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Volumn 24, Issue 12, 2017, Pages T331-T347

Endocrine side effects of cancer immunotherapy

Author keywords

Cancer immunotherapy; Endocrine side effects; Hypophysitis; Immune checkpoint inhibitors; Thyroid

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; HYDROCORTISONE; IPILIMUMAB; LEVOTHYROXINE; NIVOLUMAB;

EID: 85041076967     PISSN: 13510088     EISSN: 14796821     Source Type: Journal    
DOI: 10.1530/ERC-17-0358     Document Type: Review
Times cited : (134)

References (163)
  • 1
    • 84961325991 scopus 로고    scopus 로고
    • Risk of endocrine complications in cancer patients treated with immune check point inhibitors: A meta-analysis
    • Abdel-Rahman O, ElHalawani H & Fouad M 2016 Risk of endocrine complications in cancer patients treated with immune check point inhibitors: a meta-analysis. Future Oncology 12 413–425. (doi:10.2217/fon.15.222)
    • (2016) Future Oncology , vol.12 , pp. 413-425
    • Abdel-Rahman, O.1    ElHalawani, H.2    Fouad, M.3
  • 2
    • 84906874018 scopus 로고    scopus 로고
    • A phase i dose escalation trial of tremelimumab (CP-675,206) in combination with gemcitabine in chemotherapy-naive patients with metastatic pancreatic cancer
    • Aglietta M, Barone C, Sawyer MB, Moore MJ, Miller WH Jr, Bagalà C, Colombi F, Cagnazzo C, Gioeni L, Wang E, et al. 2014 A phase I dose escalation trial of tremelimumab (CP-675,206) in combination with gemcitabine in chemotherapy-naive patients with metastatic pancreatic cancer. Annals of Oncology 25 1750–1755. (doi:10.1093/ annonc/mdu205)
    • (2014) Annals of Oncology , vol.25 , pp. 1750-1755
    • Aglietta, M.1    Barone, C.2    Sawyer, M.B.3    Moore, M.J.4    Jr, M.W.H.5    Bagalà, C.6    Colombi, F.7    Cagnazzo, C.8    Gioeni, L.9    Wang, E.10
  • 8
    • 84938309673 scopus 로고    scopus 로고
    • Phase ib study of MEDI4736, a programmed cell death ligand-1 (PD-L1) antibody, in combination with tremelimumab, a cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) antibody, in patients (pts) with advanced NSCLC
    • Antonia SJ, Goldberg SB, Balmanoukian AS, Sanborn RE, Steele K, Narwal R, Robbins PB, Gu Y, Karakunnel JJ & Rizvi NA 2015b Phase Ib study of MEDI4736, a programmed cell death ligand-1 (PD-L1) antibody, in combination with tremelimumab, a cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) antibody, in patients (pts) with advanced NSCLC. Journal of Clinical Oncology 33 (15 Suppl) 3014 (doi:10.1200/jco.2015.33.15_suppl.3014)
    • (2015) Journal of Clinical Oncology , vol.33 , Issue.15 , pp. 3014
    • Antonia, S.J.1    Goldberg, S.B.2    Balmanoukian, A.S.3    Sanborn, R.E.4    Steele, K.5    Narwal, R.6    Robbins, P.B.7    Gu, Y.8    Karakunnel, J.J.9    Rizvi, N.A.10
  • 9
    • 84971620553 scopus 로고    scopus 로고
    • Nivolumab alone and nivolumab plus ipilimumab in recurrent small-cell lung cancer (CheckMate 032): A multicentre, open-label, phase 1/2 trial
    • Antonia SJ, López-Martin JA, Bendell J, Ott PA, Taylor M, Eder JP, Jäger D, Pietanza MC, Le DT, de Braud F, et al. 2016 Nivolumab alone and nivolumab plus ipilimumab in recurrent small-cell lung cancer (CheckMate 032): a multicentre, open-label, phase 1/2 trial. Lancet Oncology 17 883–895. (doi:10.1016/S1470-2045(16)30098-5)
    • (2016) Lancet Oncology , vol.17 , pp. 883-895
    • Antonia, S.J.1    López-Martin, J.A.2    Bendell, J.3    Ott, P.A.4    Taylor, M.5    Eder, J.P.6    Jäger, D.7    Pietanza, M.C.8    Le, D.T.9    De Braud, F.10
  • 10
    • 84958771685 scopus 로고    scopus 로고
    • Pembrolizumab (MK-3475) plus low-dose ipilimumab (IPI) in patients (pts) with advanced melanoma (MEL) or renal cell carcinoma (RCC): Data from the KEYNOTE-029 phase 1 study
    • Atkins MB, Choueiri TK, Hodi FS, Thompson JA, Hwu WJ, McDermott DF, Brookes M, Tosolini A, Ebbinghaus S, Yang Z, et al. 2015 Pembrolizumab (MK-3475) plus low-dose ipilimumab (IPI) in patients (pts) with advanced melanoma (MEL) or renal cell carcinoma (RCC): data from the KEYNOTE-029 phase 1 study. Journal of Clinical Oncology 33 (15 Suppl) 3009 (doi:10.1200/ jco.2015.33.15_suppl.3009)
    • (2015) Journal of Clinical Oncology , vol.33 , Issue.15 , pp. 3009
    • Atkins, M.B.1    Choueiri, T.K.2    Hodi, F.S.3    Thompson, J.A.4    Hwu, W.J.5    McDermott, D.F.6    Brookes, M.7    Tosolini, A.8    Ebbinghaus, S.9    Yang, Z.10
  • 13
    • 84949095628 scopus 로고    scopus 로고
    • An ongoing phase IIIb/IV safety trial of nivolumab (NIVO) in patients (pts) with advanced or metastatic non-small-cell lung cancer (NSCLC) w.ho progressed after receiving 1 or more prior systemic regimens
    • Bauer TM, McCleod M, Chandler JC, Blumenschein GR, Schwartzberg LS, Burris H, Waterhouse D, Jotte RM, Hussein M, Spigel DR, et al. 2015 An ongoing phase IIIb/IV safety trial of nivolumab (NIVO) in patients (pts) with advanced or metastatic non-small-cell lung cancer (NSCLC) w.ho progressed after receiving 1 or more prior systemic regimens. Journal of Clinical Oncology 33 (15 Suppl) 3013 (doi:10.1200/jco.2015.33.15_suppl.3013)
    • (2015) Journal of Clinical Oncology , vol.33 , Issue.15 , pp. 3013
    • Bauer, T.M.1    McCleod, M.2    Chandler, J.C.3    Blumenschein, G.R.4    Schwartzberg, L.S.5    Burris, H.6    Waterhouse, D.7    Jotte, R.M.8    Hussein, M.9    Spigel, D.R.10
  • 17
    • 84994104553 scopus 로고    scopus 로고
    • Molecular and biochemical aspects of the PD-1 checkpoint pathway
    • Boussiotis VA 2016 Molecular and biochemical aspects of the PD-1 checkpoint pathway. New England Journal of Medicine 375 1767–1778. (doi:10.1056/NEJMra1514296)
    • (2016) New England Journal of Medicine , vol.375 , pp. 1767-1778
    • Boussiotis, V.A.1
  • 19
  • 22
    • 65549114676 scopus 로고    scopus 로고
    • Specificity and affinity of human fcgamma receptors and their polymorphic variants for human IgG subclasses
    • Bruhns P, Iannascoli B, England P, Mancardi DA, Fernandez N, Jorieux S & Daëron M 2009 Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses. Blood 113 3716–3725. (doi:10.1182/blood-2008-09-179754)
    • (2009) Blood , vol.113 , pp. 3716-3725
    • Bruhns, P.1    Iannascoli, B.2    England, P.3    Mancardi, D.A.4    Fernandez, N.5    Jorieux, S.6    Daëron, M.7
