • 88
    • 84997633422 scopus 로고    scopus 로고
    • Cardiotoxicity associated with CTLA4 and PD1 blocking immunotherapy
    • PID: 27532025
    • Heinzerling, L. et al. Cardiotoxicity associated with CTLA4 and PD1 blocking immunotherapy. J. Immunother. Cancer 4, 50 (2016).
    • (2016) J. Immunother. Cancer , vol.4 , pp. 50
    • Heinzerling, L.1
  • 89
    • 85041540936 scopus 로고    scopus 로고
    • Cardiotoxicity of immune checkpoint inhibitors
    • PID: 29104763
    • Varricchi, G. et al. Cardiotoxicity of immune checkpoint inhibitors. ESMO Open 2, e000247 (2017).
    • (2017) ESMO Open , vol.2
    • Varricchi, G.1
  • 90
    • 85046363576 scopus 로고    scopus 로고
    • Fatal myocarditis following treatment with the PD-1 inhibitor nivolumab
    • PID: 28833116
    • Matson, D. R., Accola, M. A., Rehrauer, W. M. & Corliss, R. F. Fatal myocarditis following treatment with the PD-1 inhibitor nivolumab. J. Forensic Sci. 63, 954–957 (2017).
    • (2017) J. Forensic Sci. , vol.63 , pp. 954-957
    • Matson, D.R.1    Accola, M.A.2    Rehrauer, W.M.3    Corliss, R.F.4
  • 91
    • 85033798830 scopus 로고    scopus 로고
    • Neurological toxicities associated with immune-checkpoint inhibitors
    • COI: 1:CAS:528:DC%2BC2sXhslCiu7zJ, PID: 28938341
    • Touat, M., Talmasov, D., Ricard, D. & Psimaras, D. Neurological toxicities associated with immune-checkpoint inhibitors. Curr. Opin. Neurol. 30, 659–668 (2017).
    • (2017) Curr. Opin. Neurol. , vol.30 , pp. 659-668
    • Touat, M.1    Talmasov, D.2    Ricard, D.3    Psimaras, D.4
  • 92
    • 85031757174 scopus 로고    scopus 로고
    • Neurological complications associated with anti-programmed death 1 (PD-1) antibodies
    • PID: 28873125
    • Kao, J. C. et al. Neurological complications associated with anti-programmed death 1 (PD-1) antibodies. JAMA Neurol. 74, 1216–1222 (2017).
    • (2017) JAMA Neurol. , vol.74 , pp. 1216-1222
    • Kao, J.C.1
  • 94
    • 85055207067 scopus 로고    scopus 로고
    • A severe case of neuro-Sjogren’s syndrome induced by pembrolizumab
    • PID: 30348223
    • Ghosn, J. et al. A severe case of neuro-Sjogren’s syndrome induced by pembrolizumab. J. Immunother. Cancer 6, 110 (2018).
    • (2018) J. Immunother. Cancer , vol.6 , pp. 110
    • Ghosn, J.1
  • 95
    • 84981271733 scopus 로고    scopus 로고
    • Association of autoimmune encephalitis with combined immune checkpoint inhibitor treatment for metastatic cancer
    • Williams, T. J. et al. Association of autoimmune encephalitis with combined immune checkpoint inhibitor treatment for metastatic cancer. JAMA Neurol. 73, 928–933 (2016).
    • (2016) JAMA Neurol. , vol.73 , pp. 928-933
    • Williams, T.J.1
  • 96
    • 85010748396 scopus 로고    scopus 로고
    • Autoimmune limbic encephalitis with anti-contactin-associated protein-like 2 antibody secondary to pembrolizumab therapy
    • COI: 1:CAS:528:DC%2BC2sXhs1KrsLs%3D
    • Brown, M. P., Hissaria, P., Hsieh, A. H., Kneebone, C. & Vallat, W. Autoimmune limbic encephalitis with anti-contactin-associated protein-like 2 antibody secondary to pembrolizumab therapy. J. Neuroimmunol. 305, 16–18 (2017).
    • (2017) J. Neuroimmunol. , vol.305 , pp. 16-18
    • Brown, M.P.1    Hissaria, P.2    Hsieh, A.H.3    Kneebone, C.4    Vallat, W.5
  • 97
    • 85040316305 scopus 로고    scopus 로고
    • Anti-Hu-associated autoimmune limbic encephalitis in a patient with PD-1 inhibitor-responsive myxoid chondrosarcoma
    • Papadopoulos, K. P. et al. Anti-Hu-associated autoimmune limbic encephalitis in a patient with PD-1 inhibitor-responsive myxoid chondrosarcoma. Oncologist 23, 118–120 (2018).
    • (2018) Oncologist , vol.23 , pp. 118-120
    • Papadopoulos, K.P.1
  • 98
    • 85039768013 scopus 로고    scopus 로고
    • Coexisting myasthenia gravis, myositis, and polyneuropathy induced by ipilimumab and nivolumab in a patient with non-small-cell lung cancer: a case report and literature review
    • Chen, J. H., Lee, K. Y., Hu, C. J. & Chung, C. C. Coexisting myasthenia gravis, myositis, and polyneuropathy induced by ipilimumab and nivolumab in a patient with non-small-cell lung cancer: a case report and literature review. Medicine (Baltimore) 96, e9262 (2017).
