-
1
-
-
85011542577
-
Combined nivolumab and ipilimumab versus ipilimumab alone in patients with advanced melanoma: 2-year overall survival outcomes in a multicentre, randomised, controlled, phase 2 trial
-
Hodi, F.S., Chesney, J., Pavlick, A.C., Robert, C., Grossmann, K.F., McDermott, D.F., et al. Combined nivolumab and ipilimumab versus ipilimumab alone in patients with advanced melanoma: 2-year overall survival outcomes in a multicentre, randomised, controlled, phase 2 trial. Lancet Oncol 17 (2016), 1558–1568.
-
(2016)
Lancet Oncol
, vol.17
, pp. 1558-1568
-
-
Hodi, F.S.1
Chesney, J.2
Pavlick, A.C.3
Robert, C.4
Grossmann, K.F.5
McDermott, D.F.6
-
2
-
-
84938205998
-
Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial
-
Ribas, A., Puzanov, I., Dummer, R., Schadendorf, D., Hamid, O., Robert, C., et al. Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial. Lancet Oncol 16 (2015), 908–918.
-
(2015)
Lancet Oncol
, vol.16
, pp. 908-918
-
-
Ribas, A.1
Puzanov, I.2
Dummer, R.3
Schadendorf, D.4
Hamid, O.5
Robert, C.6
-
3
-
-
84940379785
-
Cancer and the immune system: basic concepts and targets for intervention
-
Pardoll, D., Cancer and the immune system: basic concepts and targets for intervention. Semin Oncol 42 (2015), 523–538.
-
(2015)
Semin Oncol
, vol.42
, pp. 523-538
-
-
Pardoll, D.1
-
4
-
-
84858766182
-
The blockade of immune checkpoints in cancer immunotherapy
-
Pardoll, D.M., The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 12 (2012), 252–264.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 252-264
-
-
Pardoll, D.M.1
-
5
-
-
84963621254
-
Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy
-
Topalian, S.L., Taube, J.M., Anders, R.A., Pardoll, D.M., Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy. Nat Rev Cancer 16 (2016), 275–287.
-
(2016)
Nat Rev Cancer
, vol.16
, pp. 275-287
-
-
Topalian, S.L.1
Taube, J.M.2
Anders, R.A.3
Pardoll, D.M.4
-
6
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi, F.S., O'Day, S.J., McDermott, D.F., Weber, R.W., Sosman, J.A., Haanen, J.B., et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 363 (2010), 711–723.
-
(2010)
N Engl J Med
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
O'Day, S.J.2
McDermott, D.F.3
Weber, R.W.4
Sosman, J.A.5
Haanen, J.B.6
-
7
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian, S.L., Hodi, F.S., Brahmer, J.R., Gettinger, S.N., Smith, D.C., McDermott, D.F., et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 366 (2012), 2443–2454.
-
(2012)
N Engl J Med
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
Gettinger, S.N.4
Smith, D.C.5
McDermott, D.F.6
-
8
-
-
84929481480
-
Pembrolizumab for the treatment of non-small-cell lung cancer
-
Garon, E.B., Rizvi, N.A., Hui, R., Leighl, N., Balmanoukian, A.S., Eder, J.P., et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med 372 (2015), 2018–2028.
-
(2015)
N Engl J Med
, vol.372
, pp. 2018-2028
-
-
Garon, E.B.1
Rizvi, N.A.2
Hui, R.3
Leighl, N.4
Balmanoukian, A.S.5
Eder, J.P.6
-
9
-
-
84862903106
-
Safety and activity of Anti-PD-L1 antibody in patients with advanced cancer
-
Brahmer, J.R., Tykodi, S.S., Chow, L.Q.M., Hwu, W.-J., Topalian, S.L., Hwu, P., et al. Safety and activity of Anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 366 (2012), 2455–2465.
-
(2012)
N Engl J Med
, vol.366
, pp. 2455-2465
-
-
Brahmer, J.R.1
Tykodi, S.S.2
Chow, L.Q.M.3
Hwu, W.-J.4
Topalian, S.L.5
Hwu, P.6
-
10
-
-
84953309212
-
Immune-related adverse events with immune checkpoint blockade: a comprehensive review
-
Michot, J.M., Bigenwald, C., Champiat, S., Collins, M., Carbonnel, F., Postel-Vinay, S., et al. Immune-related adverse events with immune checkpoint blockade: a comprehensive review. Eur J Cancer 54 (2016), 139–148.