  • 23
    • 85009968823 scopus 로고    scopus 로고
    • Cancer immunotherapy – immune checkpoint blockade and associated endocrinopathies
    • Byun DJ, Wolchok JD, Rosenberg LM & Girotra M 2017 Cancer immunotherapy – immune checkpoint blockade and associated endocrinopathies. Nature Reviews Endocrinology 13 195–207. (doi:10.1038/nrendo.2016.205)
    • (2017) Nature Reviews Endocrinology , vol.13 , pp. 195-207
    • Byun, D.J.1    Wolchok, J.D.2    Rosenberg, L.M.3    Girotra, M.4
  • 24
    • 84926418972 scopus 로고    scopus 로고
    • Efficacy and safety of an intensified schedule of tremelimumab for chemotherapy-resistant malignant mesothelioma: An open-label, single-arm, phase 2 study
    • Calabrò L, Morra A, Fonsatti E, Cutaia O, Fazio C, Annesi D, Lenoci M, Amato G, Danielli R, Altomonte M, et al. 2015 Efficacy and safety of an intensified schedule of tremelimumab for chemotherapy-resistant malignant mesothelioma: an open-label, single-arm, phase 2 study. Lancet Respiratory Medicine 3 301–309. (doi:10.1016/S2213-2600(15)00092-2)
    • (2015) Lancet Respiratory Medicine , vol.3 , pp. 301-309
    • Calabrò, L.1    Morra, A.2    Fonsatti, E.3    Cutaia, O.4    Fazio, C.5    Annesi, D.6    Lenoci, M.7    Amato, G.8    Danielli, R.9    Altomonte, M.10
  • 26
    • 84937850601 scopus 로고    scopus 로고
    • Steroid responsive encephalopathy associated with autoimmune thyroiditis following ipilimumab therapy: A case report
    • Carl D, Grüllich C, Hering S & Schabet M 2015 Steroid responsive encephalopathy associated with autoimmune thyroiditis following ipilimumab therapy: a case report. BMC Research Notes 8 316. (doi:10.1186/s13104-015-1283-9)
    • (2015) BMC Research Notes , vol.8 , pp. 316
    • Carl, D.1    Grüllich, C.2    Hering, S.3    Schabet, M.4
  • 27
    • 84871192340 scopus 로고    scopus 로고
    • Molecular pathways: Next generation immunotherapy: Inhibiting programmed death-ligand 1 and programmed death-1
    • Chen DS, Irving BA & Hodi FS 2012 Molecular pathways: next generation immunotherapy: inhibiting programmed death-ligand 1 and programmed death-1. Clinical Cancer Research 18 6580–6587. (doi:10.1158/1078-0432.CCR-12-1362)
    • (2012) Clinical Cancer Research , vol.18 , pp. 6580-6587
    • Chen, D.S.1    Irving, B.A.2    Hodi, F.S.3
  • 30
    • 77955292303 scopus 로고    scopus 로고
    • Phase II study of the anti-cytotoxic T-lymphocyte-associated antigen 4 monoclonal antibody, tremelimumab, in patients with refractory metastatic colorectal cancer
    • Chung KY, Gore I, Fong L, Venook A, Beck SB, Dorazio P, Criscitiello PJ, Healey DI, Huang B, Gomez-Navarro J, et al. 2010 Phase II study of the anti-cytotoxic T-lymphocyte-associated antigen 4 monoclonal antibody, tremelimumab, in patients with refractory metastatic colorectal cancer. Journal of Clinical Oncology 28 3485–3490. (doi:10.1200/JCO.2010.28.3994)
    • (2010) Journal of Clinical Oncology , vol.28 , pp. 3485-3490
    • Chung, K.Y.1    Gore, I.2    Fong, L.3    Venook, A.4    Beck, S.B.5    Dorazio, P.6    Criscitiello, P.J.7    Healey, D.I.8    Huang, B.9    Gomez-Navarro, J.10
  • 35
    • 84937690774 scopus 로고    scopus 로고
    • Avelumab (MSB0010718C), an anti-PD-L1 antibody, in patients with previously treated, recurrent or refractory ovarian cancer: A phase ib, open-label expansion trial
    • Disis ML, Patel MR, Pant S, Infante JR, Lockhart AC, Kelly K, Beck JT, Gordon MS Weiss GJ, Ejadi S, et al. 2015 Avelumab (MSB0010718C), an anti-PD-L1 antibody, in patients with previously treated, recurrent or refractory ovarian cancer: a phase Ib, open-label expansion trial. Journal of Clinical Oncology 33 (15 Suppl) 5509 (doi:10.1200/jco.2015.33.15_suppl.5509)
    • (2015) Journal of Clinical Oncology , vol.33 , Issue.15 , pp. 5509
    • Disis, M.L.1    Patel, M.R.2    Pant, S.3    Infante, J.R.4    Lockhart, A.C.5    Kelly, K.6    Beck, J.T.7    Gordon, M.S.8    Weiss, G.J.9    Ejadi, S.10
  • 36
    • 77949274549 scopus 로고    scopus 로고
    • Anti-CTLA-4 antibody therapy associated autoimmune hypophysitis: Serious immune related adverse events across a spectrum of cancer subtypes
    • Dillard T, Yedinak CG, Alumkal J & Fleseriu M 2010 Anti-CTLA-4 antibody therapy associated autoimmune hypophysitis: serious immune related adverse events across a spectrum of cancer subtypes. Pituitary 13 29–38. (doi:10.1007/s11102-009-0193-z)
    • (2010) Pituitary , vol.13 , pp. 29-38
    • Dillard, T.1    Yedinak, C.G.2    Alumkal, J.3    Fleseriu, M.4
  • 37
    • 84937067786 scopus 로고    scopus 로고
    • Pembrolizumab (MK-3475) for patients (pts) with advanced esophageal carcinoma: Preliminary results from KEYNOTE-028
    • Doi T, Piha-Paul SA, Jalal SI, Mai-Dang H, Yuan S, Koshiji M, Csiki I & Bennouna J 2015 Pembrolizumab (MK-3475) for patients (pts) with advanced esophageal carcinoma: Preliminary results from KEYNOTE-028. Journal of Clinical Oncology 33 (3 Suppl) 4010 (doi:10.1200/jco.2015.33.3_suppl.774)
    • (2015) Journal of Clinical Oncology , vol.33 , Issue.3 , pp. 4010
    • Doi, T.1    Piha-Paul, S.A.2    Jalal, S.I.3    Mai-Dang, H.4    Yuan, S.5    Koshiji, M.6    Csiki, I.7    Bennouna, J.8
  • 41
    • 85018660134 scopus 로고    scopus 로고
    • Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): An open-label, non-comparative, phase 1/2 dose escalation and expansion trial
    • El-Khoueiry AB, Sangro B, Yau T, Crocenzi TS, Kudo M, Hsu C, Kim TY, Choo SP, Trojan J, Welling TH, et al. 2017 Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial. Lancet 389 2492–2502. (doi:10.1016/S0140-6736(17)31046-2)
    • (2017) Lancet , vol.389 , pp. 2492-2502
    • El-Khoueiry, A.B.1    Sangro, B.2    Yau, T.3    Crocenzi, T.S.4    Kudo, M.5    Hsu, C.6    Kim, T.Y.7    Choo, S.P.8    Trojan, J.9    Welling, T.H.10
  • 42
    • 84954389695 scopus 로고    scopus 로고
    • Immunotherapy and hypophysitis: Clinical presentation, treatment, and biologic insights
    • Faje A 2016 Immunotherapy and hypophysitis: clinical presentation, treatment, and biologic insights. Pituitary 19 82–92. (doi:10.1007/ s11102-015-0671-4)
    • (2016) Pituitary , vol.19 , pp. 82-92
    • Faje, A.1
  • 45
