Interleukin-22 drives nitric oxide-dependent DNA damage and dysplasia in a murine model of colitis-associated cancer

Mucosal Immunology

Volumn 10, Issue 6, 2017, Pages 1504-1517

  Wang, C ^a   Gong, G ^b   Sheh, A ^a   Muthupalani, S ^a   Bryant, E M ^a   Puglisi, D A ^a   Holcombe, H ^a   Conaway, E A ^c   Parry, N A P ^a   Bakthavatchalu, V ^a   Short, S P ^d   Williams, C S ^b   Wogan, G N ^b   Tannenbaum, S R ^b   Fox, J G ^a,b   Horwitz, B H ^c  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Massachusetts Institute of Technology   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 22; NITRIC OXIDE; STAT3 PROTEIN; BLOCKING ANTIBODY; DNA BINDING PROTEIN; INTERLEUKIN DERIVATIVE; INTERLEUKIN-22; RAG2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; COLITIS; COLON CANCER; COLON CARCINOGENESIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA DAMAGE; DNA STRAND BREAKAGE; DYSBIOSIS; ENZYME ACTIVITY; FEMALE; GASTROINTESTINAL DYSPLASIA; HELICOBACTER HEPATICUS; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; 129 MOUSE; ANIMAL; COLON; COLON TUMOR; COMPLICATION; DISEASE MODEL; DOUBLE STRANDED DNA BREAK; GENETICS; HELICOBACTER INFECTION; HUMAN; IMMUNOLOGY; INFLAMMATION; KNOCKOUT MOUSE; METABOLISM; MICROBIOLOGY; NEOPLASM; PATHOLOGY; PATHOPHYSIOLOGY; PERITONEUM MACROPHAGE; ULCERATIVE COLITIS;

ANIMALS; ANTIBODIES, BLOCKING; COLITIS, ULCERATIVE; COLON; COLONIC NEOPLASMS; DISEASE MODELS, ANIMAL; DNA BREAKS, DOUBLE-STRANDED; DNA-BINDING PROTEINS; HELICOBACTER HEPATICUS; HELICOBACTER INFECTIONS; HUMANS; INFLAMMATION; INTERLEUKINS; MACROPHAGES, PERITONEAL; MICE; MICE, 129 STRAIN; MICE, KNOCKOUT; NEOPLASMS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II;

EID: 85029178176     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2017.9     Document Type: Article

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