-
(2016)
Eur J Cancer
, vol.54
, pp. 139-148
-
-
Michot, J.M.1
Bigenwald, C.2
Champiat, S.3
Collins, M.4
Carbonnel, F.5
Postel-Vinay, S.6
-
11
-
-
84936147067
-
Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
-
Larkin, J., Chiarion-Sileni, V., Gonzalez, R., Grob, J.J., Cowey, C.L., Lao, C.D., et al. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med 373 (2015), 23–34.
-
(2015)
N Engl J Med
, vol.373
, pp. 23-34
-
-
Larkin, J.1
Chiarion-Sileni, V.2
Gonzalez, R.3
Grob, J.J.4
Cowey, C.L.5
Lao, C.D.6
-
12
-
-
77955256254
-
Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: a multicenter single-arm phase II study
-
O'Day, S.J., Maio, M., Chiarion-Sileni, V., Gajewski, T.F., Pehamberger, H., Bondarenko, I.N., et al. Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: a multicenter single-arm phase II study. Ann Oncol: Official J Eur Soc Med Oncol 21 (2010), 1712–1717.
-
(2010)
Ann Oncol: Official J Eur Soc Med Oncol
, vol.21
, pp. 1712-1717
-
-
O'Day, S.J.1
Maio, M.2
Chiarion-Sileni, V.3
Gajewski, T.F.4
Pehamberger, H.5
Bondarenko, I.N.6
-
13
-
-
84929481481
-
Pembrolizumab versus ipilimumab in advanced melanoma
-
Robert, C., Schachter, J., Long, G.V., Arance, A., Grob, J.J., Mortier, L., et al. Pembrolizumab versus ipilimumab in advanced melanoma. N Engl J Med 372 (2015), 2521–2532.
-
(2015)
N Engl J Med
, vol.372
, pp. 2521-2532
-
-
Robert, C.1
Schachter, J.2
Long, G.V.3
Arance, A.4
Grob, J.J.5
Mortier, L.6
-
14
-
-
84938085491
-
Ipilimumab-associated hepatitis: clinicopathologic characterization in a series of 11 cases
-
Johncilla, M., Misdraji, J., Pratt, D.S., Agoston, A.T., Lauwers, G.Y., Srivastava, A., et al. Ipilimumab-associated hepatitis: clinicopathologic characterization in a series of 11 cases. Am J Surg Pathol 39 (2015), 1075–1084.
-
(2015)
Am J Surg Pathol
, vol.39
, pp. 1075-1084
-
-
Johncilla, M.1
Misdraji, J.2
Pratt, D.S.3
Agoston, A.T.4
Lauwers, G.Y.5
Srivastava, A.6
-
15
-
-
84975728236
-
Management of toxicities of immune checkpoint inhibitors
-
Spain, L., Diem, S., Larkin, J., Management of toxicities of immune checkpoint inhibitors. Cancer Treat Rev 44 (2016), 51–60.
-
(2016)
Cancer Treat Rev
, vol.44
, pp. 51-60
-
-
Spain, L.1
Diem, S.2
Larkin, J.3
-
16
-
-
84964345287
-
Cutaneous, gastrointestinal, hepatic, endocrine, and renal side-effects of anti-PD-1 therapy
-
Hofmann, L., Forschner, A., Loquai, C., Goldinger, S.M., Zimmer, L., Ugurel, S., et al. Cutaneous, gastrointestinal, hepatic, endocrine, and renal side-effects of anti-PD-1 therapy. Eur J Cancer 60 (2016), 190–209.
-
(2016)
Eur J Cancer
, vol.60
, pp. 190-209
-
-
Hofmann, L.1
Forschner, A.2
Loquai, C.3
Goldinger, S.M.4
Zimmer, L.5
Ugurel, S.6
-
17
-
-
84964573640
-
Management of immune checkpoint blockade dysimmune toxicities: a collaborative position paper
-
Champiat, S., Lambotte, O., Barreau, E., Belkhir, R., Berdelou, A., Carbonnel, F., et al. Management of immune checkpoint blockade dysimmune toxicities: a collaborative position paper. Ann Oncol: Official J Eur Soc Med Oncol 27 (2016), 559–574.