    • 77953747963 scopus 로고    scopus 로고
    • The PD-1 pathway in tolerance and autoimmunity
    • Francisco LM, Sage PT & Sharpe AH 2010 The PD-1 pathway in tolerance and autoimmunity. Immunological Reviews 236 219–242. (doi:10.1111/j.1600-065X.2010.00923.x)
    • (2010) Immunological Reviews , vol.236 , pp. 219-242
    • Francisco, L.M.1    Sage, P.T.2    Sharpe, A.H.3
  • 46
    • 85013762676 scopus 로고    scopus 로고
    • Treatment of the immune-related adverse effects of immune checkpoint inhibitors: A review
    • Friedman CF, Proverbs-Singh TA & Postow MA 2016 Treatment of the immune-related adverse effects of immune checkpoint inhibitors: a review. JAMA Oncology 2 1346–1353. (doi:10.1001/ jamaoncol.2016.1051)
    • (2016) JAMA Oncology , vol.2 , pp. 1346-1353
    • Friedman, C.F.1    Proverbs-Singh, T.A.2    Postow, M.A.3
  • 48
    • 0024424859 scopus 로고
    • The IgG subclass pattern of complement activation depends on epitope density and antibody and complement concentration
    • Garred P, Michaelsen TE & Aase A 1989 The IgG subclass pattern of complement activation depends on epitope density and antibody and complement concentration. Scandinavian Journal of Immunology 30 379–382. (doi:10.1111/j.1365-3083.1989.tb01225.x)
    • (1989) Scandinavian Journal of Immunology , vol.30 , pp. 379-382
    • Garred, P.1    Michaelsen, T.E.2    Aase, A.3
  • 49
    • 84947439090 scopus 로고    scopus 로고
    • First-line monotherapy with nivolumab (NIVO; anti-programmed death-1 [PD-1]) in advanced non-small cell lung cancer (NSCLC): Safety, efficacy and correlation of outcomes with PD-1 ligand (PD-L1) expression
    • Gettinger SN, Hellmann MD, Shepherd FA, Antonia SJ, Brahmer JR, Chow LQM, Goldman JW, Juergens RA, Borghaei H, Ready N, et al. 2015 First-line monotherapy with nivolumab (NIVO; anti-programmed death-1 [PD-1]) in advanced non-small cell lung cancer (NSCLC): safety, efficacy and correlation of outcomes with PD-1 ligand (PD-L1) expression. Journal of Clinical Oncology 33 (15 Suppl) 8025. (doi:10.1200/jco.2015.33.15_suppl.8025)
    • (2015) Journal of Clinical Oncology , vol.33 , Issue.15 , pp. 8025
    • Gettinger, S.N.1    Hellmann, M.D.2    Shepherd, F.A.3    Antonia, S.J.4    Brahmer, J.R.5    Chow, L.Q.M.6    Goldman, J.W.7    Juergens, R.A.8    Borghaei, H.9    Ready, N.10
  • 50
    • 84978523049 scopus 로고    scopus 로고
    • Immune checkpoint inhibitors: Review and management of endocrine adverse events
    • González-Rodríguez E, Rodríguez-Abreu D & Spanish Group for Cancer Immuno-Biotherapy (GETICA) 2016 Immune checkpoint inhibitors: review and management of endocrine adverse events. Oncologist 21 804–816. (doi:10.1634/theoncologist.2015-0509)
    • (2016) Oncologist , vol.21 , pp. 804-816
    • González-Rodríguez, E.1    Rodríguez-Abreu, D.2
  • 51
    • 84944751040 scopus 로고    scopus 로고
    • Avelumab (MSB0010718C), an anti-PD-L1 antibody, in advanced NSCLC patients: A phase 1b, open-label expansion trial in patients progressing after platinum-based chemotherapy
    • Gulley JL, Spigel D, Kelly K, Chandler JC, Rajan A, Hassan R, Wong DJL, Leach J, Edenfield WJ, Wang D, et al. 2015 Avelumab (MSB0010718C), an anti-PD-L1 antibody, in advanced NSCLC patients: a phase 1b, open-label expansion trial in patients progressing after platinum-based chemotherapy. Journal of Clinical Oncology 33 (15 Suppl) 8034. (doi:10.1200/jco.2015.33.15_ suppl.8034)
    • (2015) Journal of Clinical Oncology , vol.33 , Issue.15 , pp. 8034
    • Gulley, J.L.1    Spigel, D.2    Kelly, K.3    Chandler, J.C.4    Rajan, A.5    Hassan, R.6    Wong, D.J.L.7    Leach, J.8    Edenfield, W.J.9    Wang, D.10
  • 54
    • 84965020158 scopus 로고    scopus 로고
    • CheckMate 214: A phase III, randomized, open-label study of nivolumab combined with ipilimumab versus sunitinib monotherapy in patients with previously untreated metastatic renal cell carcinoma
    • Hammers HJ, Plimack ER, Sternberg C, McDermott DF, Larkin JMG, Ravaud A, Rini BI, Sharma P, Bhagavatheeswaran P, Gagnier P, et al. 2015 CheckMate 214: a phase III, randomized, open-label study of nivolumab combined with ipilimumab versus sunitinib monotherapy in patients with previously untreated metastatic renal cell carcinoma. Journal of Clinical Oncology 33 (15 Suppl) TPS4578 (doi:10.1200/jco.2015.33.15_suppl.tps4578)
    • (2015) Journal of Clinical Oncology , vol.33 , Issue.15 , pp. TPS4578
    • Hammers, H.J.1    Plimack, E.R.2    Sternberg, C.3    McDermott, D.F.4    Larkin, J.M.G.5    Ravaud, A.6    Rini, B.I.7    Sharma, P.8    Bhagavatheeswaran, P.9    Gagnier, P.10
  • 56
    • 85007425840 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab as first-line treatment for advanced non-small-cell lung cancer (CheckMate 012): Results of an open-label, phase 1, multicohort study
    • Hellmann MD, Rizvi NA, Goldman JW, Gettinger SN, Borghaei H, Brahmer JR, Ready NE, Gerber DE, Chow LQ, Juergens RA, et al. 2017 Nivolumab plus ipilimumab as first-line treatment for advanced non-small-cell lung cancer (CheckMate 012): results of an open-label, phase 1, multicohort study. Lancet Oncology 18 31–41. (doi:10.1016/S1470-2045(16)30624-6)
    • (2017) Lancet Oncology , vol.18 , pp. 31-41
    • Hellmann, M.D.1    Rizvi, N.A.2    Goldman, J.W.3    Gettinger, S.N.4    Borghaei, H.5    Brahmer, J.R.6    Ready, N.E.7    Gerber, D.E.8    Chow, L.Q.9    Juergens, R.A.10
  • 57
    • 84899782496 scopus 로고    scopus 로고
    • A case report of orbital inflammatory syndrome secondary to ipilimumab
    • Henderson AD & Thomas DA 2015 A case report of orbital inflammatory syndrome secondary to ipilimumab. Ophthalmic Plastic and Reconstructive Surgery 31 68–70. (doi:10.1097/IOP.0000000000000081)
    • (2015) Ophthalmic Plastic and Reconstructive Surgery , vol.31 , pp. 68-70
    • Henderson, A.D.1    Thomas, D.A.2
  • 62
    • 84941783535 scopus 로고    scopus 로고
    • Clinical response, progression-free survival (PFS), and safety in patients (pts) with advanced melanoma (MEL) receiving nivolumab (NIVO) combined with ipilimumab (IPI) vs IPI monotherapy in CheckMate 069 study