    • (2017) Medicine (Baltimore) , vol.96
    • Chen, J.H.1    Lee, K.Y.2    Hu, C.J.3    Chung, C.C.4
  • 99
    • 85046890226 scopus 로고    scopus 로고
    • Adjuvant pembrolizumab versus placebo in resected stage III melanoma
    • COI: 1:CAS:528:DC%2BC1cXpsFyqsbc%3D, PID: 29658430
    • Eggermont, A. M. M. et al. Adjuvant pembrolizumab versus placebo in resected stage III melanoma. N. Engl. J. Med. 378, 1789–1801 (2018).
    • (2018) N. Engl. J. Med. , vol.378 , pp. 1789-1801
    • Eggermont, A.M.M.1
  • 100
    • 85030612370 scopus 로고    scopus 로고
    • Nivolumab-related myasthenia gravis with myositis and myocarditis in Japan
    • COI: 1:CAS:528:DC%2BC2sXhsVKmtb%2FL
    • Suzuki, S. et al. Nivolumab-related myasthenia gravis with myositis and myocarditis in Japan. Neurology 89, 1127–1134 (2017).
    • (2017) Neurology , vol.89 , pp. 1127-1134
    • Suzuki, S.1
  • 101
    • 85021263317 scopus 로고    scopus 로고
    • Myasthenia gravis: An emerging toxicity of immune checkpoint inhibitors
    • COI: 1:CAS:528:DC%2BC2sXhtVGnsLjM, PID: 28666240
    • Makarious et al. Myasthenia gravis: an emerging toxicity of immune checkpoint inhibitors. Eur. J. Cancer 82, 128–136 (2017).
    • (2017) European Journal of Cancer , vol.82 , pp. 128-136
    • Makarious, D.1    Horwood, K.2    Coward, J.I.G.3
  • 102
    • 85040690617 scopus 로고    scopus 로고
    • Emergence of myasthenia gravis with myositis in a patient treated with pembrolizumab for thymic cancer
    • PID: 29629546
    • Huh, S. Y. et al. Emergence of myasthenia gravis with myositis in a patient treated with pembrolizumab for thymic cancer. J. Clin. Neurol. 14, 115–117 (2018).
    • (2018) J. Clin. Neurol. , vol.14 , pp. 115-117
    • Huh, S.Y.1
  • 103
    • 85065976818 scopus 로고    scopus 로고
    • Acute demyelinating polyneuropathy caused by nivolumab in a man with metastatic non-small cell lung cancer
    • Butt, S. & Bhaumik, S. Acute demyelinating polyneuropathy caused by nivolumab in a man with metastatic non-small cell lung cancer. J. Gerontol. Geriatr. Res. 5, 302 (2016).
    • (2016) J. Gerontol. Geriatr. Res. , vol.5 , pp. 302
    • Butt, S.1    Bhaumik, S.2
  • 104
    • 84962286789 scopus 로고    scopus 로고
    • Survivorship in immune therapy: assessing chronic immune toxicities, health outcomes, and functional status among long-term ipilimumab survivors at a single referral center
    • COI: 1:CAS:528:DC%2BC2MXnvV2msbo%3D, PID: 25649350
    • Johnson, D. B. et al. Survivorship in immune therapy: assessing chronic immune toxicities, health outcomes, and functional status among long-term ipilimumab survivors at a single referral center. Cancer Immunol. Res. 3, 464–469 (2015).
    • (2015) Cancer Immunol. Res. , vol.3 , pp. 464-469
    • Johnson, D.B.1
  • 105
    • 84930179528 scopus 로고    scopus 로고
    • Ipilimumab-associated bilateral optic neuropathy
    • PID: 25647225
    • Yeh, O. L. & Francis, C. E. Ipilimumab-associated bilateral optic neuropathy. J. Neuroophthalmol 35, 144–147 (2015).
    • (2015) J. Neuroophthalmol , vol.35 , pp. 144-147
    • Yeh, O.L.1    Francis, C.E.2
  • 106
    • 84946051731 scopus 로고    scopus 로고
    • Bilateral facial palsy following ipilimumab infusion for melanoma
    • PID: 26408564
    • Altman, A. L., Golub, J. S., Pensak, M. L. & Samy, R. N. Bilateral facial palsy following ipilimumab infusion for melanoma. Otolaryngol. Head Neck Surg. 153, 894–895 (2015).
    • (2015) Otolaryngol. Head Neck Surg. , vol.153 , pp. 894-895
    • Altman, A.L.1    Golub, J.S.2    Pensak, M.L.3    Samy, R.N.4
  • 107
    • 84872339660 scopus 로고    scopus 로고
    • The price of tumor control: an analysis of rare side effects of anti-CTLA-4 therapy in metastatic melanoma from the ipilimumab network
    • COI: 1:CAS:528:DC%2BC3sXhsVGmurc%3D, PID: 23341990
    • Voskens, C. J. et al. The price of tumor control: an analysis of rare side effects of anti-CTLA-4 therapy in metastatic melanoma from the ipilimumab network. PLOS ONE 8, e53745 (2013).
    • (2013) PLOS ONE , vol.8
    • Voskens, C.J.1
  • 109
    • 85015831479 scopus 로고    scopus 로고
    • Immune-related ocular toxicities in solid tumor patients treated with immune checkpoint inhibitors: a systematic review
    • COI: 1:CAS:528:DC%2BC2sXjsFGmt7Y%3D, PID: 28277102
    • Abdel-Rahman, O. et al. Immune-related ocular toxicities in solid tumor patients treated with immune checkpoint inhibitors: a systematic review. Expert Rev. Anticancer Ther. 17, 387–394 (2017).