-
(2016)
Ann Oncol: Official J Eur Soc Med Oncol
, vol.27
, pp. 559-574
-
-
Champiat, S.1
Lambotte, O.2
Barreau, E.3
Belkhir, R.4
Berdelou, A.5
Carbonnel, F.6
-
18
-
-
84896450857
-
Pathogenesis of idiosyncratic drug-induced liver injury and clinical perspectives
-
Fontana, R.J., Pathogenesis of idiosyncratic drug-induced liver injury and clinical perspectives. Gastroenterology 146 (2014), 914–928.
-
(2014)
Gastroenterology
, vol.146
, pp. 914-928
-
-
Fontana, R.J.1
-
19
-
-
84977090741
-
The role of hepatitis E virus infection in adult Americans with acute liver failure
-
Fontana, R.J., Engle, R.E., Scaglione, S., Araya, V., Shaikh, O., Tillman, H., et al. The role of hepatitis E virus infection in adult Americans with acute liver failure. Hepatology 64 (2016), 1870–1880.
-
(2016)
Hepatology
, vol.64
, pp. 1870-1880
-
-
Fontana, R.J.1
Engle, R.E.2
Scaglione, S.3
Araya, V.4
Shaikh, O.5
Tillman, H.6
-
20
-
-
85014932328
-
The spectrum of serious infections among patients receiving immune checkpoint blockade for the treatment of melanoma
-
Del Castillo, M., Romero, F.A., Arguello, E., Kyi, C., Postow, M.A., Redelman-Sidi, G., The spectrum of serious infections among patients receiving immune checkpoint blockade for the treatment of melanoma. Clin Infect Dis: An official publication of the Infect Dis Soc Am 63 (2016), 1490–1493.
-
(2016)
Clin Infect Dis: An official publication of the Infect Dis Soc Am
, vol.63
, pp. 1490-1493
-
-
Del Castillo, M.1
Romero, F.A.2
Arguello, E.3
Kyi, C.4
Postow, M.A.5
Redelman-Sidi, G.6
-
21
-
-
84991110530
-
Sequential administration of nivolumab and ipilimumab with a planned switch in patients with advanced melanoma (CheckMate 064): an open-label, randomised, phase 2 trial
-
Weber, J.S., Gibney, G., Sullivan, R.J., Sosman, J.A., Slingluff, C.L. Jr., Lawrence, D.P., et al. Sequential administration of nivolumab and ipilimumab with a planned switch in patients with advanced melanoma (CheckMate 064): an open-label, randomised, phase 2 trial. Lancet Oncol 17 (2016), 943–955.
-
(2016)
Lancet Oncol
, vol.17
, pp. 943-955
-
-
Weber, J.S.1
Gibney, G.2
Sullivan, R.J.3
Sosman, J.A.4
Slingluff, C.L.5
Lawrence, D.P.6
-
22
-
-
84991585137
-
Incidence and risk of hepatic toxicities with PD-1 inhibitors in cancer patients: a meta-analysis
-
Zhang, X., Ran, Y., Wang, K., Zhu, Y., Li, J., Incidence and risk of hepatic toxicities with PD-1 inhibitors in cancer patients: a meta-analysis. Drug Des Devel Ther 10 (2016), 3153–3161.
-
(2016)
Drug Des Devel Ther
, vol.10
, pp. 3153-3161
-
-
Zhang, X.1
Ran, Y.2
Wang, K.3
Zhu, Y.4
Li, J.5
-
23
-
-
84879777241
-
Nivolumab plus ipilimumab in advanced melanoma
-
Wolchok, J.D., Kluger, H., Callahan, M.K., Postow, M.A., Rizvi, N.A., Lesokhin, A.M., et al. Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med 369 (2013), 122–133.
-
(2013)
N Engl J Med
, vol.369
, pp. 122-133
-
-
Wolchok, J.D.1
Kluger, H.2
Callahan, M.K.3
Postow, M.A.4
Rizvi, N.A.5
Lesokhin, A.M.6
-
24
-
-
84875785905
-
Hepatotoxicity with combination of vemurafenib and ipilimumab
-
Ribas, A., Hodi, F.S., Callahan, M., Konto, C., Wolchok, J., Hepatotoxicity with combination of vemurafenib and ipilimumab. N Engl J Med 368 (2013), 1365–1366.