    • Hodi FS, Postow MA, Chesney JA, Pavlick AC, Robert C, Grossmann KF, McDermott DF, Linette GP, Meyer N, Giguere JK, et al. 2015 Clinical response, progression-free survival (PFS), and safety in patients (pts) with advanced melanoma (MEL) receiving nivolumab (NIVO) combined with ipilimumab (IPI) vs IPI monotherapy in CheckMate 069 study. Journal of Clinical Oncology 33 (15 Suppl) 9004. (doi:10.1200/jco.2015.33.15_suppl.9004)
    • (2015) Journal of Clinical Oncology , vol.33 , Issue.15 , pp. 9004
    • Hodi, F.S.1    Postow, M.A.2    Chesney, J.A.3    Pavlick, A.C.4    Robert, C.5    Grossmann, K.F.6    McDermott, D.F.7    Linette, G.P.8    Meyer, N.9    Giguere, J.K.10
  • 63
    • 84944261579 scopus 로고    scopus 로고
    • Immune-related adverse events, need for systemic immunosuppression, and effects on survival and time to treatment failure in patients with melanoma treated with ipilimumab at memorial sloan kettering cancer center
    • Horvat TZ, Adel NG, Dang TO, Momtaz P, Postow MA, Callahan MK, Carvajal RD, Dickson MA, D’Angelo SP, Woo KM, et al. 2015 Immune-related adverse events, need for systemic immunosuppression, and effects on survival and time to treatment failure in patients with melanoma treated with ipilimumab at memorial sloan kettering cancer center. Journal of Clinical Oncology 33 3193–3198. (doi:10.1200/JCO.2015.60.8448)
    • (2015) Journal of Clinical Oncology , vol.33 , pp. 3193-3198
    • Horvat, T.Z.1    Adel, N.G.2    Dang, T.O.3    Momtaz, P.4    Postow, M.A.5    Callahan, M.K.6    Carvajal, R.D.7    Dickson, M.A.8    D’Angelo, S.P.9    Woo, K.M.10
  • 65
    • 85026410910 scopus 로고    scopus 로고
    • Phase i study to evaluate the safety and tolerability of MEDI4736, an anti-programmed cell death ligand-1 (PD-L1) antibody, in Japanese patients with advanced solid tumors
    • Iguchi H, Nogami N, Kozuki T, Matsumoto T, Tamura K, Yamamoto N, Shimomura A, Hoshino Y, Michibata Y, Nii M, et al. 2015 Phase I study to evaluate the safety and tolerability of MEDI4736, an anti-programmed cell death ligand-1 (PD-L1) antibody, in Japanese patients with advanced solid tumors. Journal of Clinical Oncology 33 (15 Suppl) 3039. (doi:10.1200/jco.2015.33.15_suppl.3039)
    • (2015) Journal of Clinical Oncology , vol.33 , Issue.15 , pp. 3039
    • Iguchi, H.1    Nogami, N.2    Kozuki, T.3    Matsumoto, T.4    Tamura, K.5    Yamamoto, N.6    Shimomura, A.7    Hoshino, Y.8    Michibata, Y.9    Nii, M.10
  • 66
    • 84899071058 scopus 로고    scopus 로고
    • Pituitary expression of CTLA-4 mediates hypophysitis secondary to administration of CTLA-4 blocking antibody
    • Iwama S, De Remigis A, Callahan MK, Slovin SF, Wolchok JD & Caturegli P 2014 Pituitary expression of CTLA-4 mediates hypophysitis secondary to administration of CTLA-4 blocking antibody. Science Translational Medicine 6 230ra245. (doi:10.1126/ scitranslmed.3008002)
    • (2014) Science Translational Medicine , vol.6 , pp. 230ra245
    • Iwama, S.1    De Remigis, A.2    Callahan, M.K.3    Slovin, S.F.4    Wolchok, J.D.5    Caturegli, P.6
  • 67
    • 84982124780 scopus 로고    scopus 로고
    • Immune checkpoint inhibitor-related hypophysitis and endocrine dysfunction: Clinical review
    • Joshi MN, Whitelaw BC, Palomar MT, Wu Y & Carroll PV 2016 Immune checkpoint inhibitor-related hypophysitis and endocrine dysfunction: clinical review. Clinical Endocrinology 85 331–339. (doi:10.1111/cen.13063)
    • (2016) Clinical Endocrinology , vol.85 , pp. 331-339
    • Joshi, M.N.1    Whitelaw, B.C.2    Palomar, M.T.3    Wu, Y.4    Carroll, P.V.5
  • 69
    • 84951764509 scopus 로고    scopus 로고
    • Avelumab (MSB0010718C), an anti-PD-L1 antibody, in patients with metastatic or locally advanced solid tumors: Assessment of safety and tolerability in a phase i, open-label expansion study
    • Kelly K, Patel MR, Infante JR, Iannotti N, Nikolinakos P, Leach J, Wang D, Chandler JC, Jerusalem GHM, Gurtler JS, et al. 2015 Avelumab (MSB0010718C), an anti-PD-L1 antibody, in patients with metastatic or locally advanced solid tumors: assessment of safety and tolerability in a phase I, open-label expansion study. Journal of Clinical Oncology 33 (15 Suppl) 3044. (doi:10.1200/jco.2015.33.15_ suppl.3044)
    • (2015) Journal of Clinical Oncology , vol.33 , Issue.15 , pp. 3044
    • Kelly, K.1    Patel, M.R.2    Infante, J.R.3    Iannotti, N.4    Nikolinakos, P.5    Leach, J.6    Wang, D.7    Chandler, J.C.8    Jerusalem, G.H.M.9    Gurtler, J.S.10
  • 70
    • 84991693168 scopus 로고    scopus 로고
    • Tremelimumab as second- or third-line treatment of unresectable malignant mesothelioma (MM): Results from the global, double-blind, placebo-controlled determine study
    • Kindler HL, Scherpereel A, Calabrò L, Aerts J, Perez SC, Bearz A, Nackaerts K, Fennell DA, Kowalski D, Tsao AS, et al. 2016 Tremelimumab as second- or third-line treatment of unresectable malignant mesothelioma (MM): results from the global, double-blind, placebo-controlled determine study. Journal of Clinical Oncology 34 (15 Suppl) 8502. (doi:10.1200/JCO.2016.34.15_ suppl.8502)
    • (2016) Journal of Clinical Oncology , vol.34 , Issue.15 , pp. 8502
    • Kindler, H.L.1    Scherpereel, A.2    Calabrò, L.3    Aerts, J.4    Perez, S.C.5    Bearz, A.6    Nackaerts, K.7    Fennell, D.A.8    Kowalski, D.9    Tsao, A.S.10
  • 72
  • 73
    • 84964778827 scopus 로고    scopus 로고
    • Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
    • Klocke K, Sakaguchi S, Holmdahl R & Wing K 2016 Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood. PNAS 113 E2383–E2392. (doi:10.1073/pnas.1603892113)
    • (2016) PNAS , vol.113 , pp. E2383-E2392
    • Klocke, K.1    Sakaguchi, S.2    Holmdahl, R.3    Wing, K.4
  • 74
    • 77950258677 scopus 로고    scopus 로고
    • Single-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting: Lymphocyte count after 2 doses correlates with survival
    • Ku GY, Yuan J, Page DB, Schroeder SE, Panageas KS, Carvajal RD, Chapman PB, Schwartz GK, Allison JP & Wolchok JD 2010 Single-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting: lymphocyte count after 2 doses correlates with survival. Cancer 116 1767–1775. (doi:10.1002/ cncr.24951)
    • (2010) Cancer , vol.116 , pp. 1767-1775
    • Ku, G.Y.1    Yuan, J.2    Page, D.B.3    Schroeder, S.E.4    Panageas, K.S.5    Carvajal, R.D.6    Chapman, P.B.7    Schwartz, G.K.8    Allison, J.P.9    Wolchok, J.D.10