    • (2017) Expert Rev. Anticancer Ther. , vol.17 , pp. 387-394
    • Abdel-Rahman, O.1
  • 110
    • 56749180605 scopus 로고    scopus 로고
    • Immunotherapy of autoimmunity and cancer: the penalty for success
    • COI: 1:CAS:528:DC%2BD1cXhsVWlsLfP, PID: 19008897
    • Caspi, R. R. Immunotherapy of autoimmunity and cancer: the penalty for success. Nat. Rev. Immunol. 8, 970–976 (2008).
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 970-976
    • Caspi, R.R.1
  • 111
    • 85032464761 scopus 로고    scopus 로고
    • Checkpoint inhibitor-induced uveitis: a case series
    • PID: 29080102
    • Conrady, C. D. et al. Checkpoint inhibitor-induced uveitis: a case series. Graefes Arch. Clin. Exp. Ophthalmol. 256, 187–191 (2018).
    • (2018) Graefes Arch. Clin. Exp. Ophthalmol. , vol.256 , pp. 187-191
    • Conrady, C.D.1
  • 112
    • 0035021332 scopus 로고    scopus 로고
    • Complications and prognostic factors in Vogt-Koyanagi-Harada disease
    • COI: 1:STN:280:DC%2BD3M3ovVygsQ%3D%3D, PID: 11336934
    • Read, R. W. et al. Complications and prognostic factors in Vogt-Koyanagi-Harada disease. Am. J. Ophthalmol. 131, 599–606 (2001).
    • (2001) Am. J. Ophthalmol. , vol.131 , pp. 599-606
    • Read, R.W.1
  • 113
    • 77956389310 scopus 로고    scopus 로고
    • A look at autoimmunity and inflammation in the eye
    • COI: 1:CAS:528:DC%2BC3cXhtFertbzE, PID: 20811163
    • Caspi, R. R. A look at autoimmunity and inflammation in the eye. J. Clin. Invest. 120, 3073–3083 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 3073-3083
    • Caspi, R.R.1
  • 114
    • 0027167846 scopus 로고
    • Experimental autoimmune anterior uveitis (EAAU). III. Induction by immunization with purified uveal and skin melanins
    • COI: 1:CAS:528:DyaK3sXkslShsbc%3D, PID: 8500566
    • Broekhuyse, R. M., Kuhlmann, E. D. & Winkens, H. J. Experimental autoimmune anterior uveitis (EAAU). III. Induction by immunization with purified uveal and skin melanins. Exp. Eye Res. 56, 575–583 (1993).
    • (1993) Exp. Eye Res. , vol.56 , pp. 575-583
    • Broekhuyse, R.M.1    Kuhlmann, E.D.2    Winkens, H.J.3
  • 115
    • 67651222016 scopus 로고    scopus 로고
    • Constitutive neuronal expression of the immune regulator, programmed death 1 (PD-1), identified during experimental autoimmune uveitis
    • COI: 1:CAS:528:DC%2BD1MXlvV2qsLg%3D, PID: 19294574
    • Chen, L. et al. Constitutive neuronal expression of the immune regulator, programmed death 1 (PD-1), identified during experimental autoimmune uveitis. Ocul. Immunol. Inflamm. 17, 47–55 (2009).
    • (2009) Ocul. Immunol. Inflamm. , vol.17 , pp. 47-55
    • Chen, L.1
  • 116
    • 85034741543 scopus 로고    scopus 로고
    • Vogt-Koyanagi-Harada disease-like posterior uveitis in the course of nivolumab (anti-PD-1 antibody), interposed by vemurafenib (BRAF inhibitor), for metastatic cutaneous malignant melanoma
    • PID: 28469878
    • Matsuo, T. & Yamasaki, O. Vogt-Koyanagi-Harada disease-like posterior uveitis in the course of nivolumab (anti-PD-1 antibody), interposed by vemurafenib (BRAF inhibitor), for metastatic cutaneous malignant melanoma. Clin. Case Rep. 5, 694–700 (2017).
    • (2017) Clin. Case Rep. , vol.5 , pp. 694-700
    • Matsuo, T.1    Yamasaki, O.2
  • 117
    • 85049916401 scopus 로고    scopus 로고
    • Vogt-Koyanagi-Harada syndrome induced by pembrolizumab in a patient with non-small-cell lung cancer
    • PID: 29730378
    • Tamura, T. et al. Vogt-Koyanagi-Harada syndrome induced by pembrolizumab in a patient with non-small-cell lung cancer. J. Thorac Oncol. 13, 1606–1607 (2018).
    • (2018) J. Thorac Oncol. , vol.13 , pp. 1606-1607
    • Tamura, T.1
  • 118
    • 84922698461 scopus 로고    scopus 로고
    • Vogt-Koyanagi-Harada-like syndrome after CTLA-4 inhibition with ipilimumab for metastatic melanoma
    • PID: 25658618
    • Crosson, J. N. et al. Vogt-Koyanagi-Harada-like syndrome after CTLA-4 inhibition with ipilimumab for metastatic melanoma. J. Immunother. 38, 80–84 (2015).
