Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

Nature Medicine

Volumn 23, Issue 11, 2017, Pages 1362-1368

  Romero, Rodrigo ^a   Sayin, Volkan I ^b   Davidson, Shawn M ^a   Bauer, Matthew R ^a   Singh, Simranjit X ^b   Leboeuf, Sarah E ^b   Karakousi, Triantafyllia R ^b   Ellis, Donald C ^a   Bhutkar, Arjun ^a   Sánchez Rivera, Francisco J ^a   Subbaraj, Lakshmipriya ^a   Martinez, Britney ^b   Bronson, Roderick T ^c,d   Prigge, Justin R ^e   Schmidt, Edward E ^e   Thomas, Craig J ^f   Goparaju, Chandra ^g   Davies, Angela ^h   Dolgalev, Igor ^b   Heguy, Adriana ^b   Allaj, Viola ⁱ   Poirier, John T ⁱ   Moreira, Andre L ^b   Rudin, Charles M ⁱ   Pass, Harvey I ^g   Vander Heiden, Matthew G ^a   Jacks, Tyler ^a,j   Papagiannakopoulos, Thales ^b,g   more..

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c TUFTS UNIVERSITY   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e MONTANA STATE UNIVERSITY   (United States)

^f NATIONAL INSTITUTES OF HEALTH   (United States)

^g NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^h Champions Oncology   (United States)

ⁱ MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^j HOWARD HUGHES MEDICAL INSTITUTE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMINASE; K RAS PROTEIN; KELCH LIKE ECH ASSOCIATED PROTEIN 1; TRANSCRIPTION FACTOR NRF2; GLUTAMINE; KEAP1 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CONTROLLED STUDY; CRISPR-CAS9 SYSTEM; ENZYME INHIBITION; FEMALE; GENE MUTATION; GENETIC SCREENING; GLUTAMINOLYSIS; HUMAN; HUMAN CELL; LUNG CANCER; LUNG CARCINOGENESIS; LYSIS; MALE; METABOLOMICS; MOUSE; NONHUMAN; ONCOGENE K RAS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEPLETION; ADENOCARCINOMA; ANIMAL; ANTAGONISTS AND INHIBITORS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; GENETICS; HYDROLYSIS; LUNG TUMOR; METABOLISM; ONCOGENE RAS; PATHOLOGY;

ADENOCARCINOMA; ANIMALS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; GENES, RAS; GLUTAMINASE; GLUTAMINE; HUMANS; HYDROLYSIS; KELCH-LIKE ECH-ASSOCIATED PROTEIN 1; LUNG NEOPLASMS; MICE;

EID: 85032896356     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4407     Document Type: Article

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