  • 76
    • 85014218501 scopus 로고    scopus 로고
    • Current diagnosis and management of immune related adverse events (irAEs) induced by immune checkpoint inhibitor therapy
    • Kumar V, Chaudhary N, Garg M, Floudas CS, Soni P & Chandra AB 2017 Current diagnosis and management of immune related adverse events (irAEs) induced by immune checkpoint inhibitor therapy. Frontiers in Pharmacology 8 49. (doi:10.3389/fphar.2017.00049)
    • (2017) Frontiers in Pharmacology , vol.8 , pp. 49
    • Kumar, V.1    Chaudhary, N.2    Garg, M.3    Floudas, C.S.4    Soni, P.5    Chandra, A.B.6
  • 77
    • 84901641673 scopus 로고    scopus 로고
    • Ipilimumab versus placebo after radiotherapy in patientswith metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): A multicentre, randomised, double-blind, phase 3 trial
    • Kwon ED, Drake CG, Scher HI, Fizazi K, Bossi A, van den Eertwegh AJ, Krainer M, Houede N, Santos R, Mahammedi H, et al. 2014 Ipilimumab versus placebo after radiotherapy in patientswith metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial. Lancet Oncology 15 700–712. (doi:10.1016/S1470-2045(14)70189-5)
    • (2014) Lancet Oncology , vol.15 , pp. 700-712
    • Kwon, E.D.1    Drake, C.G.2    Scher, H.I.3    Fizazi, K.4    Bossi, A.5    Van Den Eertwegh, A.J.6    Krainer, M.7    Houede, N.8    Santos, R.9    Mahammedi, H.10
  • 82
    • 85010809728 scopus 로고    scopus 로고
    • Prognostic significance of cutaneous adverse events associated with pembrolizumab therapy
    • Lo JA, Fisher DE & Flaherty KT 2015 Prognostic significance of cutaneous adverse events associated with pembrolizumab therapy. JAMA Oncology 1 1340–1341. (doi:10.1001/jamaoncol.2015.2274)
    • (2015) JAMA Oncology , vol.1 , pp. 1340-1341
    • Lo, J.A.1    Fisher, D.E.2    Flaherty, K.T.3
  • 85
    • 84863911486 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: Results from a randomized, double-blind, multicenter phase II study
    • Lynch TJ, Bondarenko I, Luft A, Serwatowski P, Barlesi F, Chacko R, Sebastian M, Neal J, Lu H, Cuillerot JM, et al. 2012 Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study. Journal of Clinical Oncology 30 2046–2054. (doi:10.1200/JCO.2011.38.4032)
    • (2012) Journal of Clinical Oncology , vol.30 , pp. 2046-2054
    • Lynch, T.J.1    Bondarenko, I.2    Luft, A.3    Serwatowski, P.4    Barlesi, F.5    Chacko, R.6    Sebastian, M.7    Neal, J.8    Lu, H.9    Cuillerot, J.M.10
  • 88
    • 84908611245 scopus 로고    scopus 로고
    • Thyroid-like ophthalmopathy in a euthyroid patient receiving ipilimumab
    • McElnea E, Ní Mhéalóid A, Moran S, Kelly R & Fulcher T 2014 Thyroid-like ophthalmopathy in a euthyroid patient receiving Ipilimumab. Orbit 33 424–427. (doi:10.3109/01676830.2014.949792)
    • (2014) Orbit , vol.33 , pp. 424-427
    • McElnea, E.1    Ní Mhéalóid, A.2    Moran, S.3    Kelly, R.4    Fulcher, T.5
  • 89
    • 0026016571 scopus 로고
    • Human IgG subclass pattern of inducing complement-mediated cytolysis depends on antigen concentration and to a lesser extent on epitope patchiness, antibody affinity and complement concentration
    • Michaelsen TE, Garred P & Aase A 1991 Human IgG subclass pattern of inducing complement-mediated cytolysis depends on antigen concentration and to a lesser extent on epitope patchiness, antibody affinity and complement concentration. European Journal of Immunology 21 11–16. (doi:10.1002/eji.1830210103)
    • (1991) European Journal of Immunology , vol.21 , pp. 11-16
    • Michaelsen, T.E.1    Garred, P.2    Aase, A.3
  • 91
    • 84907996539 scopus 로고    scopus 로고
    • Anti-PD1 following ipilimumab for mucosal melanoma: Durable tumor response associated with severe hypothyroidism and rhabdomyolysis
    • Min L & Hodi FS 2014 Anti-PD1 following ipilimumab for mucosal melanoma: durable tumor response associated with severe hypothyroidism and rhabdomyolysis. Cancer Immunology Research 2 15–18. (doi:10.1158/2326-6066.CIR-13-0146)
    • (2014) Cancer Immunology Research , vol.2 , pp. 15-18
    • Min, L.1    Hodi, F.S.2
  • 92
    • 78751559991 scopus 로고    scopus 로고
    • Thyroid autoimmunity and ophthalmopathy related to melanoma biological therapy
    • Min L, Vaidya A & Becker C 2011 Thyroid autoimmunity and ophthalmopathy related to melanoma biological therapy. European Journal of Endocrinology 164 303–307. (doi:10.1530/EJE-10-0833)
    • (2011) European Journal of Endocrinology , vol.164 , pp. 303-307
    • Min, L.1    Vaidya, A.2    Becker, C.3
  • 93
    • 84923186196 scopus 로고    scopus 로고
    • Systemic high-dose corticosteroid treatment does not improve the outcome of ipilimumab-related hypophysitis: A retrospective cohort study
    • Min L, Hodi FS, Giobbie-Hurder A, Ott PA, Luke JJ, Donahue H, Davis M, Carroll RS & Kaiser UB 2015 Systemic high-dose corticosteroid treatment does not improve the outcome of ipilimumab-related hypophysitis: a retrospective cohort study. Clinical Cancer Research 21 749–755. (doi:10.1158/1078-0432.CCR-14-2353)
    • (2015) Clinical Cancer Research , vol.21 , pp. 749-755
    • Min, L.1    Hodi, F.S.2    Giobbie-Hurder, A.3    Ott, P.A.4    Luke, J.J.5    Donahue, H.6    Davis, M.7    Carroll, R.S.8    Kaiser, U.B.9
  • 97
    • 84947428286 scopus 로고    scopus 로고
    • Phase II studies of nivolumab (anti-PD-1, BMS-936558, ONO-4538) in patients with advanced squamous (sq) or nonsquamous (non-sq) non-small cell lung cancer (NSCLC)
    • Nishio M, Hida T, Nakagawa K, Sakai H, Nogami N, Atagi S, Takahashi T, Nokihara H, Saka H, Takenoyama M, et al. 2015 Phase II studies of nivolumab (anti-PD-1, BMS-936558, ONO-4538) in patients with advanced squamous (sq) or nonsquamous (non-sq) non-small cell lung cancer (NSCLC). Journal of Clinical Oncology 33 (15 Suppl) 8027. (doi:10.1200/jco.2015.33.15_suppl.8027)
    • (2015) Journal of Clinical Oncology , vol.33 , Issue.15 , pp. 8027
    • Nishio, M.1    Hida, T.2    Nakagawa, K.3    Sakai, H.4    Nogami, N.5    Atagi, S.6    Takahashi, T.7    Nokihara, H.8    Saka, H.9    Takenoyama, M.10
  • 100
    • 84939548996 scopus 로고    scopus 로고