    • (2015) J. Immunother. , vol.38 , pp. 80-84
    • Crosson, J.N.1
  • 119
    • 84964703568 scopus 로고    scopus 로고
    • Ocular and orbital side-effects of checkpoint inhibitors: a review article
    • COI: 1:CAS:528:DC%2BC28XptFGksrk%3D, PID: 27136135
    • Antoun, J., Titah, C. & Cochereau, I. Ocular and orbital side-effects of checkpoint inhibitors: a review article. Curr. Opin. Oncol. 28, 288–294 (2016).
    • (2016) Curr. Opin. Oncol. , vol.28 , pp. 288-294
    • Antoun, J.1    Titah, C.2    Cochereau, I.3
  • 120
    • 85044448400 scopus 로고    scopus 로고
    • Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis
    • PID: 29511745
    • Gonzales, J. A., Shantha, J. & Acharya, N. R. Combination nivolumab- and cabiralizumab-associated acute bilateral anterior and posterior scleritis and anterior uveitis. Am. J. Ophthalmol. Case Rep. 10, 117–118 (2018).
    • (2018) Am. J. Ophthalmol. Case Rep. , vol.10 , pp. 117-118
    • Gonzales, J.A.1    Shantha, J.2    Acharya, N.R.3
  • 122
    • 85051276165 scopus 로고    scopus 로고
    • Severe inflammatory ophthalmopathy in a euthyroid patient during nivolumab treatment
    • COI: 1:CAS:528:DC%2BC1cXktlOgtb0%3D, PID: 29594059
    • Campredon, P. et al. Severe inflammatory ophthalmopathy in a euthyroid patient during nivolumab treatment. Eur. Thyroid J 7, 84–87 (2018).
    • (2018) Eur. Thyroid J , vol.7 , pp. 84-87
    • Campredon, P.1
  • 123
    • 85030215805 scopus 로고    scopus 로고
    • Rheumatic and musculoskeletal immune-related adverse events due to immune checkpoint inhibitors: a systematic review of the literature
    • Cappelli, L. C., Gutierrez, A. K., Bingham, C. O. 3rd & Shah, A. A. Rheumatic and musculoskeletal immune-related adverse events due to immune checkpoint inhibitors: a systematic review of the literature. Arthritis Care Res. (Hoboken) 69, 1751–1763 (2017).
    • (2017) Arthritis Care Res. (Hoboken) , vol.69 , pp. 1751-1763
    • Cappelli, L.C.1    Gutierrez, A.K.2    Bingham, C.O.3    Shah, A.A.4
  • 124
    • 84896290367 scopus 로고    scopus 로고
    • Drug-associated polymyalgia rheumatica/giant cell arteritis occurring in two patients after treatment with ipilimumab, an antagonist of ctla-4
    • PID: 24574239
    • Goldstein, B. L., Gedmintas, L. & Todd, D. J. Drug-associated polymyalgia rheumatica/giant cell arteritis occurring in two patients after treatment with ipilimumab, an antagonist of ctla-4. Arthritis Rheumatol. 66, 768–769 (2014).
    • (2014) Arthritis Rheumatol. , vol.66 , pp. 768-769
    • Goldstein, B.L.1    Gedmintas, L.2    Todd, D.J.3
  • 125
    • 85065978773 scopus 로고    scopus 로고
    • Management of checkpoint inhibitor-associated renal toxicities
    • Vanoverbeke, L. & Sprangers, B. Management of checkpoint inhibitor-associated renal toxicities. Expert Rev. Qual. Life Cancer Care 2, 215–223 (2017).
    • (2017) Expert Rev. Qual. Life Cancer Care , vol.2 , pp. 215-223
    • Vanoverbeke, L.1    Sprangers, B.2
  • 126
    • 84963948616 scopus 로고    scopus 로고
    • Association of acute interstitial nephritis with programmed cell death 1 inhibitor therapy in lung cancer patients
    • COI: 1:CAS:528:DC%2BC28Xms1Wmsrc%3D, PID: 27113507
    • Shirali, A. C., Perazella, M. A. & Gettinger, S. Association of acute interstitial nephritis with programmed cell death 1 inhibitor therapy in lung cancer patients. Am. J. Kidney Dis. 68, 287–291 (2016).
    • (2016) Am. J. Kidney Dis. , vol.68 , pp. 287-291
    • Shirali, A.C.1    Perazella, M.A.2    Gettinger, S.3
  • 127
    • 84994383033 scopus 로고    scopus 로고
    • Clinicopathological features of acute kidney injury associated with immune checkpoint inhibitors
    • COI: 1:CAS:528:DC%2BC28Xhtlehu7rM, PID: 27282937
    • Cortazar, F. B. et al. Clinicopathological features of acute kidney injury associated with immune checkpoint inhibitors. Kidney Int. 90, 638–647 (2016).
    • (2016) Kidney Int. , vol.90 , pp. 638-647
    • Cortazar, F.B.1
  • 128
    • 85049982716 scopus 로고    scopus 로고
    • Anticancer drug-induced acute kidney injury
    • PID: 29318217
    • Izzedine, H. & Perazella, M. A. Anticancer drug-induced acute kidney injury. Kidney Int. Rep. 2, 504–514 (2017).