-
(2013)
N Engl J Med
, vol.368
, pp. 1365-1366
-
-
Ribas, A.1
Hodi, F.S.2
Callahan, M.3
Konto, C.4
Wolchok, J.5
-
25
-
-
84979790762
-
Vemurafenib-induced granulomatous hepatitis
-
Spengler, E.K., Kleiner, D.E., Fontana, R.J., Vemurafenib-induced granulomatous hepatitis. Hepatology 65 (2017), 745–748.
-
(2017)
Hepatology
, vol.65
, pp. 745-748
-
-
Spengler, E.K.1
Kleiner, D.E.2
Fontana, R.J.3
-
26
-
-
84902240512
-
New-onset mediastinal and central nervous system sarcoidosis in a patient with metastatic melanoma undergoing CTLA4 monoclonal antibody treatment
-
Murphy, K.P., Kennedy, M.P., Barry, J.E., O'Regan, K.N., Power, D.G., New-onset mediastinal and central nervous system sarcoidosis in a patient with metastatic melanoma undergoing CTLA4 monoclonal antibody treatment. Oncol Res Treat 37 (2014), 351–353.
-
(2014)
Oncol Res Treat
, vol.37
, pp. 351-353
-
-
Murphy, K.P.1
Kennedy, M.P.2
Barry, J.E.3
O'Regan, K.N.4
Power, D.G.5
-
27
-
-
84944275182
-
Late development of splenic sarcoidosis-like lesions in a patient with metastatic melanoma and long-lasting clinical response to ipilimumab
-
Andersen, R., Norgaard, P., Al-Jailawi, M.K., Svane, I.M., Late development of splenic sarcoidosis-like lesions in a patient with metastatic melanoma and long-lasting clinical response to ipilimumab. Oncoimmunology, 3, 2014, e954506.
-
(2014)
Oncoimmunology
, vol.3
, pp. e954506
-
-
Andersen, R.1
Norgaard, P.2
Al-Jailawi, M.K.3
Svane, I.M.4
-
28
-
-
84863938356
-
Pulmonary sarcoid-like granulomatosis induced by ipilimumab
-
Berthod, G., Lazor, R., Letovanec, I., Romano, E., Noirez, L., Mazza Stalder, J., et al. Pulmonary sarcoid-like granulomatosis induced by ipilimumab. J Clin Oncol: Official J Am Soc Clin Oncol 30 (2012), e156–e159.
-
(2012)
J Clin Oncol: Official J Am Soc Clin Oncol
, vol.30
, pp. e156-e159
-
-
Berthod, G.1
Lazor, R.2
Letovanec, I.3
Romano, E.4
Noirez, L.5
Mazza Stalder, J.6
-
29
-
-
84992692374
-
Fibrin ring granulomas in checkpoint inhibitor-induced hepatitis
-
Everett, J., Srivastava, A., Misdraji, J., Fibrin ring granulomas in checkpoint inhibitor-induced hepatitis. Am J Surg Pathol 41 (2017), 134–137.
-
(2017)
Am J Surg Pathol
, vol.41
, pp. 134-137
-
-
Everett, J.1
Srivastava, A.2
Misdraji, J.3
-
30
-
-
85007158514
-
Pathological characterization of nivolumab-related liver injury in a patient with glioblastoma
-
Simonelli, M., Di Tommaso, L., Baretti, M., Santoro, A., Pathological characterization of nivolumab-related liver injury in a patient with glioblastoma. Immunotherapy 8 (2016), 1363–1369.
-
(2016)
Immunotherapy
, vol.8
, pp. 1363-1369
-
-
Simonelli, M.1
Di Tommaso, L.2
Baretti, M.3
Santoro, A.4
-
31
-
-
85009286690
-
Managing immune checkpoint-inhibitor-induced severe autoimmune-like hepatitis by liver-directed topical steroids
-
Ziemer, M., Koukoulioti, E., Beyer, S., Simon, J.C., Berg, T., Managing immune checkpoint-inhibitor-induced severe autoimmune-like hepatitis by liver-directed topical steroids. J Hepatol 66 (2017), 657–659.