    • Pembrolizumab (MK-3475) in patients (pts) with extensive-stage small cell lung cancer (SCLC): Preliminary safety and efficacy results from KEYNOTE-028
    • Ott PA, Fernandez MEE, Hiret S, Kim DW, Moss RA, Winser T, Yuan S, Cheng JD, Piperdi B & Mehnert JM 2015 Pembrolizumab (MK-3475) in patients (pts) with extensive-stage small cell lung cancer (SCLC): preliminary safety and efficacy results from KEYNOTE-028. Journal of Clinical Oncology 33 (15 Suppl) 7502. (doi:10.1200/jco.2015.33.15_ suppl.7502)
    • (2015) Journal of Clinical Oncology , vol.33 , Issue.15 , pp. 7502
    • Ott, P.A.1    Fernandez, M.E.E.2    Hiret, S.3    Kim, D.W.4    Moss, R.A.5    Winser, T.6    Yuan, S.7    Cheng, J.D.8    Piperdi, B.9    Mehnert, J.M.10
  • 101
    • 84929347192 scopus 로고    scopus 로고
    • Induction of painless thyroiditis in patients receiving programmed death 1 receptor immunotherapy for metastatic malignancies
    • Orlov S, Salari F, Kashat L & Walfish PG 2015 Induction of painless thyroiditis in patients receiving programmed death 1 receptor immunotherapy for metastatic malignancies. Journal of Clinical Endocrinology and Metabolism 100 1738–1741. (doi:10.1210/jc.2014-4560)
    • (2015) Journal of Clinical Endocrinology and Metabolism , vol.100 , pp. 1738-1741
    • Orlov, S.1    Salari, F.2    Kashat, L.3    Walfish, P.G.4
  • 103
    • 84942138310 scopus 로고    scopus 로고
    • Phase 1 study of pembrolizumab (pembro; MK-3475) plus ipilimumab (IPI) as second-line therapy for advanced non-small cell lung cancer (NSCLC): KEYNOTE-021 cohort d
    • Patnaik A, Socinski MA, Gubens MA, Gandhi L, Stevenson J, Bachman RD, Bourque J, Ge JY, Im E & Gadgeel SM 2015 Phase 1 study of pembrolizumab (pembro; MK-3475) plus ipilimumab (IPI) as second-line therapy for advanced non-small cell lung cancer (NSCLC): KEYNOTE-021 cohort D. Journal of Clinical Oncology 33 (15 Suppl) 8011. (doi:10.1200/jco.2015.33.15_suppl.8011)
    • (2015) Journal of Clinical Oncology , vol.33 , Issue.15 , pp. 8011
    • Patnaik, A.1    Socinski, M.A.2    Gubens, M.A.3    Gandhi, L.4    Stevenson, J.5    Bachman, R.D.6    Bourque, J.7    Ge, J.Y.8    Im, E.9    Gadgeel, S.M.10
  • 104
    • 84931424042 scopus 로고    scopus 로고
    • Phase III, randomized trial (CheckMate 057) of nivolumab (NIVO) versus docetaxel (DOC) in advanced non-squamous cell (non-SQ) non-small cell lung cancer (NSCLC)
    • Paz-Ares L, Horn L, Borghaei H, Spigel DR, Steins M, Ready N, Chow LQM, Vokes EE, Felip E, Holgado E, et al. 2015 Phase III, randomized trial (CheckMate 057) of nivolumab (NIVO) versus docetaxel (DOC) in advanced non-squamous cell (non-SQ) non-small cell lung cancer (NSCLC). Journal of Clinical Oncology 33 (18 Suppl) LBA109. (doi:10.1200/jco.2015.33.18_suppl.lba109)
    • (2015) Journal of Clinical Oncology , vol.33 , Issue.18 , pp. LBA109
    • Paz-Ares, L.1    Horn, L.2    Borghaei, H.3    Spigel, D.R.4    Steins, M.5    Ready, N.6    Chow, L.Q.M.7    Vokes, E.E.8    Felip, E.9    Holgado, E.10
  • 111
    • 77649136167 scopus 로고    scopus 로고
    • Modulation of lymphocyte regulation for cancer therapy: A phaseII trial of tremelimumab in advanced gastric and esophageal adenocarcinoma
    • Ralph C, Elkord E, Burt DJ, O’Dwyer JF, Austin EB, Stern PL, Hawkins RE & Thistlethwaite FC 2010 Modulation of lymphocyte regulation for cancer therapy: a phaseII trial of tremelimumab in advanced gastric and esophageal adenocarcinoma. Clinical Cancer Research 16 1662–1672. (doi:10.1158/1078-0432.CCR-09-2870)
    • (2010) Clinical Cancer Research , vol.16 , pp. 1662-1672
    • Ralph, C.1    Elkord, E.2    Burt, D.J.3    O’Dwyer, J.F.4    Austin, E.B.5    Stern, P.L.6    Hawkins, R.E.7    Thistlethwaite, F.C.8
  • 112
    • 84871532643 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: Results from a randomized, double-blind, multicenter phase 2 trial
    • Reck M, Bondarenko I, Luft A, Serwatowski P, Barlesi F, Chacko R, Sebastian M, Lu H, Cuillerot JM & Lynch TJ 2013 Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: results from a randomized, double-blind, multicenter phase 2 trial. Annals of Oncology 24 75–83. (doi:10.1093/annonc/mds213)
    • (2013) Annals of Oncology , vol.24 , pp. 75-83
    • Reck, M.1    Bondarenko, I.2    Luft, A.3    Serwatowski, P.4    Barlesi, F.5    Chacko, R.6    Sebastian, M.7    Lu, H.8    Cuillerot, J.M.9    Lynch, T.J.10
  • 117
    • 84938205998 scopus 로고    scopus 로고
    • Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): A randomised, controlled, phase 2 trial
    • Ribas A, Puzanov I, Dummer R, Schadendorf D, Hamid O, Robert C, Hodi FS, Schachter J, Pavlick AC, Lewis KD, et al. 2015 Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial. Lancet Oncology 16 908–918. (doi:10.1016/ S1470-2045(15)00083-2)
    • (2015) Lancet Oncology , vol.16 , pp. 908-918
    • Ribas, A.1    Puzanov, I.2    Dummer, R.3    Schadendorf, D.4    Hamid, O.5    Robert, C.6    Hodi, F.S.7    Schachter, J.8    Pavlick, A.C.9    Lewis, K.D.10
  • 119
    • 84944734156 scopus 로고    scopus 로고
    • Safety and clinical activity of MEDI4736, an anti-programmed cell death-ligand 1 (PD-L1) antibody, in patients with non-small cell lung cancer (NSCLC)
    • Rizvi NA, Brahmer JR, Ou S-HI, Segal NH, Khleif S, Hwu W-J, Gutierrez M, Schoffski P, Hamid O, Weiss J, et al. 2015a Safety and clinical activity of MEDI4736, an anti-programmed cell death-ligand 1 (PD-L1) antibody, in patients with non-small cell lung cancer (NSCLC). Journal of Clinical Oncology 33 (15 Suppl) 8032. (doi:10.1200/jco.2015.33.15_suppl.8032)
    • (2015) Journal of Clinical Oncology , vol.33 , Issue.15 , pp. 8032
    • Rizvi, N.A.1    Brahmer, J.R.2    Ou, S.-H.I.3    Segal, N.H.4    Khleif, S.5    Hwu, W.-J.6    Gutierrez, M.7    Schoffski, P.8    Hamid, O.9    Weiss, J.10
  • 120
    • 84924901863 scopus 로고    scopus 로고
    • Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): A phase 2, single-arm trial
    • Rizvi NA, Mazières J, Planchard D, Stinchcombe TE, Dy GK, Antonia SJ, Horn L, Lena H, Minenza E, Mennecier B, et al. 2015b Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial. Lancet Oncology 16 257–265. (doi:10.1016/S1470-2045(15)70054-9)
    • (2015) Lancet Oncology , vol.16 , pp. 257-265