    • (2017) Kidney Int. Rep. , vol.2 , pp. 504-514
    • Izzedine, H.1    Perazella, M.A.2
  • 129
    • 84954498344 scopus 로고    scopus 로고
    • Autoimmune hemolytic anemia induced by anti-PD-1 therapy in metastatic melanoma
    • COI: 1:CAS:528:DC%2BC28XjvVyis7o%3D, PID: 26795275
    • Kong, B. Y., Micklethwaite, K. P., Swaminathan, S., Kefford, R. F. & Carlino, M. S. Autoimmune hemolytic anemia induced by anti-PD-1 therapy in metastatic melanoma. Melanoma Res. 26, 202–204 (2016).
    • (2016) Melanoma Res. , vol.26 , pp. 202-204
    • Kong, B.Y.1    Micklethwaite, K.P.2    Swaminathan, S.3    Kefford, R.F.4    Carlino, M.S.5
  • 130
    • 85015631155 scopus 로고    scopus 로고
    • Ipilimumab-induced thrombotic thrombocytopenic purpura (TTP)
    • PID: 28344807
    • King, J., de la Cruz, J. & Lutzky, J. Ipilimumab-induced thrombotic thrombocytopenic purpura (TTP). J. Immunother. Cancer 5, 19 (2017).
    • (2017) J. Immunother. Cancer , vol.5 , pp. 19
    • King, J.1    de la Cruz, J.2    Lutzky, J.3
  • 131
    • 80455173518 scopus 로고    scopus 로고
    • Hemophilia A induced by ipilimumab
    • COI: 1:CAS:528:DC%2BC3MXhsVans7bK, PID: 22047582
    • Delyon, J., Mateus, C. & Lambert, T. Hemophilia A induced by ipilimumab. N. Engl. J. Med. 365, 1747–1748 (2011).
    • (2011) N. Engl. J. Med. , vol.365 , pp. 1747-1748
    • Delyon, J.1    Mateus, C.2    Lambert, T.3
  • 132
    • 85013287852 scopus 로고    scopus 로고
    • Thrombocytopenia in patients with melanoma receiving immune checkpoint inhibitor therapy
    • PID: 28239462
    • Shiuan, E. et al. Thrombocytopenia in patients with melanoma receiving immune checkpoint inhibitor therapy. J. Immunother. Cancer 5, 8 (2017).
    • (2017) J. Immunother. Cancer , vol.5 , pp. 8
    • Shiuan, E.1
  • 133
    • 84873821509 scopus 로고    scopus 로고
    • PD-1 is a novel regulator of human B cell activation
    • COI: 1:CAS:528:DC%2BC3sXhsV2kt78%3D, PID: 23087177
    • Thibult, M. L. et al. PD-1 is a novel regulator of human B cell activation. Int. Immunol. 25, 129–137 (2013).
    • (2013) Int. Immunol. , vol.25 , pp. 129-137
    • Thibult, M.L.1
  • 134
    • 85019493546 scopus 로고    scopus 로고
    • Immune-related bone marrow failure following anti-PD1 therapy
    • PID: 28527392
    • Michot, J. M. et al. Immune-related bone marrow failure following anti-PD1 therapy. Eur. J. Cancer 80, 1–4 (2017).
    • (2017) Eur. J. Cancer , vol.80 , pp. 1-4
    • Michot, J.M.1
  • 135
    • 85048128875 scopus 로고    scopus 로고
    • Hemophagocytic lymphohistiocytosis with immunotherapy: brief review and case report
    • PID: 29871698
    • Sadaat, M. & Jang, S. Hemophagocytic lymphohistiocytosis with immunotherapy: brief review and case report. J. Immunother. Cancer 6, 49 (2018).
    • (2018) J. Immunother. Cancer , vol.6 , pp. 49
    • Sadaat, M.1    Jang, S.2
  • 136
    • 85029704664 scopus 로고    scopus 로고
    • Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    • COI: 1:STN:280:DC%2BC1cblslSmug%3D%3D, PID: 28881921, (Suppl. 4
    • Haanen, J. et al. Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 28, (Suppl. 4), iv119–iv142 (2017).
    • (2017) Ann. Oncol. , vol.28 , pp. iv119-iv142
    • Haanen, J.1
  • 137
    • 85034749402 scopus 로고    scopus 로고
    • Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group
    • COI: 1:STN:280:DC%2BC1M3js1Cltw%3D%3D, PID: 29162153
    • Puzanov, I. et al. Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group. J. Immunother. Cancer 5, 95 (2017).
    • (2017) J. Immunother. Cancer , vol.5 , pp. 95
    • Puzanov, I.1
  • 138
    • 85053474165 scopus 로고    scopus 로고
    • NCCN
    • National Comprehensive Cancer Network. Management of immunotherapy-related toxicities. NCCN https://www.nccn.org/professionals/physician_gls/pdf/immunotherapy.pdf (2018).
    • (2018) Management of immunotherapy-related toxicities
  • 139
    • 85059348176 scopus 로고    scopus 로고
    • New therapeutic perspectives to manage refractory immune checkpoint-related toxicities
    • COI: 1:CAS:528:DC%2BC1MXktFKksg%3D%3D, PID: 30614479
    • Martins, F. et al. New therapeutic perspectives to manage refractory immune checkpoint-related toxicities. Lancet Oncol. 20, e54–e64 (2019).
