Immune checkpoint blockade in cancer treatment: A double-edged sword cross-targeting the host as an "innocent bystander"

Toxins

Volumn 6, Issue 3, 2014, Pages 914-933

  Gelao, Lucia ^a   Criscitiello, Carmen ^a   Esposito, Angela ^a   Goldhirsch, Aron ^a   Curigliano, Giuseppe ^a  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

Author keywords

Checkpoint blocking antibodies; Immune response; Immune therapies; Ipilimumab; Toxicity

Indexed keywords

ALPHA2B INTERFERON; BMS 936559; CARBOPLATIN; CETUXIMAB; CISPLATIN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DABRAFENIB; DACARBAZINE; DENILEUKIN DIFTITOX; ETOPOSIDE; GEMCITABINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 2; INTERLEUKIN 21; IPILIMUMAB; LAMBROLIZUMAB; LENALIDOMIDE; MESYLIC ACID; MPDL3280A; NIVOLUMAB; PACLITAXEL; PLATINUM; SIPULEUCEL T; T LYMPHOCYTE RECEPTOR; TALIMOGENE LAHERPAREPVEC; TICILIMUMAB; TRAMETINIB; TUMOR ANTIGEN; UNCLASSIFIED DRUG; UNINDEXED DRUG; URELUMAB; VEMURAFENIB;

ADVANCED CANCER; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ARTICLE; CANCER THERAPY; CELL PROLIFERATION; DENDRITIC CELL; HEAD AND NECK CANCER; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; MELANOMA; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PROSTATE CANCER; REGULATORY T LYMPHOCYTE; TRANSITIONAL CELL CARCINOMA;

ANIMALS; ANTIBODIES, MONOCLONAL; HUMANS; IMMUNE TOLERANCE; IMMUNOLOGIC FACTORS; IMMUNOTHERAPY; NEOPLASMS;

EID: 84897890387     PISSN: 20726651     EISSN: None     Source Type: Journal    
DOI: 10.3390/toxins6030914     Document Type: Article

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