    • Rizvi, N.A.1    Mazières, J.2    Planchard, D.3    Stinchcombe, T.E.4    Dy, G.K.5    Antonia, S.J.6    Horn, L.7    Lena, H.8    Minenza, E.9    Mennecier, B.10
  • 121
    • 84908354848 scopus 로고    scopus 로고
    • Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: A randomised dose-comparison cohort of a phase 1 trial
    • Robert C, Ribas A, Wolchok JD, Hodi FS, Hamid O, Kefford R, Weber JS, Joshua AM, Hwu WJ, Gangadhar TC, et al. 2014 Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial. Lancet 384 1109–1117. (doi:10.1016/S0140-6736(14)60958-2)
    • (2014) Lancet , vol.384 , pp. 1109-1117
    • Robert, C.1    Ribas, A.2    Wolchok, J.D.3    Hodi, F.S.4    Hamid, O.5    Kefford, R.6    Weber, J.S.7    Joshua, A.M.8    Hwu, W.J.9    Gangadhar, T.C.10
  • 125
    • 84959577118 scopus 로고    scopus 로고
    • Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: A single-arm, multicentre, phase 2 trial
    • Rosenberg JE, Hoffman-Censits J, Powles T, van der Heijden MS, Balar AV, Necchi A, Dawson N, O’Donnell PH, Balmanoukian A, Loriot Y, et al. 2016 Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. Lancet 387 1909–1920. (doi:10.1016/ S0140-6736(16)00561-4)
    • (2016) Lancet , vol.387 , pp. 1909-1920
    • Rosenberg, J.E.1    Hoffman-Censits, J.2    Powles, T.3    Van Der Heijden, M.S.4    Balar, A.V.5    Necchi, A.6    Dawson, N.7    O’Donnell, P.H.8    Balmanoukian, A.9    Loriot, Y.10
  • 128
    • 84899873585 scopus 로고    scopus 로고
    • Endocrine-related adverse events following ipilimumab in patients with advanced melanoma: A comprehensive retrospective review from a single institution
    • Ryder M, Callahan M, Postow MA, Wolchok J & Fagin JA 2014 Endocrine-related adverse events following ipilimumab in patients with advanced melanoma: a comprehensive retrospective review from a single institution. Endocrine-Related Cancer 21 371–381. (doi:10.1530/ERC-13-0499)
    • (2014) Endocrine-Related Cancer , vol.21 , pp. 371-381
    • Ryder, M.1    Callahan, M.2    Postow, M.A.3    Wolchok, J.4    Fagin, J.A.5
  • 130
    • 79951831113 scopus 로고    scopus 로고
    • Extended dose ipilimumab with a peptide vaccine: Immune correlates associated with clinical benefit in patients with resected high-risk stage IIIc/IV melanoma
    • Sarnaik AA, Yu B, Yu D, Morelli D, Hall M, Bogle D, Yan L, Targan S, Solomon J, Nichol G, et al. 2011 Extended dose ipilimumab with a peptide vaccine: immune correlates associated with clinical benefit in patients with resected high-risk stage IIIc/IV melanoma. Clinical Cancer Research 17 896–906. (doi:10.1158/1078-0432.CCR-10-2463)
    • (2011) Clinical Cancer Research , vol.17 , pp. 896-906
    • Sarnaik, A.A.1    Yu, B.2    Yu, D.3    Morelli, D.4    Hall, M.5    Bogle, D.6    Yan, L.7    Targan, S.8    Solomon, J.9    Nichol, G.10
  • 133
  • 134
    • 84969988424 scopus 로고    scopus 로고
    • Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): An open-label, multicentre, phase 1b trial
    • Seiwert TY, Burtness B, Mehra R, Weiss J, Berger R, Eder JP, Heath K, McClanahan T, Lunceford J, Gause C, et al. 2016 Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial. Lancet Oncology 17 956–965. (doi:10.1016/S1470-2045(16)30066-3)
    • (2016) Lancet Oncology , vol.17 , pp. 956-965
    • Seiwert, T.Y.1    Burtness, B.2    Mehra, R.3    Weiss, J.4    Berger, R.5    Eder, J.P.6    Heath, K.7    McClanahan, T.8    Lunceford, J.9    Gause, C.10
  • 135
    • 84922021366 scopus 로고    scopus 로고
    • Immune-priming of the tumor microenvironment by radiotherapy: Rationale for combination with immunotherapy to improve anticancer efficacy
    • Shahabi V, Postow MA, Tuck D & Wolchok JD 2015 Immune-priming of the tumor microenvironment by radiotherapy: rationale for combination with immunotherapy to improve anticancer efficacy. American Journal of Clinical Oncology 38 90–97. (doi:10.1097/ COC.0b013e3182868ec8)
    • (2015) American Journal of Clinical Oncology , vol.38 , pp. 90-97
    • Shahabi, V.1    Postow, M.A.2    Tuck, D.3    Wolchok, J.D.4
  • 136
    • 84978537012 scopus 로고    scopus 로고
    • Phase i, open-label, multi-ascending dose trial of avelumab (MSB0010718C), an anti-PD-L1 monoclonal antibody, in Japanese patients with advanced solid tumors
    • Shitara K, Yamada Y, Yoh K, Naito Y, Iwasa S, Yamamoto N, Heydebreck Av, Achiwa H & Doi T 2015 Phase I, open-label, multi-ascending dose trial of avelumab (MSB0010718C), an anti-PD-L1 monoclonal antibody, in Japanese patients with advanced solid tumors. Journal of Clinical Oncology 33 (15 Suppl) 3023. (doi:10.1200/ jco.2015.33.15_suppl.3023)
    • (2015) Journal of Clinical Oncology , vol.33 , Issue.15 , pp. 3023
    • Shitara, K.1    Yamada, Y.2    Yoh, K.3    Naito, Y.4    Iwasa, S.5    Yamamoto, N.6    Av, H.7    Achiwa, H.8    Doi, T.9
  • 137
    • 84880709088 scopus 로고    scopus 로고
    • Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC)
    • Spigel DR, Gettinger SN, Horn L, Herbst RS, Gandhi L, Gordon MS, Cruz C, Conkling P, Cassier PA, Antonia SJ, et al. 2013 Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC). Journal of Clinical Oncology 31 (15 Suppl) 8008. (doi:10.1200/jco.2013.31.15_suppl.8008)
    • (2013) Journal of Clinical Oncology , vol.31 , Issue.15 , pp. 8008
    • Spigel, D.R.1    Gettinger, S.N.2    Horn, L.3    Herbst, R.S.4    Gandhi, L.5    Gordon, M.S.6    Cruz, C.7    Conkling, P.8    Cassier, P.A.9    Antonia, S.J.10
  • 138
    • 84880508629 scopus 로고    scopus 로고
    • Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: Results from an open-label, multicenter phase i/II study
    • Slovin SF, Higano CS, Hamid O, Tejwani S, Harzstark A, Alumkal JJ, Scher HI, Chin K, Gagnier P, McHenry MB, et al. 2013 Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: results from an open-label, multicenter phase I/II study. Annals of Oncology 24 1813–1821. (doi:10.1093/ annonc/mdt107)
    • (2013) Annals of Oncology , vol.24 , pp. 1813-1821
    • Slovin, S.F.1    Higano, C.S.2    Hamid, O.3    Tejwani, S.4    Harzstark, A.5    Alumkal, J.J.6    Scher, H.I.7    Chin, K.8    Gagnier, P.9    McHenry, M.B.10
  • 141
    • 0242636366 scopus 로고    scopus 로고
    • Ocular immune privilege: Therapeutic opportunities from an experiment of nature