    • (2019) Lancet Oncol. , vol.20 , pp. e54-e64
    • Martins, F.1
  • 140
    • 85059195471 scopus 로고    scopus 로고
    • A severe case of refractory esophageal stenosis induced by nivolumab and responding to tocilizumab therapy
    • PID: 30587227
    • Horisberger, A. et al. A severe case of refractory esophageal stenosis induced by nivolumab and responding to tocilizumab therapy. J. Immunother. Cancer 6, 156 (2018).
    • (2018) J. Immunother. Cancer , vol.6 , pp. 156
    • Horisberger, A.1
  • 141
    • 85003054266 scopus 로고    scopus 로고
    • Ipilimumab therapy in patients with advanced melanoma and preexisting autoimmune disorders
    • Johnson, D. B. et al. Ipilimumab therapy in patients with advanced melanoma and preexisting autoimmune disorders. JAMA Oncol. 2, 234–240 (2016).
    • (2016) JAMA Oncol. , vol.2 , pp. 234-240
    • Johnson, D.B.1
  • 142
    • 85019333926 scopus 로고    scopus 로고
    • Anti-PD-1 therapy in patients with advanced melanoma and preexisting autoimmune disorders or major toxicity with ipilimumab
    • COI: 1:STN:280:DC%2BC2svkvVCktg%3D%3D, PID: 27687304
    • Menzies, A. M. et al. Anti-PD-1 therapy in patients with advanced melanoma and preexisting autoimmune disorders or major toxicity with ipilimumab. Ann. Oncol. 28, 368–376 (2017).
    • (2017) Ann. Oncol. , vol.28 , pp. 368-376
    • Menzies, A.M.1
  • 143
    • 85049019882 scopus 로고    scopus 로고
    • Safety of programmed death-1 pathway inhibitors among patients with non-small-cell lung cancer and preexisting autoimmune disorders
    • COI: 1:CAS:528:DC%2BC1MXitFyksr8%3D, PID: 6553840
    • Leonardi, G. C. et al. Safety of programmed death-1 pathway inhibitors among patients with non-small-cell lung cancer and preexisting autoimmune disorders. J. Clin. Oncol. 36, 1905–1912 (2018).
    • (2018) J. Clin. Oncol. , vol.36 , pp. 1905-1912
    • Leonardi, G.C.1
  • 144
    • 85050381823 scopus 로고    scopus 로고
    • Use of immune checkpoint inhibitors in the treatment of patients with cancer and preexisting autoimmune disease
    • PID: 30014109
    • Abdel-Wahab, N., Shah, M., Lopez-Olivo, M. A. & Suarez-Almazor, M. E. Use of immune checkpoint inhibitors in the treatment of patients with cancer and preexisting autoimmune disease. Ann. Intern. Med. 169, 133–134 (2018).
    • (2018) Ann. Intern. Med. , vol.169 , pp. 133-134
    • Abdel-Wahab, N.1    Shah, M.2    Lopez-Olivo, M.A.3    Suarez-Almazor, M.E.4
  • 145
    • 84936791837 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
    • COI: 1:CAS:528:DC%2BC2MXht12qu7%2FJ, PID: 26028407
    • Brahmer, J. et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N. Engl. J. Med. 373, 123–135 (2015).
    • (2015) N. Engl. J. Med. , vol.373 , pp. 123-135
    • Brahmer, J.1
  • 146
    • 84950117835 scopus 로고    scopus 로고
    • Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial
    • COI: 1:CAS:528:DC%2BC2MXitVGrtLzI, PID: 26712084
    • Herbst, R. S. et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet 387, 1540–1550 (2016).
    • (2016) Lancet , vol.387 , pp. 1540-1550
    • Herbst, R.S.1
  • 147
    • 84994802263 scopus 로고    scopus 로고
    • Pembrolizumab versus chemotherapy for PD-L1-positive non-small-cell lung cancer
    • COI: 1:CAS:528:DC%2BC28XhvF2ks77I, PID: 27718847
    • Reck, M. et al. Pembrolizumab versus chemotherapy for PD-L1-positive non-small-cell lung cancer. N. Engl. J. Med. 375, 1823–1833 (2016).
    • (2016) N. Engl. J. Med. , vol.375 , pp. 1823-1833
    • Reck, M.1
  • 148
    • 84984920567 scopus 로고    scopus 로고
    • Selective inhibition of autoimmune exacerbation while preserving the anti-tumor clinical benefit using IL-6 blockade in a patient with advanced melanoma and Crohn’s disease: a case report
    • PID: 27595932
    • Uemura, M. et al. Selective inhibition of autoimmune exacerbation while preserving the anti-tumor clinical benefit using IL-6 blockade in a patient with advanced melanoma and Crohn’s disease: a case report. J. Hematol. Oncol. 9, 81 (2016).
    • (2016) J. Hematol. Oncol. , vol.9 , pp. 81
    • Uemura, M.1
  • 149
    • 84861325625 scopus 로고    scopus 로고
    • Anthracycline cardiotoxicity: prevalence, pathogenesis and treatment
    • COI: 1:CAS:528:DC%2BC38Xmt12qsrc%3D, PID: 22758622
    • Volkova, M. & Russell, R. 3rd. Anthracycline cardiotoxicity: prevalence, pathogenesis and treatment. Curr. Cardiol. Rev. 7, 214–220 (2011).
