Immune-related bone marrow failure following anti-PD1 therapy

European Journal of Cancer

Volumn 80, Issue , 2017, Pages 1-4

  Michot, Jean Marie ^a,f   Vargaftig, Jacques ^b   Leduc, Charlotte ^c   Quere, Gilles ^d   Burroni, Barbara ^e   Lazarovici, Julien ^a   Champiat, Stéphane ^a   Ribrag, Vincent ^a   Lambotte, Olivier ^f,g,h,i  

^a INSTITUT GUSTAVE ROUSSY   (France)

^b INSTITUT CURIE   (France)

^c UNIVERSITY HOSPITAL OF STRASBOURG   (France)

^d BREST UNIVERSITY HOSPITAL   (France)

^e Institut Cochin   (France)

^f BICÊTRE HOSPITAL   (France)

^g UNIVERSITÉ PARIS SACLAY   (France)

^h INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

ⁱ INSERM   (France)

Author keywords

Anti PD1 therapy; Aplastic anaemia; Bone marrow failure; Emergent adverse event; Immune related adverse event

Indexed keywords

CD8 ANTIGEN; CORTICOSTEROID; GRANULOCYTE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN; NIVOLUMAB; STEROID; MONOCLONAL ANTIBODY; PDCD1 PROTEIN, HUMAN; PROGRAMMED DEATH 1 RECEPTOR;

ACUTE CORONARY SYNDROME; AGED; APLASTIC ANEMIA; AUTOIMMUNITY; BLOOD CELL COUNT; BLOOD EXAMINATION; BONE MARROW BIOPSY; BONE MARROW DEPRESSION; BONE METASTASIS; CASE REPORT; CD8+ T LYMPHOCYTE; CYTOPENIA; DRUG SURVEILLANCE PROGRAM; ERYTHROCYTE TRANSFUSION; FEBRILE NEUTROPENIA; HEMOLYSIS; HUMAN; LETTER; LUNG ADENOCARCINOMA; PANCYTOPENIA; PRIORITY JOURNAL; RETICULOCYTE COUNT; SEPSIS; THROMBOCYTE TRANSFUSION; TREATMENT RESPONSE; ADENOCARCINOMA; ANTAGONISTS AND INHIBITORS; BONE MARROW; CHEMICALLY INDUCED; COMPLICATION; DRUG EFFECTS; FATALITY; FEMALE; IMMUNOLOGY; LUNG TUMOR; MALE; PATHOLOGY; SEVERITY OF ILLNESS INDEX;

ADENOCARCINOMA; AGED; ANEMIA, APLASTIC; ANTIBODIES, MONOCLONAL; ANTIBODIES, MONOCLONAL, HUMANIZED; BONE MARROW; FATAL OUTCOME; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; PANCYTOPENIA; PROGRAMMED CELL DEATH 1 RECEPTOR; SEVERITY OF ILLNESS INDEX;

EID: 85019493546     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2017.04.004     Document Type: Letter

References (10)

1. Postow, M.A., Callahan, M.K., Wolchok, J.D., Immune checkpoint blockade in cancer therapy. J Clin Oncol Off J Am Soc Clin Oncol 33 (2015), 1974–1982, 10.1200/JCO.2014.59.4358.
2. Champiat, S., Lambotte, O., Barreau, E., Belkhir, R., Berdelou, A., Carbonnel, F., et al. Management of immune checkpoint blockade dysimmune toxicities: a collaborative position paper. Ann Oncol Off J Eur Soc Med Oncol ESMO 27 (2016), 559–574, 10.1093/annonc/mdv623.
3. Kanameishi, S., Otsuka, A., Nonomura, Y., Fujisawa, A., Endo, Y., Kabashima, K., Idiopathic thrombocytopenic purpura induced by nivolumab in a metastatic melanoma patient with elevated PD-1 expression on B cells. Ann Oncol Off J Eur Soc Med Oncol 27 (2016), 546–547, 10.1093/annonc/mdv580.
4. Le Roy, A., Kempf, E., Ackermann, F., Routier, E., Robert, C., Turpin, A., et al. Two cases of immune thrombocytopenia associated with pembrolizumab. Eur J Cancer Oxf Engl 2016:54 (1990), 172–174, 10.1016/j.ejca.2015.10.073.
5. Kong, B.Y., Micklethwaite, K.P., Swaminathan, S., Kefford, R.F., Carlino, M.S., Autoimmune hemolytic anemia induced by anti-PD-1 therapy in metastatic melanoma. Melanoma Res 26 (2016), 202–204, 10.1097/CMR.0000000000000232.
6. Palla, A.R., Kennedy, D., Mosharraf, H., Doll, D., Autoimmune hemolytic anemia as a complication of nivolumab therapy. Case Rep Oncol 9 (2016), 691–697, 10.1159/000452296.
7. Schwab, K.S., Heine, A., Weimann, T., Kristiansen, G., Brossart, P., Development of hemolytic anemia in a nivolumab-treated patient with refractory metastatic squamous cell skin cancer and chronic lymphatic leukemia. Case Rep Oncol 9 (2016), 373–378, 10.1159/000447508.
8. Tardy, M.P., Gastaud, L., Boscagli, A., Peyrade, F., Gallamini, A., Thyss, A., Autoimmune hemolytic anemia after nivolumab treatment in Hodgkin lymphoma responsive to immunosuppressive treatment. A case report. Hematol Oncol, 2016, 10.1002/hon.2338.
9. Tabchi, S., Weng, X., Blais, N., Severe agranulocytosis in a patient with metastatic non-small-cell lung cancer treated with nivolumab. Lung Cancer Amst Neth 99 (2016), 123–126, 10.1016/j.lungcan.2016.06.026.
10. Nair, R., Gheith, S., Nair, S.G., Immunotherapy-associated hemolytic anemia with pure red-cell aplasia. N Engl J Med 374 (2016), 1096–1097, 10.1056/NEJMc1509362.