    • Streilein JW 2003 Ocular immune privilege: therapeutic opportunities from an experiment of nature. Nature Reviews Immunology 3 879–889. (doi:10.1038/nri1224)
    • (2003) Nature Reviews Immunology , vol.3 , pp. 879-889
    • Streilein, J.W.1
  • 143
    • 84925326818 scopus 로고    scopus 로고
    • Vitiligo-like depigmentation in patients with stage III-IV melanoma receiving immunotherapy and its association with survival: A systematic review and meta-analysis
    • Teulings H-E, Limpens J, Jansen SN, Zwinderman AH, Reitsma JB, Spuls PI & Luiten RM 2015 Vitiligo-like depigmentation in patients with stage III-IV melanoma receiving immunotherapy and its association with survival: a systematic review and meta-analysis. Journal of Clinical Oncology 33 773–781. (doi:10.1200/ JCO.2014.57.4756)
    • (2015) Journal of Clinical Oncology , vol.33 , pp. 773-781
    • Teulings, H.-E.1    Limpens, J.2    Jansen, S.N.3    Zwinderman, A.H.4    Reitsma, J.B.5    Spuls, P.I.6    Luiten, R.M.7
  • 147
    • 85027919782 scopus 로고    scopus 로고
    • Detection of early onset of hypophysitis by (18)F-FDG PET-CT in a patient with advanced stage melanoma treated with ipilimumab
    • van der Hiel B, Blank CU, Haanen JB & Stokkel MP 2013 Detection of early onset of hypophysitis by (18)F-FDG PET-CT in a patient with advanced stage melanoma treated with ipilimumab. Clinical Nuclear Medicine 38 e182–e184. (doi:10.1097/RLU.0b013e3182639765)
    • (2013) Clinical Nuclear Medicine , vol.38 , pp. e182-e184
    • Van Der Hiel, B.1    Blank, C.U.2    Haanen, J.B.3    Stokkel, M.P.4
  • 149
    • 84918825382 scopus 로고    scopus 로고
    • IgG subclasses and allotypes: From structure to effector functions
    • Vidarsson G, Dekkers G & Rispens T 2014 IgG subclasses and allotypes: from structure to effector functions. Frontiers in Immunology 5 520. (doi:10.3389/fimmu.2014.00520)
    • (2014) Frontiers in Immunology , vol.5 , pp. 520
    • Vidarsson, G.1    Dekkers, G.2    Rispens, T.3
  • 150
    • 61349114199 scopus 로고    scopus 로고
    • Ipilimumab: Controversies in its development, utility and autoimmune adverse events
    • Weber J 2009 Ipilimumab: controversies in its development, utility and autoimmune adverse events. Cancer Immunology, Immunotherapy 58 823–830. (doi:10.1007/s00262-008-0653-8)
    • (2009) Cancer Immunology, Immunotherapy , vol.58 , pp. 823-830
    • Weber, J.1
  • 152
    • 69949095926 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumabadministered with or without prophylactic budesonide in patients with unresectable stage III or IV melanoma
    • Weber J, Thompson JA, Hamid O, Minor D, Amin A, Ron I, Ridolfi R, Assi H, Maraveyas A, Berman D, et al. 2009 A randomized, double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumabadministered with or without prophylactic budesonide in patients with unresectable stage III or IV melanoma. Clinical Cancer Research 15 5591–5598. (doi:10.1158/1078-0432.CCR-09-1024)
    • (2009) Clinical Cancer Research , vol.15 , pp. 5591-5598
    • Weber, J.1    Thompson, J.A.2    Hamid, O.3    Minor, D.4    Amin, A.5    Ron, I.6    Ridolfi, R.7    Assi, H.8    Maraveyas, A.9    Berman, D.10
  • 154
    • 84931083080 scopus 로고    scopus 로고
    • Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): A randomised, controlled, open-label, phase 3 trial
    • Weber JS, D’Angelo SP, Minor D, Hodi FS, Gutzmer R, Neyns B, Hoeller C, Khushalani NI, Miller WH, Lao CD, et al. 2015a Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial. Lancet Oncology 16 375–384. (doi:10.1016/S1470-2045(15)70076-8)
    • (2015) Lancet Oncology , vol.16 , pp. 375-384
    • Weber, J.S.1    D’Angelo, S.P.2    Minor, D.3    Hodi, F.S.4    Gutzmer, R.5    Neyns, B.6    Hoeller, C.7    Khushalani, N.I.8    Miller, W.H.9    Lao, C.D.10
  • 157
    • 85016744413 scopus 로고    scopus 로고
    • Acute symptomatic hypocalcemia from immune checkpoint therapy-induced hypoparathyroidism
    • Win MA, Thein KZ, Qdaisat A & Yeung SJ 2017 Acute symptomatic hypocalcemia from immune checkpoint therapy-induced hypoparathyroidism. American Journal of Emergency Medicine 35 1039. e5–1039.e7. (doi:10.1016/j.ajem.2017.02.048)
    • (2017) American Journal of Emergency Medicine , vol.35 , pp. 1039e5-1039e7
    • Win, M.A.1    Thein, K.Z.2    Qdaisat, A.3    Yeung, S.J.4
  • 158
    • 75249100054 scopus 로고    scopus 로고
    • Ipilimumab monotherapy in patients with pretreated advanced melanoma: A randomised, double-blind, multicentre, phase 2, dose-ranging study
    • Wolchok JD, Neyns B, Linette G, Negrier S, Lutzky J, Thomas L, Waterfield W, Schadendorf D, Smylie M, Guthrie T, et al. 2010 Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study. Lancet Oncology 11 155–164. (doi:10.1016/S1470-2045(09)70334-1)
    • (2010) Lancet Oncology , vol.11 , pp. 155-164
    • Wolchok, J.D.1    Neyns, B.2    Linette, G.3    Negrier, S.4    Lutzky, J.5    Thomas, L.6    Waterfield, W.7    Schadendorf, D.8    Smylie, M.9    Guthrie, T.10
  • 160
    • 84977645542 scopus 로고    scopus 로고
    • A phase i dose expansion trial of avelumab (MSB0010718C), an anti-PD-L1 antibody, in Japanese patients with advanced gastric cancer
    • Yamada Y, Nishina T, Iwasa S, Shitara K, Muro K, Esaki T, Hironaka S, Yamaguchi K, Machida N, Satoh T, et al. 2015 A phase I dose expansion trial of avelumab (MSB0010718C), an anti-PD-L1 antibody, in Japanese patients with advanced gastric cancer. Journal of Clinical Oncology 33 (15 Suppl) 4047. (doi:10.1200/jco.2015.33.15_ suppl.4047)
    • (2015) Journal of Clinical Oncology , vol.33 , Issue.15 , pp. 4047
    • Yamada, Y.1    Nishina, T.2    Iwasa, S.3    Shitara, K.4    Muro, K.5    Esaki, T.6    Hironaka, S.7    Yamaguchi, K.8    Machida, N.9    Satoh, T.10
  • 162
    • 84930179528 scopus 로고    scopus 로고
    • Ipilimumab-associated bilateral optic neuropathy
    • Yeh OL & Francis CE 2015 Ipilimumab-associated bilateral optic neuropathy. Journal of Neuro-Ophthalmology 35 144–147. (doi:10.1097/WNO.0000000000000217)
    • (2015) Journal of Neuro-Ophthalmology , vol.35 , pp. 144-147
    • Yeh, O.L.1    Francis, C.E.2


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