-
(2017)
J Hepatol
, vol.66
, pp. 657-659
-
-
Ziemer, M.1
Koukoulioti, E.2
Beyer, S.3
Simon, J.C.4
Berg, T.5
-
32
-
-
84949988089
-
Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies
-
Naidoo, J., Page, D.B., Li, B.T., Connell, L.C., Schindler, K., Lacouture, M.E., et al. Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies. Ann Oncol 26 (2015), 2375–2391.
-
(2015)
Ann Oncol
, vol.26
, pp. 2375-2391
-
-
Naidoo, J.1
Page, D.B.2
Li, B.T.3
Connell, L.C.4
Schindler, K.5
Lacouture, M.E.6
-
33
-
-
79952745218
-
Resolution of severe ipilimumab-induced hepatitis after antithymocyte globulin therapy
-
Chmiel, K.D., Suan, D., Liddle, C., Nankivell, B., Ibrahim, R., Bautista, C., et al. Resolution of severe ipilimumab-induced hepatitis after antithymocyte globulin therapy. J Clin Oncol: Official J Am Soc Clin Oncol 29 (2011), e237–e240.
-
(2011)
J Clin Oncol: Official J Am Soc Clin Oncol
, vol.29
, pp. e237-e240
-
-
Chmiel, K.D.1
Suan, D.2
Liddle, C.3
Nankivell, B.4
Ibrahim, R.5
Bautista, C.6
-
34
-
-
84962068691
-
Immune suppression and response to ipilimumab: assessing risk-to-benefit ratio
-
Indini, A., Di Nicola, M., Del Vecchio, M., De Braud, F., Immune suppression and response to ipilimumab: assessing risk-to-benefit ratio. J Clin Oncol: Official J Am Soc Clin Oncol 34 (2016), 1017–1018.
-
(2016)
J Clin Oncol: Official J Am Soc Clin Oncol
, vol.34
, pp. 1017-1018
-
-
Indini, A.1
Di Nicola, M.2
Del Vecchio, M.3
De Braud, F.4
-
35
-
-
36748999428
-
Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade
-
Downey, S.G., Klapper, J.A., Smith, F.O., Yang, J.C., Sherry, R.M., Royal, R.E., et al. Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade. Clin Cancer Res: An official J Am Assoc Cancer Res 13 (2007), 6681–6688.
-
(2007)
Clin Cancer Res: An official J Am Assoc Cancer Res
, vol.13
, pp. 6681-6688
-
-
Downey, S.G.1
Klapper, J.A.2
Smith, F.O.3
Yang, J.C.4
Sherry, R.M.5
Royal, R.E.6
-
36
-
-
84944261579
-
Immune-related adverse events, need for systemic immunosuppression, and effects on survival and time to treatment failure in patients with melanoma treated with ipilimumab at memorial Sloan kettering cancer center
-
Horvat, T.Z., Adel, N.G., Dang, T.O., Momtaz, P., Postow, M.A., Callahan, M.K., et al. Immune-related adverse events, need for systemic immunosuppression, and effects on survival and time to treatment failure in patients with melanoma treated with ipilimumab at memorial Sloan kettering cancer center. J Clin Oncol: Official J Am Soc Clin Oncol 33 (2015), 3193–3198.
-
(2015)
J Clin Oncol: Official J Am Soc Clin Oncol
, vol.33
, pp. 3193-3198
-
-
Horvat, T.Z.1
Adel, N.G.2
Dang, T.O.3
Momtaz, P.4
Postow, M.A.5
Callahan, M.K.6
-
37
-
-
84949951840
-
Safety profile of nivolumab (NIVO) in patients (pts) with advanced melanoma (MEL): A pooled analysis
-
9018–9018
-
Weber, J.S., Antonia, S.J., Topalian, S.L., Schadendorf, D., Larkin, J.M.G., Sznol, M., et al. Safety profile of nivolumab (NIVO) in patients (pts) with advanced melanoma (MEL): A pooled analysis. J Clin Oncol, 33, 2015 9018–9018.
-
(2015)
J Clin Oncol
, vol.33
-
-
Weber, J.S.1
Antonia, S.J.2
Topalian, S.L.3
Schadendorf, D.4
Larkin, J.M.G.5
Sznol, M.6
|