    • (2011) Curr. Cardiol. Rev. , vol.7 , pp. 214-220
    • Volkova, M.1    Russell, R.2
  • 150
    • 84962377131 scopus 로고    scopus 로고
    • Cisplatin-induced ototoxicity: effects, mechanisms and protection strategies
    • COI: 1:CAS:528:DC%2BC1cXlsFansLY%3D, PID: 29051464
    • Callejo, A., Sedó-Cabezón, L., Juan, I. D. & Llorens, J. Cisplatin-induced ototoxicity: effects, mechanisms and protection strategies. Toxics 3, 268–293 (2015).
    • (2015) Toxics , vol.3 , pp. 268-293
    • Callejo, A.1    Sedó-Cabezón, L.2    Juan, I.D.3    Llorens, J.4
  • 151
    • 1842782633 scopus 로고    scopus 로고
    • Clinical significance of antinuclear antibodies in malignant diseases: association with rheumatic and connective tissue paraneoplastic syndromes
    • COI: 1:STN:280:DC%2BD2c3itFWksg%3D%3D, PID: 15119543
    • Solans-Laque, R. et al. Clinical significance of antinuclear antibodies in malignant diseases: association with rheumatic and connective tissue paraneoplastic syndromes. Lupus 13, 159–164 (2004).
    • (2004) Lupus , vol.13 , pp. 159-164
    • Solans-Laque, R.1
  • 152
    • 85012941098 scopus 로고    scopus 로고
    • Cutaneous adverse effects of the immune checkpoint inhibitors
    • PID: 28190531
    • Collins, L. K., Chapman, M. S., Carter, J. B. & Samie, F. H. Cutaneous adverse effects of the immune checkpoint inhibitors. Curr. Probl. Cancer 41, 125–128 (2017).
    • (2017) Curr. Probl. Cancer , vol.41 , pp. 125-128
    • Collins, L.K.1    Chapman, M.S.2    Carter, J.B.3    Samie, F.H.4
  • 153
    • 85031793563 scopus 로고    scopus 로고
    • Immune-related adverse events associated with anti-PD-1/PD-L1 treatment for malignancies: a meta-analysis
    • PID: 29093678
    • Wang, P. F. et al. Immune-related adverse events associated with anti-PD-1/PD-L1 treatment for malignancies: a meta-analysis. Front. Pharmacol. 8, 730 (2017).
    • (2017) Front. Pharmacol. , vol.8 , pp. 730
    • Wang, P.F.1
  • 154
    • 84940746759 scopus 로고    scopus 로고
    • Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis
    • PID: 26337719
    • Bertrand, A., Kostine, M., Barnetche, T., Truchetet, M. E. & Schaeverbeke, T. Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis. BMC Med. 13, 211 (2015).
    • (2015) BMC Med. , vol.13
    • Bertrand, A.1    Kostine, M.2    Barnetche, T.3    Truchetet, M.E.4    Schaeverbeke, T.5
  • 155
    • 84957941892 scopus 로고    scopus 로고
    • Combination immune checkpoint blockade with ipilimumab and nivolumab in the management of advanced melanoma
    • COI: 1:CAS:528:DC%2BC28XitlOrtbg%3D, PID: 26750801
    • Spain, L. & Larkin, J. Combination immune checkpoint blockade with ipilimumab and nivolumab in the management of advanced melanoma. Expert Opin. Biol. Ther. 16, 389–396 (2016).
    • (2016) Expert Opin. Biol. Ther. , vol.16 , pp. 389-396
    • Spain, L.1    Larkin, J.2
  • 156
    • 85052707584 scopus 로고    scopus 로고
    • Enterocolitis due to immune checkpoint inhibitors: a systematic review
    • COI: 1:CAS:528:DC%2BC1MXjtlKitr4%3D, PID: 30131322
    • Soularue, E. et al. Enterocolitis due to immune checkpoint inhibitors: a systematic review. Gut 67, 2056–2067 (2018).
    • (2018) Gut , vol.67 , pp. 2056-2067
    • Soularue, E.1
  • 157
    • 33744792341 scopus 로고    scopus 로고
    • Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4
    • COI: 1:CAS:528:DC%2BD28XlvV2ksb4%3D, PID: 16710025
    • Beck, K. E. et al. Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4. J. Clin. Oncol. 24, 2283–2289 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , pp. 2283-2289
    • Beck, K.E.1
  • 158
    • 85006410852 scopus 로고    scopus 로고
    • Systematic review: colitis associated with anti-CTLA-4 therapy
    • COI: 1:CAS:528:DC%2BC2MXhtF2lt7%2FI, PID: 26079306
    • Gupta, A., De Felice, K. M., Loftus, E. V. Jr & Khanna, S. Systematic review: colitis associated with anti-CTLA-4 therapy. Aliment. Pharmacol. Ther. 42, 406–417 (2015).
    • (2015) Aliment. Pharmacol. Ther. , vol.42 , pp. 406-417
    • Gupta, A.1    De Felice, K.M.2    Loftus, E.V.3    Khanna, S.4
  • 159
    • 85062652227 scopus 로고    scopus 로고
    • The current understanding of the endocrine effects from immune checkpoint inhibitors and recommendations for management
    • PID: 30057972
    • Girotra, M. et al. The current understanding of the endocrine effects from immune checkpoint inhibitors and recommendations for management. JNCI Cancer Spectr. 2, pky021 (2018).
    • (2018) JNCI Cancer Spectr. , vol.2 , pp. pky021
    • Girotra, M.1
  • 160
    • 84910011365 scopus 로고    scopus 로고
    • Ipilimumab-induced hypophysitis: a detailed longitudinal analysis in a large cohort of patients with metastatic melanoma
    • COI: 1:CAS:528:DC%2BC2cXhvFGiu77O, PID: 25078147
    • Faje, A. T. et al. Ipilimumab-induced hypophysitis: a detailed longitudinal analysis in a large cohort of patients with metastatic melanoma. J. Clin. Endocrinol. Metab. 99, 4078–4085 (2014).
    • (2014) J. Clin. Endocrinol. Metab. , vol.99 , pp. 4078-4085
    • Faje, A.T.1
  • 161
    • 85047661921 scopus 로고    scopus 로고
    • Incidence of thyroid function test abnormalities in patients receiving immune-checkpoint inhibitors for cancer treatment
    • COI: 1:CAS:528:DC%2BC1cXit1yntrrI, PID: 29769383
    • Patel, N. S., Oury, A., Daniels, G. A., Bazhenova, L. & Patel, S. P. Incidence of thyroid function test abnormalities in patients receiving immune-checkpoint inhibitors for cancer treatment. Oncologist 23, 1236–1241 (2018).
    • (2018) Oncologist , vol.23 , pp. 1236-1241
    • Patel, N.S.1    Oury, A.2    Daniels, G.A.3    Bazhenova, L.4    Patel, S.P.5
  • 162
    • 85044253460 scopus 로고    scopus 로고
    • Characterization of liver injury induced by cancer immunotherapy using immune checkpoint inhibitors
    • PID: 29427729
    • De Martin, E. et al. Characterization of liver injury induced by cancer immunotherapy using immune checkpoint inhibitors. J. Hepatol. 68, 1181–1190 (2018).
    • (2018) J. Hepatol. , vol.68 , pp. 1181-1190
    • De Martin, E.1
  • 163
    • 85049560618 scopus 로고    scopus 로고
    • Immune-related hepatitis with immunotherapy: are corticosteroids always needed?
    • PID: 29747956
    • Gauci, M. L. et al. Immune-related hepatitis with immunotherapy: are corticosteroids always needed? J. Hepatol. 69, 548–550 (2018).
    • (2018) J. Hepatol. , vol.69 , pp. 548-550
    • Gauci, M.L.1
  • 164
    • 85009344282 scopus 로고    scopus 로고
    • Adverse renal effects of immune checkpoint inhibitors: a narrative review
    • COI: 1:CAS:528:DC%2BC2sXjtVKjsrw%3D, PID: 28076863
    • Wanchoo, R. et al. Adverse renal effects of immune checkpoint inhibitors: a narrative review. Am. J. Nephrol. 45, 160–169 (2017).
    • (2017) Am. J. Nephrol. , vol.45 , pp. 160-169
    • Wanchoo, R.1
  • 165
    • 85015958229 scopus 로고    scopus 로고
    • Rheumatic immune-related adverse events of checkpoint therapy for cancer: case series of a new nosological entity
    • COI: 1:STN:280:DC%2BC1cvnsVaiug%3D%3D, PID: 28405474
    • Calabrese, C., Kirchner, E., Kontzias, K., Velcheti, V. & Calabrese, L. H. Rheumatic immune-related adverse events of checkpoint therapy for cancer: case series of a new nosological entity. RMD Open 3, e000412 (2017).
    • (2017) RMD Open , vol.3
    • Calabrese, C.1    Kirchner, E.2    Kontzias, K.3    Velcheti, V.4    Calabrese, L.H.5
  • 166
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • COI: 1:CAS:528:DC%2BC3cXhtVCrtrbN, PID: 20525992
    • Hodi, F. S. et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363, 711–723 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 711-723
    • Hodi, F.S.1
  • 167
    • 84944937210 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
    • COI: 1:CAS:528:DC%2BC28XjsFyitL0%3D, PID: 26412456
    • Borghaei, H. et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N. Engl. J. Med. 373, 1627–1639 (2015).
    • (2015) N. Engl. J. Med. , vol.373 , pp. 1627-1639
    • Borghaei, H.1
  • 168
    • 85030460514 scopus 로고    scopus 로고
    • Overall survival with combined nivolumab and ipilimumab in advanced melanoma
    • COI: 1:CAS:528:DC%2BC2sXhs1Git73I, PID: 28889792
    • Wolchok, J. D. et al. Overall survival with combined nivolumab and ipilimumab in advanced melanoma. N. Engl. J. Med. 377, 1345–1356 (2017).
    • (2017) N. Engl. J. Med. , vol.377 , pp. 1345-1356
    • Wolchok, J.D.1
  • 171
    • 85008239423 scopus 로고    scopus 로고
    • Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial
    • Rittmeyer, A. et al. Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial. Lancet 389, 255–265 (2017).
    • (2017) Lancet , vol.389 , pp. 255-265
    • Rittmeyer, A.1
  • 172
    • 85043475986 scopus 로고    scopus 로고
    • Durvalumab as third-line or later treatment for advanced non-small-cell lung cancer (ATLANTIC): an open-label, single-arm, phase 2 study
    • Garassino, M. C. et al. Durvalumab as third-line or later treatment for advanced non-small-cell lung cancer (ATLANTIC): an open-label, single-arm, phase 2 study. Lancet Oncol. 19, 521–536 (2018).
    • (2018) Lancet Oncol , vol.19 , pp. 521-536
    • Garassino, M.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.